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151

Facile synthesis of membrane-embedded peptides utilizing lipid bilayer-assisted chemical ligationElectronic supplementary information (ESI) available: results of optimization of Ile-Cys ligation. Representative experimental procedure for the ligation. HPLC analyses of ligations of TMD 2 + 3 and TMD 6 + 7, and ISMS data of the resulting peptides. See http://www.rsc.org/suppdata/cc/b4/b404008b/

Otaka, Akira, Ueda, Satoshi, Tomita, Kenji, Yano, Yoshiaki, Tamamura, Hirokazu, Matsuzaki, Katsumi, Fujii, Nobutaka

Journal:

Chemical Communications

Year:

2004

Language:

english

File:

PDF, 334 KB

english, 2004

152

Practical synthesis of phosphopeptides using dimethyl-protected phosphoamino acid derivatives

Otaka, Akira, Miyoshi, Kengo, Roller, Peter P., Burke, Terrence R., Tamamura, Hirokazu, Fujii, Nobutaka

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1995

Language:

english

File:

PDF, 329 KB

english, 1995

153

SN2? Ring opening of aziridines bearing an ?,?-unsaturated ester group with organocopper reagents. A new stereoselective synthetic route to (E)-alkene dipeptide isosteres

Fujii, Nobutaka, Nakai, Kazuo, Tamamura, Hirokazu, Otaka, Akira, Mimura, Norio, Miwa, Yoshihisa, Taga, Tooru, Yamamoto, Yoshinori, Ibuka, Toshiro

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1995

Language:

english

File:

PDF, 1.94 MB

english, 1995

154

Development of new methodology for the synthesis of functionalized α-fluorophosphonates and its practical application to the preparation of phosphopeptide mimetics

Otaka, Akira, Mitsuyama, Etsuko, Watanabe, Hideaki, Tamamura, Hirokazu, Fujii, Nobutaka

Journal:

Chemical Communications

Year:

2000

Language:

english

File:

PDF, 325 KB

english, 2000

155

Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonistsElectronic supplementary information (ESI) available: Fig. S1: behaviors of TF14013, TF14016 and TF14013-Me in mouse serum; Fig. S2: behaviors of TF14002 (a), TF14005 (b), TF14006 (c), TF14013 (d), TF14016 (e) and TF14013 analogs (f) in rat liver homogenate; Table S1: characterization data of novel synthetic peptides; and HPLC charts for synthetic compounds of 4F-benzoyl-TE14011 (TF14013), 4F-benzoyl-TN14003 (TF14016), nicotinoyl-TE14011 (TF14031) and 4F-benzoyl-TE14011-Me (TF14013-Me), and for a degraded sample of 4F-benzoyl-TE14011 (TF14013) in rat liver homogenate and its co-injection with an authentic compound des-[Arg14-

Tamamura, Hirokazu, Hiramatsu, Kenichi, Mizumoto, Makiko, Ueda, Satoshi, Kusano, Shuichi, Terakubo, Shigemi, Akamatsu, Miki, Yamamoto, Naoki, Trent, John O., Wang, Zixuan, Peiper, Stephen C., Nakashim

Journal:

Organic & Biomolecular Chemistry

Year:

2003

Language:

english

File:

PDF, 224 KB

english, 2003

156

Synthesis of potent ?-secretase inhibitors containing a hydroxyethylamine dipeptide isostere and their structure?activity relationship studies

Tamamura, Hirokazu, Kato, Terukazu, Otaka, Akira, Fujii, Nobutaka

Journal:

Organic & Biomolecular Chemistry

Year:

2003

Language:

english

File:

PDF, 218 KB

english, 2003

157

(E)-stereoselective synthesis of vinylglycines from (R)-serine via organocopper?BF3 and related reagents

Ibuka, Toshiro, Suzuki, Keisuke, Habashita, Hiromu, Otaka, Akira, Tamamura, Hirokazu, Mimura, Norio, Miwa, Yoshihisa, Taga, Tooru, Fujii, Nobutaka

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1994

Language:

english

File:

PDF, 305 KB

english, 1994

158

A convenient one-pot synthesis of cystine-containing peptides from protected peptidyl resins using the trimethylsilyl chloride?dimethyl sulfoxide?trifluoroacetic acid system

