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51

Small molecule inhibitors of the platelet-derived growth factor receptor, the fibroblast growth factor receptor, and Src family tyrosine kinases

H.D. Hollis Showalter, Alan J. Kraker

Journal:

Pharmacology & Therapeutics

Year:

1997

Language:

english

File:

PDF, 2.02 MB

english, 1997

52

Small Molecule Inhibitors of Tumor-Promoted Angiogenesis, Including Protein Tyrosine Kinase Inhibitors

James M Hamby, H.D.Hollis Showalter

Journal:

Pharmacology & Therapeutics

Year:

1999

Language:

english

File:

PDF, 515 KB

english, 1999

53

A roadmap for drug discovery and its translation to small molecule agents in clinical development for tuberculosis treatment

H.D. Hollis Showalter, William A. Denny

Journal:

Year:

2008

Language:

english

File:

PDF, 475 KB

english, 2008

54

Concise Syntheses of the Novel 1H-Pyrrolo[3,2-g]quinazoline Ring System and its [2,3-f] Angular Isomer

Showalter, H. D. Hollis, Sun, Li, Sercel, Anthony D., Winters, R. Thomas, Denny, William A., Palmer, Brian D.

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 179 KB

english, 1996

55

Tyrosine Kinase Inhibitors. 8. An Unusually Steep Structure−Activity Relationship for Analogues of 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a Potent Inhibitor of the Epidermal Growth Factor Receptor

Bridges, Alexander J., Zhou, Hairong, Cody, Donna R., Rewcastle, Gordon W., McMichael, Amy, Showalter, H. D. Hollis, Fry, David W., Kraker, Alan J., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 302 KB

english, 1996

56

Tyrosine Kinase Inhibitors. 6. Structure−Activity Relationships among N- and 3-Substituted 2,2‘-Diselenobis(1H-indoles) for Inhibition of Protein Tyrosine Kinases and Comparative in Vitro and in Vivo Studies against Selected Sulfur Congeners

Showalter, H. D. Hollis, Sercel, Anthony D., Leja, Boguslawa M., Wolfangel, Craig D., Ambroso, Linda A., Elliott, William L., Fry, David W., Kraker, Alan J., Howard, Curtis T., Lu, Gina H.

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 477 KB

english, 1997

57

Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Boschelli, Diane H., Wu, Zhipei, Klutchko, Sylvester R., Showalter, H. D. Hollis, Hamby, James M., Lu, Gina H., Major, Terry C., Dahring, Tawny K., Batley, Brian, Panek, Robert L.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 219 KB

english, 1998

58

Investigating the prevalence of queuine in Escherichia coli RNA via incorporation of the tritium-labeled precursor, preQ1

Allen F. Brooks, Carol S. Vélez-Martínez, H.D. Hollis Showalter, George A. Garcia

Journal:

Biochemical and Biophysical Research Communications

Year:

2012

Language:

english

File:

PDF, 443 KB

english, 2012

59

Tyrosine Kinase Inhibitors. 17. Irreversible Inhibitors of the Epidermal Growth Factor Receptor: 4-(Phenylamino)quinazoline- and 4-(Phenylamino)pyrido[3,2- d ]pyrimidine-6-acrylamides Bearing Additional Solubilizing Functions

Smaill, Jeff B., Rewcastle, Gordon W., Loo, Joseph A., Greis, Kenneth D., Chan, O. Helen, Reyner, Eric L., Lipka, Elke, Showalter, H. D. Hollis, Vincent, Patrick W., Elliott, William L., Denny, Willia

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 286 KB

english, 2000

60

Tyrosine Kinase Inhibitors. 16. 6,5,6-Tricyclic Benzothieno[3,2- d ]pyrimidines and Pyrimido[5,4- b ]- and -[4,5- b ]indoles as Potent Inhibitors of the Epidermal Growth Factor Receptor Tyrosine Kinase

