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1

Effects of Celecoxib, a Novel Cyclooxygenase-2 Inhibitor, on Platelet Function in Healthy Adults: A Randomized, Controlled Trial

Leese, Philip T., Hubbard, Richard C., Karim, Aziz, Isakson, Peter C., Yu, Shawn S., Geis, G. Steven

Journal:

Journal of Clinical Pharmacology

Year:

2000

Language:

english

File:

PDF, 1.44 MB

english, 2000

2

A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors

WALKER, Mark C., KURUMBAIL, Ravi G., KIEFER, James R., MORELAND, Kirby T., KOBOLDT, Carol M., ISAKSON, Peter C., SEIBERT, Karen, GIERSE, James K.

Journal:

Biochemical Journal

Year:

2001

Language:

english

File:

PDF, 191 KB

english, 2001

3

Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: Efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects

Lee S. Simon, Frank L. Lanza, Peter E. Lipsky, Richard C. Hubbard, Sheela Talwalker, Benjamin D. Schwartz, Peter C. Isakson, G. Steven Geis

Journal:

Arthritis & Rheumatism

Year:

1998

Language:

english

File:

PDF, 1.22 MB

english, 1998

4

Isotype switching in anti-immunoglobulin-activated B lymphoblasts: differential requirements for interleukin 4 and other lymphokines to elicit membrane vs. secreted IgG1

Jeffrey M. Purkerson, Peter C. Isakson

Journal:

European Journal of Immunology

Year:

1991

Language:

english

File:

PDF, 784 KB

english, 1991

5

Rapid Quantitation of a Large Scope of Eicosanoids in Two Models of Inflammation: Development of an Electrospray and Tandem Mass Spectrometry Method and Application to Biological Studies

Alon Margalit, Kevin L. Duffin, Peter C. Isakson

Journal:

Analytical Biochemistry

Year:

1996

Language:

english

File:

PDF, 159 KB

english, 1996

6

Diaryl indenes and benzofurans: Novel classes of potent and selective cyclooxygenase-2 inhibitors

Horng-Chih Huang, Timothy S. Chamberlain, Karen Selbert, Carol M. Koboldt, Peter C. Isakson, David B. Reitz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 219 KB

english, 1995

7

3,4-diarylpyrazoles: Potent and selective inhibitors of cyclooxygenase-2

Thomas D. Penning, Steven W. Kramer, Len F. Lee, Paul W. Collins, Carol M. Koboldt, Karen Seibert, Amy W. Veenhuizen, Yan Y. Zhang, Peter C. Isakson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 179 KB

english, 1997

8

Comparative evaluation of arachidonic acid (AA)- and tetradecanoylphorbol acetate (TPA)-induced dermal inflammation

Tadimeti S. Rao, Jerry L. Currie, Alexander F. Shaffer, Peter C. Isakson

Journal:

Year:

1993

Language:

english

File:

PDF, 961 KB

english, 1993

9

Role of mast cells in calcium ionophore (A23187)-induced peritoneal inflammation in mice

Tadimeti S. Rao, Alexander F. Shaffer, Jerry L. Currie, Peter C. Isakson

Journal:

Year:

1994

Language:

english

File:

PDF, 331 KB

english, 1994

10

Selective cyclooxygenase inhibitors: Novel 4-spiro 1,2-diarylcyclopentenes are potent and orally active cox-2 inhibitors

David B. Reitz, Horng-Chih Huang, James J. Li, Danny J. Garland, Robert E. Manning, Gary D. Anderson, Susan A. Gregory, Carol M. Koboldt, William E. Perkins, Karen Seibert, Peter C. Isakson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 305 KB

english, 1995

11

BCL1, a Murine Model for Chronic Lymphocytic Leukemia: Use of the Surface Immunoglobulin Idiotype for the Detection and Treatment of Tumor

Keith A. Krolick, Peter C. Isakson, Jonathan W. Uhr, Ellen S. Vitetta

Journal:

Immunological Reviews

Year:

1979

Language:

english

File:

PDF, 6.09 MB

english, 1979

12

The Activation of Murine B Cells: The Role of Surface Immunoglobulins

Ellen Vitetta, ELLEN PURÉ, Peter Isakson, Linda Buck, Jonathan Uhr

Journal:

Immunological Reviews

Year:

1980

Language:

english

File:

PDF, 4.48 MB

english, 1980

13

10.1038/9465

Seibert, Karen, Lefkowith, James, Tripp, Catherine, Isakson, Peter, Needleman, Philip

Journal:

Nature Medicine

Year:

1999

Language:

english

File:

PDF, 45 KB

english, 1999

14

Transformation of intestinal epithelial cells by chronic TGF-β1 treatment results in downregulation of the type II TGF-β receptor and induction of cyclooxygenase-2

Sheng, Hongmiao, Shao, Jinyi, O'Mahony, Christine A, Lamps, Laura, Albo, Daniel, Isakson, Peter C, Berger, David H, DuBois, Raymond N, Beauchamp, R Daniel

Journal:

Year:

1999

Language:

english

File:

PDF, 396 KB

english, 1999

15

Neuronal overexpression of COX-2 results in dominant production of PGE2and altered fever response

Svetlana Vidensky, Yan Zhang, Tracey Hand, Joe Goellner, Alex Shaffer, Peter Isakson, Katrin Andreasson

Journal:

NeuroMolecular Medicine

Year:

2003

Language:

english

File:

PDF, 399 KB

english, 2003

16

Cyclooxygenases and the Central Nervous System

Walter E. Kaufmann, Katrin I. Andreasson, Peter C. Isakson, Paul F. Worley

Journal:

Year:

1997

Language:

english

File:

PDF, 3.62 MB

english, 1997

17

Celecoxib versus diclofenac in long-term management of rheumatoid arthritis: randomised double-blind comparison

Paul Emery, Henning Zeidler, Tore K Kvien, Mario Guslandi, Raphael Naudin, Helen Stead, Kenneth M Verburg, Peter C Isakson, Richard C Hubbard, G Steven Geis

Journal:

Year:

1999

Language:

english

File:

PDF, 112 KB

english, 1999

18

Cyclooxygenase-2 expression during rat neocortical development and in Rett syndrome

Walter E. Kaufmann, Paul F. Worley, Christopher V. Taylor, Margaret Bremer, Peter C. Isakson

Journal:

Brain and Development

Year:

1997

Language:

english

File:

PDF, 4.08 MB

english, 1997

19

1,2-Diarylpyrroles as Potent and Selective Inhibitors of Cyclooxygenase-2

Khanna, Ish K., Weier, Richard M., Yu, Yi, Collins, Paul W., Miyashiro, Julie M., Koboldt, Carol M., Veenhuizen, Amy W., Currie, Jerry L., Seibert, Karen, Isakson, Peter C.

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 569 KB

english, 1997

20

Evaluation of 5-lipoxygenase inhibitors, zileuton, A-78773 and ICI-D-2138 in an ionophore (A-23187)-induced pleural inflammation model in the rat

Tadimeti S. Rao, Jerry L. Currie, Alexander F. Shaffer, Peter C. Isakson

Journal:

Year:

1993

Language:

english

File:

PDF, 365 KB

english, 1993

21

Preparation of stable erythrocyte target cells suitable for detection of the antibody response to the haptens azobenezenearsonate, azophenyltrimethylammonium and azophenylphosphorylcholine by plaque-forming cell assay

Peter C. Isakson, Joy L. Honegger, Stephen C. Kinsky

Journal:

Journal of Immunological Methods

Year:

1979

Language:

english

File:

PDF, 399 KB

english, 1979

22

A novel method for synchronizing a B cell lymphoma

Peter C. Isakson, Jeffrey Purkerson, Katrina Catron, Timothy P. Bender

Journal:

Journal of Immunological Methods

Year:

1991

Language:

english

File:

PDF, 757 KB

english, 1991

23

Selective incorporation of 14C-arachidonic acid into the phospholipids of intact tissues and subsequent metabolism to 14C-prostaglandins

Peter C. Isakson, Amiram Raz, Philip Needleman

Journal:

Year:

1976

Language:

english

File:

PDF, 416 KB

english, 1976

24

Hormone selective lipase activation in the isolated rabbit heart

Wei Hsueh, Peter C. Isakson, Philip Needleman

Journal:

Year:

1977

Language:

english

File:

PDF, 930 KB

english, 1977

25

Hormonal stimulation of arachidonic release from isolated perfused organs relationship to prostaglandin biosynthesis

Peter C. Isakson, Amiram Raz, Susan E. Denny, Angela Wyche, Philip Needleman

Journal:

Year:

1977

Language:

english

File:

PDF, 942 KB

english, 1977

26

Effect of spinal cyclooxygenase inhibitors in rat using the formalin test and in vitro prostaglandin E2 release

David M Dirig, Gabrielle P Konin, Peter C Isakson, Tony L Yaksh

Journal:

European Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 217 KB

english, 1997

27

Relationship between oxygen tension, coronary vasodilation and prostaglandin biosynthesis in the isolated rabbit heart

Philip Needleman, Sharon L. Key, Peter C. Isakson, Prasad S. Kulkarni

Journal:

Year:

1975

Language:

english

File:

PDF, 590 KB

english, 1975

28

Cytokine Regulation of Eicosanoid Generation

PETER ISAKSON, SCOTT HAUSER, YAN ZHANG, KATHLEEN LEAHY, JAIME MASFERRER, KAREN SEIBERT

Journal:

Annals of the New York Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 149 KB

english, 1994

29

Novel Terphenyls as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents

Li, James J., Norton, Monica B., Reinhard, Emily J., Anderson, Gary D., Gregory, Susan A., Isakson, Peter C., Koboldt, Carol M., Masferrer, Jaime L., Perkins, William E., Seibert, Karen, Zhang, Yan, Z

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 414 KB

english, 1996

30

Selective Cyclooxygenase-2 Inhibitors: Heteroaryl Modified 1,2-Diarylimidazoles Are Potent, Orally Active Antiinflammatory Agents

Khanna, Ish K., Yu, Yi, Huff, Renee M., Weier, Richard M., Xu, Xiangdong, Koszyk, Francis J., Collins, Paul W., Cogburn, J. Nita, Isakson, Peter C., Koboldt, Carol M., Masferrer, Jaime L., Perkins, Wi

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 390 KB

english, 2000

31

Chronic Venous Ulcer: Minimally Invasive Treatment of Superficial Axial and Perforator Vein Reflux Speeds Healing and Reduces Recurrence

Alden, Peter B., Lips, Erin M., Zimmerman, Kate P., Garberich, Ross F., Rizvi, Adnan Z., Tretinyak, Alexander S., Alexander, Jason Q., Dorr, Kathryn M., Hutchinson, Mark, Isakson, Sarah L.

Journal:

Annals of Vascular Surgery

Year:

2013

Language:

english

File:

PDF, 241 KB

english, 2013

32

CYCLOOXYGENASE-2 INHIBITORS

Masferrer, Jaime L., Isakson, Peter C., Seibert, Karen

Journal:

Gastroenterology Clinics of North America

Year:

1996

Language:

english

File:

PDF, 634 KB

english, 1996

33

Interleukin 4

Journal:

Advances in Neuroimmunology

Year:

1992

Language:

english

File:

PDF, 865 KB

english, 1992

34

REPORT ON A HEALTH SHOP

Journal:

Year:

1978

Language:

english

File:

PDF, 171 KB

english, 1978

35

Role of cyclooxygenase-2 in inflammation

Seibert, Karen, Masferrer, Jaime, Isakson, Peter

Journal:

Pathophysiology

Year:

1994

Language:

english

File:

PDF, 89 KB

english, 1994

36

Treatment of Osteoarthritis With Celecoxib, a Cyclooxygenase-2 Inhibitor: A Randomized Controlled Trial

