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51

Potent agonist action of 2-thioether derivatives of adenine nucleotides at adenylyl cyclase-linked P2y-purinoceptors

José L. Boyer, John W. O'Tuel, Bilha Fischer, Kenneth A. Jacobson, T. Kendall Harden

Journal:

British Journal of Pharmacology

Year:

1995

Language:

english

File:

PDF, 1.15 MB

english, 1995

52

Enzymatic synthesis of UTPγS, a potent hydrolysis resistant agonist of P2U-purinoceptors

Eduardo R. Lazarowski, William C. Watt, M. Jackson Stutts, H. Alex Brown, Richard C. Boucher, T. Kendall Harden

Journal:

British Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.27 MB

english, 1996

53

Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor

Joel B. Schachter, Qing Li, José L. Boyer, Robert A. Nicholas, T. Kendall Harden

Journal:

British Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.60 MB

english, 1996

54

Identification of potent P2Y-purinoceptor agonists that are derivatives of adenosine 5′-monophosphate

José L. Boyer, Suhaib Siddiqi, Bilha Fischer, Teresa Romero-Avila, Kenneth A. Jacobson, T. Kendall Harden

Journal:

British Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.17 MB

english, 1996

55

Structure−Activity Relationships of Bisphosphate Nucleotide Derivatives as P2Y1 Receptor Antagonists and Partial Agonists

Nandanan, Erathodiyil, Camaioni, Emidio, Jang, Soo-Yeon, Kim, Yong-Chul, Cristalli, Gloria, Herdewijn, Piet, Secrist, John A., Tiwari, Kamal N., Mohanram, Arvind, Harden, T. Kendall

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 170 KB

english, 1999

56

Lack of Nucleotide-Promoted Second Messenger Signaling Responses in 1321N1 Cells Expressing the Proposed P2Y Receptor, p2y7

Christopher L. Herold, Qing Li, Joel B. Schachter, T.Kendall Harden, Robert A. Nicholas

Journal:

Biochemical and Biophysical Research Communications

Year:

1997

Language:

english

File:

PDF, 113 KB

english, 1997

57

The 6H1 Orphan Receptor, Claimed to Be the p2y5 Receptor, Does Not Mediate Nucleotide-Promoted Second Messenger Responses

Qing Li, Joel B. Schachter, T.Kendall Harden, Robert A. Nicholas

Journal:

Biochemical and Biophysical Research Communications

Year:

1997

Language:

english

File:

PDF, 120 KB

english, 1997

58

Dexamethasone increases β-adrenoceptor density in human astrocytoma cells

Stephen J. Foster, T.Kendall Harden

Journal:

Biochemical Pharmacology

Year:

1980

Language:

english

File:

PDF, 328 KB

english, 1980

59

Interaction of β-adrenergic receptors with the inhibitory guanine nucleotide-binding protein of adenylate cyclase in membranes prepared from cyc− S49 lymphoma cells

Stewart N. Abramson, Michael W. Martin, Arlene R. Hughes, T.Kendall Harden, Kim A. Neve, Debra A. Barret, Perry B. Molinoff

Journal:

Biochemical Pharmacology

Year:

1988

Language:

english

File:

PDF, 1.05 MB

english, 1988

60

General and Versatile Autoinhibition of PLC Isozymes

Stephanie N. Hicks, Mark R. Jezyk, Svetlana Gershburg, Jason P. Seifert, T. Kendall Harden, John Sondek

Journal:

Year:

2008

Language:

english

File:

PDF, 2.20 MB

english, 2008

61

Cyclic AMP-induced desensitization of G-protein-regulated phospholipase C in turkey erythrocyte membranes

Marie-Christine Galas, T.Kendall Harden

Journal:

European Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 824 KB

english, 1996

62

Soil N and 15N variation with time in a California annual grassland ecosystem

Dana L. Brenner, Ronald Amundson, W.Troy Baisden, Carol Kendall, Jennifer Harden

Journal:

Geochimica et Cosmochimica Acta

Year:

2001

Language:

english

File:

PDF, 351 KB

english, 2001

63

HEK293 human embryonic kidney cells endogenously express the P2Y1 and P2Y2 receptors

Joel B. Schachter, Susan M. Sromek, Robert A. Nicholas, T.Kendall Harden

Journal:

Neuropharmacology

Year:

1997

Language:

english

File:

PDF, 869 KB

english, 1997

64

Towards a revised nomenclature for P1 and P2 receptors

Bertil B. Fredholm, Maria P. Abbracchio, Geoffrey Burnstock, George R. Dubyak, T.Kendall Harden, Kenneth A. Jacobson, Ulrich Schwabe, Michael Williams

