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1

Crystal structures of Trypanosoma brucei hypoxanthine – guanine – xanthine phosphoribosyltransferase in complex with IMP , GMP and XMP

Terán, David, Doleželová, Eva, Keough, Dianne T., Hocková, Dana, Zíková, Alena, Guddat, Luke W.

Journal:

Year:

2019

Language:

english

File:

PDF, 761 KB

english, 2019

2

Regioselective Preparation of N7- and N9-Alkyl Derivatives of N6-[(Dimethylamino)methylene]adenine Bearing an Active Methylene Group and Their Further Derivatization Leading to α-Branched Acyclic Nucleoside Analogues

Dana Hocková, Miloš Buděšínský, Radek Marek, Jaromír Marek, Antonín Holý

Journal:

European Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 341 KB

english, 1999

3

ChemInform Abstract: Synthesis and Cytostatic Activity of Nucleosides and Acyclic Nucleoside Analogues Derived from 6-(Trifluoromethyl)purines.

Dana Hockova, Michal Hocek, Hana Dvorakova, Ivan Votruba

Journal:

Year:

2000

File:

PDF, 28 KB

2000

4

ChemInform Abstract: 7-(1-Cyanobut-3-en-1-yl)-N6- [(N,N-dimethylamino)methylene]adenine as a Starting Compound for the Synthesis of α-Branched Acyclic Analogues of N7-Isomer of Adenosine.

Dana Hockova, Milena Masojidkova, Antonin Holy

Journal:

Year:

2000

File:

PDF, 42 KB

2000

5

Cytostatic 6-Arylpurine Nucleosides. Part 5. Synthesis of 8-Substituted 6-Phenylpurine Ribonucleosides.

Michal Hocek, Dana Hockova, Jan Stambasky

Journal:

Year:

2003

File:

PDF, 122 KB

2003

6

Dichotomy in Regioselective Cross-Coupling Reactions of 6,8-Dichloropurines with Phenylboronic Acid and Methylmagnesium Chloride: Synthesis of 6,8-Disubstituted Purines.

Michal Hocek, Dana Hockova, Hana Dvorakova

Journal:

Year:

2004

File:

PDF, 105 KB

2004

7

An Efficient Synthesis of Cytostatic Mono and Bis-Alkynylpyrimidine Derivatives by the Sonogashira Cross-Coupling Reactions of 2,4-Diamino-6-iodopyrimidine and 2-Amino-4,6-dichloropyrimidine.

Dana Hockova, Antonin Holy, Milena Masojidkova, Ivan Votruba

Journal:

Year:

2004

File:

PDF, 114 KB

2004

8

Sonogashira Cross-Coupling in the Synthesis of Acyclic Nucleoside Phosphonates: Preparation of 6-[(Phosphonomethoxy)alkynyl]- and 6-[(Phosphonomethoxy)alkyl]pyrimidines.

Dana Hockova, Milena Masojidkova, Antonin Holy

Journal:

Year:

2005

File:

PDF, 23 KB

2005

9

Synthesis and Properties of a Novel Type of Acyclic Nucleoside Phosphonates: 2-(Purin-9-yl)ethoxyphenylphosphonic Acids

Dana Hocková, Martin Dračínský, Antonín Holý

Journal:

European Journal of Organic Chemistry

Year:

2010

Language:

english

File:

PDF, 404 KB

english, 2010

10

N7- and N9-substituted purine derivatives: a 15N NMR study

Radek Marek, Jiří Brus, Jaromír Toušek, Lajos Kovács, Dana Hocková

Journal:

Magnetic Resonance in Chemistry

Year:

2002

Language:

english

File:

PDF, 356 KB

english, 2002

11

Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds

Dana Hocková, Antonı́n Holý, Milena Masojı́dková, Graciela Andrei, Robert Snoeck, Erik De Clercq, Jan Balzarini

Journal:

Bioorganic & Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 299 KB

english, 2004

12

Synthesis and chiroptical properties of some abbreviated NAD+ analogues

Dana Hocková, Hana Votavová, Antonín Holý

Journal:

Tetrahedron: Asymmetry

Year:

1995

Language:

english

File:

PDF, 416 KB

english, 1995

13

Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine–guanine–xanthine phosphoribosyltransferase

Dana Hocková, Antonín Holý, Milena Masojídková, Dianne T. Keough, John de Jersey, Luke W. Guddat

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 710 KB

english, 2009

14

Direct determination of tautomerism in purine derivatives by low-temperature NMR spectroscopy

