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1

From Phage Display to Dendrimer Display: Insights into Multivalent Binding

Bastings, Maartje M. C., Helms, Brett A., van Baal, Ingrid, Hackeng, Tilman M., Merkx, Maarten, Meijer, E. W.

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 2.79 MB

english, 2011

2

Regulation of coagulation by protein S

Castoldi, Elisabetta, Hackeng, Tilman M

Journal:

Current Opinion in Hematology

Year:

2008

Language:

english

File:

PDF, 315 KB

english, 2008

3

Reduced vitamin K status as a potentially modifiable risk factor of severe COVID-19

Dofferhoff, Anton S M, Piscaer, Ianthe, Schurgers, Leon J, Visser, Margot P J, van den Ouweland, Jody M W, de Jong, Pim A, Gosens, Reinoud, Hackeng, Tilman M, van Daal, Henny, Lux, Petra, Maassen, Cec

Journal:

Clinical Infectious Diseases

Year:

2020

File:

PDF, 929 KB

2020

4

Chemical synthesis of human protein S thrombin-sensitive module and first epidermal growth factor module

Tilman M. Hackeng, Philip E. Dawson, Stephen B.H. Kent, John H. Griffin

Journal:

Year:

1998

Language:

english

File:

PDF, 171 KB

english, 1998

5

Multivalent Peptide and Protein Dendrimers Using Native Chemical Ligation

Ingrid van Baal, Hinke Malda, Silvia A. Synowsky, Joost L. J. van Dongen, Tilman M. Hackeng, Maarten Merkx, E. W. Meijer

Journal:

Angewandte Chemie

Year:

2005

Language:

english

File:

PDF, 266 KB

english, 2005

6

Nucleophilic Catalysis of Oxime Ligation

Anouk Dirksen, Tilman M. Hackeng, Philip E. Dawson

Journal:

Angewandte Chemie

Year:

2006

Language:

english

File:

PDF, 114 KB

english, 2006

7

Multivalent Peptide and Protein Dendrimers Using Native Chemical Ligation

Ingrid van Baal, Hinke Malda, Silvia A. Synowsky, Joost L. J. van Dongen, Tilman M. Hackeng, Maarten Merkx, E. W. Meijer

Journal:

Angewandte Chemie International Edition

Year:

2005

Language:

english

File:

PDF, 266 KB

english, 2005

8

Nucleophilic Catalysis of Oxime Ligation

Anouk Dirksen, Tilman M. Hackeng, Philip E. Dawson

Journal:

Angewandte Chemie International Edition

Year:

2006

Language:

english

File:

PDF, 115 KB

english, 2006

9

Nε-(thiaprolyl)-lysine as a handle for site-specific protein conjugation

Pieter Van de Vijver, Dennis Suylen, Anouk Dirksen, Philip E. Dawson, Tilman M. Hackeng

Journal:

Year:

2010

Language:

english

File:

PDF, 529 KB

english, 2010

10

Noncovalent Synthesis of Protein Dendrimers

Edith H. M. Lempens, Ingrid van Baal, Joost L. J. van Dongen, Tilman M. Hackeng, Maarten Merkx, E. W. Meijer

Journal:

Chemistry - A European Journal

Year:

2009

Language:

english

File:

PDF, 515 KB

english, 2009

11

Pharmacokinetics of contrast agents targeted to the tumor vasculature in molecular magnetic resonance imaging

Marlies Oostendorp, Kim Douma, Tilman M. Hackeng, Marc A. M. J. van Zandvoort, Mark J. Post, Walter H. Backes

Journal:

Contrast Media & Molecular Imaging

Year:

2010

Language:

english

File:

PDF, 400 KB

english, 2010

12

Structure-function studies on human C4b-binding protein using monoclonal antibodies

Martin Hessing, Harry F. G. Heijnen, Tilman M. Hackeng, Jan J. Sixma, Bonno N. Bouma

Journal:

European Journal of Immunology

Year:

1991

Language:

english

File:

PDF, 1.02 MB

english, 1991

13

Solid-Phase Synthesis of a Cyclic NGR-Functionalized GdIIIDTPA Complex

Sander Langereis, Anouk Dirksen, Bas F. M. De Waal, Marcel H. P. Van Genderen, Quido G. De Lussanet, Tilman M. Hackeng, E. W. Meijer

Journal:

European Journal of Organic Chemistry

Year:

2005

Language:

english

File:

PDF, 152 KB

english, 2005

14

Gadolinium-labeled quantum dots for molecular magnetic resonance imaging: R1 versus R2 mapping

