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51

Kinetic and spectroscopic probes of motions and catalysis in the cytochrome P450 reductase family of enzymes

Christopher R. Pudney, Derren J. Heyes, Basile Khara, Sam Hay, Stephen E. J. Rigby, Nigel S. Scrutton

Journal:

Year:

2012

Language:

english

File:

PDF, 633 KB

english, 2012

52

Do obese but metabolically normal women differ in intra-abdominal fat and physical activity levels from those with the expected metabolic abnormalities? A cross-sectional study

Louise Hayes, Mark S Pearce, Michael J Firbank, Mark Walker, Roy Taylor, Nigel C Unwin

Journal:

BMC Public Health

Year:

2010

Language:

english

File:

PDF, 291 KB

english, 2010

53

"Obesity" and "Clinical Obesity" Men's understandings of obesity and its relation to the risk of diabetes: A qualitative study

Nicola F Weaver, Louise Hayes, Nigel C Unwin, Madeleine J Murtagh

Journal:

BMC Public Health

Year:

2008

Language:

english

File:

PDF, 227 KB

english, 2008

54

A Role in vivo for Penicillin-Binding Protein-4 of Staphylococcus aureus

Anne W. WYKE, J.Barrie WARD, Michael V. HAYES, Nigel A.C. CURTIS

Journal:

Year:

1981

Language:

english

File:

PDF, 574 KB

english, 1981

55

Reduction by inhibitors of mono(ADP-ribosyl)transferase of chemotaxis in human neutrophil leucocytes by inhibition of the assembly of filamentous actin

Jennifer R. Allport, Louise E. Donnelly, Brian P. Hayes, Stephen Murray, Nigel B. Rendell, Keith P. Ray, John MacDermot

Journal:

British Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.55 MB

english, 1996

56

Protein Motions Are Coupled to the Reaction Chemistry in Coenzyme B12-Dependent Ethanolamine Ammonia Lyase

Henry J. Russell, Dr. Alex R. Jones, Dr. Sam Hay, Dr. Gregory M. Greetham, Dr. Michael Towrie, Prof. Nigel S. Scrutton

Journal:

Angewandte Chemie

Year:

2012

Language:

english

File:

PDF, 877 KB

english, 2012

57

Protein Motions Are Coupled to the Reaction Chemistry in Coenzyme B12-Dependent Ethanolamine Ammonia Lyase

Henry J. Russell, Dr. Alex R. Jones, Dr. Sam Hay, Dr. Gregory M. Greetham, Dr. Michael Towrie, Prof. Nigel S. Scrutton

Journal:

Angewandte Chemie International Edition

Year:

2012

Language:

english

File:

PDF, 888 KB

english, 2012

58

GAPDH and Autophagy Preserve Survival after Apoptotic Cytochrome c Release in the Absence of Caspase Activation

Anna Colell, Jean-Ehrland Ricci, Stephen Tait, Sandra Milasta, Ulrich Maurer, Lisa Bouchier-Hayes, Patrick Fitzgerald, Ana Guio-Carrion, Nigel J. Waterhouse, Cindy Wei Li, Bernard Mari, Pascal Barbry,

Journal:

Year:

2007

Language:

english

File:

PDF, 1.76 MB

english, 2007

59

GAPDH and Autophagy Preserve Survival after Apoptotic Cytochrome c Release in the Absence of Caspase Activation

Anna Colell, Jean-Ehrland Ricci, Stephen Tait, Sandra Milasta, Ulrich Maurer, Lisa Bouchier-Hayes, Patrick Fitzgerald, Ana Guio-Carrion, Nigel J. Waterhouse, Cindy Wei Li, Bernard Mari, Pascal Barbry,

Journal:

Year:

2007

Language:

english

File:

PDF, 43 KB

english, 2007

60

O21. Ca2+-calmodulin exerts thermodynamic and conformational regulation over electron transport in nNOS

Andrew W. Munro, Adrian J. Dunford, Sam Hay, Derren J. Heyes, Anne-Marie Quinn, Stephen E.J. Rigby, Nigel S. Scrutton

Journal:

Year:

2008

Language:

english

File:

PDF, 57 KB

english, 2008

61

Early Lung Cancer Action Project

Nigel E Drury, Ivan Brown, Malcolm JR Dalrymple-Hay, David J Delany, Peter Halson

Journal:

Year:

1999

Language:

english

File:

PDF, 23 KB

english, 1999

62

DDT congener effects on secondary sex coloration in the reed frog Hyperolius argus: a partial evaluation of the Hyperolius argus endocrine screen

Nigel C Noriega, Tyrone B Hayes

Journal:

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology

Year:

2000

Language:

english

File:

PDF, 440 KB

english, 2000

63

Organophosphonate metabolism by a moderately halophilic bacterial isolate

Velma E.A Hayes, Nigel G Ternan, Geoffrey McMullan

Journal:

FEMS Microbiology Letters

Year:

2000

Language:

english

File:

PDF, 171 KB

english, 2000

64

An investigation of collisional processes in a Dicke narrowed transition of water vapor in the 7.8 μm spectral region by frequency down-chirped quantum cascade laser spectroscopy

Tasinato, Nicola, Duxbury, Geoffrey, Langford, Nigel, Hay, Kenneth G.

