H.-G. Holzhütter: search on Z-Library

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51

Mathematical modelling of metabolic pathways affected by an enzyme deficiency : Energy and redox metabolism of glucose-6-phosphate-dehydrogenase-deficient erythrocytes

Ronny SCHUSTER, Gisela JACOBASCH, Hermann-Georg HOLZHÜTTER

Journal:

Year:

1989

Language:

english

File:

PDF, 683 KB

english, 1989

52

Mathematical analysis of enzymic reaction systems using optimization principles

Reinhart HEINRICH, Stefan SCHUSTER, Hermann-Georg HOLZHÜTTER

Journal:

Year:

1991

Language:

english

File:

PDF, 2.09 MB

english, 1991

53

Use of Mathematical Models for Predicting the Metabolic Effect of Large-Scale Enzyme Activity Alterations : Application to Enzyme Deficiencies of Red Blood Cells

Ronny Schuster, Hermann-Georg Holzhütter

Journal:

Year:

1995

Language:

english

File:

PDF, 1.50 MB

english, 1995

54

A Kinetic Model for the Interaction of Nitric Oxide with a Mammalian Lipoxygenase

Hermann-Georg Holzhütter, Rainer Wiesner, Jörg Rathmann, Reinhard Stösser, Hartmut Kühn

Journal:

Year:

1997

Language:

english

File:

PDF, 927 KB

english, 1997

55

A theoretical approach towards the identification of cleavage-determining amino acid motifs of the 20s proteasome

Hermann-Georg Holzhütter, Cornelius Frömmel, Peter-Michael Kloetzel

Journal:

Journal of Molecular Biology

Year:

1999

Language:

english

File:

PDF, 359 KB

english, 1999

56

A mathematical model to study short-term regulation of mitochondrial energy transduction

Hermann-Georg Holzhütter, Wolfgang Henke, Wolfgang Dubiel, Gerhard Gerber

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

1985

Language:

english

File:

PDF, 1.14 MB

english, 1985

57

Nitric oxide oxidises a ferrous mammalian lipoxygenase to a pre-activated ferric species

Rainer Wiesner, Jörg Rathmann, Hermann-Georg Holzhütter, Reinhard Stöβer, Karsten Mäder, Hans Nolting, Hartmut Kühn

Journal:

Year:

1996

Language:

english

File:

PDF, 359 KB

english, 1996

58

Modern biostatistical methods for assessing in vitro/in vivo correlation of severely eye irritating chemicals in a validation study of in vitro alternatives to the Draize eye test

H. Spielmann, M. Liebsch, F. Moldenhauer, H.-G. Holzhutter, O. de Silva

Journal:

Toxicology in Vitro

Year:

1995

Language:

english

File:

PDF, 811 KB

english, 1995

59

Structural biology of mammalian lipoxygenases: Enzymatic consequences of targeted alterations of the protein structure

Hartmut Kuhn, Jan Saam, Sebastian Eibach, Hermann-Georg Holzhütter, Igor Ivanov, Matthias Walther

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 338 KB

english, 2005

60

Modeling the in Vitro 20S Proteasome Activity: The Effect of PA28–αβ and of the Sequence and Length of Polypeptides on the Degradation Kinetics

Michele Mishto, Fabio Luciani, Hermann-Georg Holzhütter, Elena Bellavista, Aurelia Santoro, Kathrin Textoris-Taube, Claudio Franceschi, Peter M. Kloetzel, Alexey Zaikin

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 840 KB

english, 2008

61

The proteasome inhibitor PI31 competes with PA28 for binding to 20S proteasomes

Dietmar M.W. Zaiss, Sybille Standera, Hergo Holzhütter, Peter-M. Kloetzel, Alice J.A.M. Sijts

Journal:

Year:

1999

Language:

english

File:

PDF, 302 KB

english, 1999

62

Assessment of Proteasomal Cleavage Probabilities from Kinetic Analysis of Time-dependent Product Formation

Björn Peters, Katharina Janek, Ulrike Kuckelkorn, Hermann-Georg Holzhütter

Journal:

Journal of Molecular Biology

Year:

2002

Language:

english

File:

PDF, 744 KB

english, 2002

63

Statistical planning and analysis considerations in the evaluation of in vitro alternatives to whole animal use for eye irritation testing

P. Feder, G. Carr, H.-G. Holzhütter, D. Lovell, J. Springer

Journal:

Food and Chemical Toxicology

Year:

1997

Language:

english

File:

PDF, 739 KB

english, 1997

64

IRAG Working Group 2: CAM-based assays

H. Spielmann, M. Liebsch, F. Moldenhauer, H.-G. Holzhütter, D.M. Bagley, J.M. Lipman, W.J.W. Pape, H. Miltenburger, O. de Silva, H. Hofer, W. Steiling

Journal:

Food and Chemical Toxicology

Year:

1997

Language:

english

File:

PDF, 2.35 MB

english, 1997

65

The International EU/COLIPA In Vitro Phototoxicity Validation Study: Results of Phase II (Blind Trial). Part 1: The 3T3 NRU Phototoxicity Test

H. Spielmann, M. Balls, J. Dupuis, W.J. Pape, G. Pechovitch, O. de Silva, H.-G. Holzhütter, R. Clothier, P. Desolle, F. Gerberick, M. Liebsch, W.W. Lovell, T. Maurer, U. Pfannenbecker, J.M. Potthast,

Journal:

Toxicology in Vitro

Year:

1998

Language:

english

File:

PDF, 1.32 MB

english, 1998

66

The ECVAM International Validation Study on In Vitro Tests for Skin Corrosivity. 2. Results and Evaluation by the Management Team

J.H. Fentem, G.E.B. Archer, M. Balls, P.A. Botham, R.D. Curren, L.K. Earl, D.J. Esdaile, H.-G. Holzhütter, M. Liebsch

Journal:

Toxicology in Vitro

Year:

1998

Language:

english

File:

PDF, 14.17 MB

english, 1998

67

Mathematical modelling of the purine metabolism of the rat liver

Thomas Bartel, Hermann-Georg Holzhütter

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

1990

Language:

english

File:

PDF, 659 KB

english, 1990

68

Kinetic Modeling of Human Hepatic Glucose Metabolism in Type 2 Diabetes Mellitus Predicts Higher Risk of Hypoglycemic Events in Rigorous Insulin Therapy

Konig, M., Holzhutter, H.-G.

Journal:

Journal of Biological Chemistry

Year:

2012

Language:

english

File:

PDF, 2.21 MB

english, 2012

69

A Kinetic Model of Vertebrate 20S Proteasome Accounting for the Generation of Major Proteolytic Fragments from Oligomeric Peptide Substrates

Holzhütter, Hermann-Georg, Kloetzel, Peter-Michael

Journal:

Biophysical Journal

Year:

2000

Language:

english

File:

PDF, 212 KB

english, 2000

70

Stochastic Simulation of Hemagglutinin-Mediated Fusion Pore Formation

Schreiber, Susanne, Ludwig, Kai, Herrmann, Andreas, Holzhütter, Hermann-Georg

Journal:

Biophysical Journal

Year:

2001

Language:

english

File:

PDF, 254 KB

english, 2001

71

Effects of reactive oxygen species on eicosanoid metabolism in human endothelial cells

I. Schimke, A. Griesmacher, G. Weigel, M.M. Muller, H.G. Holzhutter

Journal:

Year:

1992

Language:

english

File:

PDF, 639 KB

english, 1992

72

IGERS: Inferring Gibbs Energy Changes of Biochemical Reactions from Reaction Similarities

Rother, Kristian, Hoffmann, Sabrina, Bulik, Sascha, Hoppe, Andreas, Gasteiger, Johann, Holzhütter, Herrmann-Georg

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 529 KB

english, 2010

73

Network-based assessment of the selectivity of metabolic drug targets inPlasmodium falciparumwith respect to human liver metabolism

Susanna Bazzani, Andreas Hoppe, Hermann-Georg Holzhütter

Journal:

BMC Systems Biology

Year:

2012

Language:

english

File:

PDF, 395 KB

english, 2012

74

Oxygen consumption rates during three different neuronal activity states in the hippocampal CA3 network

Huchzermeyer, Christine, Berndt, Nikolaus, Holzhütter, Hermann-Georg, Kann, Oliver

Journal:

Journal of Cerebral Blood Flow and Metabolism

Year:

2013

Language:

english

File:

PDF, 521 KB

english, 2013

75

[Lecture Notes in Computer Science] Medical Data Analysis Volume 2868 ||

Perner, Petra, Brause, Rüdiger, Holzhütter, Hermann-Georg

Year:

2003

Language:

english

File:

PDF, 2.31 MB

english, 2003

76

Enantioselective Substrate Specificity of 15-Lipoxygenase 1 †

Ivanov, Igor, Romanov, Stepan, Ozdoba, Christopher, Holzhütter, Herrman G., Myagkova, Galina, Kuhn, Hartmut

