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1

Effect of Combined Treatment With α-Lipoic Acid and Acetyl-L-Carnitine on Vascular Function and Blood Pressure in Patients With Coronary Artery Disease

Craig J. McMackin, Michael E. Widlansky, Naomi M. Hamburg, Alex L. Huang, Susan Weller, Monika Holbrook, Noyan Gokce, Tory M. Hagen, John F. Keaney Jr, Joseph A. Vita

Journal:

Journal of Clinical Hypertension

Year:

2007

Language:

english

File:

PDF, 153 KB

english, 2007

2

Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential

Kate Petersen Shay, Régis F. Moreau, Eric J. Smith, Anthony R. Smith, Tory M. Hagen

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2009

Language:

english

File:

PDF, 724 KB

english, 2009

3

Delaying the mitochondrial decay of aging in the brain

Bruce N. Ames, Jiankang Liu, Hani Atamna, Tory M. Hagen

Journal:

Clinical Neuroscience Research

Year:

2003

Language:

english

File:

PDF, 160 KB

english, 2003

4

Acetyl-l-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the l-carnitine content in the rat heart

Luis A. Gómez, Shi-Hua D. Heath, Tory M. Hagen

Journal:

Mechanisms of Ageing and Development

Year:

2012

Language:

english

File:

PDF, 894 KB

english, 2012

5

Supercomplexes of the mitochondrial electron transport chain decline in the aging rat heart

Luis A. Gómez, Jeffrey S. Monette, Juan D. Chavez, Claudia S. Maier, Tory M. Hagen

Journal:

Archives of Biochemistry and Biophysics

Year:

2009

Language:

english

File:

PDF, 928 KB

english, 2009

6

A Randomized Controlled Trial of Long-Term (R)-Î±-Lipoic Acid Supplementation Promotes Weight Loss in Overweight or Obese Adults without Altering Baseline Elevated Plasma Triglyceride Concentrations

Bobe, Gerd, Michels, Alexander J, Zhang, Wei-Jian, Purnell, Jonathan Q, Woffendin, Clive, Pereira, Cliff, Vita, Joseph A, Thomas, Nicholas O, Traber, Maret G, Frei, Balz, Hagen, Tory M

Journal:

Journal of Nutrition

Year:

2020

File:

PDF, 1.89 MB

2020

7

Is α-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity

Kate Petersen Shay, Régis F. Moreau, Eric J. Smith, Tory M. Hagen

Journal:

Year:

2008

Language:

english

File:

PDF, 96 KB

english, 2008

8

Gender differences in glutathione metabolism in Alzheimer's disease

Honglei Liu, Lindy E. Harrell, Swapna Shenvi, Tory Hagen, Rui-Ming Liu

Journal:

Journal of Neuroscience Research

Year:

2005

Language:

english

File:

PDF, 159 KB

english, 2005

9

Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A

Kate Petersen Shay, Tory M. Hagen

Journal:

Year:

2009

Language:

english

File:

PDF, 542 KB

english, 2009

10

Glutathione in food

Grazyna T. Wierzbicka, Tory M. Hagen, Dean P. Tones

Journal:

Journal of Food Composition and Analysis

Year:

1989

Language:

english

File:

PDF, 766 KB

english, 1989

11

Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A

Anthony R. Smith, Francesco Visioli, Balz Frei, Tory M. Hagen

Journal:

Year:

2006

Language:

english

File:

PDF, 231 KB

english, 2006

12

Mitochondrial Decay in Aging: Reversal through Supplementation of Acetyl-l-Carnitine and N-tert-Butyl-α-phenyl-nitrone

TORY M. HAGEN, CAROL M. WEHR, BRUCE N. AMES

Journal:

Annals of the New York Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 191 KB

english, 1998

13

Mitochondrial Decay in the Aging Rat Heart : Evidence for Improvement by Dietary Supplementation with Acetyl-l-Carnitine and/or Lipoic Acid

TORY M. HAGEN, RÉGIS MOREAU, JUNG H. SUH, FRANCESCO VISIOLI

Journal:

Annals of the New York Academy of Sciences

Year:

2002

Language:

english

File:

PDF, 322 KB

english, 2002

14

Glutathione uptake and protection against oxidative injury in isolated kidney cells