Pavlı́na Sečkářová, Radek Marek, Kateřina Maliňáková, Erkki Kolehmainen, Dana Hocková, Michal Hocek, Vladimír Sklenář

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 282 KB

english, 2004

15

Synthesis and cytostatic activity of nucleosides and acyclic nucleoside analogues derived from 6-(trifluoromethyl)purines

Dana Hocková, Michal Hocek, Hana Dvořáková, Ivan Votruba

Journal:

Year:

1999

Language:

english

File:

PDF, 533 KB

english, 1999

16

Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: Efficient synthesis and antiviral activity

Dana Hocková, Antonín Holý, Graciela Andrei, Robert Snoeck, Jan Balzarini

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 375 KB

english, 2011

17

An efficient synthesis of cytostatic mono and bis-alkynylpyrimidine derivatives by the Sonogashira cross-coupling reactions of 2,4-diamino-6-iodopyrimidine and 2-amino-4,6-dichloropyrimidine

Dana Hocková, Antonı́n Holý, Milena Masojı́dková, Ivan Votruba

Journal:

Year:

2004

Language:

english

File:

PDF, 136 KB

english, 2004

18

Synthesis of 2-Deoxy-β-D-ribonucleosides and 2,3-Dideoxy-β-D-pentofuranosides on Immobilized Bacterial Cells

Votruba, Ivan, Holý, Antonín, Dvořáková, Hana, Günter, Jaroslav, Hocková, Dana, Hřebabecký, Hubert, Cihlar, Tomas, Masojídková, Milena

Journal:

Collection of Czechoslovak Chemical Communications

Year:

1994

Language:

english

File:

PDF, 344 KB

english, 1994

19

Antiviral Activity of Acyclic Nucleoside Phosphonates with Branched 2-(2-Phosphonoethoxy)ethyl Chain

Dana Hocková, Antonín Holý, Graciela Andrei, Robert Snoeck, Jan Balzarini

Journal:

Antiviral Research

Year:

2010

Language:

english

File:

PDF, 81 KB

english, 2010

20

Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: Evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine–guanine–(xanthine) phosphoribosyltransferases

Michal Česnek, Dana Hocková, Antonín Holý, Martin Dračínský, Ondřej Baszczyňski, John de Jersey, Dianne T. Keough, Luke W. Guddat

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 553 KB

english, 2012

21

Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents

Marcela Krečmerová, Martin Dračínský, Dana Hocková, Antonín Holý, Dianne T. Keough, Luke W. Guddat

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 533 KB

english, 2012

22

Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy

Dianne T. Keough, Dana Hocková, Marcela Krečmerová, Michal Česnek, Antonín Holý, Lieve Naesens, Ian M. Brereton, Donald J. Winzor, John de Jersey, Luke W. Guddat

Journal:

Molecular and Biochemical Parasitology

Year:

2010

Language:

english

File:

PDF, 205 KB

english, 2010

23

Synthesis of Novel N -Branched Acyclic Nucleoside Phosphonates As Potent and Selective Inhibitors of Human, Plasmodium falciparum and Plasmodium vivax 6-Oxopurine Phosphoribosyltransferases

Hocková, Dana, Keough, Dianne T., Janeba, Zlatko, Wang, Tzu-Hsuan, de Jersey, John, Guddat, Luke W.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.77 MB

english, 2012

24

5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidinesAcyclic Nucleoside Phosphonate Analogues with Antiviral Activity

Hocková, Dana, Holý, Antonín, Masojídková, Milena, Andrei, Graciela, Snoeck, Robert, De Clercq, Erik, Balzarini, Jan

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 142 KB

english, 2003

25

Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase by Acyclic Nucleoside Phosphonates: A New Class of Antimalarial Therapeutics

Keough, Dianne T., Hocková, Dana, Holý, Antonín, Naesens, Lieve M. J., Skinner-Adams, Tina S., Jersey, John de, Guddat, Luke W.

