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51

Synthesis and Biological Evaluation of an N10-Psec Substituted Pyrrolo[2,1-c][1,4]benzodiazepine Prodrug.

Jane M. Berry, Philip W. Howard, Lloyd R. Kelland, David E. Thurston

Journal:

Year:

2002

File:

PDF, 31 KB

2002

52

Synthesis of Novel C2-Aryl Pyrrolobenzodiazepines (PBDs) as Potential Antitumor Agents.

Nectaroula Cooper, David R. Hagan, Arnaud Tiberghien, Temitope Ademefun, Charles S. Matthews, Philip W. Howard, David E. Thurston

Journal:

Year:

2002

File:

PDF, 31 KB

2002

53

Synthesis of the First Examples of A-C8/C-C2 Amide-Linked Pyrrolo[2,1-c][1,4]benzodiazepine Dimers.

Stephen J. Gregson, Philip W. Howard, David E. Thurston

Journal:

Year:

2003

Language:

english

File:

PDF, 169 KB

english, 2003

54

Design and Synthesis of Two Cytotoxic Analogues of the Novel Pyrrolo[1′,2′:1,2][1,4]diazepin[7,6-b]indol-5(6H)-one Nucleus.

Andrew Tsotinis, Margarita Vlachou, Konstantinos Kiakos, John A. Hartley, David E. Thurston

Journal:

Year:

2003

File:

PDF, 117 KB

2003

55

Synthesis of a Novel C2-Aryl Substituted 1,2-Unsaturated Pyrrolobenzodiazepine.

Gyoung-Dong Kang, Philip W. Howard, David E. Thurston

Journal:

Year:

2003

File:

PDF, 159 KB

2003

56

Synthesis and Biological Evaluation of Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 Cyclic Amine Conjugates.

Luke A. Masterson, Stephen J. Croker, Terence C. Jenkins, Philip W. Howard, David E. Thurston

Journal:

Year:

2004

File:

PDF, 128 KB

2004

57

A Novel Approach to the Synthesis of Cytotoxic C2—C3 Unsaturated Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) with Conjugated Acrylyl C2-Substituents.

Zhizhi Chen, Stephen J. Gregson, Philip W. Howard, David E. Thurston

Journal:

Year:

2004

File:

PDF, 193 KB

2004

58

Application of the Stille Coupling Reaction to the Synthesis of C2-Substituted endo—exo Unsaturated Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs).

Arnaud C. Tiberghien, David Hagan, Philip W. Howard, David E. Thurston

Journal:

Year:

2005

File:

PDF, 22 KB

2005

59

ChemInform Abstract: Facile Oxidation of Electron-Poor Benzo[b]thiophenes to the Corresponding Sulfones with an Aqueous Solution of H2O2 and P2O5.

Dyeison Antonow, Teresa Marrafa, Irfaan Dawood, Tauheed Ahmed, Mohammad R. Haque, David E. Thurston, Giovanni Zinzalla

Journal:

Year:

2010

File:

PDF, 49 KB

2010

60

ChemInform Abstract: Synthesis of DNA-Interactive Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs)

Dyeison Antonow, David E. Thurston

Journal:

Year:

2011

File:

PDF, 18 KB

2011

61

ChemInform Abstract: One-Pot Synthesis of Fused-Tetracyclic Scaffolds Employing a Lewis Acid Promoted Domino Reaction of Naphthoquinones.

Yassine Bendiabdellah, Isabel Villanueva-Margalef, Antonio Misale, Kazi S. Nahar, Mohammad R. Haque, David E. Thurston, Giovanna Zinzalla

Journal:

Year:

2011

File:

PDF, 38 KB

2011

62

Expression of a novel tropomyosin isoform in axolotl heart and skeletal muscle

Anish Thomas, Sudarsan Rajan, Harold L. Thurston, Sreeharsha N. Masineni, Preeti Dube, Abhishek Bose, Vasundhara Muthu, Syamalima Dube, David F. Wieczorek, Bernard J. Poiesz, Dipak K. Dube

Journal:

Journal of Cellular Biochemistry

Year:

2010

Language:

english

File:

PDF, 405 KB

english, 2010

63

Studies on the stability of vinblastine sulfate in aqueous solution

Jimmy Black, Douglas D. Buechter, John W. Chinn, John Gard, David E. Thurston

Journal:

Journal of Pharmaceutical Sciences

Year:

1988

Language:

english

File:

PDF, 647 KB

english, 1988

64

Studies on the stability of trimelamol, a carbinolamine-containing antitumor drug

Claire Jackson, Trevor A. Crabb, Mark Gibson, Russell Godfrey, Richard Saunders, David E. Thurston

Journal:

Journal of Pharmaceutical Sciences

Year:

1991

Language:

english

File:

PDF, 806 KB

english, 1991

65

Design and synthesis of a novel epoxide-containing pyrrolo[2,1-c][1,4]benzodiazepine (PBD) via a new cyclization procedure

Stuart C. Wilson, Philip W. Howard, David E. Thurston

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 192 KB

english, 1995

66

Application of the Stille coupling reaction to the synthesis of C2-substituted endo–exo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs)

