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51

Efficient and β-Stereoselective Synthesis of 4(5)-(β- d -Ribofuranosyl)- and 4(5)-(2-Deoxyribofuranosyl)imidazoles 1

Harusawa, Shinya, Murai, Yoshihiko, Moriyama, Hideki, Imazu, Tomonari, Ohishi, Hirofumi, Yoneda, Ryuji, Kurihara, Takushi

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 191 KB

english, 1996

52

Synthesis of Novel C4-Linked C 2 -Imidazole Ribonucleoside Phosphoramidite and Its Application to Probing the Catalytic Mechanism of a Ribozyme

Araki, Lisa, Morita, Keiji, Yamaguchi, Maho, Zhao, Zheng-yun, Wilson, Timothy J., Lilley, David M. J., Harusawa, Shinya

Journal:

Journal of Organic Chemistry

Year:

2009

Language:

english

File:

PDF, 366 KB

english, 2009

53

Dephosphorylation of cyano diethyl phosphates by reduction with lithium?liquid ammonia: an efficient method for conversion of carbonyl compounds into nitriles

Yoneda, Ryuji, Osaki, Takahiro, Harusawa, Shinya, Kurihara, Takushi

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1990

Language:

english

File:

PDF, 490 KB

english, 1990

54

Meisenheimer rearrangement of azetopyridoindoles. Part 4. Ring expansion of 2-vinyl-1,2,4,5,10,10b-hexahydroazeto[1?,2?:1,2]pyrido[3,4-b]indole N-oxides

Kurihara, Takushi, Sakamoto, Yasuhiko, Tsukamoto, Kiyoko, Ohishi, Hirofumi, Harusawa, Shinya, Yoneda, Ryuji

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1993

Language:

english

File:

PDF, 882 KB

english, 1993

55

Synthesis of (Z)-predominant ?,?-unsaturated nitriles from enone cyanohydrin diethyl phosphates: application to the synthesis of (�)-nuciferal, (�)-(E)- and -(Z)-nuciferol, and (�)-manicone

Yoneda, Ryuji, Harusawa, Shinya, Kurihara, Takushi

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1988

Language:

english

File:

PDF, 848 KB

english, 1988

56

Chemistry of ethyl 2-{[t-butoxycarbonyl(methyl)amino]methyl}-3-hydroxy-3-phenyl (or 3-vinyl)propionate: mechanistic considerations in the formation of tetrahydro-1,3-oxazin-2-ones

Kurihara, Takushi, Matsubara, Yoshitaka, Harusawa, Shinya, Yoneda, Ryuji

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1991

Language:

english

File:

PDF, 896 KB

english, 1991

57

Microwave-Aided One-Pot Dehydration of the Alcohol Derived from (−)-Shikimic Acid for Efficient Synthesis of Pericosines

Usami, Yoshihide, Mizuki, Koji, Yoneshige, Yusuke, Kawahata, Rikiya, Yoneyama, Hiroki, Harusawa, Shinya

Journal:

Year:

2014

Language:

english

File:

PDF, 1011 KB

english, 2014

58

A New Synthesis of Polysubstituted Cyclopropanes

Yoneda, Ryuji, Santo, Kazunori, Harusawa, Shinya, Kurihara, Takushi

Journal:

Synthetic Communications

Year:

1987

Language:

english

File:

PDF, 216 KB

english, 1987

59

Regiospecific arylation of 1,4-benzoquinone cyanohydrin phosphate: synthesis of 3-aryl-4-hydroxybenzonitriles

Kurihara, Takushi, Harusawa, Shinya, Hirai, Jun-Ichi, Yoneda, Ryuji

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1987

Language:

english

File:

PDF, 651 KB

english, 1987

60

A Simple One-Pot Synthesis of Silylated and Acylated Cyanohydrins

Yoneda, Ryuji, Santo, Kazunori, Harusawa, Shinya, Kurihara, Takushi

Journal:

Year:

1986

File:

PDF, 161 KB

1986

61

Efficient Synthesis of N-[4-(4-Chlorophenyl)butyl]-S-(3-piperidinopropyl)isothiourea (OUP-186) and Its Analogues Using 2-Nitrophenylacetyl Isothiocyanate: Application to Novel Histamine H3R Antagonists

Yoneyama, Hiroki, Magata, Takuji, Uemura, Kenji, Usami, Yoshihide, Tanaka, Satoshi, Takaoka, Masanori, Harusawa, Shinya

Journal:

Year:

2015

File:

PDF, 74 KB

2015

62

Simple N -Alkylation and N -Acylation of 3-Acetylindole and 3-Indolecarbaldehyde

Kurihara, Takushi, Fujimoto, Toshiro, Harusawa, Shinya, Yoneda, Ryuji

Journal:

Year:

1987

File:

