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51

Selective Inhibition of Type II Dehydroquinases

Frederickson, Martyn, Parker, Emily J., Hawkins, Alastair R., Coggins, John R., Abell, Chris

Journal:

Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 81 KB

english, 1999

52

Mycobacterium tuberculosis Shikimate Kinase Inhibitors: Design and Simulation Studies of the Catalytic Turnover

Blanco, Beatriz, Prado, Verónica, Lence, Emilio, Otero, José M., Garcia-Doval, Carmela, van Raaij, Mark J., Llamas-Saiz, Antonio L., Lamb, Heather, Hawkins, Alastair R., González-Bello, Concepción

Journal:

Journal of the American Chemical Society

Year:

2013

Language:

english

File:

PDF, 1.49 MB

english, 2013

53

Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases 1

Coderch, Claire, Lence, Emilio, Peón, Antonio, Lamb, Heather, Hawkins, Alastair R., Gago, Federico, González‑Bello, Concepción

Journal:

Biochemical Journal

Year:

2014

Language:

english

File:

PDF, 2.96 MB

english, 2014

54

Actin in the oomycetous fungus Phytophthora infestans is the product of several genes

Unities, Shiela E., Moon, Richard P., Hawkins, Alastair R., Duncan, James M., Kinghorn, James R.

Journal:

Year:

1991

Language:

english

File:

PDF, 1.16 MB

english, 1991

55

EDINBURGH MEDICO-CHIRURGICAL SOCIETY.

Unities, Shiela E., Moon, Richard P., Hawkins, Alastair R., Duncan, James M., Kinghorn, James R.

Journal:

Year:

1904

Language:

english

File:

PDF, 650 KB

english, 1904

56

Foreign Cleanings.

Unities, Shiela E., Moon, Richard P., Hawkins, Alastair R., Duncan, James M., Kinghorn, James R.

Journal:

Year:

1867

Language:

english

File:

PDF, 407 KB

english, 1867

57

Evolution of transcription-regulating proteins by enzyme recruitment: molecular models for nitrogen metabolite repression and ethanol utilisation in eukaryotes

Hawkins, Alastair R., Lamb, Heather K., Radford, Alan, Moore, Jonathan D.

Journal:

Year:

1994

Language:

english

File:

PDF, 1.81 MB

english, 1994

58

A second gene (qutH) within the Aspergillus nidulans-quinic-acid utilisation gene cluster encodes a protein with a putative zinc-cluster motif

Lamb, Heather K., Roberts, Clive F., Hawkins, Alastair R.

Journal:

Year:

1992

Language:

english

File:

PDF, 706 KB

english, 1992

59

Genesis of eukaryotic transcriptional activator and repressor proteins by splitting a multidomain anabolic enzyme

Hawkins, Alastair R., Lamb, Heather K., Moore, Jonathan D., Roberts, Clive F.

Journal:

Year:

1993

Language:

english

File:

PDF, 796 KB

english, 1993

60

Structure of the Aspergillus nidulans qut repressor-encoding gene: implications for the regulation of transcription initiation

Hawkins, Alastair R., Lamb, Heather K., Roberts, Clive F.

Journal:

Year:

1992

Language:

english

File:

PDF, 704 KB

english, 1992

61

Insights into substrate binding and catalysis in bacterial type I dehydroquinase

Maneiro, María, Peón, Antonio, Lence, Emilio, Otero, José M., Van Raaij, Mark J., Thompson, Paul, Hawkins, Alastair R., González‑Bello, Concepción

Journal:

Biochemical Journal

Year:

2014

Language:

english

File:

PDF, 1.52 MB

english, 2014

62

Exploring the Water-Binding Pocket of the Type II Dehydroquinase Enzyme in the Structure-Based Design of Inhibitors

Blanco, Beatriz, Sedes, Antía, Peón, Antonio, Otero, José M., van Raaij, Mark J., Thompson, Paul, Hawkins, Alastair R., González-Bello, Concepción

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 6.15 MB

english, 2014

63

Reactivation of 3-Dehydroquinate Synthase by Lanthanide Cations

Moore, Jonathan D., Skinner, Murray A., Swatman, David R., Hawkins, Alastair R., Brown, Katherine A.

