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1

Structure-based optimization of FDA-approved drug methylene blue as a c-myc G-quadruplex DNA stabilizer

Daniel Shiu-Hin Chan, Hui Yang, Maria Hiu-Tung Kwan, Zhen Cheng, Paul Lee, Li-Ping Bai, Zhi-Hong Jiang, Chun-Yuen Wong, Wang-Fun Fong, Chung-Hang Leung, Dik-Lung Ma

Journal:

Year:

2011

Language:

english

File:

PDF, 1.18 MB

english, 2011

2

Synergistic anti-cancer effect of baicalein and silymarin on human hepatoma HepG2 Cells

Ching-Hsein Chen, Tien-Shang Huang, Chung-Hang Wong, Chian-Lang Hong, Yung-Hong Tsai, Chia-Ching Liang, Fung-Jou Lu, Wen-Huei Chang

Journal:

Food and Chemical Toxicology

Year:

2009

Language:

english

File:

PDF, 573 KB

english, 2009

3

Recent advances in luminescent heavy metal complexes for sensing

Dik-Lung Ma, Victor Pui-Yan Ma, Daniel Shiu-Hin Chan, Ka-Ho Leung, Hong-Zhang He, Chung-Hang Leung

Journal:

Coordination Chemistry Reviews

Year:

2012

Language:

english

File:

PDF, 3.11 MB

english, 2012

4

Bioactive Luminescent Transition-Metal Complexes for Biomedical Applications

Ma, Dik-Lung, He, Hong-Zhang, Leung, Ka-Ho, Chan, Daniel Shiu-Hin, Leung, Chung-Hang

Journal:

Angewandte Chemie International Edition

Year:

2013

Language:

english

File:

PDF, 2.54 MB

english, 2013

5

Luminescent detection of human serum albumin in aqueous solution using a cyclometallated iridium(III) complex

Lu, Lihua, He, Hong-Zhang, Zhong, Hai-Jing, Liu, Li-Juan, Chan, Daniel Shiu-Hin, Leung, Chung-Hang, Ma, Dik-Lung

Journal:

Sensors and Actuators B: Chemical

Year:

2014

Language:

english

File:

PDF, 393 KB

english, 2014

6

Visualization of Zn 2+ Ions in Live Zebrafish Using a Luminescent Iridium(III) Chemosensor

Ma, Dik-Lung, He, Hong-Zhang, Zhong, Hai-Jing, Lin, Sheng, Chan, Daniel Shiu-Hin, Wang, Liang, Lee, Simon Ming-Yuen, Leung, Chung-Hang, Wong, Chun-Yuen

Journal:

ACS Applied Materials & Interfaces

Year:

2014

Language:

english

File:

PDF, 3.86 MB

english, 2014

7

Using two-phase solvent systems for sample pretreatment increases yield of counter-current chromatography: Anemarrhena asphodeloides saponins, a case study

Liu, Meng-Shun, Chau, Siu-Leung, Ma, Dik-Lung, Leung, Chung-Hang, Bian, Zhao-Xiang, Lu, Ai-Ping, Xu, Hong-Xi, Han, Quan-Bin

Journal:

Separation and Purification Technology

Year:

2014

Language:

english

File:

PDF, 885 KB

english, 2014

8

Akt downstream of NFκB, MAPKs and IRF3 pathway involved in macrophage activation induced by Astragalus polysaccharide RAP

Li, Zhi-Peng, Li, Li-Feng, Zhang, Quan-Wei, Wei, Wei, Liu, Hong-Bing, Bao, Wan-Rong, Ma, Dik-Lung, Leung, Chung-Hang, Bian, Zhao-Xiang, Lu, Ai-Ping, Han, Quan-Bin

Journal:

Journal of Functional Foods

Year:

2017

Language:

english

File:

PDF, 1.27 MB

english, 2017

9

A robust photoluminescence screening assay identifies uracil-DNA glycosylase inhibitors against prostate cancer

Li, Guodong, Henry, Stuart Adam, Liu, Hao, Kang, Tian-Shu, Nao, Sang-Cuo, Zhao, Yichao, Wu, Chun, Jin, Jianwen, Zhang, Jia-Tong, Leung, Chung-Hang, Wai Hong Chan, Philip, Ma, Dik-Lung

Journal:

Chemical Science

Year:

2020

Language:

english

File:

PDF, 1.18 MB

english, 2020

10

Label-free sensing of pH and silver nanoparticles using an “OR” logic gate

Dik-Lung Ma, Hong-Zhang He, Victor Pui-Yan Ma, Daniel Shiu-Hin Chan, Ka-Ho Leung, Hai-Jing Zhong, Lihua Lu, Jean-Louis Mergny, Chung-Hang Leung

Journal:

Analytica Chimica Acta

Year:

2012

Language:

english

File:

PDF, 592 KB

english, 2012

11

Discovery of a natural product inhibitor targeting protein neddylation by structure-based virtual screening

Zhong, Hai-Jing, Pui-Yan Ma, Victor, Cheng, Zhen, Shiu-Hin Chan, Daniel, He, Hong-Zhang, Leung, Ka-Ho, Ma, Dik-Lung, Leung, Chung-Hang

Journal:

Year:

2012

Language:

english

File:

PDF, 432 KB

english, 2012

12

Label-free detection of sub-nanomolar lead(II) ions in aqueous solution using a metal-based luminescent switch-on probe

Hong-Zhang He, Ka-Ho Leung, Hui Yang, Daniel Shiu-Hin Chan, Chung-Hang Leung, Jun Zhou, Anne Bourdoncle, Jean-Louis Mergny, Dik-Lung Ma

Journal:

Biosensors and Bioelectronics

Year:

2013

Language:

english

File:

PDF, 365 KB

english, 2013

13

Label-free luminescent oligonucleotide-based probes

Ma, Dik-Lung, He, Hong-Zhang, Leung, Ka-Ho, Zhong, Hai-Jing, Chan, Daniel Shiu-Hin, Leung, Chung-Hang

Journal:

Chemical Society Reviews

Year:

2013

Language:

english

File:

PDF, 3.14 MB

english, 2013

14

A highly selective G-quadruplex-based luminescent switch-on probe for the detection of gene deletion

He, Hong-Zhang, Chan, Daniel Shiu-Hin, Leung, Chung-Hang, Ma, Dik-Lung

Journal:

Chemical Communications

Year:

2012

Language:

english

File:

PDF, 2.54 MB

english, 2012

15

A highly selective G-quadruplex-based luminescent switch-on probe for the detection of nanomolar strontium(ii) ions in sea water

Leung, Ka-Ho, Ma, Victor Pui-Yan, He, Hong-Zhang, Chan, Daniel Shiu-Hin, Yang, Hui, Leung, Chung-Hang, Ma, Dik-Lung

Journal:

Year:

2012

Language:

english

File:

PDF, 474 KB

english, 2012

16

A label-free G-quadruplex-based switch-on fluorescence assay for the selective detection of ATP

He, Hong-Zhang, Pui-Yan Ma, Victor, Leung, Ka-Ho, Shiu-Hin Chan, Daniel, Yang, Hui, Cheng, Zhen, Leung, Chung-Hang, Ma, Dik-Lung

Journal:

The Analyst (Royal Society of Chemistry)

Year:

2012

Language:

english

File:

PDF, 188 KB

english, 2012

17

Simple DNA-based logic gates responding to biomolecules and metal ions

Ma, Dik-Lung, He, Hong-Zhang, Chan, Daniel Shiu-Hin, Leung, Chung-Hang

Journal:

Chemical Science

Year:

2013

Language:

english

File:

PDF, 1.44 MB

english, 2013

18

Detection of base excision repair enzyme activity using a luminescent G-quadruplex selective switch-on probe

Leung, Ka-Ho, He, Hong-Zhang, Ma, Victor Pui-Yan, Zhong, Hai-Jing, Chan, Daniel Shiu-Hin, Zhou, Jun, Mergny, Jean-Louis, Leung, Chung-Hang, Ma, Dik-Lung

Journal:

Chemical Communications

Year:

2013

Language:

english

File:

PDF, 1.74 MB

english, 2013

19

Luminescent oligonucleotide-based detection of enzymes involved with DNA repair

Leung, Chung-Hang, Zhong, Hai-Jing, He, Hong-Zhang, Lu, Lihua, Chan, Daniel Shiu-Hin, Ma, Dik-Lung

Journal:

Chemical Science

Year:

2013

Language:

english

File:

PDF, 1.33 MB

english, 2013

20

Metal complexes as inhibitors of transcription factor activity

Leung, Chung-Hang, He, Hong-Zhang, Liu, Li-Juan, Wang, Modi, Chan, Daniel Shiu-Hin, Ma, Dik-Lung

