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51

4-Aminobiphenyl induces liver DNA adducts in both neonatal and adult mice but induces liver mutations only in neonatal mice

Tao Chen, Roberta A. Mittelstaedt, Frederick A. Beland, Robert H. Heflich, Martha M. Moore, Barbara L. Parsons

Journal:

International Journal of Cancer

Year:

2005

Language:

english

File:

PDF, 123 KB

english, 2005

52

DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide

Linda S. Von Tungeln, Mona I. Churchwell, Daniel R. Doerge, Joseph G. Shaddock, Lynda J. McGarrity, Robert H. Heflich, Gonçalo Gamboa da Costa, M. Matilde Marques, Frederick A. Beland

Journal:

International Journal of Cancer

Year:

2009

Language:

english

File:

PDF, 374 KB

english, 2009

53

Microbial transformation of the antihistaminic drug triprolidine hydrochloride

Eugene B. Hansen Jr., Robert H. Heflich, Walter A. Korfmacher, Dwight W. Miller, Carl E. Cerniglia

Journal:

Journal of Pharmaceutical Sciences

Year:

1988

Language:

english

File:

PDF, 604 KB

english, 1988

54

Levels of 4-aminobiphenyl-induced somatic H-ras mutation in mouse liver DNA correlate with potential for liver tumor development

Barbara L. Parsons, Frederick A. Beland, Linda S. Von Tungeln, Robert R. Delongchamp, Peter P. Fu, Robert H. Heflich

Journal:

Molecular Carcinogenesis

Year:

2005

Language:

english

File:

PDF, 201 KB

english, 2005

55

Rapid isolation, hydrolysis and chromatography of formaldehyde-modified DNA

Frederick A. Beland, Nancy F. Fullerton, Robert H. Heflich

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1984

Language:

english

File:

PDF, 683 KB

english, 1984

56

Metabolism of 1,8-dinitropyrene by human, rhesus monkey, and rat intestinal microflora

Carl E. Cerniglia, Kenneth J. Lambert, Gail L. White, Robert H. Heflich, Wirt Franklin, E. Kim Fifer, Frederick A. Beland

Journal:

Environmental Toxicology

Year:

1988

Language:

english

File:

PDF, 585 KB

english, 1988

57

Fungal metabolism and detoxification of polycyclic aromatic hydrocarbons

Carl E. Cerniglia, Gail L. White, Robert H. Heflich

Journal:

Archives of Microbiology

Year:

1985

Language:

english

File:

PDF, 541 KB

english, 1985

58

Mutagenicity of comfrey (Symphytum Officinale) in rat liver

Chen, T, Mei, N, Guo, L, Fu, P P, Heflich, R H

Journal:

British Journal of Cancer

Year:

2005

Language:

english

File:

PDF, 70 KB

english, 2005

59

The frequency of Pig-a mutant red blood cells in rats exposed in utero to N-ethyl-N-nitrosourea

Vasily N. Dobrovolsky, Robert H. Heflich, Sherry A. Ferguson

Journal:

Environmental and Molecular Mutagenesis

Year:

2012

Language:

english

File:

PDF, 1.46 MB

english, 2012

60

Mutagenic activation of 2-aminofluorene by fluorescent light

G. L. White, R. H. Heflich

Journal:

Teratogenesis, Carcinogenesis, and Mutagenesis

Year:

1985

Language:

english

File:

PDF, 679 KB

english, 1985

61

Evaluation of the genotoxicity of gentian violet in bacterial and mammalian cell systems

Anane Aidoo, Ning Gao, Robin E. Neft, Henry M. Schol, Bruce S. Hass, Toni Y. Minor, Robert H. Heflich

Journal:

Teratogenesis, Carcinogenesis, and Mutagenesis

Year:

1990

Language:

english

File:

PDF, 800 KB

english, 1990

62

Analysis of rat lymphocyte activation of benzo[a]pyrene, 2-acetylaminofluorene, and several of their metabolites to mutagenic and DNA-damaging species in vitro

Ning Gao, Anane Aidoo, Robert H. Heflich

Journal:

Teratogenesis, Carcinogenesis, and Mutagenesis

Year:

1991

Language:

english

File:

PDF, 727 KB

english, 1991

63

A comparison of the DNA binding, cytotoxicity and repair synthesis induced in human fibroblasts by reactive derivatives of aromatic amide carcinogens