Marlies Oostendorp, Kim Douma, Tilman M. Hackeng, Mark J. Post, Marc A. M. J. van Zandvoort, Walter H. Backes

Journal:

Magnetic Resonance in Medicine

Year:

2010

Language:

english

File:

PDF, 552 KB

english, 2010

15

Nanoparticles for Optical Molecular Imaging of Atherosclerosis

Kim Douma, Lenneke Prinzen, Dick W. Slaaf, Chris P. M. Reutelingsperger, Erik A. L. Biessen, Tilman M. Hackeng, Mark J. Post, Marc A. M. J. van Zandvoort

Journal:

Year:

2009

Language:

english

File:

PDF, 542 KB

english, 2009

16

Total chemical synthesis of human matrix Gla protein

Tilman M. Hackeng, Jan Rosing, Henri M.H. Spronk, Cees Vermeer

Journal:

Protein Science

Year:

2001

Language:

english

File:

PDF, 222 KB

english, 2001

17

Inhibition of the interaction between Platelet Factor 4 and RANTES reduces atherosclerosis in apolipoprotein E-deficient mice

Rory R. Koenen, Philipp von Hundelshausen, Elisa Liehn, Tilman M. Hackeng, Wencke Adriaens, Andreas Kungl, Alma Zernecke, Christian Weber

Journal:

Vascular Pharmacology

Year:

2006

Language:

english

File:

PDF, 49 KB

english, 2006

18

Cardiolipin Enhances Protein C Pathway Anticoagulant Activity

José A Fernández, Kazuhisa Kojima, Jari Petäjä, Tilman M Hackeng, John H Griffin

Journal:

Blood Cells, Molecules, and Diseases

Year:

2000

Language:

english

File:

PDF, 565 KB

english, 2000

19

Importance of the α3-fragment of complement C4 for the binding with C4b-binding protein

Martin Hessing, Cornells van't Veer, Tilman M. Hackeng, Bonno N. Bouma, Sadaaki Iwanaga

Journal:

Year:

1990

Language:

english

File:

PDF, 716 KB

english, 1990

20

The region Ser333-Arg356 of the α-chain of human C4b-binding protein is involved in the binding of complement C4b

Martin Hessing, Deon Kanters, Hiroyuki Takeya, Cornelis van't Veer, Tilman M. Hackeng, Sadaaki Iwanaga, Bonno N. Bourna

Journal:

Year:

1993

Language:

english

File:

PDF, 551 KB

english, 1993

21

Vascular calcification: The price to pay for anticoagulation therapy with vitamin K-antagonists

Martijn L.L. Chatrou, Kristien Winckers, Tilman M. Hackeng, Chris P. Reutelingsperger, Leon J. Schurgers

Journal:

Year:

2012

Language:

english

File:

PDF, 1.16 MB

english, 2012

22

TFPI-dependent activities of Protein S

Sameera Peraramelli, Jan Rosing, Tilman M. Hackeng

Journal:

Thrombosis Research

Year:

2012

Language:

english

File:

PDF, 316 KB

english, 2012

23

Protein S Multimers Are Generated In Vitro and Affect Protein S Structure-Function Analyses

Kristin M. Seré, George M. Willems, Jan Rosing, Tilman M. Hackeng

Journal:

Seminars in Hematology

Year:

2006

Language:

english

File:

PDF, 261 KB

english, 2006

24

Incorporation of Disulfide Containing Protein Modules into Multivalent Antigenic Conjugates: Generation of Antibodies against the Thrombin-Sensitive Region of Murine Protein S

Van de Vijver, Pieter, Schmitt, Martin, Suylen, Dennis, Scheer, Liesbeth, Thomassen, M. Christella L. G. D., Schurgers, Leon J., Griffin, John H., Koenen, Rory R., Hackeng, Tilman M.

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 1.12 MB

english, 2012

25

Nucleophilic Catalysis of Hydrazone Formation and Transimination: Implications for Dynamic Covalent Chemistry

Dirksen, Anouk, Dirksen, Sjoerd, Hackeng, Tilman M., Dawson, Philip E.