Journal:

Journal of the American Chemical Society

Year:

1998

Language:

english

File:

PDF, 31 KB

english, 1998

64

Structure-Based Design, Synthesis, and Biological Evaluation of Inhibitors of Mycobacterium t uberculosis Type II Dehydroquinase

Sánchez-Sixto, Cristina, Prazeres, Verónica F. V., Castedo, Luis, Lamb, Heather, Hawkins, Alastair R., González-Bello, Concepción

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 372 KB

english, 2005

65

Synthesis of 4-deoxyquinic, 4-deoxyshikimic and 4-deoxy-3-dehydroshikimic acids

González-Bello, Concepción, Coggins, John R., Hawkins, Alastair R., Abell, Chris

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1999

Language:

english

File:

PDF, 176 KB

english, 1999

66

Comparison of the substrate specificity of type I and type II dehydroquinases with 5-deoxy- and 4,5-dideoxy-dehydroquinic acid

Harris, Joanna M., Watkins, William J., Hawkins, Alastair R., Coggins, John R., Abell, Chris

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1996

Language:

english

File:

PDF, 1.14 MB

english, 1996

67

Poly-(4- and 5-acrylamidosalicylic acids). Part IV. Selectivity in the extraction of metal cations from aqueous solution

Kennedy, John F., Barker, S. Alan, Nicol, Alastair W., Hawkins, Alan

Journal:

Journal of the Chemical Society Dalton Transactions

Year:

1973

Language:

english

File:

PDF, 554 KB

english, 1973

68

Different mechanistic and stereochemical courses for the reactions catalysed by type I and type II dehydroquinases

Harris, Joanna, Kleanthous, Colin, Coggins, John R., Hawkins, Alastair R., Abell, Chris

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1993

Language:

english

File:

PDF, 238 KB

english, 1993

69

Irreversible covalent modification of type I dehydroquinase with a stable Schiff base

Tizón, Lorena, Maneiro, María, Peón, Antonio, Otero, José M., Lence, Emilio, Poza, Sergio, van Raaij, Mark J., Thompson, Paul, Hawkins, Alastair R., González-Bello, Concepción

Journal:

Organic & Biomolecular Chemistry

Year:

2015

Language:

english

File:

PDF, 1.97 MB

english, 2015

70

Isolation and characterization of the positively acting regulatory gene QUTA from Aspergillus nidulans

Beri, Raj K., Whittington, Hayley, Roberts, Clive F., Hawkins, Alastair R.

Journal:

Nucleic Acids Research

Year:

1987

Language:

english

File:

PDF, 417 KB

english, 1987

71

Nucleotide sequence encoding the biosynthetic dehydroquinase function of the penta-functional AROM locus of Aspergillus nidulans

Charles, Ian G., Keyte, John W., Brammar, William J., Hawkins, Alastair R.

Journal:

Nucleic Acids Research

Year:

1985

Language:

english

File:

PDF, 921 KB

english, 1985

72

The isolation and nucleotide sequence of the complex AROM locus of Aspergillus nidulans

Charles, Ian G., Keyte, John W., Brammar, William J., Smith, Melanie, Hawkins, Alastair R.

Journal:

Nucleic Acids Research

Year:

1986

Language:

english

File:

PDF, 556 KB

english, 1986

73

Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct

González-Bello, Concepción, Tizón, Lorena, Lence, Emilio, Otero, José M., van Raaij, Mark J., Martinez-Guitian, Marta, Beceiro, Alejandro, Thompson, Paul, Hawkins, Alastair R.

Journal:

Journal of the American Chemical Society

Year:

2015

Language:

english

File:

PDF, 1.24 MB

english, 2015

74

Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme

Prado, Verónica, Lence, Emilio, Maneiro, María, Vázquez-Ucha, Juan C., Beceiro, Alejandro, Thompson, Paul, Hawkins, Alastair R., González-Bello, Concepción

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 2.03 MB

english, 2016

75

Study of the Phosphoryl-Transfer Mechanism of Shikimate Kinase by NMR Spectroscopy

Prado, Verónica, Lence, Emilio, Vallejo, Juan A., Beceiro, Alejandro, Thompson, Paul, Hawkins, Alastair R., González-Bello, Concepción

Journal:

Chemistry - A European Journal

Year:

2016

Language:

english

File:

PDF, 5.71 MB

english, 2016

76

The folding and assembly of the dodecameric type II dehydroquinases

PRICE, Nicholas C., BOAM, Deborah J., KELLY, Sharon M., DUNCAN, Doris, KRELL, Tino, GOURLEY, David G., COGGINS, John R., VIRDEN, Richard, HAWKINS, Alastair R.