Showalter, H. D. Hollis, Bridges, Alexander J., Zhou, Hairong, Sercel, Anthony D., McMichael, Amy, Fry, David W.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 315 KB

english, 1999

61

243 Use of Enterally-Delivered Angiotensin II Type IA Receptor Antagonists to Reduce the Severity of Colitis

Manabu Okawada, Hiroyuki Koga, Scott D. Larsen, Hollis D. Showalter, Peter C. Lucas, Daniel H. Teitelbaum

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 144 KB

english, 2009

62

AN IMPROVED SYNTHESIS OF 4,7-DIMETHOXY-1H-INDOLE

Hollis Showalter, H. D., Pohlmann, Gerd

Journal:

Organic Preparations and Procedures International

Year:

1992

Language:

english

File:

PDF, 320 KB

english, 1992

63

Synthesis and Structure−Activity Relationships of 7-Substituted 3-(2,6-Dichlorophenyl)-1,6-naphthyridin-2(1 H )-ones as Selective Inhibitors of pp60 c - src

Thompson, Andrew M., Rewcastle, Gordon W., Boushelle, Stacey L., Hartl, Brian G., Kraker, Alan J., Lu, Gina H., Batley, Brian L., Panek, Robert L., Showalter, H. D. Hollis, Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 255 KB

english, 2000

64

Tyrosine Kinase Inhibitors. 4. Structure-Activity Relationships among N- and 3-Substituted 2,2'-Dithiobis(1H-indoles) for in vitro Inhibition of Receptor and Nonreceptor Protein Tyrosine Kinases

Palmer, Brian D., Rewcastle, Gordon W., Thompson, Andrew M., Boyd, Maruta, Showalter, H. D. Hollis, Sercel, Anthony D., Fry, David W., Kraker, Alan J., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 2.14 MB

english, 1995

65

Progress in the Synthesis of Canthine Alkaloids and Ring-Truncated Congeners

Showalter, H. D. Hollis

Journal:

Journal of Natural Products

Year:

2013

Language:

english

File:

PDF, 1.18 MB

english, 2013

66

Simple Synthesis of 4‐Substituted 1(2 H )‐Isoquinolinones via Electrophilic Trapping of Lithiated Mono‐ and Dianion Precursors

Sercel, Anthony D., Sanchez, Joseph P., Hollis Showalter, H. D.

Journal:

Synthetic Communications

Year:

2007

Language:

english

File:

PDF, 135 KB

english, 2007

67

Tyrosine Kinase Inhibitors. 13. Structure−Activity Relationships for Soluble 7-Substituted 4-[(3-Bromophenyl)amino]pyrido[4,3- d ]pyrimidines Designed as Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor

Thompson, Andrew M., Murray, Donna K., Elliott, William L., Fry, David W., Nelson, James A., Hollis Showalter, H. D., Roberts, Bill J., Vincent, Patrick W., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 262 KB

english, 1997

68

Synthesis and structure–activity relationships of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors

Titchenell, Paul M., Hollis Showalter, H.D., Pons, Jean-François, Barber, Alistair J., Jin, Yafei, Antonetti, David A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 997 KB

english, 2013

69

Development of a Novel Silyl Ether Linker for Solid-Phase Organic Synthesis 1

Boehm, Terri L., Showalter, H. D. Hollis

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 92 KB

english, 1996

70

Tyrosine Kinase Inhibitors. 9. Synthesis and Evaluation of Fused Tricyclic Quinazoline Analogues as ATP Site Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor

Rewcastle, Gordon W., Palmer, Brian D., Bridges, Alexander J., Showalter, H. D. Hollis, Sun, Li, Nelson, James, McMichael, Amy, Kraker, Alan J., Fry, David W., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 398 KB

english, 1996

71

X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins

Molodtsov, Vadim, Nawarathne, Irosha N., Scharf, Nathan T., Kirchhoff, Paul D., Showalter, H. D. Hollis, Garcia, George A., Murakami, Katsuhiko S.