Tamamura, Hirokazu, Ishihara, Tsunehito, Otaka, Akira, Koide, Takaki, Miyoshi, Kengo, Ibuka, Toshiro, Fujii, Nobutaka

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1996

Language:

english

File:

PDF, 285 KB

english, 1996

159

Regiospecific ring-opening reactions of aziridines bearing an α,β-unsaturated ester group with trifluoroacetic acid or methanesulfonic acid: application to the stereoselective synthesis of (E)-alkene dipeptide isosteres

Tamamura, Hirokazu

Journal:

Chemical Communications

Year:

1997

Language:

english

File:

PDF, 54 KB

english, 1997

160

Biological and Genetic Characterization of a Human Immunodeficiency Virus Strain Resistant to CXCR4 Antagonist T134

Kanbara, Kenji, Sato, Setsuko, Tanuma, Jun-Ichi, Tamamura, Hirokazu, Gotoh, Kazuyo, Yoshimori, Manabu, Kanamoto, Taisei, Kitano, Motoo, Fujii, Nobutaka, Nakashima, Hideki

Journal:

AIDS Research and Human Retroviruses

Year:

2001

Language:

english

File:

PDF, 189 KB

english, 2001

161

Anti-HIV-1 Peptide Derivatives Based on the HIV-1 Co-receptor CXCR4

Hashimoto, Chie, Nomura, Wataru, Narumi, Tetsuo, Fujino, Masayuki, Tsutsumi, Hiroshi, Haseyama, Masaki, Yamamoto, Naoki, Murakami, Tsutomu, Tamamura, Hirokazu

Journal:

Year:

2013

Language:

english

File:

PDF, 561 KB

english, 2013

162

Peptide-based ligand screening and functional analysis of protein kinase C

Ohashi, Nami, Nomura, Wataru, Narumi, Tetsuo, Tamamura, Hirokazu

Journal:

Year:

2013

Language:

english

File:

PDF, 585 KB

english, 2013

163

Imidazolium Salt-Catalyzed Friedel-Crafts-Type Conjugate Addition of Indoles: Analysis of Indole/Imidazolium Complex by High Level ab Initio Calculations

Narumi, Tetsuo, Tsuzuki, Seiji, Tamamura, Hirokazu

Journal:

Asian Journal of Organic Chemistry

Year:

2014

Language:

english

File:

PDF, 533 KB

english, 2014

164

ChemInform Abstract: Imidazolium Salt-Catalyzed Friedel-Crafts-Type Conjugate Addition of Indoles: Analysis of Indole/Imidazolium Complex by High Level ab initio Calculations.

Narumi, Tetsuo, Tsuzuki, Seiji, Tamamura, Hirokazu

Journal:

Year:

2014

File:

PDF, 27 KB

2014

165

Marked Increase in Anti-HIV Activity, as Well as Inhibitory Activity against HIV Entry Mediated by CXCR4, Linked to Enhancement of the Binding Ability of Tachyplesin Analogs to CXCR4

Xu, Younong, Tamamura, Hirokazu, Arakaki, Rieko, Nakashima, Hideki, Zhang, Xiaoyan, Fujii, Nobutaka, Uchiyama, Takashi, Hattori, Toshio

Journal:

AIDS Research and Human Retroviruses

Year:

1999

Language:

english

File:

PDF, 217 KB

english, 1999

166

The therapeutic potential of CXCR4 antagonists in the treatment of HIV infection, cancer metastasis and rheumatoid arthritis

Tamamura, Hirokazu, Fujii, Nobutaka

Journal:

Expert Opinion on Therapeutic Targets

Year:

2005

Language:

english

File:

PDF, 329 KB

english, 2005

167

400. Peptide-Mediated Gene Transfer of Lipid/ DNA-Based Complexes to Cells Expressing CXC- Receptor 4

Driessen, Wouter H., Fujii, Nobutaka, Tamamura, Hirokazu, Sullivan, Sean M.