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 3.15 MB

english, 2009

26

Acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group Are Potent Inhibitors of 6-Oxopurine Phosphoribosyltransferases and Have Antimalarial Activity

Keough, Dianne T., Špaček, Petr, Hocková, Dana, Tichý, Tomáš, Vrbková, Silvie, Slavětínská, Lenka, Janeba, Zlatko, Naesens, Lieve, Edstein, Michael D., Chavchich, Marina, Wang, Tzu-Hsuan, de Jersey, J

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 712 KB

english, 2013

27

Sonogashira Cross-Coupling in the Synthesis of Acyclic Nucleoside Phosphonates: Preparation of 6-[(Phosphonomethoxy)alkynyl]- and 6-[(Phosphonomethoxy)alkyl]pyrimidines

Hocková, Dana, Masojídková, Milena, Holý, Antonín

Journal:

Collection of Czechoslovak Chemical Communications

Year:

2005

Language:

english

File:

PDF, 110 KB

english, 2005

28

The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine–guanine–(xanthine) phosphoribosyltransferases

Baszczyňski, Ondřej, Hocková, Dana, Janeba, Zlatko, Holý, Antonín, Jansa, Petr, Dračínský, Martin, Keough, Dianne T., Guddat, Luke W.

Journal:

European Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 707 KB

english, 2013

29

Inhibition of the Escherichia coli 6-Oxopurine Phosphoribosyltransferases by Nucleoside Phosphonates: Potential for New Antibacterial Agents

Keough, Dianne T., Hocková, Dana, Rejman, Dominik, Špaček, Petr, Vrbková, Silvie, Krečmerová, Marcela, Eng, Wai Soon, Jans, Harmen, West, Nicholas P., Naesens, Lieve M. J., de Jersey, John, Guddat, Lu

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 4.95 MB

english, 2013

30

Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents

Keough, Dianne T., Hocková, Dana, Janeba, Zlatko, Wang, Tzu-Hsuan, Naesens, Lieve, Edstein, Michael D., Chavchich, Marina, Guddat, Luke W.

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.91 MB

english, 2015

31

Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of the 6-oxopurine phosphoribosyltransferases and have antimalarial activity

Keough, Dianne, Špaček, Petr, Hocková, Dana, Tichý, Tomáš, Vrbková, Silvie, Slavětínská, Lenka, Janeba, Zlatko, Naesens, Lieve, Edstein, Michael, Chavchich, Marina, Wang, Tzu, de Jersey, John, Guddat,

Journal:

Malaria Journal

Year:

2014

Language:

english

File:

PDF, 262 KB

english, 2014

32

N-Branched acyclic nucleoside phosphonates as monomers for the synthesis of modified oligonucleotides

Hocková, Dana, Rosenbergová, Šárka, Ménová, Petra, Páv, Ondřej, Pohl, Radek, Novák, Pavel, Rosenberg, Ivan

Journal:

Organic & Biomolecular Chemistry

Year:

2015

Language:

english

File:

PDF, 2.98 MB

english, 2015

33

First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity

Eng, Wai Soon, Hocková, Dana, Špaček, Petr, Janeba, Zlatko, West, Nicholas P., Woods, Kyra, Naesens, Lieve M. J., Keough, Dianne T., Guddat, Luke W.

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 8.82 MB

english, 2015

34

Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases

Hocková, Dana, Janeba, Zlatko, Naesens, Lieve, Edstein, Michael D., Chavchich, Marina, Keough, Dianne T., Guddat, Luke W.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 684 KB

english, 2015

35

Dichotomy in Regioselective Cross-Coupling Reactions of 6,8-Dichloropurines with Phenylboronic Acid and Methylmagnesium Chloride: Synthesis of 6,8-Disubstituted Purines

Hocek, Michal, Hocková, Dana, Dvořáková, Hana

Journal:

Year:

2004

Language:

english

File:

PDF, 112 KB

english, 2004

36

6-Oxopurine Phosphoribosyltransferase: A Target for the Development of Antimalarial Drugs

de Jersey, John, Holy, Antonin, Hockova, Dana, Naesens, Lieve, T. Keough, Dianne, W. Guddat, Luke

Journal:

Current Topics in Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 768 KB

english, 2011

37

Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases

Kaiser, Martin M., Hocková, Dana, Wang, Tzu-Hsuan, Dračínský, Martin, Poštová-Slavětínská, Lenka, Procházková, Eliška, Edstein, Michael D., Chavchich, Marina, Keough, Dianne T., Guddat, Luke W., Janeb

Journal:

Year:

2015

Language:

english

File:

PDF, 2.15 MB

english, 2015

38

Cover Picture: Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases (ChemMedChem 10/2015)

Kaiser, Martin M., Hocková, Dana, Wang, Tzu-Hsuan, Dračínský, Martin, Poštová-Slavětínská, Lenka, Procházková, Eliška, Edstein, Michael D., Chavchich, Marina, Keough, Dianne T., Guddat, Luke W., Janeb

Journal:

Year:

2015

File:

PDF, 727 KB

2015

39

Crystal Structures of Acyclic Nucleoside Phosphonates in Complex with Escherichia coli Hypoxanthine Phosphoribosyltransferase

Eng, Wai Soon, Hocková, Dana, Špaček, Petr, Baszczyňski, Ondřej, Janeba, Zlatko, Naesens, Lieve, Keough, Dianne T., Guddat, Luke W.