Journal:

Coordination Chemistry Reviews

Year:

2013

Language:

english

File:

PDF, 887 KB

english, 2013

21

A parallel G-quadruplex-selective luminescent probe for the detection of nanomolar calcium(II) ion

He, Hong-Zhang, Wang, Modi, Chan, Daniel Shiu-Hin, Leung, Chung-Hang, Lin, Xuexia, Lin, Jin-Ming, Ma, Dik-Lung

Journal:

Year:

2013

Language:

english

File:

PDF, 926 KB

english, 2013

22

A highly sensitive G-quadruplex-based luminescent switch-on probe for the detection of polymerase 3′–5′ proofreading activity

Leung, Ka-Ho, He, Hong-Zhang, Zhong, Hai-Jing, Lu, Lihua, Chan, Daniel Shiu-Hin, Ma, Dik-Lung, Leung, Chung-Hang

Journal:

Year:

2013

Language:

english

File:

PDF, 645 KB

english, 2013

23

Structure-based repurposing of FDA-approved drugs as inhibitors of NEDD8-activating enzyme

Zhong, Hai-Jing, Liu, Li-Juan, Chan, Daniel Shiu-Hin, Wang, Hui-Min, Chan, Philip Wai Hong, Ma, Dik-Lung, Leung, Chung-Hang

Journal:

Year:

2014

Language:

english

File:

PDF, 591 KB

english, 2014

24

Detection of 3′→5′ exonuclease activity using a metal-based luminescent switch-on probe

He, Hong-Zhang, Chan, Weng-I, Mak, Tsun-Yin, Liu, Li-Juan, Wang, Modi, Chan, Daniel Shiu-Hin, Ma, Dik-Lung, Leung, Chung-Hang

Journal:

Year:

2013

Language:

english

File:

PDF, 952 KB

english, 2013

25

An oligonucleotide-based switch-on luminescent probe for the detection of kanamycin in aqueous solution

Leung, Ka-Ho, He, Hong-Zhang, Chan, Daniel Shiu-Hin, Fu, Wai-Chung, Leung, Chung-Hang, Ma, Dik-Lung

Journal:

Sensors and Actuators B: Chemical

Year:

2013

Language:

english

File:

PDF, 502 KB

english, 2013

26

A label-free G-quadruplex-based luminescent switch-on assay for the selective detection of histidine

He, Hong-Zhang, Wang, Modi, Chan, Daniel Shiu-Hin, Leung, Chung-Hang, Qiu, Jian-Wen, Ma, Dik-Lung

Journal:

Year:

2013

Language:

english

File:

PDF, 1.05 MB

english, 2013

27

Synthesis of highly substituted indene derivatives by Brønsted acid catalyzed Friedel–Crafts reaction of homoallylic alcohols

Zhang, Xiaoxiang, Teo, Wan Teng, Rao, Weidong, Ma, Dik-Lung, Leung, Chung-Hang, Chan, Philip Wai Hong

Journal:

Tetrahedron Letters

Year:

2014

Language:

english

File:

PDF, 1.58 MB

english, 2014

28

SCOTLAND.

Zhang, Xiaoxiang, Teo, Wan Teng, Rao, Weidong, Ma, Dik-Lung, Leung, Chung-Hang, Chan, Philip Wai Hong

Journal:

Year:

1912

Language:

english

File:

PDF, 427 KB

english, 1912

29

Label-Free Luminescent Switch-on Detection of Endonuclease IV Activity Using a G-Quadruplex-Selective Iridium(III) Complex

Leung, Ka-Ho, He, Hong-Zhang, Wang, Wei, Zhong, Hai-Jing, Chan, Daniel Shiu-Hin, Leung, Chung-Hang, Ma, Dik-Lung

Journal:

ACS Applied Materials & Interfaces

Year:

2013

Language:

english

File:

PDF, 704 KB

english, 2013

30

Crystal violet as a fluorescent switch-on probe for i-motif: label-free DNA-based logic gate

Ma, Dik-Lung, Kwan, Maria Hiu-Tung, Chan, Daniel Shiu-Hin, Lee, Paul, Yang, Hui, Ma, Victor Pui-Yan, Bai, Li-Ping, Jiang, Zhi-Hong, Leung, Chung-Hang

Journal:

The Analyst (Royal Society of Chemistry)

Year:

2011

Language:

english

File:

PDF, 341 KB

english, 2011

31

Group 9 metal-based inhibitors of β-amyloid (1–40) fibrillation as potential therapeutic agents for Alzheimer's disease

Man, Bradley Yat-Wah, Chan, Ho-Man, Leung, Chung-Hang, Chan, Daniel Shiu-Hin, Bai, Li-Ping, Jiang, Zhi-Hong, Li, Hung-Wing, Ma, Dik-Lung

Journal:

Chemical Science

Year:

2011

Language:

english

File:

PDF, 268 KB

english, 2011

32

A G-quadruplex-based platform for the detection of Hg 2+ ions using a luminescent iridium( iii ) complex

Lin, Sheng, He, Bingyong, Shiu-Hin Chan, Daniel, Hong Chan, Philip Wai, Leung, Chung-Hang, Ma, Dik-Lung

Journal:

Year:

2014

Language:

english

File:

PDF, 535 KB

english, 2014

33

[IEEE Communication (HPCC) - Banff, AB, Canada (2011.09.2-2011.09.4)] 2011 IEEE International Conference on High Performance Computing and Communications - Energy-Efficient Visual Eyes System for Wildlife

Chen, Chia-Pang, Lin, Chi-Hung, Lai, Ta-Wei, Chuang, Cheng-Long, Lin, Tzu-Shiang, Jiang, Joe-Air, Yuan, Hsiao-Wei, Chiou, Chyi-Rong, Hong, Chung-Hang

Year:

2011

Language:

english

File:

PDF, 998 KB

english, 2011

34

Ytterbium(III) triflate catalyzed annulation of propargylic 1,4-diols with aryl sulfonamides to give highly substituted pyrrole derivatives

Zhang, Xiaoxiang, Teo, Jing Wei, Ma, Dik-Lung, Leung, Chung-Hang, Chan, Philip Wai Hong

Journal:

Tetrahedron Letters

Year:

2014

Language:

english

File:

PDF, 682 KB

english, 2014

35

Discovery of a small-molecule inhibitor of STAT3 by ligand-based pharmacophore screening

Leung, Ka-Ho, Liu, Li-Juan, Lin, Sheng, Lu, Lihua, Zhong, Hai-Jing, Susanti, Dewi, Rao, Weidong, Wang, Modi, Che, Weng Ian, Chan, Daniel Shiu-Hin, Leung, Chung-Hang, Chan, Philip Wai Hong, Ma, Dik-Lun

Journal:

Year:

2015

Language:

english

File:

PDF, 971 KB

english, 2015

36

Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe

Leung, Ka-Ho, He, Hong-Zhang, He, Bingyong, Zhong, Hai-Jing, Lin, Sheng, Wang, Yi-Tao, Ma, Dik-Lung, Leung, Chung-Hang

Journal:

Chemical Science

Year:

2015

Language:

english

File:

PDF, 590 KB

english, 2015

37

Pharmacophore modeling for the identification of small-molecule inhibitors of TACE

Liu, Li-Juan, Leung, Ka-Ho, Lin, Sheng, Chan, Daniel Shiu-Hin, Susanti, Dewi, Rao, Weidong, Chan, Philip Wai Hong, Ma, Dik-Lung, Leung, Chung-Hang

Journal:

Year:

2015

Language:

english

File:

PDF, 928 KB

english, 2015

38

Detection of nicking endonuclease activity using a G-quadruplex-selective luminescent switch-on probe

Lu, Lihua, Shiu-Hin Chan, Daniel, Kwong, Daniel W. J., He, Hong-Zhang, Leung, Chung-Hang, Ma, Dik-Lung

Journal:

Chemical Science

Year:

2014

Language:

english

File:

PDF, 1.47 MB

english, 2014

39

Application of a DNA-based luminescence switch-on method for the detection of mercury(II) ions in water samples from Hong Kong

He, Hong-Zhang, Leung, Ka-Ho, Fu, Wai-Chung, Chan, Daniel Shiu-Hin, Leung, Chung-Hang, Ma, Dik-Lung

Journal:

Environmental Research Letters

Year:

2012

Language:

english

File:

PDF, 495 KB

english, 2012

40

Evaluation of Cinnamomum osmophloeum Kanehira Extracts on Tyrosinase Suppressor, Wound Repair Promoter, and Antioxidant