Journal:

Year:

2004

Language:

english

File:

PDF, 249 KB

english, 2004

77

The High Energy Demand of Neuronal Cells Caused by Passive Leak Currents is Not a Waste of Energy

Nikolaus Berndt, Hermann-Georg Holzhütter

Journal:

Cell Biochemistry and Biophysics

Year:

2013

Language:

english

File:

PDF, 502 KB

english, 2013

78

Rapid degradation of solid-phase bound peptides by the 20S proteasome

Hovestädt, Marc, Kuckelkorn, Ulrike, Niewienda, Agathe, Keller, Christin, Goede, Andrean, Ay, Bernhard, Günther, Stefan, Janek, Katharina, Volkmer, Rudolf, Holzhütter, Hermann-Georg

Journal:

Journal of Peptide Science

Year:

2013

Language:

english

File:

PDF, 653 KB

english, 2013

79

Rapid Flip-Flop of Phospholipids in Endoplasmic Reticulum Membranes Studied by a Stopped-Flow Approach

Marx, Uwe, Lassmann, Günter, Holzhütter, Hermann-Georg, Wüstner, Daniel, Müller, Peter, Höhlig, Astrid, Kubelt, Janek, Herrmann, Andreas

Journal:

Biophysical Journal

Year:

2000

Language:

english

File:

PDF, 259 KB

english, 2000

80

Th-P15:248 Computational approaches towards prediction

Hübner, K., Schwager, T., Winkler, K., Reich, J.G., Holzhütter, H.G.

Journal:

Atherosclerosis Supplements

Year:

2006

Language:

english

File:

PDF, 149 KB

english, 2006

81

SEE: structured representation of scientific evidence in the biomedical domain using Semantic Web techniques

Bölling, Christian, Weidlich, Michael, Holzhütter, Hermann-Georg

Journal:

Journal of Biomedical Semantics

Year:

2014

Language:

english

File:

PDF, 1.80 MB

english, 2014

82

Metabolic gradients as key regulators in zonation of tumor energy metabolism: A tissue-scale model-based study

König, Matthias, Holzhütter, Hermann-Georg, Berndt, Nikolaus

Journal:

Biotechnology Journal

Year:

2013

Language:

english

File:

PDF, 1.54 MB

english, 2013

83

Implications of enzyme deficiencies on mitochondrial energy metabolism and reactive oxygen species formation of neurons involved in rotenone-induced Parkinson's disease: a model-based analysis

Berndt, Nikolaus, Holzhütter, Herrmann-Georg, Bulik, Sascha

Journal:

Year:

2013

Language:

english

File:

PDF, 1.03 MB

english, 2013

84

The virtual liver: state of the art and future perspectives

Drasdo, Dirk, Bode, Johannes, Dahmen, Uta, Dirsch, Olaf, Dooley, Steven, Gebhardt, Rolf, Ghallab, Ahmed, Godoy, Patricio, Häussinger, Dieter, Hammad, Seddik, Hoehme, Stefan, Holzhütter, Hermann-Georg,

Journal:

Archives of Toxicology

Year:

2014

Language:

english

File:

PDF, 186 KB

english, 2014

85

METANNOGEN: annotation of biological reaction networks

Gille, C., Hubner, K., Hoppe, A., Holzhutter, H.-G.

Journal:

Year:

2011

Language:

english

File:

PDF, 127 KB

english, 2011

86

Identification of HLA-B27-Restricted Peptides from the Chlamydia trachomatis Proteome with Possible Relevance to HLA-B27-Associated Diseases

Kuon, W., Holzhutter, H.-G., Appel, H., Grolms, M., Kollnberger, S., Traeder, A., Henklein, P., Weiss, E., Thiel, A., Lauster, R., Bowness, P., Radbruch, A., Kloetzel, P.-M., Sieper, J.

Journal:

The Journal of Immunology

Year:

2001

Language:

english

File:

PDF, 373 KB

english, 2001

87

Identifying MHC Class I Epitopes by Predicting the TAP Transport Efficiency of Epitope Precursors

Peters, B., Bulik, S., Tampe, R., van Endert, P. M., Holzhutter, H.-G.

Journal:

The Journal of Immunology

Year:

2003

Language:

english

File:

PDF, 343 KB

english, 2003

88

Quantifying the Contribution of Defective Ribosomal Products to Antigen Production: A Model-Based Computational Analysis

Bulik, S., Peters, B., Holzhutter, H.-G.