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 99 KB

english, 2006

168

The therapeutic potential of CXCR4 antagonists in the treatment of HIV

Fujii, Nobutaka, Nakashima, Hideki, Tamamura, Hirokazu

Journal:

Expert Opinion on Investigational Drugs

Year:

2003

Language:

english

File:

PDF, 379 KB

english, 2003

169

Retrograde migration of pectoral girdle muscle precursors depends on CXCR4/SDF-1 signaling

Masyuk, Maryna, Abduelmula, Aisha, Morosan-Puopolo, Gabriela, Ödemis, Veysel, Rehimi, Rizwan, Khalida, Nargis, Yusuf, Faisal, Engele, Jürgen, Tamamura, Hirokazu, Theiss, Carsten, Brand-Saberi, Beate

Journal:

Histochemistry and Cell Biology

Year:

2014

Language:

english

File:

PDF, 3.01 MB

english, 2014

170

Remote Stereoinduction in the Organocuprate-Mediated Allylic Alkylation of Allylic gem -Dichlorides: Highly Diastereoselective Synthesis of ( Z )-Chloroalkene Dipeptide Isosteres

Kobayakawa, Takuya, Narumi, Tetsuo, Tamamura, Hirokazu

Journal:

Organic Letters

Year:

2015

Language:

english

File:

PDF, 538 KB

english, 2015

171

An In-Cell Fluorogenic Tag–Probe System for Protein Dynamics Imaging Enabled by Cell-Penetrating Peptides

Nomura, Wataru, Ohashi, Nami, Mori, Atsumi, Tamamura, Hirokazu

Journal:

Bioconjugate Chemistry

Year:

2015

Language:

english

File:

PDF, 2.52 MB

english, 2015

172

Development of Anti-HIV Agents Targeting Dynamic Supramolecular Mechanism: Entry and Fusion Inhibitors Based on CXCR4/CCR5 Antagonists and gp41-C34-Remodeling Peptides

Tamamura, Hirokazu, Otaka, Akira, Fujii, Nobutaka

Journal:

Current HIV Research

Year:

2005

Language:

english

File:

PDF, 188 KB

english, 2005

173

Inhibitors of the Chemokine Receptor CXCR4: Chemotherapy of AIDS, Metastatic Cancer, Leukemia and Rheumatoid Arthritis

Tsutsumi, Hiroshi, Tamamura, Hirokazu, Fujii, Nobutaka

Journal:

Letters in Drug Design & Discovery

Year:

2007

Language:

english

File:

PDF, 107 KB

english, 2007

174

The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases

Tamamura, Hirokazu, Tsutsumi, Hiroshi, Fujii, Nobutaka

Journal:

Mini Reviews in Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 214 KB

english, 2006

175

Anti-HIV screening for cell-penetrating peptides using chloroquine and identification of anti-HIV peptides derived from matrix proteins

Mizuguchi, Takaaki, Ohashi, Nami, Nomura, Wataru, Komoriya, Mao, Hashimoto, Chie, Yamamoto, Naoki, Murakami, Tsutomu, Tamamura, Hirokazu

Journal:

Bioorganic & Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 548 KB

english, 2015

176

Development of Low Molecular Weight CXCR4 Antagonists by Exploratory Structural Tuning of Cyclic Tetra- and Pentapeptide-Scaffolds Towards the Treatment of HIV Infection, Cancer Metastasis and Rheumatoid Arthritis

Tamamura, Hirokazu, Tsutsumi, Hiroshi, Masuno, Hiroyuki, Fujii, Nobutaka

Journal:

Current Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 71 KB

english, 2007

177

Development of Peptide-targeted Lipoplexes to CXCR4-expressing Rat Glioma Cells and Rat Proliferating Endothelial Cells

Driessen, Wouter HP, Fujii, Nobutaka, Tamamura, Hirokazu, Sullivan, Sean M

Journal:

Molecular Therapy

Year:

2008

Language:

english

File:

PDF, 630 KB

english, 2008

178

Trivalent ligands for CXCR4 bearing polyproline linkers show specific recognition for cells with increased CXCR4 expression

Nomura, Wataru, Koseki, Taisuke, Ohashi, Nami, Mizuguchi, Takaaki, Tamamura, Hirokazu

Journal:

Organic & Biomolecular Chemistry

Year:

2015

Language:

english

File:

PDF, 1.79 MB

english, 2015

179

Utilization of the Heavy Atom Effect for the Development of a Photosensitive 8-Azacoumarin-Type Photolabile Protecting Group

Takano, Hikaru, Narumi, Tetsuo, Nomura, Wataru, Furuta, Toshiaki, Tamamura, Hirokazu