Lee, Man-Gang, Kuo, Su-Yu, Yen, Shih-Yu, Hsu, Hsia-Fen, Leung, Chung-Hang, Ma, Dik-Lung, Wen, Zhi-Hong, Wang, Hui-Min David

Journal:

The Scientific World JOURNAL

Year:

2015

Language:

english

File:

PDF, 1.96 MB

english, 2015

41

Luminescent G-quadruplex Probes

Ma, Dik-Lung, Shiu-Hin Chan, Daniel, Yang, Hui, He, Hong-Zhang, Leung, Chung-Hang

Journal:

Current Pharmaceutical Design

Year:

2012

File:

PDF, 751 KB

2012

42

Luminescent G-quadruplex Probes

Ma, Dik-Lung, Shiu-Hin Chan, Daniel, Yang, Hui, He, Hong-Zhang, Leung, Chung-Hang

Journal:

Current Pharmaceutical Design

Year:

2012

Language:

english

File:

PDF, 751 KB

english, 2012

43

A label-free G-quadruplex-based mercury detection assay employing the exonuclease III-mediated cleavage of T–Hg 2+ –T mismatched DNA

Wang, Wanhe, Kang, Tian-Shu, Chan, Philip Wai Hong, Lu, Jin-Jian, Chen, Xiu-Ping, Leung, Chung-Hang, Ma, Dik-Lung

Journal:

Science and Technology of Advanced Materials

Year:

2015

Language:

english

File:

PDF, 1007 KB

english, 2015

44

Isocryptotanshinone, a STAT3 inhibitor, induces apoptosis and pro-death autophagy in A549 lung cancer cells

Guo, Shuhui, Luo, Weiwei, Liu, Lijuan, Pang, Xiaocong, Zhu, Hong, Liu, Ailin, Lu, Jinjian, Ma, Dik-Lung, Leung, Chung-Hang, Wang, Yitao, Chen, Xiuping

Journal:

Journal of Drug Targeting

Year:

2016

Language:

english

File:

PDF, 1.39 MB

english, 2016

45

Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin–MLL interaction

Zhong, Hai-Jing, Lee, Bo Ra, Boyle, Joshua William, Wang, Wanhe, Ma, Dik-Lung, Hong Chan, Philip Wai, Leung, Chung-Hang

Journal:

Chemical Communications

Year:

2016

Language:

english

File:

PDF, 1.76 MB

english, 2016

46

ChemInform Abstract: Gold-Catalyzed Cycloisomerization and Diels-Alder Reaction of 1,4,9-Dienyne Esters to 3a,6-Methanoisoindole Esters with Pro-Inflammatory Cytokine Antagonist Activity.

Susanti, Dewi, Liu, Li-Juan, Rao, Weidong, Lin, Sheng, Ma, Dik-Lung, Leung, Chung-Hang, Chan, Philip Wai Hong

Journal:

Year:

2015

File:

PDF, 28 KB

2015

47

Bioaktive lumineszierende Übergangsmetallkomplexe für biomedizinische Anwendungen

Ma, Dik-Lung, He, Hong-Zhang, Leung, Ka-Ho, Chan, Daniel Shiu-Hin, Leung, Chung-Hang

Journal:

Angewandte Chemie

Year:

2013

Language:

german

File:

PDF, 2.29 MB

german, 2013

48

ChemInform Abstract: Label-Free Luminescent Oligonucleotide-Based Probes

Ma, Dik-Lung, He, Hong-Zhang, Leung, Ka-Ho, Zhong, Hai-Jing, Chan, Daniel Shiu-Hin, Leung, Chung-Hang

Journal:

Year:

2013

File:

PDF, 27 KB

2013

49

ChemInform Abstract: Silver Triflate Catalyzed Cyclopropyl Carbinol Rearrangement for Benzo[b]oxepine and 2H-Chromene Synthesis.

Chan, Philip Wai Hong, Teo, Wan Teng, Koh, Shaun Wei Yong, Lee, Bo Ra, Ayers, Benjamin James, Ma, Dik-Lung, Leung, Chung-Hang

Journal:

Year:

2015

File:

PDF, 24 KB

2015

50

ChemInform Abstract: Luminescent Oligonucleotide-Based Detection of Enzymes Involved with DNA Repair

Leung, Chung-Hang, Zhong, Hai-Jing, He, Hong-Zhang, Lu, Lihua, Chan, Daniel Shiu-Hin, Ma, Dik-Lung

Journal:

Year:

2013

File:

PDF, 18 KB

2013