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51

A Comprehensive Review of Retinal Gene Therapy

Boye, Shannon E, Boye, Sanford L, Lewin, Alfred S, Hauswirth, William W

Journal:

Molecular Therapy

Year:

2013

Language:

english

File:

PDF, 273 KB

english, 2013

52

Origin and termination of adeno-associated virus DNA replication

William W. Hauswirth, Kenneth I. Berns

Journal:

Year:

1977

Language:

english

File:

PDF, 1.54 MB

english, 1977

53

Adeno-associated virus DNA replication: Nonunit-length molecules

William W. Hauswirth, Kenneth I. Berns

Journal:

Year:

1979

Language:

english

File:

PDF, 2.00 MB

english, 1979

54

Topographical regulation of cone and rod opsin genes: parallel, position dependent levels of transcription

Paul R. van Ginkel, Adrian M. Timmers, Agoston Szél, William W. Hauswirth

Journal:

Developmental Brain Research

Year:

1995

Language:

english

File:

PDF, 426 KB

english, 1995

55

Conserved restriction sites within the ribosomal RNA genes of vertebrates

Susan M. Tanhauser, William W. Hauswirth, Philip J. Laipis

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1986

Language:

english

File:

PDF, 607 KB

english, 1986

56

Studies on Retinal and Choroidal Disorders || Mechanisms of Pathological VEGF Production in the Retina and Modification with VEGF-Antagonists

Stratton, Robert D., Hauswirth, William W., Gardner, Thomas W.

Year:

2012

Language:

english

File:

PDF, 435 KB

english, 2012

57

High-efficiency Transduction of the Mouse Retina by Tyrosine-mutant AAV Serotype Vectors

Petrs-Silva, Hilda, Dinculescu, Astra, Li, Qiuhong, Min, Seok-Hong, Chiodo, Vince, Pang, Ji-Jing, Zhong, Li, Zolotukhin, Sergei, Srivastava, Arun, Lewin, Alfred S, Hauswirth, William W

Journal:

Molecular Therapy

Year:

2009

Language:

english

File:

PDF, 3.45 MB

english, 2009

58

Human RPE65 Gene Therapy for Leber Congenital Amaurosis: Persistence of Early Visual Improvements and Safety at 1 Year

Cideciyan, Artur V., Hauswirth, William W., Aleman, Tomas S., Kaushal, Shalesh, Schwartz, Sharon B., Boye, Sanford L., Windsor, Elizabeth A.M., Conlon, Thomas J., Sumaroka, Alexander, Pang, Ji-jing, R

Journal:

Human Gene Therapy

Year:

2009

Language:

english

File:

PDF, 16.03 MB

english, 2009

59

Dual Adeno-Associated Virus Vectors Result in Efficient In Vitro and In Vivo Expression of an Oversized Gene, MYO7A

Dyka, Frank M., Boye, Sanford L., Chiodo, Vince A., Hauswirth, William W., Boye, Shannon E.

Journal:

Human Gene Therapy Methods

Year:

2014

Language:

english

File:

PDF, 1.33 MB

english, 2014

60

Development of an anti-angiogenic therapeutic model combining scAAV2-delivered siRNAs and noninvasive photoacoustic imaging of tumor vasculature development

Ruan, Qing, Xi, Lei, Boye, Sanford L., Han, Song, Chen, Zhi J., Hauswirth, William W., Lewin, Alfed S., Boulton, Michael E., Law, Brian K., Jiang, Wen G., Jiang, Huabei, Cai, Jun

Journal:

Year:

2013

Language:

english

File:

PDF, 1.64 MB

english, 2013

61

[Part 1: Biological Sciences] || Mitochondrial DNA Polymorphism in a Maternal Lineage of Holstein Cows

William W. Hauswirth and Philip J. Laipis

Journal:

Proceedings of the National Academy of Sciences

Year:

1982

Language:

english

File:

PDF, 1.40 MB

english, 1982

62

Unequal Partitioning of Bovine Mitochondrial Genotypes among Siblings

Philip J. Laipis, Michael J. Van De Walle and William W. Hauswirth

Journal:

Proceedings of the National Academy of Sciences

Year:

1988

Language:

english

File:

PDF, 897 KB

english, 1988

63

Efficient Photoreceptor-Targeted Gene Expression in vivo by Recombinant Adeno-Associated Virus

John G. Flannery, Sergei Zolotukhin, M. Isabel Vaquero, Matthew M. LaVail, Nicholas Muzyczka and William W. Hauswirth

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.62 MB

english, 1997

64

Adeno-Associated Viral-Mediated Catalase Expression Suppresses Optic Neuritis in Experimental Allergic Encephalomyelitis

John Guy, Xiaoping Qi and William W. Hauswirth

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.56 MB

english, 1998

65

Gene Therapy with Brain-Derived Neurotrophic Factor As a Protection: Retinal Ganglion Cells in a Rat Glaucoma Model

Martin, Keith R. G., Quigley, Harry A., Zack, Donald J., Levkovitch-Verbin, Hana, Kielczewski, Jennifer, Valenta, Danielle, Baumrind, Lisa, Pease, Mary Ellen, Klein, Ronald L., Hauswirth, William W.

Journal:

Investigative Ophthalmology & Visual Science

Year:

2003

Language:

english

File:

PDF, 513 KB

english, 2003

66

Gene Therapy With Mitochondrial Heat Shock Protein 70 Suppresses Visual Loss and Optic Atrophy in Experimental Autoimmune Encephalomyelitis

Talla, Venu, Porciatti, Vittorio, Chiodo, Vince, Boye, Sanford L., Hauswirth, William W., Guy, John

Journal:

Investigative Opthalmology & Visual Science

Year:

2014

Language:

english

File:

PDF, 1.90 MB

english, 2014

67

Vision 1 Year after Gene Therapy for Leber's Congenital Amaurosis

Cideciyan, Artur V., Hauswirth, William W., Aleman, Tomas S., Kaushal, Shalesh, Schwartz, Sharon B., Boye, Sanford L., Windsor, Elizabeth A.M., Conlon, Thomas J., Sumaroka, Alexander, Roman, Alejandro

Journal:

Boston Medical and Surgical Journal

Year:

2009

Language:

english

File:

PDF, 234 KB

english, 2009

68

Inhibition of Choroidal Neovascularization in a Nonhuman Primate Model by Intravitreal Administration of an AAV2 Vector Expressing a Novel Anti-VEGF Molecule

Lukason, Michael, DuFresne, Elizabeth, Rubin, Hillard, Pechan, Peter, Li, Qiuhong, Kim, Ivana, Kiss, Szilard, Flaxel, Christina, Collins, Margaret, Miller, Joan, Hauswirth, William, MacLachlan, Timoth

Journal:

Molecular Therapy

Year:

2011

Language:

english

File:

PDF, 394 KB

english, 2011

69

[Methods in Enzymology] Vertebrate Phototransduction and the Visual Cycle, Part B Volume 316 || [48] Production and purification of recombinant adeno-associated virus

Hauswirth, William W.

Year:

2000

Language:

english

File:

PDF, 4.04 MB

english, 2000

70

Retinal Gene Therapy Using Adeno-Associated Viral Vectors: Multiple Applications for a Small Virus

Hauswirth, William W.

Journal:

Human Gene Therapy

Year:

2014

Language:

english

File:

PDF, 301 KB

english, 2014

71

Long-Term Rescue of Retinal Structure and Function by Rhodopsin RNA Replacement with a Single Adeno-Associated Viral Vector in P23H RHO Transgenic Mice

Mao, Haoyu, Gorbatyuk, Marina S., Rossmiller, Brian, Hauswirth, William W., Lewin, Alfred S.

Journal:

Human Gene Therapy

Year:

2012

Language:

english

File:

PDF, 785 KB

english, 2012

72

Adeno-Associated Virus-Vectored Gene Therapy for Retinal Disease

Dinculescu, Astra, Glushakova, Lyudmyla, Min, Seok-Hong, Hauswirth, William W.