Journal:

Biochemical Journal

Year:

1999

Language:

english

File:

PDF, 232 KB

english, 1999

77

Identification of domains responsible for signal recognition and transduction within the QUTR transcription repressor protein

LEVETT, Lisa J., SI-HOE, Shi Ming, LIDDLE, Stuart, WHEELER, Kerry, SMITH, Deborah, LAMB, Heather K., NEWTON, Giles H., COGGINS, John R., HAWKINS, Alastair R.

Journal:

Biochemical Journal

Year:

2000

Language:

english

File:

PDF, 226 KB

english, 2000

78

Comparative analysis of the QUTR transcription repressor protein and the three C-terminal domains of the pentafunctional AROM enzyme

LAMB, Heather K., MOORE, Jonathan D., LAKEY, Jeremy H., LEVETT, Lisa J., WHEELER, Kerry A., LAGO, Hugo, COGGINS, John R., HAWKINS, Alastair R.

Journal:

Biochemical Journal

Year:

1996

Language:

english

File:

PDF, 562 KB

english, 1996

79

Control of metabolic flux through the quinate pathway in Aspergillus nidulans

WHEELER, Kerry A., LAMB, Heather K., HAWKINS, Alastair R.

Journal:

Biochemical Journal

Year:

1996

Language:

english

File:

PDF, 605 KB

english, 1996

80

Conformational changes and the role of metals in the mechanism of type II dehydroquinase from Aspergillus nidulans

BOTTOMLEY, Joanna R, HAWKINS, Alastair R., KLEANTHOUS, Colin

Journal:

Biochemical Journal

Year:

1996

Language:

english

File:

PDF, 751 KB

english, 1996

81

Evidence from kinetic isotope studies for an enolate intermediate in the mechanism of type II dehydroquinases

HARRIS, Joanna M, GONZALEZ-BELLO, Concepcion, KLEANTHOUS, Colin, HAWKINS, Alastair R., COGGINS, John R., ABELL, Chris

Journal:

Biochemical Journal

Year:

1996

Language:

english

File:

PDF, 360 KB

english, 1996

82

The folding and assembly of the dodecameric type II dehydroquinases

PRICE, Nicholas C., BOAM, Deborah J., KELLY, Sharon M., DUNCAN, Doris, KRELL, Tino, GOURLEY, David G., COGGINS, John R., VIRDEN, Richard, HAWKINS, Alastair R.

Journal:

Biochemical Journal

Year:

1999

Language:

english

File:

PDF, 232 KB

english, 1999

83

Identification of domains responsible for signal recognition and transduction within the QUTR transcription repressor protein

LEVETT, Lisa J., SI-HOE, Shi Ming, LIDDLE, Stuart, WHEELER, Kerry, SMITH, Deborah, LAMB, Heather K., NEWTON, Giles H., COGGINS, John R., HAWKINS, Alastair R.

Journal:

Biochemical Journal

Year:

2000

Language:

english

File:

PDF, 226 KB

english, 2000

84

The molecular biology of the pentafunctional AROM protein

Hawkins, Alastair R., Moore, Jonathan D., Lamb, Heather K.

Journal:

Biochemical Society Transactions

Year:

1993

Language:

english

File:

PDF, 551 KB

english, 1993

85

184 progress in cloning, expression and purification of 5-enolpyruvylshikimate-3-phosphate synthase from pathogens causing meningitis

GALLAY, OLIVER, SERVOS, SPIROS, HAWKINS, ALASTAIR, MASKELL, DUNCAN, BROWN, KATHERINE

Journal:

Biochemical Society Transactions

Year:

1997

Language:

english

File:

PDF, 161 KB

english, 1997

86

73 Dehydroquinate Synthase Binds Divalent and Trivalent Cations: Role of Metal Binding in Catalysis

Skinner, Murray A, Günel-Özcan, Aysen, Moore, Jonathan, Hawkins, Alastair R, Brown, Katherine A

Journal:

Biochemical Society Transactions

Year:

1997

Language:

english

File:

PDF, 131 KB

english, 1997

87

Freezing the Dynamic Gap for Selectivity: Motion-Based Design of Inhibitors of the Shikimate Kinase Enzyme

Prado, Verónica, Lence, Emilio, Thompson, Paul, Hawkins, Alastair R., González-Bello, Concepción

Journal:

Chemistry - A European Journal

Year:

2016

Language:

english

File:

PDF, 11.19 MB

english, 2016

88

Frontispiece: Freezing the Dynamic Gap for Selectivity: Motion-Based Design of Inhibitors of the Shikimate Kinase Enzyme