PDF, 129 KB

1987

63

Efficient and β-Stereoselective Synthesis of Pyrazole C -Nucleosides

Harusawa, Shinya, Matsuda, Chiharu, Araki, Lisa, Kurihara, Takushi

Journal:

Year:

2006

Language:

english

File:

PDF, 138 KB

english, 2006

64

Synthesis of C4-Linked C0- and C2-Imidazole 2′-Deoxyribonucleoside Phosphoramidites and Imidazole Base-Pairing Effects on DNA

Harusawa, Shinya, Yoneyama, Hiroki, Usami, Yoshihide, Yamamoto, Daisuke, Zhao, Zheng-yun

Journal:

Year:

2014

Language:

english

File:

PDF, 403 KB

english, 2014

65

Efficient Synthesis of N-[4-(4-Chlorophenyl)butyl]-S-(3-piperidinopropyl)isothiourea (OUP-186) and Its Analogues Using 2-Nitrophenylacetyl Isothiocyanate: Application to Novel Histamine H3R Antagonists

Yoneyama, Hiroki, Magata, Takuji, Uemura, Kenji, Usami, Yoshihide, Tanaka, Satoshi, Takaoka, Masanori, Harusawa, Shinya

Journal:

Year:

2015

Language:

english

File:

PDF, 259 KB

english, 2015

66

New Methods and Reagents in Organic Synthesis; 4 1 . Reaction of Enamines with Diethyl Phosphorocyanidate

Harusawa, Shinya, Hamada, Yasumasa, Shioiri, Takayuki

Journal:

Year:

1979

File:

PDF, 145 KB

1979

67

A Simple One-Pot Synthesis of Acylated Cyanohydrins of 3-Indolecarbaldehydes

Kurihara, Takushi, Fujimoto, Toshiro, Harusawa, Shinya, Yoneda, Ryuji

Journal:

Year:

1987

File:

PDF, 140 KB

1987

68

An Efficient and Convenient Synthesis of 4-Vinylimidazoles Using a Novel Horner-Wadsworth-Emmons (HWE) Reagent: Synthetic Studies Toward Novel Histamine H3-Ligands

Harusawa, Shinya, Koyabu, Shuji, Inoue, Yasutoshi, Sakamoto, Yasuhiko, Araki, Lisa, Kurihara, Takushi

Journal:

Year:

2002

Language:

english

File:

PDF, 126 KB

english, 2002

69

Formation of Two 4-Imidazolylmethylphosphonium Salts and their Synthetic Studies Toward Histamine H 3 -Ligands

Harusawa, Shinya, Kawamura, Makoto, Koyabu, Shuji, Hosokawa, Tomoko, Araki, Lisa, Sakamoto, Yasuhiko, Hashimoto, Takeshi, Yamamoto, Yumiko, Yamatodani, Atsushi, Kurihara, Takushi

Journal:

Year:

2003

Language:

english

File:

PDF, 114 KB

english, 2003

70

Synthesis of 5-(4-Pyrazolyl and 4-Isoxazolyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-ones

Kurihara, Takushi, Sasaki, Jun, Santo, Kazunori, Nakamura, Yutaka, Yoneda, Ryuji, Harusawa, Shinya

Journal:

Year:

1989

Language:

english

File:

PDF, 380 KB

english, 1989

71

ChemInform Abstract: Synthesis of Marine Natural Product (-)-Pericosine E.

Mizuki, Koji, Iwahashi, Kaoru, Murata, Naoko, Ikeda, Mayuko, Nakai, Yutaka, Yoneyama, Hiroki, Harusawa, Shinya, Usami, Yoshihide

Journal:

Year:

2015

File:

PDF, 14 KB

2015

72

ChemInform Abstract: Microwave-Aided One-Pot Dehydration of the Alcohol Derived from (-)-Shikimic Acid for Efficient Synthesis of Pericosines.

Usami, Yoshihide, Mizuki, Koji, Yoneshige, Yusuke, Kawahata, Rikiya, Yoneyama, Hiroki, Harusawa, Shinya

Journal:

Year:

2015

File:

PDF, 15 KB

2015

73

ChemInform Abstract: Efficient Transformation of Inactive Nitriles into 5-Substituted 1H-Tetrazoles Using Microwave Irradiation and Their Applications.