Journal:

Human Gene Therapy

Year:

2005

Language:

english

File:

PDF, 133 KB

english, 2005

73

Efficient Transduction of Vascular Endothelial Cells with Recombinant Adeno-Associated Virus Serotype 1 and 5 Vectors

Chen, Sifeng, Kapturczak, Matthias, Loiler, Scott A., Zolotukhin, Sergei, Glushakova, Olena Y., Madsen, Kirsten M., Samulski, Richard J., Hauswirth, William W., Campbell-Thompson, Martha, Berns, Kenne

Journal:

Human Gene Therapy

Year:

2005

Language:

english

File:

PDF, 411 KB

english, 2005

74

Treatment of Leber Congenital Amaurosis Due to RPE65 Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial

Hauswirth, William W., Aleman, Tomas S., Kaushal, Shalesh, Cideciyan, Artur V., Schwartz, Sharon B., Wang, Lili, Conlon, Thomas J., Boye, Sanford L., Flotte, Terence R., Byrne, Barry J., Jacobson, Sam

Journal:

Human Gene Therapy

Year:

2008

Language:

english

File:

PDF, 518 KB

english, 2008

75

AAV Delivery of Wild-Type Rhodopsin Preserves Retinal Function in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa

Mao, Haoyu, James, Thomas, Schwein, Alison, Shabashvili, Arseniy E., Hauswirth, William W., Gorbatyuk, Marina S., Lewin, Alfred S.

Journal:

Human Gene Therapy

Year:

2011

Language:

english

File:

PDF, 544 KB

english, 2011

76

STAT3 promotes survival of mutant photoreceptors in inherited photoreceptor degeneration models

Jiang, Ke, Wright, Katherine L., Zhu, Ping, Szego, Michael J., Bramall, Alexa N., Hauswirth, William W., Li, Qiuhong, Egan, Sean E., McInnes, Roderick R.

Journal:

Proceedings of the National Academy of Sciences

Year:

2014

Language:

english

File:

PDF, 1.84 MB

english, 2014

77

Adeno-Associated Virus-Mediated Expression of Vascular Endothelial Growth Factor Peptides Inhibits Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy

Deng, Wen-Tao, Yan, Zuan, Dinculescu, Astra, Pang, Jijing, Teusner, Jacqueline T., Cortez, Nenita G., Berns, Kenneth I., Hauswirth, William W.

Journal:

Human Gene Therapy

Year:

2005

Language:

english

File:

PDF, 175 KB

english, 2005

78

Exploring the molecular mechanism of ocular angiogenesis inhibition by triamcinolone acetonide

Deng, Wen-Tao, Hauswirth, William W

Journal:

Expert Review of Ophthalmology

Year:

2007

Language:

english

File:

PDF, 254 KB

english, 2007

79

Recombinant Adeno-Associated Virus Vector-Based Gene Transfer for Defects in Oxidative Metabolism

Owen, Renius, Lewin, Alfred P., Peel, Alyson, Wang, Jianming, Guy, John, Hauswirth, William W., Stacpoole, Peter W., Flotte, Terence R.

Journal:

Human Gene Therapy

Year:

2000

Language:

english

File:

PDF, 1.17 MB

english, 2000

80

883. AAV-2 Based Gene Therapy Using Novel Anti-VEGF Molecules for Inhibition of Angiogenesis in the Eye

Scaria, Abraham, Pechan, Peter, Rubin, Hillard, Lukason, Michael, Barry, Elizabeth, Ardinger, Jeffrey, Qiu, Huawei, Li, Qiuhong, Peterson, James, Hauswirth, William, Wadsworth, Samuel

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 83 KB

english, 2006

81

419. Rescue of Cone Photoreceptors after Lentiviral Gene Transfer of Rpe65 cDNA in Knockout Mouse Models of Leber Congenital Amaurosis

Bemelmans, Alexis-Pierre, Kostic, Corinne, Hornfeld, Dana, Tekaya, Meriem, Crippa, Sylvain V., Hauswirth, William W., Lem, Janis, Seeliger, Mathias, Wenzel, Andreas, Arsenijevic, Yvan