Journal:

Trends in Pharmacological Sciences

Year:

1997

Language:

english

File:

PDF, 505 KB

english, 1997

65

Release, metabolism and interconversion of adenine and uridine nucleotides: implications for G protein-coupled P2 receptor agonist selectivity

T.Kendall Harden, Eduardo R. Lazarowski, Richard C. Boucher

Journal:

Trends in Pharmacological Sciences

Year:

1997

Language:

english

File:

PDF, 543 KB

english, 1997

66

Differential effects of P2-purinoceptor antagonists on phospholipase C- and adenylyl cyclase-coupled P2Y-purinoceptors

José L. Boyer, Irene E. Zohn, Kenneth A. Jacobson, T. Kendall Harden

Journal:

British Journal of Pharmacology

Year:

1994

Language:

english

File:

PDF, 1.36 MB

english, 1994

67

Structure−Activity Relationship of Uridine 5‘ - Diphosphoglucose Analogues as Agonists of the Human P2Y 14 Receptor

Ko, Hyojin, Fricks, Ingrid, Ivanov, Andrei A., Harden, T. Kendall, Jacobson, Kenneth A.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 298 KB

english, 2007

68

Virtual screening leads to the discovery of novel non-nucleotide P2Y1 receptor antagonists

Stefano Costanzi, T. Santhosh Kumar, Ramachandran Balasubramanian, T. Kendall Harden, Kenneth A. Jacobson

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.57 MB

english, 2012

69

Mechanism of Activation and Inactivation of Gq/Phospholipase C-β Signaling Nodes

Harden, T. Kendall, Waldo, Gary L., Hicks, Stephanie N., Sondek, John

Journal:

Chemical Reviews

Year:

2011

Language:

english

File:

PDF, 1017 KB

english, 2011

70

A multiisotope C and N modeling analysis of soil organic matter turnover and transport as a function of soil depth in a California annual grassland soil chronosequence

Baisden, W. T., Amundson, R., Brenner, D. L., Cook, A. C., Kendall, C., Harden, J. W.

Journal:

Global Biogeochemical Cycles

Year:

2002

Language:

english

File:

PDF, 1.39 MB

english, 2002

71

Ontogeny of β-adrenergic receptors in rat cerebral cortex

T. Kendall Harden, Barry B. Wolfe, Jonathan R. Sporn, John P. Perkins, Perry B. Molinoff

Journal:

Year:

1977

Language:

english

File:

PDF, 602 KB

english, 1977

72

Noradrenergic hyperinnervation reduces the density of β-adrenergic receptors in rat cerebellum

T. Kendall Harden, Richard B. Mailman, R.A. Mueller, George R. Breese

Journal:

Year:

1979

Language:

english

File:

PDF, 295 KB

english, 1979

73

Newly synthesized norepinephrine accumulation in the readily releasable pool of a purified adrenergic vesicle fraction

Richard L. Klein, T. Kendall Harden

Journal:

Year:

1975

Language:

english

File:

PDF, 377 KB

english, 1975

74

Hormone and growth factor receptor-mediated regulation of phospholipase C activity

JoséL. Boyer, John R. Hepler, T. Kendall Harden

Journal:

Trends in Pharmacological Sciences

Year:

1989

Language:

english

File:

PDF, 1.03 MB

english, 1989

75

Quantification of recombinant and platelet P2Y1 receptors utilizing a [125I]-labeled high-affinity antagonist 2-iodo-N6-methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphate ([125I]MRS2500)

Philippe Ohlmann, Sonia de Castro, Garth G. Brown Jr., Christian Gachet, Kenneth A. Jacobson, T. Kendall Harden

Journal:

Pharmacological Research

Year:

2010

Language:

english

File:

PDF, 322 KB

english, 2010

76

Biochemical Properties of a P2Y-Purinergic Receptor

T. KENDALL HARDEN, JOSÉ LUIS BOYER, H. ALEXANDER BROWN, CHRISTY L. COOPER, ROGER A. JEFFS, MICHAEL W. MARTIN

Journal:

Annals of the New York Academy of Sciences

Year:

1990

Language:

english

File:

PDF, 623 KB

english, 1990

77

Irreversible Activation and Photoaffinity Labeling of a P2Y-Purinergic Receptor Coupled to Phospholipase C Activation in Turkey Erythrocyte Membranes

JOSÉ L. BOYER, CRISTY L. COOPER, T. KENDALL HARDEN

Journal:

Annals of the New York Academy of Sciences

Year:

1990

Language:

english

File:

PDF, 93 KB

english, 1990

78

Human P2Y 1 Receptor: Molecular Modeling and Site-Directed Mutagenesis as Tools To Identify Agonist and Antagonist Recognition Sites

Moro, Stefano, Guo, Danping, Camaioni, Emidio, Boyer, José L., Harden, T. Kendall, Jacobson, Kenneth A.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 254 KB

english, 1998

79

P2Y 1 Antagonists: Combining Receptor-Based Modeling and QSAR for a Quantitative Prediction of the Biological Activity Based on Consensus Scoring

Costanzi, Stefano, Tikhonova, Irina G., Ohno, Michihiro, Roh, Eun Joo, Joshi, Bhalchandra V., Colson, Anny-Odile, Houston, Dayle, Maddileti, Savitri, Harden, T. Kendall, Jacobson, Kenneth A.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 518 KB

english, 2007

80

Molecular Modeling of the Human P2Y 2 Receptor and Design of a Selective Agonist, 2‘-Amino-2‘-deoxy-2-thiouridine 5‘-Triphosphate

Ivanov, Andrei A., Ko, Hyojin, Cosyn, Liesbet, Maddileti, Savitri, Besada, Pedro, Fricks, Ingrid, Costanzi, Stefano, Harden, T. Kendall, Van Calenbergh, Serge, Jacobson, Kenneth A.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 390 KB

english, 2007

81

Polyamidoamine (PAMAM) Dendrimer Conjugates of “Clickable” Agonists of the A 3 Adenosine Receptor and Coactivation of the P2Y 14 Receptor by a Tethered Nucleotide

Tosh, Dilip K., Yoo, Lena S., Chinn, Moshe, Hong, Kunlun, Kilbey, S. Michael, Barrett, Matthew O., Fricks, Ingrid P., Harden, T. Kendall, Gao, Zhan-Guo, Jacobson, Kenneth A.

Journal:

Bioconjugate Chemistry

Year:

2010

Language:

english

File:

PDF, 3.20 MB

english, 2010

82

Pyrimidine Nucleotides with 4-Alkyloxyimino and Terminal Tetraphosphate δ-Ester Modifications as Selective Agonists of the P2Y 4 Receptor

Maruoka, Hiroshi, Jayasekara, M. P. Suresh, Barrett, Matthew O., Franklin, Derek A., de Castro, Sonia, Kim, Nathaniel, Costanzi, Stefano, Harden, T. Kendall, Jacobson, Kenneth A.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 4.74 MB

english, 2011

83

Acyclic and Cyclopropyl Analogues of Adenosine Bisphosphate Antagonists of the P2Y 1 Receptor: Structure−Activity Relationships and Receptor Docking

Kim, Hak Sung, Barak, Dov, Harden, T. Kendall, Boyer, José L., Jacobson, Kenneth A.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 566 KB

english, 2001

84

Acyclic Analogues of Deoxyadenosine 3‘,5‘-Bisphosphates as P2Y 1 Receptor Antagonists

Kim, Yong-Chul, Gallo-Rodriguez, Carola, Jang, Soo-Yeon, Nandanan, Erathodiyil, Adams, Mary, Harden, T. Kendall, Boyer, José L., Jacobson, Kenneth A.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 132 KB

english, 2000

85

Molecular Recognition of Modified Adenine Nucleotides by the P2Y 1 -Receptor. 1. A Synthetic, Biochemical, and NMR Approach

Halbfinger, Efrat, Major, Dan T., Ritzmann, Marco, Ubl, Joachim, Reiser, Georg, Boyer, Jose L., Harden, Kendall T., Fischer, Bilha

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 191 KB

english, 1999

86

β-Adrenergic receptor density in brains of ethanoldependent rats

Hunt, Walter A., Harden, T.Kendall, Thurman, Ronald G.

Journal:

Drug and Alcohol Dependence

Year:

1979

Language:

english

File:

PDF, 65 KB

english, 1979

87

Births, Marriages, and Deaths.

Hunt, Walter A., Harden, T.Kendall, Thurman, Ronald G.