Journal:

The Journal of Chemical Physics

Year:

2010

Language:

english

File:

PDF, 1.21 MB

english, 2010

65

Replication of adenovirus mini-chromosomes

Ronald T. Hay, Nigel D. Stow, Iris M. McDougall

Journal:

Journal of Molecular Biology

Year:

1984

Language:

english

File:

PDF, 5.81 MB

english, 1984

66

Barrier Compression and Its Contribution to Both Classical and Quantum Mechanical Aspects of Enzyme Catalysis

Hay, Sam, Johannissen, Linus O., Sutcliffe, Michael J., Scrutton, Nigel S.

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 672 KB

english, 2010

67

Enzymatic Single-Molecule Kinetic Isotope Effects

Pudney, Christopher R., Lane, Richard S. K., Fielding, Alistair J., Magennis, Steven W., Hay, Sam, Scrutton, Nigel S.

Journal:

Journal of the American Chemical Society

Year:

2013

Language:

english

File:

PDF, 2.47 MB

english, 2013

68

Magnetic Field Effect Studies Indicate Reduced Geminate Recombination of the Radical Pair in Substrate-Bound Adenosylcobalamin-Dependent Ethanolamine Ammonia Lyase

Jones, Alex R., Hay, Sam, Woodward, Jonathan R., Scrutton, Nigel S.

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 260 KB

english, 2007

69

The Development of a Manufacturing Route for the GPIIb/IIIa Receptor Antagonist SB-214857-A. Part 2: Conversion of the Key Intermediate SB-235349 to SB-214857-A

Atkins, Richard J., Banks, Adam, Bellingham, Richard K., Breen, Gary F., Carey, John S., Etridge, Stephen K., Hayes, Jerome F., Hussain, Nigel, Morgan, David O., Oxley, Paul, Passey, Stephen C., Walsg

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 239 KB

english, 2003

70

Sensitivity of the carbon cycle in the Arctic to climate change

McGuire, A. David, Anderson, Leif G., Christensen, Torben R., Dallimore, Scott, Guo, Laodong, Hayes, Daniel J., Heimann, Martin, Lorenson, Thomas D., Macdonald, Robie W., Roulet, Nigel

Journal:

Ecological Monographs

Year:

2009

Language:

english

File:

PDF, 1.13 MB

english, 2009

71

Fast Protein Motions Are Coupled to Enzyme H-Transfer Reactions

Pudney, Christopher R., Guerriero, Andrew, Baxter, Nicola J., Johannissen, Linus O., Waltho, Jonathan P., Hay, Sam, Scrutton, Nigel S.

Journal:

Journal of the American Chemical Society

Year:

2013

Language:

english

File:

PDF, 1.54 MB

english, 2013

72

Deep Tunneling Dominates the Biologically Important Hydride Transfer Reaction from NADH to FMN in Morphinone Reductase

Pang, Jiayun, Hay, Sam, Scrutton, Nigel S., Sutcliffe, Michael J.

Journal:

Journal of the American Chemical Society

Year:

2008

Language:

english

File:

PDF, 465 KB

english, 2008

73

Dynamic, Electrostatic Model for the Generation and Control of High-Energy Radical Intermediates by a Coenzyme B 12 -Dependent Enzyme

Chen, Zhi-Gang, Ziętek, Monika A, Russell, Henry J., Tait, Shirley, Hay, Sam, Jones, Alex R., Scrutton, Nigel S.

Journal:

Year:

2013

Language:

english

File:

PDF, 504 KB

english, 2013

74

Pressure Effects on Enzyme-Catalyzed Quantum Tunneling Events Arise from Protein-Specific Structural and Dynamic Changes

Hay, Sam, Johannissen, Linus O., Hothi, Parvinder, Sutcliffe, Michael J., Scrutton, Nigel S.

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 1.59 MB

english, 2012

75

Proton tunnelling and promoting vibrations during the oxidation of ascorbate by ferricyanide?