Arnaud C. Tiberghien, David Hagan, Philip W. Howard, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 273 KB

english, 2004

67

Synthesis of a novel C2/C2′-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate

Philip W. Howard, Zhizhi Chen, Stephen J. Gregson, Luke A. Masterson, Arnaud C. Tiberghien, Nectaroula Cooper, Min Fang, Marissa J. Coffils, Sarah Klee, John A. Hartley, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 277 KB

english, 2009

68

Design of a hardware preprocessor for the ‘DIAS’ multilevel picture information system

Nikolas G. Bourbakis, David F. Thurston

Journal:

Journal of Microcomputer Applications

Year:

1989

Language:

english

File:

PDF, 1.23 MB

english, 1989

69

Analytical modeling of the performance of a distributed multiprocessor system architecture

Nikolaos G. Bourbakis, David Thurston

Journal:

Journal of Microcomputer Applications

Year:

1992

Language:

english

File:

PDF, 797 KB

english, 1992

70

An assay combining high-performance liquid chromatography and mass spectrometry to measure DNA interstrand cross-linking efficiency in oligonucleotides of varying sequences

Mathangi Narayanaswamy, William J. Griffiths, Philip W. Howard, David E. Thurston

Journal:

Analytical Biochemistry

Year:

2008

Language:

english

File:

PDF, 556 KB

english, 2008

71

Synthesis of a novel C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione library: Effect of C2-aryl substitution on cytotoxicity and non-covalent DNA binding

Dyeison Antonow, Terence C. Jenkins, Philip W. Howard, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 348 KB

english, 2007

72

Synthesis and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 cyclic amine conjugates

Luke A. Masterson, Stephen J. Croker, Terence C. Jenkins, Philip W. Howard, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 173 KB

english, 2004

73

A novel approach to the synthesis of cytotoxic C2–C3 unsaturated pyrrolo[2,1-c]benzodiazepines (PBDs) with conjugated acrylyl C2-substituents

Zhizhi Chen, Stephen J. Gregson, Philip W. Howard, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 158 KB

english, 2004

74

Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: Synthesis, DNA interaction, cytotoxicity and differential cellular localization

Geoffrey Wells, Marie Suggitt, Marissa Coffils, Mirza A.H. Baig, Philip W. Howard, Paul M. Loadman, John A. Hartley, Terence C. Jenkins, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 212 KB

english, 2008

75

An asymmetric C8/C8′-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs

Arnaud C. Tiberghien, David A. Evans, Konstantinos Kiakos, Christopher R.H. Martin, John A. Hartley, David E. Thurston, Philip W. Howard

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 575 KB

english, 2008

76

Novel C8-linked pyrrolobenzodiazepine (PBD)–heterocycle conjugates that recognize DNA sequences containing an inverted CCAAT box

Federico Brucoli, Rachel M. Hawkins, Colin H. James, Geoff Wells, Terence C. Jenkins, Tom Ellis, John A. Hartley, Philip W. Howard, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 488 KB

english, 2011

77

Direct liquid chromatography determination of the reactive imine SJG-136 (NSC 694501)

Andrew Cheung, Elaine Struble, Jingyi He, Chun Yang, Euphemia Wang, David E. Thurston, Paul Liu

Journal:

Journal of Chromatography B

Year:

2005

Language:

english

File:

PDF, 377 KB

english, 2005

78

New approaches to pyrrolo[2,1-c][1,4]benzodiazepines: synthesis, DNA-binding and cytotoxicity of DC-81

D. Subhas Bose, Gary B. Jones, David E. Thurston

Journal:

Year:

1992

Language:

english

File:

PDF, 652 KB

english, 1992

79

Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine antibiotics: Oxidation of cyclic secondary amine with TPAP

Ahmed Kamal, Philip W Howard, B.S Narayan Reddy, B.S Praveen Reddy, David E Thurston

Journal:

Year:

1997

Language:

english

File:

PDF, 384 KB

english, 1997

80

A new convenient procedure for the synthesis of pyrrolo[2,1-c][l,4]benzodiazepines

Stephen M. Courtney, David E. Thurston

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 135 KB

english, 1993

81

Sn(III)Cl2-induced regiospecific opening of the 1,3-benzodioxole ring system: A route to the novel DNA-interactive, ligand) iso-DC-81

D.Subhas Bose, David E. Thurston

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 175 KB

english, 1993

82

Boron trifluoride promoted cleavage of benzyl carbamates

D. Subhas Bose, David E. Thurston

Journal:

Tetrahedron Letters

Year:

1990

Language:

english

File:

PDF, 210 KB

english, 1990

83

Limitations and factors affecting the lactam reduction approach to the synthesis of anthramycin analogs

David E. Thurston, Pravin T.P. Kaumaya, Laurence H. Hurley

Journal:

Tetrahedron Letters

Year:

1984

Language:

english

File:

PDF, 275 KB

english, 1984

84

Reaction of pyrrolo[2,1-c][1,4]benzodiazepine-2,5,11-triones with phosphorus oxychloride

Ahmed Kamal, David E. Thurston

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 139 KB

english, 1989

85

Equivalence of regression calibration methods in main study/external validation study designs

Sally W. Thurston, Donna Spiegelman, David Ruppert

Journal:

Journal of Statistical Planning and Inference

Year:

2003

Language:

english

File:

PDF, 155 KB

english, 2003

86

Utility of crown ethers derived from methyl β-d-galactopyranoside and their lanthanide couples as chiral NMR discriminating agents

Thomas J. Wenzel, Jolene E. Thurston, David C. Sek, Jean-Pierre Joly

Journal:

Tetrahedron: Asymmetry

Year:

2001

Language:

english

File:

PDF, 113 KB

english, 2001

87

Effect of C2/C3-endo unsaturation on the cytotoxicity and dna-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines

Stephen J. Gregson, Philip W. Howard, Simona Barcella, Anthonia Nakamya, Terence C. Jenkins, Lloyd R. Kelland, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 165 KB

english, 2000

88

Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines

Stephen J. Gregson, Philip W. Howard, Kathryn E. Corcoran, Simona Barcella, Maqsood M. Yasin, Abigail A. Hurst, Terence C. Jenkins, Lloyd R. Kelland, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 158 KB

english, 2000

89

Design and synthesis of novel pyrrolobenzodiazepine (PBD) prodrugs for ADEPT and GDEPT

Marina J Sagnou, Philip W Howard, Stephen J Gregson, Ebun Eno-Amooquaye, Philip J Burke, David E Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 176 KB

english, 2000

90

Synthesis of the first example of a c2-C3/C2′-C3′-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimer

Stephen J Gregson, Philip W Howard, Kathryn E Corcoran, Terence C Jenkins, Lloyd R Kelland, David E Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 130 KB

english, 2001

91

Synthesis and antimicrobial activity of 5-thioabbeymycin: limitations of the iminothioether approach to carbinolamine-containing pyrrolobenzodiazepines

Ahmed Kamal, B.S. Praveen Reddy, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 239 KB

english, 1993

92

Synthesis of the first examples of A-C8/C-C2 amide-Linked pyrrolo[2,1-c][1,4]benzodiazepine dimers

Stephen J. Gregson, Philip W. Howard, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 160 KB

english, 2003

93

Synthesis of novel C7-aryl substituted pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) via pro-N10-troc protection and Suzuki coupling

Andrea Guiotto, Philip W. Howard, Pier Giovanni Baraldi, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 142 KB

english, 1998

94

Design, synthesis and biological activity of a pyrrolo [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid

Pier Giovanni Baraldi, Barbara Cacciari, Andrea Guiotto, Alberto Leoni, Romeo Romagnoli, Giampiero Spalluto, Nicola Mongelli, Philip W. Howard, David E. Thurston, Nicoletta Bianchi, Roberto Gambari

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 305 KB

english, 1998

95

Cleavage of DNA by brown algal polyphenols

Gerald Blunden, Janet Currie, David E. Thurston

Journal:

Journal of Applied Phycology

Year:

1994

Language:

english

File:

PDF, 266 KB

english, 1994

96

Transcriptional regulation of laccase and cellulase in relation to fruit body formation in the mycelium ofLentinula edodeson a sawdust-based substrate

Shoji Ohga, Nam-Seok Cho, Christopher F. Thurston, David A. Wood

Journal:

Year:

2000

Language:

english

File:

PDF, 461 KB

english, 2000

97

Characteristics and N-terminal amino acid sequence of manganese peroxidase from solid substrate cultures ofAgaricus bisporus

V. Pauliina Lankinen, Alice M. Bonnen, Lori H. Anton, David A. Wood, Nisse Kalkkinen, Annele Hatakka, Christopher F. Thurston

Journal:

Applied Microbiology and Biotechnology

Year:

2001

Language:

english

File:

PDF, 101 KB

english, 2001

98

Characteristics and N-terminal amino acid sequence of manganese peroxidase from solid substrate cultures ofAgaricus bisporus

Pauliina V. Lankinen, Alice M. Bonnen, Lori H. Anton, David A. Wood, Nisse Kalkkinen, Annele Hatakka, Christopher F. Thurston

Journal:

Applied Microbiology and Biotechnology

Year:

2001

Language:

english

File:

PDF, 11 KB

english, 2001

99

Pharmacokinetics, pharmacodynamics and metabolism of the dimeric pyrrolobenzodiazepine SJG-136 in rats

Joel M. Reid, Sarah A. Buhrow, Mary J. Kuffel, Lee Jia, Victoria J. Spanswick, John A. Hartley, David E. Thurston, Joseph E. Tomaszewski, Matthew M. Ames

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2011

Language:

english

File:

PDF, 436 KB

english, 2011

100

Synthesis and biological evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy

Luke A. Masterson, Victoria J. Spanswick, John A. Hartley, Richard H. Begent, Philip W. Howard, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 133 KB

english, 2006