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1

[Part 2: Biological Sciences] || Molecular Structure of a Double Helix That Has Non-Watson--Crick Type Base Pairing Formed by 2-Substituted Poly(A) and Poly(U)

Toshio Hakoshima, Toshikazu Fukui, Morio Ikehara and Ken-Ichi Tomita

Journal:

Proceedings of the National Academy of Sciences

Year:

1981

Language:

english

File:

PDF, 1.28 MB

english, 1981

2

Protein Engineering Research Institute

Morio Ikehara, Yukio Takigawa

Journal:

Year:

1988

Language:

english

File:

PDF, 480 KB

english, 1988

3

1H-nmr studies on the dinucleoside monophosphates containing 2′-halogeno-2′-deoxypurinenucleosides: Effects of 2′-substitutes on conformation

Seiichi Uesugi, Toshinori Kaneyasu, Junko Imura, Morio Ikehara, Doris M. Cheng, Lousing Kan, Paul O. P. Ts'o

Journal:

Year:

1983

Language:

english

File:

PDF, 694 KB

english, 1983

4

Multinuclear magnetic resonance studies of monomers and diemrs containing 2′-fluoro-2′-deoxyadenosine

Doris M. Cheng, Lou-Sing Kan, Paul O. P. Ts'o, Seiichi Uesugi, Yoko Takatsuka, Morio Ikehara

Journal:

Year:

1983

Language:

english

File:

PDF, 824 KB

english, 1983

5

1H- and 31P-nuclear magnetic resonance studies on the conformation of d-(CpGpCpG)2 and d-(CpGpCpGpCpG)2 short helices in B-conformation

Doris M. Cheng, Lou-Sing Kan, Denise Frechet, Paul O. P. Ts'O, Seiichi Uesugi, Toshio Shida, Morio Ikehara

Journal:

Year:

1984

Language:

english

File:

PDF, 966 KB

english, 1984

6

27 amino acid residues can be deleted from the N-terminus of human lymphotoxin without impairment of its cytotoxic activity

Satoshi Nishikawa, Noriyuki Matsuo, Yoshitaka Isaka, Seiichi Uesugi, Kazunobu Miura, Eiko Ohtsuka, Ken Takeda, Kunio Konno, Morio Ikehara

Journal:

Journal of Molecular Recognition

Year:

1990

Language:

english

File:

PDF, 604 KB

english, 1990

7

Carbon-13 NMR spectra of nucleoside 3′,5′-cyclic phosphates. Proposition for revised signal assignments

Seiichi Uesugi, Sumie Tanaka, Morio Ikehara

Journal:

Magnetic Resonance in Chemistry

Year:

1979

Language:

english

File:

PDF, 283 KB

english, 1979

8

Studies of nucleosides and nucleotides—LXXIV: Purine cyclonucleosides—34 a new method for the synthesis of 2'-substituted 2'-deoxyadenosines

Morio Ikehara, Tokumi Maruyama, Hiroko Miki

Journal:

Year:

1978

Language:

english

File:

PDF, 672 KB

english, 1978

9

Chemical synthesis of the 5-́half molecule of E.coli tRNA2GLY

Eiko Ohtsuka, Akio Yamane, Takefumi Doi, Morio Ikehara

Journal:

Year:

1984

Language:

english

File:

PDF, 685 KB

english, 1984

10

Preparation of a new phosphorylating agent: S-(N-monomethoxytrxtylaminoethyl)-O-(o-chlorophenyl)phosphorothioate and its application in oligonucleotide synthesis

Toshiki Tanaka, Yasuki Yamada, Seiichi Uesugi, Morio Ikehara

Journal:

Year:

1989

Language:

english

File:

PDF, 737 KB

english, 1989

11

Solid phase synthesis of oligoribonucleotides using o-nitrobenzyl protection of 2'-hydroxyl via a phosphotriester approach

Toshiki Tanaka, Masaya Orita, Seiichi Uesugi, Morio Ikehara

Journal:

Year:

1988

Language:

english

File:

PDF, 510 KB

english, 1988

12

Stereoselective synthesis of dinucleoside phosphate aryl esters by using new condensing reagents, arenesulfonyl 5-(pyridin-2-yl)-tetrazole

Eiko Ohtsuka, Masahiko Shiraishi, Morio Ikehara

Journal:

Year:

1985

Language:

english

File:

PDF, 474 KB

english, 1985

13

New approach to the synthesis of deoxynucleoside-phosphoramidite derivatives

Toshiki Tanaka, Sigeru Tamatsukuri, Morio Ikehara

Journal:

Tetrahedron Letters

Year:

1986

Language:

english

File:

PDF, 211 KB

english, 1986

14

Chemical synthesis of 5′-phosphorylated oligodeoxyribonucleotide on a polymer support

Toshiki Tanaka, Yasuki Yamada, Morio Ikehara

Journal:

Tetrahedron Letters

Year:

1986

Language:

english

File:

PDF, 218 KB

english, 1986

15

Trityloxyethylamino group for the protection of phosphoryl group in oligonucleotide synthesis

Toshiki Tanaka, Yasuki Yamada, Morio Ikehara

Journal:

Tetrahedron Letters

Year:

1986

Language:

english

File:

PDF, 180 KB

english, 1986

16

Cleavage of 8,2′-anhydro-8-oxy-9-β-D-arabinofuranosyladenine with hydrogen sulfide and its interconversion with 8,5′-cyclonucleoside

Morio Ikehara, Masakatsu Kaneko, Yuko Ogiso

Journal:

Tetrahedron Letters

Year:

1970

Language:

english

File:

PDF, 148 KB

english, 1970

17

Synthesis and properties of an α-cyclonucleoside

Morio Ikehara, Masakatsu Kaneko, Yuji Nakahara

Journal:

Tetrahedron Letters

Year:

1968

Language:

english

File:

PDF, 148 KB

english, 1968

18

Phosphorylating agent for the synthesis of oligonucleotide with aliphatic amino group at 5′ end

Toshiki Tanaka, Shigeru Tamatsukuri, Morio Ikehara

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 264 KB

english, 1987

19

One step rearrangement of 8,5′-o-cycloadenosine to n3,5′-cyclonucleoside

Morio Ikehara, Shoji Tanaka

Journal:

Tetrahedron Letters

Year:

1974

Language:

english

File:

PDF, 157 KB

english, 1974

20

Synthesis of adenine 8,2′-cyclonucleosides using diphenyl carbonate

Morio Ikehara, Satoru Tezuka

Journal:

Tetrahedron Letters

Year:

1972

Language:

english

File:

PDF, 105 KB

english, 1972

21

Formation of phosphodiester linkages by oxidation of a phosphoramidate

Eiko Ohtsuka, Shigeo Morioka, Morio Ikehara

Journal:

Tetrahedron Letters

Year:

1972

Language:

english

File:

PDF, 151 KB

english, 1972

22

Optical rotatory dispersion of purine cyclonucleosides

Morio Ikehara, Masakatsu Kaneko, Kei Muneyama, Hidejiro Tanaka

Journal:

Tetrahedron Letters

Year:

1967

Language:

english

File:

PDF, 191 KB

english, 1967

23

Synthesis of a protein biosynthesis inhibitor, 5′-tri-phosphoryladenylyl-(2′-5′)-adenosine

Morio Ikehara, Kazuyuki Oshie, Eiko Ohtsuka

Journal:

Tetrahedron Letters

Year:

1979

Language:

english

File:

PDF, 176 KB

english, 1979

24

A novel rearrangement of S- to O-cyclonucleosides

Morio Ikehara, Yuko Ogiso, Yasuyuki Matsuda, Toshie Morii

Journal:

Tetrahedron Letters

Year:

1971

Language:

english

File:

PDF, 204 KB

english, 1971

25

Synthesis and properties of 8,2′-N-cycloadenosines

Masakatsu Kaneko, Bunji Shimizu, Morio Ikehara

Journal:

Tetrahedron Letters

Year:

1971

Language:

english

File:

PDF, 166 KB

english, 1971

26

Selective tosylation of adenosine 5′-monophosphate

Morio Ikehara, Seiichi Uesugi

Journal:

Tetrahedron Letters

Year:

1970

Language:

english

File:

PDF, 171 KB

english, 1970

27

Untersuchungen mit magnetischem circulardichroismus, XI. Adenosin - cyclonucleoside.