Journal:

Journal of the American Chemical Society

Year:

2006

Language:

english

File:

PDF, 98 KB

english, 2006

26

Binding sites for blood coagulation factor Xa and protein S involving residues 493–506 in factor Va

Mary J. Heeb, Yumi Kojima, Tilman M. Hackeng, John H. Griffin

Journal:

Protein Science

Year:

1996

Language:

english

File:

PDF, 655 KB

english, 1996

27

Development and evaluation of a cetuximab-based imaging probe to target EGFR and EGFRvIII

Hugo J.W.L. Aerts, Ludwig Dubois, Tilman M. Hackeng, Roel Straathof, Roland K. Chiu, Natasja G. Lieuwes, Barry Jutten, Sherry A. Weppler, Guido Lammering, Bradly G. Wouters, Philippe Lambin

Journal:

Radiotherapy and Oncology

Year:

2007

Language:

english

File:

PDF, 1.32 MB

english, 2007

28

Protein lysine-Nζ alkylation and O -phosphorylation mediated by DTT-generated reactive oxygen species

Kumar, Nigam, Ippel, Hans, Weber, Christian, Hackeng, Tilman, Mayo, Kevin H.

Journal:

Protein Science

Year:

2013

Language:

english

File:

PDF, 1.49 MB

english, 2013

29

Molecular MRI of Early Thrombus Formation Using a Bimodal α2-Antiplasmin–Based Contrast Agent

Robbert-Jan J.H.M. Miserus, M. Veronica Herías, Lenneke Prinzen, Marc B.I. Lobbes, Robert-Jan Van Suylen, Anouk Dirksen, Tilman M. Hackeng, Johan W.M. Heemskerk, Jos M.A. van Engelshoven, Mat J.A.P. D

Journal:

Journal of the American College of Cardiology: Cardiovascular Imaging

Year:

2009

Language:

english

File:

PDF, 9.99 MB

english, 2009

30

Endothelin-1 and -2: Two amino acids matter

Matthijs G. Compeer, Dennis P.L. Suylen, Tilman M. Hackeng, Jo G.R. De Mey

Journal:

Year:

2012

Language:

english

File:

PDF, 721 KB

english, 2012

31

Optical and Magnetic Resonance Imaging of Cell Death and Platelet Activation Using Annexin A5-Functionalized Quantum Dots

Prinzen, Lenneke, Miserus, Robbert-Jan J. H. M., Dirksen, Anouk, Hackeng, Tilman M., Deckers, Niko, Bitsch, Nicole J., Megens,, Douma, Kim, Heemskerk, Johan W., Kooi, M. Eline, Frederik, Peter M., Sl

Journal:

Year:

2007

Language:

english

File:

PDF, 396 KB

english, 2007

32

NMR characterization of a Cu(i)-bound peptide model of copper metallochaperones: Insights on the role of methionine

Shoshan, Michal S., Shalev, Deborah E., Adriaens, Wencke, Merkx, Maarten, Hackeng, Tilman M., Tshuva, Edit Y.

Journal:

Chemical Communications

Year:

2011

Language:

english

File:

PDF, 1.46 MB

english, 2011

33

The role of tissue factor pathway inhibitor in atherosclerosis and arterial thrombosis

Winckers, Kristien, ten Cate, Hugo, Hackeng, Tilman M.

Journal:

Year:

2013

Language:

english

File:

PDF, 1005 KB

english, 2013

34

Dendrimers and magnetic resonance imaging

Langereis, Sander, Dirksen, Anouk, Hackeng, Tilman M., van Genderen, Marcel H. P., Meijer, E. W.

Journal:

New Journal of Chemistry

Year:

2007

Language:

english

File:

PDF, 1.17 MB

english, 2007

35

Synthesis and application of cNGR-containing imaging agents for detection of angiogenesis

Dijkgraaf, Ingrid, Van de Vijver, Pieter, Dirksen, Anouk, Hackeng, Tilman M.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.51 MB

english, 2013

36

Design and Synthesis of a Bimodal Target-Specific Contrast Agent for Angiogenesis

Dirksen, Anouk, Langereis, Sander, de Waal, Bas F. M., van Genderen, Marcel H. P., Meijer, E. W., de Lussanet, Quido G., Hackeng, Tilman M.

Journal:

Organic Letters

Year:

2004

Language:

english

File:

PDF, 86 KB

english, 2004

37

1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 36 proline-containing, full length 29 kDa human chimera-type galectin-3

Ippel, Hans, Miller, Michelle C., Berbís, Manuel Alvaro, Suylen, Dennis, André, Sabine, Hackeng, Tilman M., Cañada, F. Javier, Weber, Christian, Gabius, Hans-Joachim, Jiménez-Barbero, Jesús, Mayo, Kev

Journal:

Biomolecular NMR Assignments

Year:

2015

Language:

english

File:

PDF, 1.01 MB

english, 2015

38

Atherogenic mononuclear cell recruitment is facilitated by oxidized lipoprotein-induced endothelial junctional adhesion molecule-A redistribution

Schmitt, Martin M.N., Fraemohs, Line, Hackeng, Tilman M., Weber, Christian, Koenen, Rory R.