Journal:

Organic Letters

Year:

2015

Language:

english

File:

PDF, 843 KB

english, 2015

180

Plasma Pancreastatin-Like Immunoreactivity in Various Diseases

TATEISHI, KAYOKO, FUNAKOSHI, AKIHIRO, WAKASUGI, HIDEYUKI, IGUCHI, HARUO, SHINOZAKI, HIROTSUGU, ABE, MUNEAKI, FUNAKOSHI, SUSUMU, TAMAMURA, HIROKAZU, YAJIMA, HARUAKI, MATSUOKA, YUJI

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

1989

Language:

english

File:

PDF, 466 KB

english, 1989

181

Modulation of Network-Driven, GABA-Mediated Giant Depolarizing Potentials by SDF-1α in the Developing Hippocampus

Kasiyanov, Alexander, Fujii, Nobutaka, Tamamura, Hirokazu, Xiong, Huangui

Journal:

Developmental Neuroscience

Year:

2008

Language:

english

File:

PDF, 305 KB

english, 2008

182

Efficient Induction of Peptide-Specific Cytotoxic T Lymphocytes by LPS-Activated Spleen Cells

Kakugawa, Kiyokazu, Udaka, Keiko, Nakashima, Kosuke, Inaba, Kayo, Oka, Yoshihiro, Sugiyama, Haruo, Tamamura, Hirokazu, Yamagishi, Hideo

Journal:

Microbiology and Immunology

Year:

2000

Language:

english

File:

PDF, 1.74 MB

english, 2000

183

ChemInform Abstract: Remote Stereoinduction in the Organocuprate-Mediated Allylic Alkylation of Allylic gem-Dichlorides: Highly Diastereoselective Synthesis of (Z)-Chloroalkene Dipeptide Isosteres.

Kobayakawa, Takuya, Narumi, Tetsuo, Tamamura, Hirokazu

Journal:

Year:

2015

File:

PDF, 23 KB

2015

184

Multimerized HIV-gp41-derived Peptides as Fusion Inhibitors and Vaccines†

Nomura, Wataru, Mizuguchi, Takaaki, Tamamura, Hirokazu

Journal:

Year:

2015

Language:

english

File:

PDF, 1.03 MB

english, 2015

185

Efficient synthesis of Xaa-Gly type (Z)-chloroalkene dipeptide isosteres via organocuprate mediated reduction

Kobayakawa, Takuya, Tamamura, Hirokazu

Journal:

Year:

2016

Language:

english

File:

PDF, 416 KB

english, 2016

186

Functional evaluation of fluorescein-labeled derivatives of a peptide inhibitor of the EGF receptor dimerization

Toyama, Kei, Mizuguchi, Takaaki, Nomura, Wataru, Tamamura, Hirokazu

Journal:

Bioorganic & Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 759 KB

english, 2016

187

A Mild Method for the Direct Fluorination of Pyrroles by Using a Lipophilic Anionic Phase-Transfer Catalyst

Hiramatsu, Kenichi, Tamamura, Hirokazu

Journal:

European Journal of Organic Chemistry

Year:

2016

Language:

english

File:

PDF, 638 KB

english, 2016

188

Induction of Cross-Reactivity in an Endogenous Viral Peptide Non-Reactive to FBL-3 Tumor-Specific Helper T-Cell Clones

Uenishi, Hirohide, Iwanami, Norimasa, Yamagishi, Hideo, Nakatani, Takako, Kawasaki, Toshisuke, Tamamura, Hirokazu, Fujii, Nobutaka, Kuribayashi, Kagemasa

Journal:

Microbiology and Immunology

Year:

1998

Language:

english

File:

PDF, 1.13 MB

english, 1998

189

Molecular Size of an Anti-HIV Peptide, T22, Can Be Reduced without Loss of the Activity

Waki, Michinori, Waki, Koji, Miyamoto, Kenji, Matsumoto, Akiyoshi, Tamamura, Hirokazu, Fujii, Nobutaka, Murakami, Tsutomu, Nakashima, Hideki, Yamamoto, Naoki

Journal:

Chemistry Letters

Year:

1996

File:

PDF, 393 KB

1996

190

Development and validation of a cell-based assay system to assess human immunodeficiency virus type 1 integrase multimerization

