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1

Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels

Luc M. Hondeghem, Bertram G. Katzung

Journal:

Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes

Year:

1977

Language:

english

File:

PDF, 1.39 MB

english, 1977

2

Detection of Proarrhythmia in the Female Rabbit Heart: : Blinded Validation

LUC M. HONDEGHEM, HUA RONG LU, KOEN van ROSSEM, FRED De CLERCK

Journal:

Journal of Cardiovascular Electrophysiology

Year:

2003

Language:

english

File:

PDF, 328 KB

english, 2003

3

Cardiac ventricular automaticity induced by current of injury

Bertram G. Katzung, Luc M. Hondeghem, Augustus O. Grant

Journal:

Pflügers Archiv European Journal of Physiology

Year:

1975

Language:

english

File:

PDF, 462 KB

english, 1975

4

LETTERS TO THE EDITOR

Luc M. Hondeghem

Journal:

Pacing and Clinical Electrophysiology

Year:

1989

Language:

english

File:

PDF, 168 KB

english, 1989

5

LETTERS TO THE EDITOR

Luc M. Hondeghem

Journal:

Pacing and Clinical Electrophysiology

Year:

1989

Language:

english

File:

PDF, 149 KB

english, 1989

6

Computer Aided Development of Antiarrhythmic Agents with Class IIIa Properties

LUC M. HONDEGHEM

Journal:

Journal of Cardiovascular Electrophysiology

Year:

1994

Language:

english

File:

PDF, 4.92 MB

english, 1994

7

Thorough QT/QTc Not So Thorough: Removes Torsadogenic Predictors from the T-Wave, Incriminates Safe Drugs, and Misses Profibrillatory Drugs

LUC M. HONDEGHEM

Journal:

Journal of Cardiovascular Electrophysiology

Year:

2006

Language:

english

File:

PDF, 146 KB

english, 2006

8

Relative Contributions of TRIaD and QT to Proarrhythmia

LUC M. HONDEGHEM

Journal:

Journal of Cardiovascular Electrophysiology

Year:

2007

Language:

english

File:

PDF, 93 KB

english, 2007

9

Lidocaine blocks open and inactivated cardiac sodium channels

Tetsu Matsubara, Craig Clarkson, Luc Hondeghem

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1987

Language:

english

File:

PDF, 916 KB

english, 1987

10

Selective depression of 2,4-dinitrophenol depolarized canine Purkinje fibers by lidocaine

Luc M. Hondeghem, Clement Lam

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1980

Language:

english

File:

PDF, 590 KB

english, 1980

11

Use and abuse of QT and TRIaD in cardiac safety research: Importance of study design and conduct

Luc M. Hondeghem

Journal:

European Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 575 KB

english, 2008

12

Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs

Jean-Pierre Valentin, Peter Hoffmann, Fred De Clerck, Tim G Hammond, Luc Hondeghem

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2004

Language:

english

File:

PDF, 480 KB

english, 2004

13

Antiarrhythmic drug action: Selective depression of hypoxic cardiac cells

Luc M. Hondeghem, Augustus O. Grant, Richard A. Jensen

Journal:

American Heart Journal

Year:

1974

Language:

english

File:

PDF, 368 KB

english, 1974

14

Effects of lidocaine, phenytoin and quinidine on the ischemic canine myocardium

Luc M. Hondeghem

Journal:

Journal of Electrocardiology

Year:

1976

Language:

english

File:

PDF, 645 KB

english, 1976

15

Quinidine blocks cardiac sodium channels during opening and slow inactivation in guinea-pig papillary muscle

Luc M. Hondeghem, Tetsu Matsubara

Journal:

British Journal of Pharmacology

Year:

1988

Language:

english

File:

PDF, 1.16 MB

english, 1988

16

Quinidine

JAY W. MASON, LUC M. HONDEGHEM

Journal:

Annals of the New York Academy of Sciences

Year:

1984

Language:

english

File:

PDF, 822 KB

english, 1984

17

Purkinje-myocardial conduction delay: An alternative explanation

Luc M. Hondeghem, Richard A. Jensen

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1974

Language:

english

File:

PDF, 460 KB

english, 1974

18

Evidence for voltage-dependent block of cardiac sodium channels by tetrodotoxin

Craig W. Clarkson, Tetsu Matsubara, Luc M. Hondeghem

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1988

Language:

english

File:

PDF, 1020 KB

english, 1988

19

Preclinical Cardiovascular Safety Evaluations of Biologics

Hondeghem, Luc, Clerck, Fred

Journal:

Year:

2012

Language:

english

File:

PDF, 148 KB

english, 2012

20

QT prolongation is an unreliable predictor of ventricular arrhythmia

Hondeghem, Luc M.