R.H. Heflich, R.M. Hazard, L. Lommel, J.D. Scribner, V.M. Maher, J.J. McCormick

Journal:

Chemico-Biological Interactions

Year:

1980

Language:

english

File:

PDF, 831 KB

english, 1980

64

A model for the effect of excision repair on the survival of human cells exposed to chemical carcinogens

J.H. Miller, R.H. Heflich

Journal:

Chemico-Biological Interactions

Year:

1982

Language:

english

File:

PDF, 579 KB

english, 1982

65

Biologically active aromatic amines derived from carcinogenic polycyclic aromatic hydrocarbons: synthesis and mutagenicity of aminobenzo[α]pyrenes

Peter P. Fu, Robert H. Heflich, Daniel A. Casciano, Agnes Y. Huang, W.M. Trie, Fred F. Kadlubar, Frederick A. Beland

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1982

Language:

english

File:

PDF, 447 KB

english, 1982

66

Induction of mutations and sister-chromatid exchanges in Chinese hamster ovary cells by ethylating agents

R.H. Heflich, D.T. Beranek, R.L. Kodell, S.M. Morris

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1982

Language:

english

File:

PDF, 883 KB

english, 1982

67

Correlation between specific DNA-methylation products and mutation induction at the HGPRT locus in Chinese hamster ovary cells

David T. Beranek, Robert H. Heflich, Ralph L. Kodell, Suzanne M. Morris, Daniel A. Casciano

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1983

Language:

english

File:

PDF, 554 KB

english, 1983

68

1-nitrosopyrene: An intermediate in the metabolic activation of 1-nitropyrene to a mutagen in Salmonella typhimurium TA1538

Robert H. Heflich, Paul C. Howard, Frederick A. Beland

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1985

Language:

english

File:

PDF, 633 KB

english, 1985

69

An examination of the weak mutagenic response of 1-nitropyrene in Chinese hamster ovary cells

Robert H. Heflich, Nancy F. Fullerton, Frederick A. Beland

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1986

Language:

english

File:

PDF, 777 KB

english, 1986

70

Comparative direct-acting mutagenicity of 1- and 2-nitropyrene: Evidence for 2-nitropyrene mutagenesis by both guanine and adenine adducts

Shuyi Yu, Robert H. Heflich, Linda S. Von Tungeln, Karam El-Bayoumy, Fred F. Kadlubar, Peter P. Fu

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1991

Language:

english

File:

PDF, 577 KB

english, 1991

71

Analysis of in vivo mutation in exon 8 of the rat hprt gene

Roberta A. Mittelstaedt, Robert H. Heflich

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1994

Language:

english

File:

PDF, 911 KB

english, 1994

72

Low hprt mRNA levels and multiple hprt mRNA species in 6-thioguanine-resistant Chinese hamster cell mutants possessing nonsense mutations

Mugimane G. Manjanatha, Laura A. Lindsey, Roberta A. Mittelstaedt, Robert H. Heflich

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1994

Language:

english

File:

PDF, 756 KB

english, 1994

73

Lymphocyte mutant frequency in relation to DNA adduct formation in rats treated with tumorigenic doses of the mammary gland carcinogen 7,12-dimethylbenz[a]anthracene

M.G. Manjanatha, L.E. Lyn-Cook, S.J. Culp, F.A. Beland, R.H. Heflich, A. Aidoo

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1996

Language:

english

File:

PDF, 809 KB

english, 1996

74

Mutagenesis and DNA adduct formation by 1-nitropyrene in Chinese hamster ovary cells without exogenous metabolic activation

Janice R. Thornton-Manning, Beverly A. Smith, Frederick A. Beland, Robert H. Heflich

Journal:

Toxicology and Applied Pharmacology

Year:

1991

Language:

english

File:

PDF, 811 KB

english, 1991

75

A review and analysis of the Chinese hamster ovary/hypoxanthine guanine phosphoribosyl transferase assay to determine the mutagenicity of chemical agents. A report of phase III of the U.S. environmental protection agency Gene-Tox program

A.P. Li, R.S. Gupta, R.H. Heflich, J.S. Wassom

Journal:

Mutation Research/Reviews in Genetic Toxicology

Year:

1988

Language:

english

File:

PDF, 1.23 MB

english, 1988

76

Genetic toxicity of 2-acetylaminofluorene, 2-aminofluorene and some of their metabolites and model metabolites

Robert H. Heflich, Robin E. Neft

Journal:

Mutation Research/Reviews in Genetic Toxicology

Year:

1994

Language:

english

File:

PDF, 8.08 MB

english, 1994

77

Alkylation-induced sister-chromatic exchanges correlate with reduced cell survival, not mutations

S.M. Morris, R.H. Heflich, D.T. Beranek, R.L. Kodell

Journal:

Mutation Research Letters

Year:

1982

Language:

english

File:

PDF, 336 KB

english, 1982

78

The relationship between sister-chromatid exchange induction and the formation of specific methylated DNA adducts in Chinese hamster ovary cells

S.M. Morris, D.T. Beranek, R.H. Heflich

Journal:

Mutation Research Letters

Year:

1983

Language:

english

File:

PDF, 312 KB

english, 1983

79

The differential effect of benzamide upon the toxicity and mutations produced in Chinese hamster ovary cells by N-methyl nitrosourea, N-ethyl nitrosourea and N-hydroxy-2-aminofluorene

R.H. Heflich, S.M. Morris, G.L. White, F.A. Beland

Journal:

Mutation Research Letters

Year:

1985

Language:

english

File:

PDF, 332 KB

english, 1985

80

Effect of nitro substitution on the light-mediated mutagenicity of polycyclic aromatic hydrocarbons in Salmonella typhimurium TA98

G.L. White, P.P. Fu, R.H. Heflich

Journal:

Mutation Research Letters

Year:

1985

Language:

english

File:

PDF, 416 KB

english, 1985

81

Mutagenic activation of the benzidine-based dye Direct Black 38 by human intestinal microflora

Carl E. Cerniglia, Zhou Zhuo, Bradford W. Manning, Thomas W. Federle, Robert H. Heflich

Journal:

Mutation Research Letters

Year:

1986

Language:

english

File:

PDF, 456 KB

english, 1986

82

Binary mixtures containing isomers of nitrobenzo[a]pyrene induce greater-than-additive mutational responses in Salmonella typhimurium: I. Analysis by the total concentration-proportional mixture model

B.S. Hass, J.J. Chen, M.W. Chou, P.P. Fu, R.H. Heflich

Journal:

Mutation Research Letters

Year:

1987

Language:

english

File:

PDF, 466 KB

english, 1987

83

Mutagenicity of nitrofurans in Salmonella typhimurium TA98, TA98NR and TA98/1,8-DNP6

Ni Yi-Chang, Robert H. Heflich, Fred F. Kadlubar, Peter P. Fu

Journal:

Mutation Research Letters

Year:

1987

Language:

english

File:

PDF, 503 KB

english, 1987

84

Relationships among direct-acting mutagenicity, nitro group orientation and polarographic reduction potential of 6-nitrobenzo[a]pyrene, 7-nitrobenz[a]anthracene and their derivatives

Peter P. Fu, Robert H. Heflich, Leonard E. Unruh, Ali U. Shaikh, Yu-Sen Wu, Ching-Cheng Lai, Jeng-Shiow Lai

Journal:

Mutation Research Letters

Year:

1988

Language:

english

File:

PDF, 491 KB

english, 1988

85

Nitroreduction of 6-nitrobenzo[a]pyrene: a potential activation pathway in humans

Peter P. Fu, Carl E. Cerniglia, Kurt E. Richardson, Robert H. Heflich

Journal:

Mutation Research Letters

Year:

1988

Language:

english

File:

PDF, 415 KB

english, 1988

86

Comment on the non-additivity of the mutagenic response of mixtures of nitrobenzo[a]pyrenes

Robert H. Heflich, Bruce S. Hass, James J. Chen, Janice R. Thornton-Manning, Peter P. Fu

Journal:

Mutation Research Letters

Year:

1989

Language:

english

File:

PDF, 213 KB

english, 1989

87

Effect of the orientation of nitro substituent on the bacterial mutagenicity of dinitrobenzo[e]pyrenes

Peter P. Fu, Yi-Cheng Ni, Yong-Ming Zhang, Robert H. Heflich, Yu-Kuei Wang, Jeng-Shiow Lai

Journal:

Mutation Research Letters

Year:

1989

Language:

english

File:

PDF, 373 KB

english, 1989

88

Mutagenicity of 1-, 3- and 6-nitrosobenzo[a]pyrene in Salmonella typhimurium and Chinese hamster ovary cells