Kandathil, Shaun M., Driscoll, Max D., Dunn, Rachel V., Scrutton, Nigel S., Hay, Sam

Journal:

Physical Chemistry Chemical Physics

Year:

2014

Language:

english

File:

PDF, 1.13 MB

english, 2014

76

Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment

Hughes, Jim R, Roberts, Nigel, McGowan, Simon, Hay, Deborah, Giannoulatou, Eleni, Lynch, Magnus, De Gobbi, Marco, Taylor, Stephen, Gibbons, Richard, Higgs, Douglas R

Journal:

Nature Genetics

Year:

2014

Language:

english

File:

PDF, 1.67 MB

english, 2014

77

Regioselective chlorination of valine derivatives

Bowman, Nigel J., Hay, Michael P., Love, Stephen G., Easton, Christopher J.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1988

Language:

english

File:

PDF, 757 KB

english, 1988

78

Maternal alcohol intake up to and during pregnancy and risk of adverse birth outcomes: evidence from a British cohort

Nykjaer, Camilla, Alwan, Nisreen A, Greenwood, Darren C, Simpson, Nigel A B, Hay, Alastair W M, White, Kay L M, Cade, Janet E

Journal:

Year:

2013

Language:

english

File:

PDF, 54 KB

english, 2013

79

Excited State Dynamics Can Be Used to Probe Donor-Acceptor Distances for H-Tunneling Reactions Catalyzed by Flavoproteins

Hardman, Samantha J.O., Pudney, Christopher R., Hay, Sam, Scrutton, Nigel S.

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 2.55 MB

english, 2013

80

17β -Estradiol Hydroxylation Catalyzed by Human Cytochrome P450 1B1

Carrie L. Hayes, David C. Spink, Barbara C. Spink, Joan Q. Cao, Nigel J. Walker and Thomas R. Sutter

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.12 MB

english, 1996

81

Ex situ Conservation and Cryopreservation of Orchid Germplasm

Merritt, David J., Hay, Fiona R., Swarts, Nigel D., Sommerville, Karen D., Dixon, Kingsley W.

Journal:

International Journal of Plant Sciences

Year:

2014

Language:

english

File:

PDF, 534 KB

english, 2014

82

Conformational and Thermodynamic Control of Electron Transfer in Neuronal Nitric Oxide Synthase †

Dunford, Adrian J., Rigby, Stephen E. J., Hay, Sam, Munro, Andrew W., Scrutton, Nigel S.

Journal:

Year:

2007

Language:

english

File:

PDF, 493 KB

english, 2007

83

Bridgehead Lithiation-Substitution of Bridged Ketones, Lactones, Lactams, and Imides: Experimental Observations and Computational Insights

Hayes, Christopher J., Simpkins, Nigel S., Kirk, Douglas T., Mitchell, Lee, Baudoux, Jerome, Blake, Alexander J., Wilson, Claire

Journal:

Journal of the American Chemical Society

Year:

2009

Language:

english

File:

PDF, 2.93 MB

english, 2009

84

Correction of Pre-Steady-State KIEs for Isotopic Impurities and the Consequences of Kinetic Isotope Fractionation †

Hay, Sam, Pudney, Christopher R., Hothi, Parvinder, Scrutton, Nigel S.

Journal:

Journal of Physical Chemistry A

Year:

2008

Language:

english

File:

PDF, 423 KB

english, 2008

85

Mutagenesis of Morphinone Reductase Induces Multiple Reactive Configurations and Identifies Potential Ambiguity in Kinetic Analysis of Enzyme Tunneling Mechanisms

Pudney, Christopher R., Hay, Sam, Pang, Jiayun, Costello, Claire, Leys, David, Sutcliffe, Michael J., Scrutton, Nigel S.

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 305 KB

english, 2007

86

Direct Analysis of Donor−Acceptor Distance and Relationship to Isotope Effects and the Force Constant for Barrier Compression in Enzymatic H-Tunneling Reactions

Pudney, Christopher R., Johannissen, Linus O., Sutcliffe, Michael J., Hay, Sam, Scrutton, Nigel S.

Journal:

Journal of the American Chemical Society

Year:

2010

Language:

english

File:

PDF, 936 KB

english, 2010

87

Influence of pressurised liquid extraction and solid-liquid extraction methods on the phenolic content and antioxidant activities of Irish macroalgae

Tierney, Michelle S., Smyth, Thomas J., Hayes, Maria, Soler-Vila, Anna, Croft, Anna K., Brunton, Nigel

Journal:

International Journal of Food Science & Technology

Year:

2013

Language:

english

File:

PDF, 674 KB

english, 2013

88

Nature of the Energy Landscape for Gated Electron Transfer in a Dynamic Redox Protein

Hay, Sam, Brenner, Sibylle, Khara, Basile, Quinn, Anne Marie, Rigby, Stephen E. J., Scrutton, Nigel S.