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.15 MB

english, 2013

72

Structure−Activity Relationships for 5-Substituted 1-Phenylbenzimidazoles as Selective Inhibitors of the Platelet-Derived Growth Factor Receptor

Palmer, Brian D., Kraker, Alan J., Hartl, Brian G., Panopoulos, Athanasia D., Panek, Robert L., Batley, Brian L., Lu, Gina H., Trumpp-Kallmeyer, Susanne, Showalter, H. D. Hollis, Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 136 KB

english, 1999

73

Tyrosine Kinase Inhibitors. 11. Soluble Analogues of Pyrrolo- and Pyrazoloquinazolines as Epidermal Growth Factor Receptor Inhibitors: Synthesis, Biological Evaluation, and Modeling of the Mode of Binding

Palmer, Brian D., Trumpp-Kallmeyer, Susanne, Fry, David W., Nelson, James M., Showalter, H. D. Hollis, Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 348 KB

english, 1997

74

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

Shen, Dongbiao, Wang, Xiang, Li, Xinran, Zhang, Xiaoli, Yao, Zepeng, Dibble, Shannon, Dong, Xian-ping, Yu, Ting, Lieberman, Andrew P., Showalter, Hollis D., Xu, Haoxing

Journal:

Nature Communications

Year:

2012

Language:

english

File:

PDF, 6.72 MB

english, 2012

75

3-Aminoquinazolinediones as a New Class of Antibacterial Agents Demonstrating Excellent Antibacterial Activity Against Wild-Type and Multidrug Resistant Organisms

Ellsworth, Edmund L., Tran, Tuan P., Hollis Showalter, H. D., Sanchez, Joseph P., Watson, Brian M., Stier, Michael A., Domagala, John M., Gracheck, Stephen J., Joannides, E. Themis, Shapiro, Martin A.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 48 KB

english, 2006

76

Synthesis of 6-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones via directed lithiation of 2-substituted 5-aminopyridine derivatives

Rewcastle, Gordon W., Denny, William A., Winters, R. Thomas, Colbry, Norman L., Showalter, H. D. Hollis

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1996

Language:

english

File:

PDF, 872 KB

english, 1996

77

STUDIES IN THE SYNTHESIS OF HALOGENATED ANTHRAQUINONES. I. A CONVENIENT PREPARATION OF 1,4-DICHLORO-5-HYDROXY-9,10-ANTHRACENEDIONE

Johnson, Judith L., Hollis Showalter, H. D.

Journal:

Organic Preparations and Procedures International

Year:

1984

Language:

english

File:

PDF, 195 KB

english, 1984

78

Investigation of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-diones as small molecule antagonists of β-catenin/TCF transcription

Zeller, Jörg, Turbiak, Anjanette J., Powelson, Ian A., Lee, Surin, Sun, Duxin, Showalter, H.D. Hollis, Fearon, Eric R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.33 MB

english, 2013

79

Total synthesis of (8R)-3-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol (pentostatin), the potent inhibitor of adenosine deaminase

Chan, Eunice, Putt, Sterling R., Showalter, H. D. Hollis, Baker, David C.

Journal:

Journal of Organic Chemistry

Year:

1982

Language:

english

File:

PDF, 1.08 MB

english, 1982

80

Facile entry into the thiazolo[3,2-a]indol-3(2H)-one system via an unusual reaction with thionyl chloride

Showalter, H. D. Hollis, Shipchandler, Mohammed T., Mitscher, Lester A., Hagaman, Edward W.

Journal:

Journal of Organic Chemistry

Year:

1979

Language:

english

File:

PDF, 425 KB

english, 1979

81

Adenosine deaminase inhibitors. Synthesis and biological evaluation of (.+-.)-3,6,7,8-tetrahydro-3-[(2-hydroxyethoxy)methyl]imidazo[4,5-d][1,3]diazepin-8-ol and some selected C-5 homologs of pentostatin

Showalter, H. D. Hollis, Putt, Sterling R., Borondy, Pal E., Shillis, Joan L.