Yoneyama, Hiroki, Usami, Yoshihide, Komeda, Seiji, Harusawa, Shinya

Journal:

Year:

2013

File:

PDF, 33 KB

2013

74

Synthesis of 4(5)-(5'-Amino-5'-deoxy-a-L-arabinofuranosyl)imidazole and Its 5'-Derivatives Using Modified Mitsunobu Cyclization: Synthetic Studies toward Novel Histamine H3-Ligands

Kurihara, Takushi, Araki, Lisa, Harusawa, Shinya, Suzuki, Hirokazu

Journal:

Year:

2000

File:

PDF, 522 KB

2000

75

Meisenheimer Rearrangement of 2-Ethyl-1,4,5,10b-tetrahydro-2 H -azetopyrido[3,4- b ]indole N -Oxides. Formation of 3,6-Epoxy-1,2,3,4,5,6-hexahydroazocino[5,6- b ]indoles

Kurihara, Takushi, Ohuchi, Kaori, Kawamoto, Mitsuko, Harusawa, Shinya, Yoneda, Ryuji

Journal:

Chemistry Letters

Year:

1991

File:

PDF, 308 KB

1991

76

Diethyl phosphorocyanidate (DEPC): a versatile reagent for organic synthesis

Harusawa, Shinya, Shioiri, Takayuki

Journal:

Year:

2016

Language:

english

File:

PDF, 3.72 MB

english, 2016

77

Histamine H3 receptor antagonist OUP-186 attenuates the proliferation of cultured human breast cancer cell lines

Tanaka, Satoshi, Sakaguchi, Minoru, Yoneyama, Hiroki, Usami, Yoshihide, Harusawa, Shinya

Journal:

Biochemical and Biophysical Research Communications

Year:

2016

Language:

english

File:

PDF, 1.26 MB

english, 2016

78

Synthetic studies of (.+-.)-lysergic acid and related compounds.

KURIHARA, TAKUSHI, TERADA, TATSUYA, HARUSAWA, SHINYA, YONEDA, RYUJI

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1987

Language:

english

File:

PDF, 1.82 MB

english, 1987

79

Allylic rearrangement of .ALPHA.,.BETA.-unsaturated ketone-diethyl phosphorocyanidate adducts.

Harusawa, Shinya, Miki, Masuo, Yoneda, Ryuji, Kurihara, Takushi

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1985

File:

PDF, 400 KB

1985

80

Reaction of methyl vinyl ketone cyanohydrin phosphate with aromatic compounds.

Miki, Masuo, Wakita, Taeko, Harusawa, Shinya, Kurihara, Takushi

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1985

File:

PDF, 366 KB

1985

81

Allylic rearrangement of cyanophosphate. II Synthesis of .BETA.-cyano-.ALPHA.,.BETA.-unsaturated ketones.

KURIHARA, TAKASHI, MIKI, MASUO, YONEDA, RYUJI, HARUSAWA, SHINYA

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1986

File:

PDF, 773 KB

1986

82

Synthesis and cycloaddition reaction of 2-cyano-3-indoleacetonitriles.

KURIHARA, TAKUSHI, HANAKAWA, MITSUKO, HARUSAWA, SHINYA, YONEDA, RYUJI

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1986

File:

PDF, 934 KB

1986

83

Allylic rearrangement of cyanophosphates. III Reaction of acyclic enone cyanophosphates.

KURIHARA, TAKUSHI, MIKI, MASUO, SANTO, KAZUNORI, HARUSAWA, SHINYA, YONEDA, RYUJI

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1986

File:

PDF, 1002 KB

1986

84

A simple one-pot synthesis of tert-butyldimethylsilyl-protected cyanohydrins.

YONEDA, RYUJI, HISAKAWA, HIDEKI, HARUSAWA, SHINYA, KURIHARA, TAKUSHI

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1987

Language:

english

File:

PDF, 419 KB

english, 1987

85

A new and facile synthesis of 2-alkenenitriles using 3-buten-2-one cyanohydrin diethyl phosphate ; Application to (.+-.)-(E)-Nuciferol synthesis.

Yoneda, Ryuji, Harusawa, Shinya, Kurihara, Takushi

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1987

Language:

english

File:

PDF, 281 KB

english, 1987

86

Recyclization of 2-oxotetrahydro-1,3-oxazines accompanied by decarboxylation: A convenient synthesis of tetrahydropyridine, quinolizidine, and indolizidine skeletons.

Matsubara, Yoshitaka, Yoneda, Ryuji, Harusawa, Shinya, Kurihara, Takushi

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1988

File:

PDF, 366 KB

1988

87

Reductive deoxygenation of .ALPHA.,.BETA.-unsaturated ketones via cyanophosphates by lithium in liquid ammonia.

YONEDA, Ryuji, OSAKI, Hirotaka, HARUSAWA, Shinya, KURIHARA, Takushi

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1989

File:

PDF, 380 KB

1989

88

Novel transformation of azabicyclothionocarbonate to azaspirolactone.

HARUSAWA, Shinya, SHIBATA, Norio, YAMAZAKI, Naoki, SAKANOUE, Satomi, ISHIDA, Toshimasa, YONEDA, Ryuji, KURIHARA, Takushi

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1989

File:

PDF, 629 KB

1989

89

A New Synthesis of Allenic Nitriles from Ynones via Cyano Phosphates.