Journal:

Year:

1881

Language:

english

File:

PDF, 176 KB

english, 1881

88

Adaptive changes in the responsiveness of adenylate cyclase to catecholamines

Perkins, John P., Su, Ying-fu, Harden, T.Kendall

Journal:

Drug and Alcohol Dependence

Year:

1979

Language:

english

File:

PDF, 1.09 MB

english, 1979

89

[Part 1: Biological Sciences] || High-Affinity Binding of Agonists to β -adrenergic Receptors on Intact Cells

Myron L. Toews, T. Kendall Harden and John P. Perkins

Journal:

Proceedings of the National Academy of Sciences

Year:

1983

Language:

english

File:

PDF, 874 KB

english, 1983

90

[Part 1: Biological Sciences] || Pertussis Toxin Differentiates between Two Mechanisms of Attenuation of Cyclic AMP Accumulation by Muscarinic Cholinergic Receptors

Arlene R. Hughes, Michael W. Martin and T. Kendall Harden

Journal:

Proceedings of the National Academy of Sciences

Year:

1984

Language:

english

File:

PDF, 1.51 MB

english, 1984

91

UDP Activates a Mucosal-Restricted Receptor on Human Nasal Epithelial Cells that is Distinct from the P2Y2Receptor

Eduardo R. Lazarowski, Anthony M. Paradiso, William C. Watt, T. Kendall Harden and Richard C. Boucher

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 849 KB

english, 1997

92

β -Adrenergic Receptors in Rat Liver: Effects of Adrenalectomy

Barry B. Wolfe, T. Kendall Harden and Perry B. Molinoff

Journal:

Proceedings of the National Academy of Sciences

Year:

1976

Language:

english

File:

PDF, 1.16 MB

english, 1976

93

Human P2Y 6 Receptor: Molecular Modeling Leads to the Rational Design of a Novel Agonist Based on a Unique Conformational Preference

Costanzi, Stefano, Joshi, Bhalchandra V., Maddileti, Savitri, Mamedova, Liaman, Gonzalez-Moa, Maria J., Marquez, Victor E., Harden, T. Kendall, Jacobson, Kenneth A.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 163 KB

english, 2005

94

Structure−Activity Relationships of Uridine 5‘-Diphosphate Analogues at the Human P2Y 6 Receptor

Besada, Pedro, Shin, Dae Hong, Costanzi, Stefano, Ko, Hyojin, Mathé, Christophe, Gagneron, Julien, Gosselin, Gilles, Maddileti, Savitri, Harden, T. Kendall, Jacobson, Kenneth A.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 465 KB

english, 2006

95

Dependence of the Activity of Phospholipase Cβ on Surface Pressure and Surface Composition in Phospholipid Monolayers and Its Implications for Their Regulation †

James, Stephen R., Paterson, Andrew, Harden, T. Kendall, Demel, Rudy A., Downes, C. Peter

Journal:

Year:

1997

Language:

english

File:

PDF, 185 KB

english, 1997

96

Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-γ Isozymes

Hajicek, Nicole, Charpentier, Thomas H., Rush, Jeremy R., Harden, T. Kendall, Sondek, John

Journal:

Year:

2013

Language:

english

File:

PDF, 5.71 MB

english, 2013

97

Pyrimidine Ribonucleotides with Enhanced Selectivity as P2Y 6 Receptor Agonists: Novel 4-Alkyloxyimino, (S)-Methanocarba, and 5′-Triphosphate γ-Ester Modifications †

Maruoka, Hiroshi, Barrett, Matthew O., Ko, Hyojin, Tosh, Dilip K., Melman, Artem, Burianek, Lauren E., Balasubramanian, Ramachandran, Berk, Barkin, Costanzi, Stefano, Harden, T. Kendall, Jacobson, Ken

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 4.42 MB

english, 2010

98

Fluorescent Phosphatidylinositol 4,5-Bisphosphate Derivatives with Modified 6-Hydroxy Group as Novel Substrates for Phospholipase C

Wang, Xiaoyang, Barrett, Matthew, Sondek, John, Harden, T. Kendall, Zhang, Qisheng

Journal:

Year:

2012

Language:

english

File:

PDF, 1.59 MB

english, 2012

99

Methanocarba Modification of Uracil and Adenine Nucleotides: High Potency of Northern Ring Conformation at P2Y 1 , P2Y 2 , P2Y 4 , and P2Y 11 but Not P2Y 6 Receptors

Kim, Hak Sung, Ravi, R. Gnana, Marquez, Victor E., Maddileti, Savitri, Wihlborg, Anna-Karin, Erlinge, David, Malmsjö, Malin, Boyer, José L., Harden, T. Kendall, Jacobson, Kenneth A.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 137 KB

english, 2002

100

2-Thioether 5‘- O -(1-Thiotriphosphate)adenosine Derivatives as New Insulin Secretagogues Acting through P2Y-Receptors

Fischer, Bilha, Chulkin, Ana, Boyer, Jose L., Harden, Kendall T., Gendron, Fernand-Pierre, Beaudoin, Adrien R., Chapal, Jeannie, Hillaire-Buys, Dominique, Petit, Pierre

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 149 KB

english, 1999