Journal:

Journal of Medicinal Chemistry

Year:

1983

Language:

english

File:

PDF, 806 KB

english, 1983

82

Anthrapyrazole anticancer agents. Synthesis and structure-activity relationships against murine leukemias

Showalter, H. D. Hollis, Johnson, Judith L., Hoftiezer, Jeanne M., Turner, William R., Werbel, Leslie M., Leopold, Wilbur R., Shillis, Joan L., Jackson, Robert C., Elslager, Edward F.

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 1.37 MB

english, 1987

83

Tyrosine Kinase Inhibitors. 18. 6-Substituted 4-Anilinoquinazolines and 4-Anilinopyrido[3,4- d ]pyrimidines as Soluble, Irreversible Inhibitors of the Epidermal Growth Factor Receptor

Smaill, Jeff B., Showalter, H. D. Hollis, Zhou, Hairong, Bridges, Alexander J., McNamara, Dennis J., Fry, David W., Nelson, James M., Sherwood, Veronika, Vincent, Patrick W., Roberts, Bill J., Elliott

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 160 KB

english, 2001

84

Tyrosine Kinase Inhibitors. 17. Irreversible Inhibitors of the Epidermal Growth Factor Receptor: 4-(Phenylamino)quinazoline- and 4-(Phenylamino)pyrido[3,2- d ]pyrimidine-6-acrylamides Bearing Additional Solubilizing Functions.

Smaill, Jeff B., Rewcastle, Gordon W., Bridges, Alexander J., Zhou, Hairong, Showalter, H. D. Hollis, Fry, David W., Nelson, James M., Sherwood, Veronika, Elliott, William L., Vincent, Patrick W., DeJ

Journal:

Journal of Medicinal Chemistry

Year:

2000

File:

PDF, 7 KB

2000

85

Short syntheses of eburnamonine via .beta.-oxycyclopropylcarbonyl and related intermediates

Wenkert, Ernest, Hudlicky, Tomas, Showalter, H. D. Hollis

Journal:

Journal of the American Chemical Society

Year:

1978

Language:

english

File:

PDF, 274 KB

english, 1978

86

5-[(Aminoalkyl)amino]-substituted anthra[1,9-cd]pyrazol-6(2H)-ones as novel anticancer agents. Synthesis and biological evaluation

Showalter, H. D. Hollis, Johnson, Judith L., Werbel, Leslie M., Leopold, Wilbur R., Jackson, Robert C., Elslager, Edward F.

Journal:

Journal of Medicinal Chemistry

Year:

1984

Language:

english

File:

PDF, 378 KB

english, 1984

87

Anticancer activity in murine and human tumor cell lines of bis(platinum) complexes incorporating straight-chain aliphatic diamine linker groups

Kraker, Alan J., Hoeschele, James D., Elliott, William L., Showalter, H. D. Hollis, Sercel, Anthony D., Farrell, Nicholas P.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 843 KB

english, 1992

88

Benzothiopyranoindazoles, a new class of chromophore modified anthracenedione anticancer agents. Synthesis and activity against murine leukemias

Showalter, H. D. Hollis, Angelo, Mario M., Berman, Ellen M., Kanter, Gerald D., Ortwine, Daniel F., Ross-Kesten, Suzanne G., Sercel, Anthony D., Turner, William R., Werbel, Leslie M.