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 88 KB

english, 2006

82

503. A Novel Herpes Simplex Virus Helper Based Production of Adeno-Associated Virus Vectors for Treatment of Retinal Angiogenesis

Ye, Guo-jie, Drogemuller, Chris, Thomas, Darby, Scotti, Marina, Kang, Wen, Knop, David, Boye, Sanford, Pechan, Peter, Peterson, James, Hauswirth, William, Scaria, Abraham, Wadsworth, Samuel

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 83 KB

english, 2006

83

495. Transfer of LEDGF to the Mouse Retina Via Systemic AAV Vector Administration

Glushakova, Lyudmyla G., Gorbatuyk, Marina, Lu, Yuanging, Song, Sihong, Zheng, Min, Shinohara, Toshimichi, Hauswirth, William W.

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 83 KB

english, 2006

84

Gene Delivery of a Viral Anti-Inflammatory Protein to Combat Ocular Inflammation

Ildefonso, Cristhian J., Jaime, Henrique, Rahman, Masmudur M., Li, Qiuhong, Boye, Shannon E., Hauswirth, William W., Lucas, Alexandra R., McFadden, Grant, Lewin, Alfred S.

Journal:

Human Gene Therapy

Year:

2015

Language:

english

File:

PDF, 893 KB

english, 2015

85

Whirlin Replacement Restores the Formation of the USH2 Protein Complex in Whirlin Knockout Photoreceptors

Zou, Junhuang, Luo, Ling, Shen, Zuolian, Chiodo, Vince A., Ambati, Balamurali K., Hauswirth, William W., Yang, Jun

Journal:

Investigative Ophthalmology & Visual Science

Year:

2011

Language:

english

File:

PDF, 5.23 MB

english, 2011

86

Correction: In vivo and in vitro Evidence for Slipped Mispairing in Mammalian Mitochondria

Cort S. Madsen, Steven C. Ghivizzani and William W. Hauswirth

Journal:

Proceedings of the National Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 159 KB

english, 1993

87

Diabetic eNOS-Knockout Mice Develop Accelerated Retinopathy

Li, Qiuhong, Verma, Amrisha, Han, Ping-yang, Nakagawa, Takahiko, Johnson, Richard J., Grant, Maria B., Campbell-Thompson, Martha, Jarajapu, Yagna P. R., Lei, Bo, Hauswirth, William W.

Journal:

Investigative Ophthalmology & Visual Science

Year:

2010

Language:

english

File:

PDF, 1.25 MB

english, 2010

88

Effects on XIAP Retinal Detachment–Induced Photoreceptor Apoptosis

Zadro-Lamoureux, Laura A., Zacks, David N., Baker, Adam N., Zheng, Qiong-Duan, Hauswirth, William W., Tsilfidis, Catherine

Journal:

Investigative Ophthalmology & Visual Science

Year:

2009

Language:

english

File:

PDF, 703 KB

english, 2009

89

Long-term Suppression of Neurodegeneration in Chronic Experimental Optic Neuritis: Antioxidant Gene Therapy

Qi, Xiaoping, Sun, Liang, Lewin, Alfred S., Hauswirth, William W., Guy, John

Journal:

Investigative Ophthalmology & Visual Science

Year:

2007

Language:

english

File:

PDF, 1.63 MB

english, 2007

90

Flicker cone function in normal and day blind sheep: a large animal model for human achromatopsia caused by CNGA3 mutation

Ezra-Elia, Raaya, Banin, Eyal, Honig, Hen, Rosov, Alexander, Obolensky, Alexey, Averbukh, Edward, Hauswirth, William W., Gootwine, Elisha, Ofri, Ron

Journal:

Documenta Ophthalmologica

Year:

2014

Language:

english

File:

PDF, 2.58 MB

english, 2014

91

Length heterogeneity of a conserved displacement-loop sequence in human mitochondrial DNA

Hauswirth, William W., Clayton, David A.