Hagen, Tory M, Aw, Tak Yee, Jones, Dean P

Journal:

Kidney International

Year:

1988

Language:

english

File:

PDF, 706 KB

english, 1988

15

Vascular oxidative stress and inflammation increase with age: ameliorating effects of α-lipoic acid supplementation

Lixin Li, Anthony Smith, Tory M. Hagen, Balz Frei

Journal:

Annals of the New York Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 329 KB

english, 2010

16

Glutathione Metabolism during Aging and in Alzheimer Disease

HONGLEI LIU, HONG WANG, SWAPNA SHENVI, TORY M. HAGEN, RUI-MING LIU

Journal:

Annals of the New York Academy of Sciences

Year:

2004

File:

PDF, 121 KB

2004

17

Noninvasive assays for oxidative RNA damage

Mark K. Shigenaga, Eun-Mi Park, Tory Hagen, William Haddon, Bruce N. Ames

Journal:

Free Radical Biology and Medicine

Year:

1990

Language:

english

File:

PDF, 118 KB

english, 1990

18

Increased oxidative DNA damage following partial hepatectomy

Tory M. Hagen, Mark K. Shigenaga, Jeffrey W. Kitzler, Bruce N. Ames

Journal:

Free Radical Biology and Medicine

Year:

1990

Language:

english

File:

PDF, 124 KB

english, 1990

19

Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response

Kate Petersen Shay, Alexander J. Michels, Wenge Li, Ah-Ng Tony Kong, Tory M. Hagen

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2012

Language:

english

File:

PDF, 810 KB

english, 2012

20

Reversal by aminoguanidine of the age-related increase in glycoxidation and lipoxidation in the cardiovascular system of Fischer 344 rats

Régis Moreau, Binh T. Nguyen, Catalin E. Doneanu, Tory M. Hagen

Journal:

Biochemical Pharmacology

Year:

2005

Language:

english

File:

PDF, 559 KB

english, 2005

21

Aging Promotes a Necro-inflammatory Phenotype and Increased Lipid Synthesis, Which is Attenuated by Chronic R-α-lipoic acid Supplementation

Liam Finlay, Judy A Butler, Alex J Michels, Eric Smith, Jeff S Monette, Regis F Moreau, Kate Peterson-Shay, Deborah Hobbs, Balz Frei, Tory M Hagen

Journal:

Free Radical Biology and Medicine

Year:

2010

Language:

english

File:

PDF, 415 KB

english, 2010

22

Genetic and Pharmacologic Modulation of Thioredoxin and Glutathione Systems Alters Lipopolysaccharide-induced Acute Liver Inflammatory Responses by Affecting NFκB and Nrf2 Pathways in Mice

Wei-Jian Zhang, Balz Frei, Tory Hagen, Gary Merrill

Journal:

Free Radical Biology and Medicine

Year:

2010

Language:

english

File:

PDF, 405 KB

english, 2010

23

Immunodetection of 3-nitrotyrosine in the liver of zymosan-treated rats with a new monoclonal antibody: comparison to analysis by HPLC

Isabelle Girault, Alexander E Karu, Manuela Schaper, Mary Helen Barcellos-Hoff, Tory Hagen, David S Vogel, Bruce N Ames, Stephan Christen, Mark K Shigenaga

Journal:

Free Radical Biology and Medicine

Year:

2001

Language:

english

File:

PDF, 399 KB

english, 2001

24

Two subpopulations of mitochondria in the aging rat heart display heterogenous levels of oxidative stress

Jung H Suh, Shi-Hua Heath, Tory M Hagen

Journal:

Free Radical Biology and Medicine

Year:

2003

Language:

english

File:

PDF, 199 KB

english, 2003

25

Identification of age-specific Nrf2 binding to a novel antioxidant response element locus in the Gclc promoter: a compensatory means for the loss of glutathione synthetic capacity in the aging rat liver?