Danny L. Elder, Edward Bunnenberg, Carl Djerassi, Morio Ikehara, Wolfgang Voelter

Journal:

Tetrahedron Letters

Year:

1970

File:

PDF, 203 KB

1970

28

1H NMR studies of deuterated ribonuclease HI selectively labeled with protonated amino acids

Yasushi Oda, Haruki Nakamura, Toshio Yamazaki, Kuniaki Nagayama, Mayumi Yoshida, Shigenori Kanaya, Morio Ikehara

Journal:

Journal of Biomolecular NMR

Year:

1992

Language:

english

File:

PDF, 650 KB

english, 1992

29

Binding of metal ions toE. coliRNase HI observed by1H−15N heteronuclear 2D NMR

Yasushi Oda, Haruki Nakamura, Shigenori Kanaya, Morio Ikehara

Journal:

Journal of Biomolecular NMR

Year:

1991

Language:

english

File:

PDF, 599 KB

english, 1991

30

A new method for the synthesis of 2′-substituted purine nucleosides total synthesis of an antibiotic 2′-amino-2′-deoxyguanosine

Morio Ikehara, Tokumi Maruyama, Hiroko Miki

Journal:

Tetrahedron Letters

Year:

1976

Language:

english

File:

PDF, 222 KB

english, 1976

31

Solid-phase synthesis of protected oligonucleotide blocks : Applications to block condensation on a polymer support and synthesis of a 3'-modified oligonucleotides

Shigenori Iwai, Makoto Koizumi, Morio Ikehara, Eiko Ohtsuka

Journal:

Year:

1987

Language:

english

File:

PDF, 627 KB

english, 1987

32

A linear relationship between electronegativity of 2′-substituents and conformation of adenine nucleosides

Seiichi Uesugi, Hiroko Miki, Morio Ikehara, Hideo Iwahashi, Yoshimasa Kyogoku

Journal:

Tetrahedron Letters

Year:

1979

Language:

english

File:

PDF, 208 KB

english, 1979

33

A Possible Mechanism of the Transformation of Purine Ribonucleoside to Deoxyribonucleoside

IKEHARA, MORIO, TADA, HIROSHI, NOMURA, AKIHIKO

Journal:

Year:

1964

File:

PDF, 105 KB

1964

34

Synthesis and properties of CpG analogs containing an 8-bromoguanosine residue. Evidence for Z-RNA duplex formation

Uesugi, Seiichi, Shida, Toshio, Ikehara, Morio

Journal:

Year:

1982

Language:

english

File:

PDF, 1.04 MB

english, 1982

35

Studies in organic mass spectrometry. III. Adenosine 8-Cyclonucleosides

Masazumi Ikeda, Yasumitsu Tamura, Morio Ikehara

Journal:

Journal of Heterocyclic Chemistry

Year:

1970

Language:

english

File:

PDF, 191 KB

english, 1970

36

Conformational features of signal sequences and folding of secretory proteins in yeasts

Masakazu Kikuchi, Morio Ikehara

Journal:

Trends in Biotechnology

Year:

1991

Language:

english

File:

PDF, 597 KB

english, 1991

37

Unusal rapid cleavage of terminal phosphate group of N-6-disubstituted adenosine 5′-triphosphate by divalent cation

Morio Ikehara, Hitoshi Uno

Journal:

Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects

Year:

1964

Language:

english

File:

PDF, 184 KB

english, 1964

38

SYNTHESIS OF RIBO-OLIGONUCLEOTIDES HAVING THE SEQUENCE OF TRANSFER RIBONUCLEIC ACID

Journal:

Annals of the New York Academy of Sciences

Year:

1975

Language:

english

File:

PDF, 510 KB

english, 1975

39

Synthesis and Properties of Poly(2-Methyladenylic Acid) : Formation of a Poly(A) · Poly(U) Complex with Hoogsteen-Type Hydrogen Bonding

Morio Ikehara, Masao Hattori, Toshikazu Fukui

Journal:

Year:

1972

Language:

english

File:

PDF, 438 KB

english, 1972

40

Joining of Synthetic Ribotrinucleotides with Defined Sequences Catalyzed by T4 RNA Ligase

Eiko OHTSUKA, Satoshi NISHIKAWA, Ryoichi FUKUMOTO, Shoji TANAKA, Alexander Fred MARKHAM, Morio IKEHARA, Masahiro SUGIURA

Journal:

Year:

1977

Language:

english

File:

PDF, 551 KB

english, 1977

41

Interferon Induction by a 2′-Modified Double-Helical RNA, Poly(2′-azido-2′-deoxyinosinic acid) · polycytidylic acid

Erik DE CLERCQ, Paul F. TORRENCE, B. David STOLLAR, John HOBBS, Toshikazu FUKUI, Nobuko KAKIUCHI, Morio IKEHARA

Journal:

Year:

1978

Language:

english

File:

PDF, 787 KB

english, 1978

42

Carbon-13 Nuclear-Magnetic-Resonance Spectra of Adenine Cyclonucleosides and Their Phosphates : Effects of Neighboring Groups for Elucidation of Fine Structure of Nucleosides and Nucleotides

Seiichi UESUGI, Sumie TANAKA, Morio IKEHARA

Journal:

Year:

1978

Language:

english

File:

PDF, 766 KB

english, 1978

43

Synthesis of 5′ Fragments of Formylmethionine Transfer Ribonucleic Acid and Their Reconstitution with a Natural Three-Quarter Molecule

Eiko OHTSUKA, Satoshi NISHIKAWA, Ryoichi FUKUMOTO, Haruki UEMURA, Toshiki TANAKA, Eiko NAKAGAWA, Tetsuo MIYAKE, Morio IKEHARA

Journal:

Year:

1980

Language:

english

File:

PDF, 524 KB

english, 1980

44

Interferon Induction by Two 2′-Modified Double-Helical RNAs, Poly(2′-nuoro-2′-deoxymosimc acid) · poly(cytidylic acid) and Poly(2′-chloro-2′-deoxyinosinic acid) · poly(cytidylic acid)

Erik DE CLERCQ, B. David STOLLAR, John HOBBS, Toshikazu FUKUI, Nobuku KAKIUCHI, Morio IKEHARA

Journal:

Year:

1980

Language:

english

File:

PDF, 922 KB

english, 1980

45

Recognition by restriction endonuclease EcoRI of deoxyoctanucleotides containing modified sugar moieties

Eiko OHTSUKA, Yoshizumi ISHINO, Kazuhiko IBARAKI, Morio IKEHARA

Journal:

Year:

1984

Language:

english

File:

PDF, 319 KB

english, 1984

46

Synthesis and expression of a human growth hormone (somatotropin) gene mutated to change cysteine-165 to alanine

Tomoko TOKUNAGA, Toshiki TANAKA, Morio IKEHARA, Eiko OHTSUKA

Journal:

Year:

1985

Language:

english

File:

PDF, 890 KB

english, 1985

47

The in vivo stability, maturation and aminoacylation of anticodon-substituted Escherichia coli initiator methionine tRNAs

Henri GROSJEAN, Suzy DE HENAU, Takefumi DOI, Akio YAMANE, Eiko OHTSUKA, Morio IKEHARA, Nicole BEAUCHEMIN, Krikor NICOGHOSIAN, Robert CEDERGREN

Journal:

Year:

1987

Language:

english

File:

PDF, 1.38 MB

english, 1987

48

Increase in nucleolytic activity of ribonuclease T1 by substitution of tryptophan 45 for tyrosine 45

Satoshi NISHIKAWA, Hiroshi MORIOKA, Tsuyoshi KIMURA, Yukari UEDA, Toshiki TANAKA, Seiichi UESUGI, Toshio HAKOSHIMA, Ken-ichi TOMITA, Eiko OHTSUKA, Morio IKEHARA

Journal:

Year:

1988

Language:

english

File:

PDF, 748 KB

english, 1988

49

Effect of mutagenesis at each of five histidine residues on enzymatic activity and stability of ribonuclease H from Escherichia coli

Shigenori KANAYA, Katsuo KATAYANAGI, Kosuke MORIKAWA, Hideo INOUE, Eiko OHTSUKA, Morio IKEHARA

Journal:

Year:

1991

Language:

english

File:

PDF, 426 KB

english, 1991

50

Effect of cavity-modulating mutations on the stability of Escherichia coli ribonuclease HI

Shigenobu KIMURA, Yasushi ODA, Takahisa NAKAI, Katsuo KATAYANAGI, Eiichi KITAKUNI, Chieko NAKAI, Haruki NAKAMURA, Morio IKEHARA, Shigenori KANAYA

Journal:

Year:

1992

Language:

english

File:

PDF, 800 KB

english, 1992