Journal:

The Journal of Immunology

Year:

2005

Language:

english

File:

PDF, 489 KB

english, 2005

89

MATHEMATICAL MODELLING OF CELLULAR RESPONSES TO EXTERNAL SIGNALS

HOLZHÜTTER, HERMANN-GEORG, QUEDENAU, JÖRN

Journal:

Journal of Biological System

Year:

1995

Language:

english

File:

PDF, 727 KB

english, 1995

90

THE POSSIBLE CONSEQUENCES OF LARGE-SCALE ENZYME ALTERATIONS ON THE METABOLIC EFFICIENCY OF RED BLOOD CELLS AS STUDIED ON THE BASIS OF A MATHEMATICAL MODEL

SCHUSTER, RONNY, HOLZHÜTTER, HERMANN-GEORG

Journal:

Journal of Biological System

Year:

1995

Language:

english

File:

PDF, 413 KB

english, 1995

91

Molecular dioxygen enters the active site of 12/15-lipoxygenase via dynamic oxygen access channels

Saam, J., Ivanov, I., Walther, M., Holzhutter, H.-G., Kuhn, H.

Journal:

Proceedings of the National Academy of Sciences

Year:

2007

Language:

english

File:

PDF, 1.70 MB

english, 2007

92

SIMFIT: a microcomputer software-toolkit for modelistic studies in biochemistry

Holzhütter, Hermann Georg, Colosimo, Alfredo

Journal:

Year:

1990

Language:

english

File:

PDF, 529 KB

english, 1990

93

Physiology-based kinetic modeling of neuronal energy metabolism unravels the molecular basis of NAD(P)H fluorescence transients

Berndt, Nikolaus, Kann, Oliver, Holzhütter, Hermann-Georg

Journal:

Journal of Cerebral Blood Flow and Metabolism

Year:

2015

Language:

english

File:

PDF, 3.03 MB

english, 2015

94

Evidence for the Existence of a Non-catalytic Modifier Site of Peptide Hydrolysis by the 20 S Proteasome

Schmidtke, G., Emch, S., Groettrup, M., Holzhutter, H.-G.

Journal:

Journal of Biological Chemistry

Year:

2000

Language:

english

File:

PDF, 628 KB

english, 2000

95

CySBML: a Cytoscape plugin for SBML

Konig, M., Drager, A., Holzhutter, H.-G.

Journal:

Year:

2012

Language:

english

File:

PDF, 283 KB

english, 2012

96

[Lecture Notes in Computer Science] Medical Data Analysis Volume 2868 || Isobologram Analysis in MATLAB for Combined Effects of Two Agents in Dose-Response Experiments

Perner, Petra, Brause, Rüdiger, Holzhütter, Hermann-Georg

Year:

2003

Language:

english

File:

PDF, 245 KB

english, 2003

97

Modeling function–perfusion behavior in liver lobules including tissue, blood, glucose, lactate and glycogen by use of a coupled two-scale PDE–ODE approach

Ricken, T., Werner, D., Holzhütter, H. G., König, M., Dahmen, U., Dirsch, O.

Journal:

Biomechanics and Modeling in Mechanobiology

Year:

2015

Language:

english

File:

PDF, 3.76 MB

english, 2015

98

Hepatitis B Virus HBx Peptide 116–138 and Proteasome Activator PA28 Compete for Binding to the Proteasome α4/MC6 Subunit

Stohwasser, R., Holzhütter, H.-G., Lehmann, U., Henklein, P., Kloetzel, P.-M.

Journal:

Biological Chemistry

Year:

2003

Language:

english

File:

PDF, 607 KB

english, 2003

99

Characterizing the N-Terminal Processing Motif of MHC Class I Ligands

Schatz, M. M., Peters, B., Akkad, N., Ullrich, N., Martinez, A. N., Carroll, O., Bulik, S., Rammensee, H.-G., van Endert, P., Holzhutter, H.-G., Tenzer, S., Schild, H.

Journal:

The Journal of Immunology

Year:

2008

Language:

english

File:

PDF, 576 KB

english, 2008

100

Modelling Proteasome and Proteasome Regulator Activities

Liepe, Juliane, Holzhütter, Herman-Georg, Kloetzel, Peter, Stumpf, Michael, Mishto, Michele

Journal:

Year:

2014

Language:

english

File:

PDF, 330 KB

english, 2014