Journal:

Journal of the American Chemical Society

Year:

2010

Language:

english

File:

PDF, 1.63 MB

english, 2010

89

Conformational Dynamics of the Cytochrome P450 BM3/ N -Palmitoylglycine Complex: The Proposed “Proximal−Distal” Transition Probed by Temperature-Jump Spectroscopy

Brenner, Sibylle, Hay, Sam, Girvan, Hazel M., Munro, Andrew W., Scrutton, Nigel S.

Journal:

Journal of Physical Chemistry B

Year:

2007

Language:

english

File:

PDF, 207 KB

english, 2007

90

Evidence To Support the Hypothesis That Promoting Vibrations Enhance the Rate of an Enzyme Catalyzed H-Tunneling Reaction

Pudney, Christopher R, Hay, Sam, Levy, Colin, Pang, Jiayun, Sutcliffe, Michael J, Leys, David, Scrutton, Nigel S.

Journal:

Journal of the American Chemical Society

Year:

2009

Language:

english

File:

PDF, 151 KB

english, 2009

91

Delayed rapid passage and transient gain signals generated using a chirped 8 μm quantum cascade laser

Duxbury, Geoffrey, Langford, Nigel, Hay, Kenneth

Journal:

Journal of Modern Optics

Year:

2008

Language:

english

File:

PDF, 675 KB

english, 2008

92

α-Secondary Isotope Effects as Probes of “Tunneling-Ready” Configurations in Enzymatic H-Tunneling: Insight from Environmentally Coupled Tunneling Models

Pudney, Christopher R., Hay, Sam, Sutcliffe, Michael J., Scrutton, Nigel S.

Journal:

Journal of the American Chemical Society

Year:

2006

Language:

english

File:

PDF, 172 KB

english, 2006

93

Glutathione S-transferase mu locus: use of genotyping and phenotyping assays to assess association with lung cancer susceptibility

Zhong, Shan, Howie, A. Forbes, Ketterer, Brian, Taylor, John, Hayes, John D., Beckett, Geoffrey J., Wathen, Christopher G., Wolf, C.Roland, Spurr, Nigel K.

Journal:

Year:

1991

Language:

english

File:

PDF, 2.49 MB

english, 1991

94

Proton Tunneling in Aromatic Amine Dehydrogenase is Driven by a Short-Range Sub-Picosecond Promoting Vibration: Consistency of Simulation and Theory with Experiment

Johannissen, Linus O., Hay, Sam, Scrutton, Nigel S., Sutcliffe, Michael J.

Journal:

Journal of Physical Chemistry B

Year:

2007

Language:

english

File:

PDF, 383 KB

english, 2007

95

Incorporation of Hydrostatic Pressure into Models of Hydrogen Tunneling Highlights a Role for Pressure-Modulated Promoting Vibrations †

Hay, Sam, Scrutton, Nigel S.

Journal:

Year:

2008

Language:

english

File:

PDF, 402 KB

english, 2008

96

Ultrafast Infrared Spectral Fingerprints of Vitamin B 12 and Related Cobalamins

Jones, Alex R., Russell, Henry J., Greetham, Gregory M., Towrie, Michael, Hay, Sam, Scrutton, Nigel S.

Journal:

Journal of Physical Chemistry A

Year:

2012

Language:

english

File:

PDF, 1.98 MB

english, 2012

97

Study of the Q Branch Structure of the 14 N and 15 N Isotopologues of the ν 4 Band of Ammonia Using Frequency Chirped Quantum Cascade Lasers

Duxbury, Geoffrey, Wilson, David, Hay, Kenneth, Langford, Nigel

Journal:

Journal of Physical Chemistry A

Year:

2013

Language:

english

File:

PDF, 3.37 MB

english, 2013

98

Hydration of tricalcium silicate followed by solid-state 29Si n.m.r. spectroscopy

Clayden, Nigel J., Dobson, Christopher M., Hayes, Catherine J., Rodger, Sally A.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1984

Language:

english

File:

PDF, 252 KB

english, 1984

99

Bridgehead enolate or bridgehead organolithium? DFT calculations provide insights into a difficult bridgehead substitution reaction in the synthesis of the polycyclic polyprenylated acylphloroglucinol (PPAP) nemorosone

Hayes, Christopher J., Simpkins, Nigel S.

Journal:

Organic & Biomolecular Chemistry

Year:

2013

Language:

english

File:

PDF, 863 KB

english, 2013

100

Photolysis of polychlorinated benzenes in cyclohexane solution

Bunce, Nigel J., Hayes, Patrick J., Lemke, Mary E.

Journal:

Canadian Journal of Chemistry

Year:

1983

Language:

english

File:

PDF, 162 KB

english, 1983