Nakamura, Tomofumi, Campbell, Joseph R., Moore, Amber R., Otsu, Sachiko, Aikawa, Haruo, Tamamura, Hirokazu, Mitsuya, Hiroaki

Journal:

Journal of Virological Methods

Year:

2016

Language:

english

File:

PDF, 2.59 MB

english, 2016

191

High plasma pancreastatinlike immunoreactivity in a patient with malignant insulinoma

Tateishi, Kayoko, Funakoshi, Akihiro, Jimi, Atsuo, Funakoshi, Susumu, Tamamura, Hirokazu, Yajima, Haruaki, Matsuoka, Yuji

Journal:

Gastroenterology

Year:

1989

Language:

english

File:

PDF, 825 KB

english, 1989

192

Antimicrobial Activity and Conformation of Tachyplesin I and Its Analogs.

TAMAMURA, Hirokazu, IKOMA, Rie, NIWA, Makoto, FUNAKOSHI, Susumu, MURAKAMI, Tsukasa, FUJII, Nobutaka

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1993

File:

PDF, 577 KB

1993

193

Acceleration of the N.ALPHA.-Deprotection Rate by the Addition of m-Cresol to Diluted Methanesulfonic Acid and Its Application to the Z(OMe)-Based Solid-Phase Syntheses of Human Pancreastatin-29 and Magainin 1.

TAMAMURA, Hirokazu, NAKAMURA, Junko, NOGUCHI, Katsuhiro, FUNAKOSHI, Susumu, FUJII, Nobutaka

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1993

File:

PDF, 725 KB

1993

194

Synthesis of Optically Pure 2-Aziridinemethanols: Versatile Synthetic Building Blocks.

FUJII, Nobutaka, NAKAI, Kazuo, HABASHITA, Hiromu, HOTTA, Yuka, TAMAMURA, Hirokazu, OTAKA, Akira, IBUKA, Toshiro

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1994

File:

PDF, 1.71 MB

1994

195

Synthesis of Protegrin-Related Peptides and Their Antibacterial and Anti-human Immunodeficiency Virus Activity.

TAMAMURA, Hirokazu, MURAKAMI, Tsutomu, HORIUCHI, Sankichi, SUGIHARA, Keiji, OTAKA, Akira, TAKADA, Wataru, IBUKA, Toshiro, WAKI, Michinori, YAMAMOTO, Naoki, FUJII, Nobutaka

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1995

File:

PDF, 956 KB

1995

196

Solution-Phase Synthesis of an Anti-human Immunodeficiency Virus Peptide, T22 ((Tyr5,12, Lys7)-Polyphemusin II), and the Modification of Trp by the p-Methoxybenzyl Group of Cys during Trimethylsilyl Trifluoromethanesulfonate Deprotection.

TAMAMURA, Hirokazu, OTAKA, Akira, TAKADA, Wataru, TERAKAWA, Yoshihiro, YOSHIZAWA, Hidenori, MASUDA, Masao, IBUKA, Toshiro, MURAKAMI, Tsutomu, NAKASHIMA, Hideki, WAKI, Michinori, MATSUMOTO, Akiyoshi, Y

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1995

File:

PDF, 1.09 MB

1995

197

A New Practical Strategy for the Synthesis of Long-Chain Phosphopeptide.

MIYOSHI, Kengo, OTAKA, AKira, KANEKO, Midori, TAMAMURA, Hirokazu, FUJII, Nobutaka

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2000

File:

PDF, 693 KB

2000

198

Screening for Protein Kinase C Ligands Using Fluorescence Resonance Energy Transfer

Ohashi, Nami, Nomura, Wataru, Minato, Natsuki, Tamamura, Hirokazu

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2014

Language:

english

File:

PDF, 900 KB

english, 2014

199

Development of Selective Antagonists against an HIV Second Receptor.

TAMAMURA, Hirokazu

Journal:

YAKUGAKU ZASSHI

Year:

2001

Language:

english

File:

PDF, 1004 KB

english, 2001

200

Development of Anti-HIV Agents Based on Chemical Biology

Tamamura, Hirokazu

Journal:

YAKUGAKU ZASSHI

Year:

2012

Language:

english

File:

PDF, 843 KB

english, 2012