Journal:

Nucleic Acids Research

Year:

1985

Language:

english

File:

PDF, 2.32 MB

english, 1985

92

Molecular and Cellular Alterations Induced by Sustained Expression of Ciliary Neurotrophic Factor in a Mouse Model of Retinitis Pigmentosa

Rhee, Kun Do, Ruiz, Alberto, Duncan, Jacque L., Hauswirth, William W., LaVail, Matthew M., Bok, Dean, Yang, Xian-Jie

Journal:

Investigative Ophthalmology & Visual Science

Year:

2007

Language:

english

File:

PDF, 1.28 MB

english, 2007

93

Targeted Gene Delivery to the Enteric Nervous System Using AAV: A Comparison Across Serotypes and Capsid Mutants

Benskey, Matthew J, Kuhn, Nathan C, Galligan, James J, Garcia, Joanna, Boye, Shannon E, Hauswirth, William W, Mueller, Christian, Boye, Sanford L, Manfredsson, Fredric P

Journal:

Molecular Therapy

Year:

2015

Language:

english

File:

PDF, 3.84 MB

english, 2015

94

Improvement and Decline in Vision with Gene Therapy in Childhood Blindness

Jacobson, Samuel G., Cideciyan, Artur V., Roman, Alejandro J., Sumaroka, Alexander, Schwartz, Sharon B., Heon, Elise, Hauswirth, William W.

Journal:

New England Journal of Medicine

Year:

2015

Language:

english

File:

PDF, 556 KB

english, 2015

95

Safety and Effects of the Vector for the Leber Hereditary Optic Neuropathy Gene Therapy Clinical Trial

Koilkonda, Rajeshwari D., Yu, Hong, Chou, Tsung-Han, Feuer, William J., Ruggeri, Marco, Porciatti, Vittorio, Tse, David, Hauswirth, William W., Chiodo, Vince, Boye, Sanford L., Lewin, Alfred S., Neuri

Journal:

JAMA Ophthalmology

Year:

2014

Language:

english

File:

PDF, 1.06 MB

english, 2014

96

Longitudinal evaluation of expression of virally delivered transgenes in gerbil cone photoreceptors

MAUCK, MATTHEW C., MANCUSO, KATHERINE, KUCHENBECKER, JAMES A., CONNOR, THOMAS B., HAUSWIRTH, WILLIAM W., NEITZ, JAY, NEITZ, MAUREEN

Journal:

Visual Neuroscience

Year:

2008

Language:

english

File:

PDF, 627 KB

english, 2008

97

Ribozyme Knockdown of the γ-Subunit of Rod cGMP Phosphodiesterase Alters the ERG and Retinal Morphology in Wild-Type Mice

Liu, Jianwen, Timmers, Adrian M., Lewin, Alfred S., Hauswirth, William W.

Journal:

Investigative Ophthalmology & Visual Science

Year:

2005

Language:

english

File:

PDF, 374 KB

english, 2005

98

SOD2 Knockdown Mouse Model of Early AMD

Justilien, Verline, Pang, Ji-Jing, Renganathan, Kutralanathan, Zhan, Xianquan, Crabb, John W., Kim, So Ra, Sparrow, Janet R., Hauswirth, William W., Lewin, Alfred S.

Journal:

Investigative Ophthalmology & Visual Science

Year:

2007

Language:

english

File:

PDF, 1.03 MB

english, 2007

99

Optic Neuropathy Induced by Reductions in Mitochondrial Superoxide Dismutase

Qi, Xiaoping, Lewin, Alfred S., Hauswirth, William W., Guy, John

Journal:

Investigative Ophthalmology & Visual Science

Year:

2003

Language:

english

File:

PDF, 829 KB

english, 2003

100

Stability and Safety of an AAV Vector for Treating RPGR-ORF15 X-Linked Retinitis Pigmentosa

Deng, Wen-Tao, Dyka, Frank M., Dinculescu, Astra, Li, Jie, Zhu, Ping, Chiodo, Vince A., Boye, Sanford L., Conlon, Thomas J., Erger, Kirsten, Cossette, Travis, Hauswirth, William W.

Journal:

Human Gene Therapy

Year:

2015

Language:

english

File:

PDF, 1.33 MB

english, 2015