YONEDA, Ryuji, INAGAKI, Noriko, HARUSAWA, Shinya, KURIHARA, Takushi

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1992

File:

PDF, 502 KB

1992

90

Chemistry of Tetrahydro-1,3-oxazin-2-one: New Method for the Synthesis of Indoloquinlizidine Derivatives.

KURIHARA, Takushi, SOKAWA, Yumi, YOKODE, Kayo, OHISHI, Hirofumi, HARUSAWA, Shinya, YONEDA, Ryuji

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1991

File:

PDF, 950 KB

1991

91

Meisenheimer rearrangement of 2-ethenyl-1, 4, 5, 10b-tetrahydro-2H-azetopyrido(3, 4-b)indole N-oxides: New route to the 12(S)carba-eudistomin skeleton.

KURIHARA, Takushi, DOI, Miki, HAMAURA, Kayo, OHISHI, Hirofumi, HARUSAWA, Shinya, YONEDA, Ryuji

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1991

File:

PDF, 401 KB

1991

92

Meisenheimer Rearrangement of Azetopyridoindoles. III. Synthesis of 3,6-Epoxyhexahydroazocino(5,4-b) indoles.

KURIHARA, Takushi, SAKAMOTO, Yasuhiko, TAKAI, Masato, OHUCHI, Kaori, HARUSAWA, Shinya, YONEDA, Ryuji

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1993

File:

PDF, 869 KB

1993

93

(3,3)Sigmatropic Ring Expansion of Cyclic Thionocarbonates. VII. On the Formation of 8-Membered Thionocarbonates as the Intermediates.

HARUSAWA, Shinya, TOMII, Sachiko, TAKEHISA, Chiaki, OHISHI, Hirofumi, YONEDA, Ryouji, KUEIHARA, Takushi

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1992

File:

PDF, 661 KB

1992

94

Meisenheimer Rearrangement of Azetopyridoindoles. VII. Ring Expansion of 2-Phenylhexahydroazeto(1',2':1,2)pyrido(3,4-b)indoles by Oxidation with m-Chloroperbenzoic Acid.

KURIHARA, Takushi, SAKAMOTO, Yasuhiko, TAKAI, Masato, OHISHI, Hirofumi, HARUSAWA, Shinya, YONEDA, Ryuji

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1995

File:

PDF, 1005 KB

1995

95

Meisenheimer Rearrangement of Azetopyridoindoles. V. Synthesis of 9-Methyl-12-carbaeudistomin and Related Compounds.

KURIHARA, Takushi, SAKAMOTO, Yasuhiko, TAKAI, Masato, TSUKAMOTO, Kiyoko, SAKAI, Tomoko, HARUSAWA, Shinya, YONEDA, Ryuji

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1994

File:

PDF, 1.17 MB

1994

96

Meisenheimer Rearrangement of Azetopyridoindoles. VI. Synthesis of 12-Carbaeudistomin and Related Compounds.

KURIHARA, Takushi, SAKAMOTO, Yasuhiko, MATSUMOTO, Hiromi, KAWABATA, Natsuki, HARUSAWA, Shinya, YONEDA, Ryuji

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1994

File:

PDF, 1.01 MB

1994

97

New Route to 1-(5-Imidazolyl)ribofuranoid Glycals from Ribofuranosyl Chloride and 5-Lithio-imidazole.

HARUSAWA, Shinya, KAWABATA, Masayo, MURAI, Yoshihiko, YONEDA, Ryuji, KURIHARA, Takushi

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1995

File:

PDF, 612 KB

1995

98

Meisenheimer Rearrangement of Azetopyridoindoles. VIII. Synthesis and Antiviral Activities of 12-Carbaeudistomin Analogs.

KURIHARA, Takushi, SAKAMOTO, Yasuhiko, KIMURA, Tetsuya, OHISHI, Hirofumi, HARUSAWA, Shinya, YONEDA, Ryuji, SUZUTANI, Tatsuo, AZUMA, Masanobu

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1996

File:

PDF, 1.40 MB

1996

99

Efficient and .BETA.-Stereoselective Synthesis of 4(5)-Methyl-5(4)-(5-amino-5-deoxy-.BETA.-D-ribofuranosyl)imidazole and Related Compounds Exhibiting Antiulcer Activity.

HARUSAWA, Shinya, MORIYAMA, Hideki, MURAI, Yoshihiko, IMAZU, Tomonari, OHISHI, Hirofumi, YONEDA, Ryuji, KURIHARA, Takushi, HATA, Hiroyoshi, SAKAMOTO, Yasuhiko

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1997

File:

PDF, 1.26 MB

1997

100

Studies on the [2,3]-Meisenheimer Rearrangement of 2-Vinylazetidine N-Oxides.

YONEDA, Ryuji, ARAKI, Lisa, HARUSAWA, Shinya, KURIHARA, Takushi

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1998

File:

PDF, 663 KB

1998