Journal:

Year:

2008

Language:

english

File:

PDF, 133 KB

english, 2008

21

Refining detection of drug-induced proarrhythmia: QT interval and TRIaD

Shah, Rashmi R., Hondeghem, Luc M.

Journal:

Year:

2005

Language:

english

File:

PDF, 311 KB

english, 2005

22

Temperature and Voltage Dependence of Sodium Channel Blocking and Unblocking by O-Demethyl Encainide in Isolated Guinea Pig Myocytes

Johns, James A., Anno, Takafumi, Bennett, Paul B., Snyders, Dirk J., Hondeghem, Luc M.

Journal:

Journal of Cardiovascular Pharmacology

Year:

1989

File:

PDF, 785 KB

1989

23

Disturbances of cardiac wavelength and repolarization precede Torsade de Pointes and ventricular fibrillation in Langendorff perfused rabbit hearts

Hondeghem, Luc M.

Journal:

Progress in Biophysics and Molecular Biology

Year:

2016

Language:

english

File:

PDF, 571 KB

english, 2016

24

Blinded Test in Isolated Female Rabbit Heart Reliably Identifies Action Potential Duration Prolongation and Proarrhythmic Drugs: Importance of Triangulation, Reverse Use Dependence, and Instability

Hondeghem, Luc M., Hoffmann, Peter

Journal:

Journal of Cardiovascular Pharmacology

Year:

2003

Language:

english

File:

PDF, 653 KB

english, 2003

25

Short Patent Lives Jeopardize Drug and Patient Safety

Hondeghem, Luc M, De Clerck, Fred, Camm, John

Journal:

Journal of Cardiovascular Pharmacology

Year:

2007

Language:

english

File:

PDF, 110 KB

english, 2007

26

Drug-Induced QTC Prolongation Dangerously Underestimates Proarrhythmic Potential: Lessons From Terfenadine

Hondeghem, Luc M, Dujardin, Karl, Hoffmann, Peter, Dumotier, Berengere, De Clerck, Fred

Journal:

Journal of Cardiovascular Pharmacology

Year:

2011

Language:

english

File:

PDF, 494 KB

english, 2011

27

Domperidone

Hondeghem, Luc M.

Journal:

Journal of Cardiovascular Pharmacology

Year:

2013

Language:

english

File:

PDF, 435 KB

english, 2013

28

Development of Class III Antiarrhythmic Agents

Hondeghem, Luc M.

Journal:

Journal of Cardiovascular Pharmacology

Year:

1992

File:

PDF, 3.66 MB

1992

29

Mechanism for Bupivacaine Depression of Cardiac Conduction

Clarkson, Craig W., Hondeghem, Luc M.

Journal:

Year:

1985

File:

PDF, 807 KB

1985

30

Should Domperidone be Used as a Galactagogue? Possible Safety Implications for Mother and Child

Hondeghem, Luc M., Logghe, Noël H.

Journal:

Year:

2017

Language:

english

File:

PDF, 477 KB

english, 2017

31

QTc prolongation as a surrogate for drug-induced arrhythmias: fact or fallacy?

Hondeghem, Luc M.

Journal:

Acta Cardiologica

Year:

2011

Language:

english

File:

PDF, 1.24 MB

english, 2011

32

Drug-Induced QT Prolongation and Torsades de Pointes: An All-Exclusive Relationship or Time for an Amicable Separation?

Hondeghem, Luc M.

Journal:

Year:

2018

Language:

english

File:

PDF, 1.02 MB

english, 2018

33

Low safety index of domperidone: mechanism for increased odds ratio for sudden cardiac death

Hondeghem, Luc M.

Journal:

Acta Cardiologica

Year:

2011

Language:

english

File:

PDF, 1.16 MB

english, 2011