Journal:

ChemistrySelect

Year:

2016

Language:

english

File:

PDF, 2.42 MB

english, 2016

40

Novel nucleotide analogues bearing (1H-1,2,3-triazol-4-yl)phosphonic acid moiety as inhibitors of Plasmodium and human 6-oxopurine phosphoribosyltransferases

Lukáč, Miloš, Hocková, Dana, Keough, Dianne T., Guddat, Luke W., Janeba, Zlatko

Journal:

Year:

2017

Language:

english

File:

PDF, 658 KB

english, 2017

41

Oligomeric state of hypoxanthine−guanine phosphoribosyltransferase from Mycobacterium tuberculosis

Eng, Wai Soon, Keough, Dianne T., Hockova, Dana, Winzor, Donald J., Guddat, Luke W.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.35 MB

english, 2017

42

Crystal structures and inhibition of Trypanosoma brucei hypoxanthine–guanine phosphoribosyltransferase

Terán, David, Hocková, Dana, Česnek, Michal, Zíková, Alena, Naesens, Lieve, Keough, Dianne T., Guddat, Luke W.

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 2.07 MB

english, 2016

43

Acyclic nucleoside phosphonates containing 9-deazahypoxanthine and a 5-membered heterocycle as selective inhibitors of plasmodial 6-oxopurine phosphoribosyltransferases

Kaiser, Martin Maxmilian, Baszczyňski, Ondřej, Hocková, Dana, Poštová-Slavětínská, Lenka, Dračínský, Martin, Keough, Dianne T., Guddat, Luke W., Janeba, Zlatko

Journal:

Year:

2017

Language:

english

File:

PDF, 1.91 MB

english, 2017

44

Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase

Špaček, Petr, Keough, Dianne T., Chavchich, Marina, Dracinsky, Martin, Janeba, Zlatko, Naesens, Lieve, Edstein, Michael D., Guddat, Luke W, Hocková, Dana

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.59 MB

english, 2017

45

The Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics

Keough, Dianne T., Rejman, Dominik, Pohl, Radek, Zborníková, Eva, Hockova, Dana, Croll, Tristan, Edstein, Michael D., Birrell, Geoff W., Chavchich, Marina, Naesens, Lieve M. J., Pierens, Gregory K., B

Journal:

ACS Chemical Biology

Year:

2017

Language:

english

File:

PDF, 4.42 MB

english, 2017

46

"Abbreviated" NAD+ Analogues Containinga Phosphonate Function

Hocková, Dana, Masojídková, Milena, Holý, Antonín

Journal:

Collection of Czechoslovak Chemical Communications

Year:

1996

Language:

english

File:

PDF, 73 KB

english, 1996

47

Cytostatic 6-Arylpurine Nucleosides V. Synthesis of 8-Substituted 6-Phenylpurine Ribonucleosides

Hocek, Michal, Hocková, Dana, Štambaský, Jan

Journal:

Collection of Czechoslovak Chemical Communications

Year:

2003

Language:

english

File:

PDF, 113 KB

english, 2003

48

Synthesis of Some "Abbreviated" NAD+ Analogues

Hocková, Dana, Holý, Antonín

Journal:

Collection of Czechoslovak Chemical Communications

Year:

1997

Language:

english

File:

PDF, 62 KB

english, 1997

49

Acyclic nucleoside phosphonates with unnatural nucleobases, favipiravir and allopurinol, designed as potential inhibitors of the human and Plasmodium falciparum 6-oxopurine phosphoribosyltransferases

Klejch, Tomáš, Pohl, Radek, Janeba, Zlatko, Sun, Minghan, Keough, Dianne T., Guddat, Luke W., Hocková, Dana

Journal:

Year:

2018

Language:

english

File:

PDF, 1.45 MB

english, 2018

50

Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: Synthesis and evaluation

Klejch, Tomáš, Keough, Dianne T., Chavchich, Marina, Travis, Jye, Skácel, Jan, Pohl, Radek, Janeba, Zlatko, Edstein, Michael D., Avery, Vicky M., Guddat, Luke W., Hocková, Dana

Journal:

European Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 2.10 MB

english, 2019