Swapna V. Shenvi, Eric Smith, Tory M. Hagen

Journal:

Year:

2012

Language:

english

File:

PDF, 421 KB

english, 2012

26

Protection against paraquat-induced injury by exogenous GSH in pulmonary alveolar type II cells

Tory M. Hagen, Lou Ann Brown, Dean P. Jones

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 567 KB

english, 1986

27

Mitochondrial decay in aging

Bruce N. Ames, Mark K. Shigenaga, Tory M. Hagen

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

1995

Language:

english

File:

PDF, 530 KB

english, 1995

28

(R)-α-Lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis

Jung H. Suh, Hong Wang, Rui-Ming Liu, JianKang Liu, Tory M. Hagen

Journal:

Archives of Biochemistry and Biophysics

Year:

2004

Language:

english

File:

PDF, 194 KB

english, 2004

29

Plasma membrane-associated endothelial nitric oxide synthase and activity in aging rat aortic vascular endothelia markedly decline with age

Anthony R. Smith, Francesco Visioli, Tory M. Hagen

Journal:

Archives of Biochemistry and Biophysics

Year:

2006

Language:

english

File:

PDF, 318 KB

english, 2006

30

Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion

Judy A. Butler, Tory M. Hagen, Régis Moreau

Journal:

Archives of Biochemistry and Biophysics

Year:

2009

Language:

english

File:

PDF, 718 KB

english, 2009

31

Age-related compensatory activation of pyruvate dehydrogenase complex in rat heart

Régis Moreau, Shi-Hua D. Heath, Catalin E. Doneanu, Robert A. Harris, Tory M. Hagen

Journal:

Biochemical and Biophysical Research Communications

Year:

2004

Language:

english

File:

PDF, 930 KB

english, 2004

32

Thiol supplementation inhibits metalloproteinase activity independent of glutathione status

Paola Bogani, Monica Canavesi, Tory M. Hagen, Francesco Visioli, Stefano Bellosta

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 250 KB

english, 2007

33

Characteristics of the rat cardiac sphingolipid pool in two mitochondrial subpopulations

Jeffrey S. Monette, Luis A. Gómez, Régis F. Moreau, Brett A. Bemer, Alan W. Taylor, Tory M. Hagen

Journal:

Biochemical and Biophysical Research Communications

Year:

2010

Language:

english

File:

PDF, 657 KB

english, 2010

34

Corrigendum to “Characteristics of the rat cardiac sphingolipid pool in two mitochondrial subpopulations” [Biochem. Biophys. Res. Commun. 398 (2010) 272–277]

Jeffrey S. Monette, Luis A. Gómez, Régis F. Moreau, Brett A. Bemer, Alan W. Taylor, Tory M. Hagen

Journal:

Biochemical and Biophysical Research Communications

Year:

2011

Language:

english

File:

PDF, 131 KB

english, 2011

35

Age-related decline of sodium-dependent ascorbic acid transport in isolated rat hepatocytes

Alexander J Michels, Neha Joisher, Tory M Hagen

Journal:

Archives of Biochemistry and Biophysics

Year:

2003

Language:

english

File:

PDF, 237 KB

english, 2003

36

Nutritional strategies for healthy cardiovascular aging: Focus on micronutrients

Francesco Visioli, Tory M. Hagen

Journal:

Pharmacological Research

Year:

2007

Language:

english

File:

PDF, 144 KB

english, 2007

37

Transcriptional regulation of rat γ-glutamate cysteine ligase catalytic subunit gene is mediated through a distal antioxidant response element

Swapna V. Shenvi, Eric J. Smith, Tory M. Hagen

Journal:

Pharmacological Research

Year:

2009

Language:

english

File:

PDF, 388 KB

english, 2009

38

Antioxidants to enhance fertility: Role of eNOS and potential benefits

Francesco Visioli, Tory M. Hagen

Journal:

Pharmacological Research

Year:

2011

Language:

english

File:

PDF, 316 KB

english, 2011

39

Age and gender dependent bioavailability of R- and R,S-α-lipoic acid: A pilot study

Dove J. Keith, Judy A. Butler, Brett Bemer, Brian Dixon, Shawn Johnson, Mary Garrard, Daniel L. Sudakin, J. Mark Christensen, Cliff Pereira, Tory M. Hagen

Journal:

Pharmacological Research

Year:

2012

Language:

english

File:

PDF, 860 KB

english, 2012

40

Age-related decline in mitochondrial bioenergetics: Does supercomplex destabilization determine lower oxidative capacity and higher superoxide production?