Journal:

Atherosclerosis

Year:

2014

Language:

english

File:

PDF, 3.69 MB

english, 2014

39

Imaging of the binding of ET-1 and of linear ET-1 in rat mesenteric resistance arteries

Kapsokalyvas, Dimitrios, Schiffers, Paul M.H./INS, , Maij, Nathan, Hackeng, Tilman M., Suylen, Dennis P., van Zandvoort, Marrc A.M.J./INS, , De Mey, Jo G.R./INS,

Journal:

Year:

2013

Language:

english

File:

PDF, 43 KB

english, 2013

40

Total Chemical Synthesis of Enzymatically Active Human Type II Secretory Phospholipase A2

Tilman M. Hackeng, Carine M. Mounier, Cassian Bon, Philip E. Dawson, John H. Griffin and Stephen B. H. Kent

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.04 MB

english, 1997

41

A Factor IX-Deficient Mouse Model for Hemophilia B Gene Therapy

Lili Wang, Monica Zoppe, Tilman M. Hackeng, John H. Griffin, Kuo-Fen Lee and Inder M. Verma

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.04 MB

english, 1997

42

Protein Synthesis by Native Chemical Ligation: Expanded Scope by Using Straightforward Methodology

Tilman M. Hackeng, John H. Griffin and Philip E. Dawson

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.05 MB

english, 1999

43

Imaging evidence for endothelin ETA/ETB receptor heterodimers in isolated rat mesenteric resistance arteries

Kapsokalyvas, Dimitrios, Schiffers, Paul M.H., Maij, Nathan, Suylen, Dennis P., Hackeng, Tilman M., van Zandvoort, Marc A.M.J., De Mey, Jo G.R.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.07 MB

english, 2014

44

Impaired Processing of Human Pro-Islet Amyloid Polypeptide Is Not a Causative Factor for Fibril Formation or Membrane Damage in Vitro

Khemtémourian, Lucie, Lahoz Casarramona, Gemma, Suylen, Dennis P. L., Hackeng, Tilman M., Meeldijk, Johannes D., de Kruijff, Ben, Höppener, Jo W. M., Killian, J. Antoinette

Journal:

Year:

2009

Language:

english

File:

PDF, 3.06 MB

english, 2009

45

Kinetic characterization of Escherichia coli outer membrane phospholipase A using mixed detergent-lipid micelles

Horrevoets, Anton J. G., Hackeng, Tilman M., Verheij, Hubertus M., Dijkman, Ruud, De Haas, Gerard H.

Journal:

Year:

1989

Language:

english

File:

PDF, 1.11 MB

english, 1989

46

A supramolecular approach to multivalent target-specific MRI contrast agents for angiogenesis

Dirksen, Anouk, Langereis, Sander, de Waal, Bas F. M., van Genderen, Marcel H. P., Hackeng, Tilman M., Meijer, E. W.

Journal:

Chemical Communications

Year:

2005

Language:

english

File:

PDF, 342 KB

english, 2005

47

Analysis of Protein S C4b-Binding Protein Interactions by Homology Modeling and Inhibitory Antibodies

Fernandez, Jose A., Villoutreix, Bruno O., Hackeng, Tilman M., Griffin, John H., Bouma, Bonno N.

Journal:

Year:

1994

Language:

english

File:

PDF, 2.00 MB

english, 1994

48

Purified Protein S Contains Multimeric Forms with Increased APC-Independent Anticoagulant Activity †

Seré,, Kristin M., Janssen, Marie P., Willems, George M., Tans, Guido, Rosing, Jan, Hackeng, Tilman M.

Journal:

Year:

2001

Language:

english

File:

PDF, 172 KB

english, 2001

49

Application of an omonasteine ligation strategy for the total chemical synthesis of the BRD7 bromodomain

Van de Vijver, Pieter, Scheer, Liesbeth, van Beijnum, Judy, Griffioen, Arjan, Hackeng, Tilman M.

Journal:

Chemical Communications

Year:

2012

Language:

english

File:

PDF, 1.40 MB

english, 2012

50

Strategy for the synthesis of multivalent peptide-based nonsymmetric dendrimers by native chemical ligation

Dirksen, Anouk, Meijer, E. W., Adriaens, Wencke, Hackeng, Tilman M.

Journal:

Chemical Communications

Year:

2006

Language:

english

File:

PDF, 410 KB

english, 2006