Robert H. Heflich, Leonard E. Unruh, Janice R. Thornton-Manning, Linda S. von Tungeln, Peter P. Fu

Journal:

Mutation Research Letters

Year:

1989

Language:

english

File:

PDF, 493 KB

english, 1989

89

Mutagenicity of nitrofurantoin and furazolidone in Chinese hamster ovary cell strains

Ning Gao, Yi-Chang Ni, Janice R. Thornton-Manning, Peter P. Fu, Robert H. Heflich

Journal:

Mutation Research Letters

Year:

1989

Language:

english

File:

PDF, 410 KB

english, 1989

90

Mutagenicity of mononitrodihydrobenzo[a]pyrenes

Peter P. Fu, Hyewook Jung, Linda S. Von Tungeln, Robert H. Heflich

Journal:

Mutation Research Letters

Year:

1990

Language:

english

File:

PDF, 584 KB

english, 1990

91

Analysis of mutations and bone marrow micronuclei in Big Blue® rats fed leucomalachite green

M.G. Manjanatha, S.D. Shelton, M. Bishop, J.G. Shaddock, V.N. Dobrovolsky, R.H. Heflich, P.J. Webb, L.R. Blankenship, F.A. Beland, K.J. Greenlees, S.J. Culp

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2004

Language:

english

File:

PDF, 131 KB

english, 2004

92

Analysis of mutations in the Tk gene of Tk+/− mice treated as neonates with 3′-azido-3′-deoxythymidine (AZT)

Roberta A. Mittelstaedt, Linda S. Von Tungeln, Joseph G. Shaddock, Vasily N. Dobrovolsky, Frederick A. Beland, Robert H. Heflich

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2004

Language:

english

File:

PDF, 85 KB

english, 2004

93

Micronucleated erythrocyte frequency in control and azidothymidine-treated Tk+/+, Tk+/− and Tk−/− mice

Vasily N. Dobrovolsky, Lynda J. McGarrity, Linda S. VonTungeln, Roberta A. Mittelstaedt, Suzanne M. Morris, Frederick A. Beland, Robert H. Heflich

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2005

Language:

english

File:

PDF, 280 KB

english, 2005

94

Lymphocyte Hprt mutant frequency and sperm toxicity in C57BL/6 mice treated chronically with Azathioprine

Sachin V. Bendre, Joseph G. Shaddock, Ralph E. Patton, Vasily N. Dobrovolsky, Richard J. Albertini, Robert H. Heflich

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2005

Language:

english

File:

PDF, 434 KB

english, 2005

95

Age-dependent sensitivity of Big Blue transgenic mice to the mutagenicity of N-ethyl-N-nitrosourea (ENU) in liver

Nan Mei, Robert H. Heflich, Martha M. Moore, Tao Chen

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2005

Language:

english

File:

PDF, 142 KB

english, 2005

96

Frequency and types of spontaneous Hprt lymphocyte mutations in Pms2-deficient mice

Joseph G. Shaddock, Vasily N. Dobrovolsky, Roberta A. Mittelstaedt, Robert H. Heflich, Barbara L. Parsons

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2006

Language:

english

File:

PDF, 135 KB

english, 2006

97

DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver

Nan Mei, Volker M. Arlt, David H. Phillips, Robert H. Heflich, Tao Chen

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2006

Language:

english

File:

PDF, 312 KB

english, 2006

98

In vivo mutation analysis using the ΦX174 transgenic mouse and comparisons with other transgenes and endogenous genes

Carrie R. Valentine, Robert R. Delongchamp, Mason G. Pearce, Heather F. Rainey, Vasily N. Dobrovolsky, Heinrich V. Malling, Robert H. Heflich

Journal:

Mutation Research/Reviews in Mutation Research

Year:

2010

Language:

english

File:

PDF, 446 KB

english, 2010

99

Analysis of in vivo mutation data can inform cancer risk assessment

Martha M. Moore, Robert H. Heflich, Lynne T. Haber, Bruce C. Allen, Annette M. Shipp, Ralph L. Kodell

Journal:

Regulatory Toxicology and Pharmacology

Year:

2008

Language:

english

File:

PDF, 226 KB

english, 2008

100

Aerobic and anaerobic reduction of nitrated pyrenes in vitro

Zora Djurić, David W. Potter, Robert H. Heflich, Frederick A. Beland

Journal:

Chemico-Biological Interactions

Year:

1986

Language:

english

File:

PDF, 1.08 MB

english, 1986