Journal:

Journal of Medicinal Chemistry

Year:

1988

Language:

english

File:

PDF, 1.54 MB

english, 1988

89

Trimethylsilyl polyphosphate for intramolecular Friedel-Crafts cyclizations

Berman, Ellen M., Showalter, H. D. Hollis

Journal:

Journal of Organic Chemistry

Year:

1989

Language:

english

File:

PDF, 320 KB

english, 1989

90

Development of Polymer-Supported Benzotriazole as a Novel Traceless Linker for Solid-Phase Organic Synthesis 1

Schiemann, Kai, Showalter, H. D. Hollis

Journal:

Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 61 KB

english, 1999

91

3-Substituted- N -(4-Hydroxynaphthalen-1-yl)arylsulfonamides as a Novel Class of Selective Mcl-1 Inhibitors: Structure-Based Design, Synthesis, SAR, and Biological Evaluation

Abulwerdi, Fardokht A., Liao, Chenzhong, Mady, Ahmed S., Gavin, Jordan, Shen, Chenxi, Cierpicki, Tomasz, Stuckey, Jeanne A., Showalter, H. D. Hollis, Nikolovska-Coleska, Zaneta

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 8.26 MB

english, 2014

92

Development of a Binding Model to Protein Tyrosine Kinases for Substituted Pyrido[2,3- d ]pyrimidine Inhibitors ‖

Trumpp-Kallmeyer, Susanne, Rubin, J. Ronald, Humblet, Christine, Hamby, James M., Hollis Showalter, H. D.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 266 KB

english, 1998

93

Synthesis, Structural Characterization, and Antitumor Properties of a Novel Class of Large-Ring Platinum(II) Chelate Complexes Incorporating the cis-1,4-Diaminocyclohexane Ligand in a Unique Locked Boat Conformation

Hoeschele, James D., Showalter, H. D. Hollis, Kraker, Alan J., Elliott, William L., Roberts, Billy J., Kampf, Jeff W.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 950 KB

english, 1994

94

Synthesis of 7-substituted 3-aryl-1,6-naphthyridin-2-amines and 7-substituted 3-aryl-1,6-naphthyridin-2(1H )-ones via diazotization of 3-aryl-1,6-naphthyridine-2,7-diamines

Thompson, Andrew M., Hollis Showalter, H. D., Denny, William A.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

2000

Language:

english

File:

PDF, 229 KB

english, 2000

95

Fragmentation process occurring in proton-transfer chemical-ionization mass spectrometry

Foltz, Rodger L., Fentiman, Allison F., Mitscher, Lester A., Showalter, H. D. Hollis

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1973

Language:

english

File:

PDF, 232 KB

english, 1973

96

A Pathway of Synthesis Toward the Aspidosperma Alkaloids

Wenkert, Ernest, Gottlieb, Hugo E., Hollis Showalter, H. D.

Journal:

Synthetic Communications

Year:

1979

Language:

english

File:

PDF, 288 KB

english, 1979

97

Inhibitors of Adenosine Deaminase: Synthesis of Coformycin and 3′-Deoxycoformycin

Hawkins, L. D., Hanvey, J. C., Boyd, F. L., Baker, David C., Showalter, H. D. Hollis

Journal:

Nucleosides and Nucleotides

Year:

1983

Language:

english

File:

PDF, 647 KB

english, 1983

98

Novel Carboxaldehyde Mediated Synthetic Pathway for 5′-Amino Adenosine Analogues

Gibbons, Garrett S., Showalter, Hollis D., Nikolovska-Coleska, Zaneta

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2015

Language:

english

File:

PDF, 335 KB

english, 2015

99

Antiviral Activity of a Small Molecule Deubiquitinase Inhibitor Occurs via Induction of the Unfolded Protein Response

Perry, Jeffrey W., Ahmed, Mohammad, Chang, Kyeong-Ok, Donato, Nicholas J., Showalter, Hollis D., Wobus, Christiane E., Heise, Mark T.

Journal:

Year:

2012

Language:

english

File:

PDF, 1.03 MB

english, 2012

100

Substrate-Competitive Activity-Based Profiling of Ester Prodrug Activating Enzymes

Xu, Hao, Majmudar, Jaimeen D., Davda, Dahvid, Ghanakota, Phani, Kim, Ki H., Carlson, Heather A., Showalter, Hollis D., Martin, Brent R., Amidon, Gordon L.

Journal:

Molecular Pharmaceutics

Year:

2015

Language:

english

File:

PDF, 4.04 MB

english, 2015

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