Prado, Verónica, Lence, Emilio, Thompson, Paul, Hawkins, Alastair R., González-Bello, Concepción

Journal:

Chemistry - A European Journal

Year:

2016

File:

PDF, 2.46 MB

2016

89

Matriptase induces metalloproteinase-dependent aggrecanolysis in vitro and in vivo : multiple mechanisms promote cartilage damage in osteoarthritis

Wilkinson, David J, Habgood, Angela, Lamb, Heather K, Thompson, Paul, Hawkins, Alastair R, Désilets, Antoine, Leduc, Richard, Steinmetzer, Torsten, Hammami, Maya, Lee, Melody S, Craik, Charles S, Wats

Journal:

Arthritis & Rheumatology

Year:

2017

Language:

english

File:

PDF, 1.67 MB

english, 2017

90

Reducing the Flexibility of Type II Dehydroquinase Enzyme for Inhibition - A Fragment-Based Approach and Molecular Dynamics Simulation Study

Peón, Antonio, Robles, Adrián, Blanco, Beatriz, Convertino, Marino, Thompson, Paul, Hawkins, Alastair R., Caflisch, Amedeo, Gonzalez-Bello, Concepcion

Journal:

Year:

2017

Language:

english

File:

PDF, 2.24 MB

english, 2017

91

The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover

Wilkinson, David J., Desilets, Antoine, Lin, Hua, Charlton, Sarah, del Carmen Arques, Maria, Falconer, Adrian, Bullock, Craig, Hsu, Yu-Chen, Birchall, Kristian, Hawkins, Alastair, Thompson, Paul, Ferr

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 6.04 MB

english, 2017

92

Crystal structure of NucB, a biofilm-degrading endonuclease

Baslé, Arnaud, Hewitt, Lorraine, Koh, Alan, Lamb, Heather K, Thompson, Paul, Burgess, J Grant, Hall, Michael J, Hawkins, Alastair R, Murray, Heath, Lewis, Richard J

Journal:

Nucleic Acids Research

Year:

2018

Language:

english

File:

PDF, 5.12 MB

english, 2018

93

ChemInform Abstract: POLY-(4- AND 5-ACRYLAMIDOSALICYLIC ACIDS) PART 4, SELECTIVITY IN THE EXTRACTION OF METAL CATIONS FROM AQUEOUS SOLUTION

KENNEDY, JOHN F., BARKER, S. ALAN, NICOL, ALASTAIR W., HAWKINS, ALAN

Journal:

Chemischer Informationsdienst

Year:

1973

File:

PDF, 129 KB

1973

94

Synthesis of Rigidified Shikimic Acid Derivatives by Ring-Closing Metathesis to Imprint Inhibitor Efficacy against Shikimate Kinase Enzyme

Pernas, Marina, Blanco, Beatriz, Lence, Emilio, Thompson, Paul, Hawkins, Alastair R, Gonzalez-Bello, Concepcion

Journal:

Organic Chemistry Frontiers

Year:

2019

Language:

english

File:

PDF, 600 KB

english, 2019

95

Hydroxylammonium derivatives for selective active-site lysine modification in the anti-virulence bacterial target DHQ1 enzyme

Maneiro, María, Lence, Emilio, Sanz-Gaitero, Marta, Otero, José M., van Raaij, Mark J., Thompson, Paul, Hawkins, Alastair R., González-Bello, Concepción

Journal:

Organic Chemistry Frontiers

Year:

2019

File:

PDF, 3.42 MB

2019

96

Self-Immolation of a Bacterial Dehydratase Enzyme by its Epoxide Product

Lence, Emilio, Maneiro, MarÃa, Sanz-Gaitero, Marta, van Raaij, MarK J., Thompson, Paul, Hawkins, Alastair R., Gonzalez-Bello, Concepcion

Journal:

Chemistry - A European Journal

Year:

2020

File:

PDF, 1.68 MB

2020

97

Cover Feature: SelfâImmolation of a Bacterial Dehydratase Enzyme by its Epoxide Product (Chem. Eur. J. 36/2020)

Lence, Emilio, Maneiro, MarÃa, SanzâGaitero, Marta, Raaij, Mark J., Thompson, Paul, Hawkins, Alastair R., GonzÃ¡lezâBello, ConcepciÃ³n

Journal:

Chemistry (Weinheim an der Bergstrasse, Germany)

Year:

2020

File:

PDF, 888 KB

2020