Gómez, Luis A., Hagen, Tory M.

Journal:

Seminars in Cell & Developmental Biology

Year:

2012

Language:

english

File:

PDF, 429 KB

english, 2012

41

Altered mitochondrial membrane potential, mass, and morphology in the mononuclear cells of humans with type 2 diabetes

Michael E. Widlansky, Jingli Wang, Sherene M. Shenouda, Tory M. Hagen, Anthony R. Smith, Tinoy J. Kizhakekuttu, Matthew A. Kluge, Dorothee Weihrauch, David D. Gutterman, Joseph A. Vita

Journal:

Translational Research

Year:

2010

Language:

english

File:

PDF, 751 KB

english, 2010

42

Human Genetic Variation Influences Vitamin C Homeostasis by Altering Vitamin C Transport and Antioxidant Enzyme Function

Michels, Alexander J., Hagen, Tory M., Frei, Balz

Journal:

Annual Review of Nutrition

Year:

2013

Language:

english

File:

PDF, 1.05 MB

english, 2013

43

Oxidative Stress, Redox Imbalance, and the Aging Process

Journal:

Antioxidants & Redox Signaling

Year:

2003

Language:

english

File:

PDF, 96 KB

english, 2003

44

(R)-α-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria

Monette, Jeffrey S., Gómez, Luis A., Moreau, Régis F., Dunn, Kevin C., Butler, Judy A., Finlay, Liam A., Michels, Alexander J., Shay, Kate Petersen, Smith, Eric J., Hagen, Tory M.

Journal:

Pharmacological Research

Year:

2011

Language:

english

File:

PDF, 285 KB

english, 2011

45

Exogenous Glutathione Protects Intestinal Epithelial Cells from Oxidative Injury

Lawrence H. Lash, Tory M. Hagen and Dean P. Jones

Journal:

Proceedings of the National Academy of Sciences

Year:

1986

Language:

english

File:

PDF, 720 KB

english, 1986

46

Mitochondrial Decay in Hepatocytes from Old Rats: Membrane Potential Declines, Heterogeneity and Oxidants Increase

Tory M. Hagen, David L. Yowe, James C. Bartholomew, Carol M. Wehr, Katherine L. Do, Jin-Y. Park and Bruce N. Ames

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.79 MB

english, 1997

47

Acetyl-L-Carnitine Fed to Old Rats Partially Restores Mitochondrial Function and Ambulatory Activity

Tory M. Hagen, Russell T. Ingersoll, Carol M. Wehr, Jens Lykkesfeldt, Vladimir Vinarsky, James C. Bartholomew, Mi-Hye Song and Bruce N. Ames

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 910 KB

english, 1998

48

Mass Tagging Approach for Mitochondrial Thiol Proteins

Marley, Kevin, Mooney, Duane T., Clark-Scannell, Gretchen, Tong, Tony T.-H., Watson, Jeffrey, Hagen, Tory M., Stevens, Jan F., Maier, Claudia S.

Journal:

Journal of Proteome Research

Year:

2005

Language:

english

File:

PDF, 506 KB

english, 2005

49

Lipoic Acid Supplementation Decreases Biomarkers of Inflammation and Lipid Peroxidation in Overweight or Obese Adults: Results of a Randomized, Double-Blind, Placebo-Controlled Study

Zhang, Weijian, Purnell, Jonathan, Woffendin, Clive, Pereira, Cliff, Michels, Alexander J, Vita, Joseph A, Traber, Maret G, Hagen, Tory M, Bobe, Gerd, Frei, Balz

Journal:

Free Radical Biology and Medicine

Year:

2014

Language:

english

File:

PDF, 73 KB

english, 2014

50

Lipoic Acid Supplementation Promotes Weight Loss and Improves Body Composition in Overweight or Obese Women: Results of a Randomized, Double-Blind, Placebo-Controlled Study

Zhang, Weijian, Purnell, Jonathan, Woffendin, Clive, Pereira, Cliff, Michels, Alexander J, Vita, Joseph A, Traber, Maret G, Hagen, Tory M, Bobe, Gerd, Frei, Balz

Journal:

Free Radical Biology and Medicine

Year:

2014

Language:

english

File:

PDF, 52 KB

english, 2014