Bensen, William G., Fiechtner, Justus J., McMillen, James I., Zhao, William W., Yu, Shawn S., Woods, Emmett M., Hubbard, Richard C., Isakson, Peter C., Verburg, Kenneth M., Geis, G. Steven

Journal:

Mayo Clinic Proceedings

Year:

1999

Language:

english

File:

PDF, 9.20 MB

english, 1999

37

Biochemical and clinical evidence that aspirin-intolerant asthmatic subjects tolerate the cyclooxygenase 2-selective analgetic drug celecoxib

Gyllfors, Pär, Bochenek, Grazyna, Overholt, John, Drupka, Diane, Kumlin, Maria, Sheller, James, Nizankowska, Ewa, Isakson, Peter C., Mejza, Filip, Lefkowith, James B., Dahlén, Sven-Erik, Szczeklik, An

Journal:

Journal of Allergy and Clinical Immunology

Year:

2003

Language:

english

File:

PDF, 108 KB

english, 2003

38

[Part2: Biological Sciences] || Induction of Proliferation and Differentiation of Neoplastic B Cells by Anti-Immunoglobulin and T-Cell Factors

Peter C. Isakson, Ellen Puré, Jonathan W. Uhr and Ellen S. Vitetta

Journal:

Proceedings of the National Academy of Sciences

Year:

1981

Language:

english

File:

PDF, 982 KB

english, 1981

39

COX-2, a Synaptically Induced Enzyme, is Expressed by Excitatory Neurons at Postsynaptic Sites in Rat Cerebral Cortex

Walter E. Kaufmann, Paul F. Worley, Jodi Pegg, Margaret Bremer and Peter Isakson

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.31 MB

english, 1996

40

Cyclooxygenase-2 Inhibition Prevents Delayed Death of CA1 Hippocampal Neurons Following Global Ischemia

Masaki Nakayama, Koichi Uchimura, Raymond Li Zhu, Tetsuya Nagayama, Marie E. Rose, R. Anne Stetler, Peter C. Isakson, Jun Chen and Steven H. Graham

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.46 MB

english, 1998

41

Pharmacological Analysis of Cyclooxygenase-1 in Inflammation

Christopher J. Smith, Yan Zhang, Carol M. Koboldt, Jerry Muhammad, Ben S. Zweifel, Alex Shaffer, John J. Talley, Jaime L. Masferrer, Karen Seibert and Peter C. Isakson

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.53 MB

english, 1998

42

Mechanism and Modification of Bradykinin-Induced Coronary Vasodilation

Philip Needleman, Sharon L. Key, Susan E. Denny, Peter C. Isakson and Garland R. Marshall

Journal:

Proceedings of the National Academy of Sciences

Year:

1975

Language:

english

File:

PDF, 732 KB

english, 1975

43

A Novel Prostaglandin is the Major Product of Arachidonic Acid Metabolism in Rabbit Heart

Peter C. Isakson, Amiram Raz, Sue E. Denny, Ellen Pure and Philip Needleman

Journal:

Proceedings of the National Academy of Sciences

Year:

1977

Language:

english

File:

PDF, 1.05 MB

english, 1977

44

1,2-Diarylcyclopentenes as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents

Li, James J., Anderson, Gary D., Burton, Earl G., Cogburn, J. Nita, Collins, Joe T., Garland, Danny J., Gregory, Susan A., Huang, Horng-Chih, Isakson, Peter C.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.16 MB

english, 1995

45

Interleukin-1 Stimulates Interleukin-6 Release from Rat Anterior Pituitary Cells in Vitro *

SPANGELO, BRYAN L., JUDD, ALLAN M., ISAKSON, PETER C., MACLEOD, ROBERT M.

Journal:

Year:

1991

Language:

english

File:

PDF, 1.00 MB

english, 1991

46

Antibody Bingling Boyding to the Juxtamembr are Ahch of the Insulin Receptor Alters Reotr Affinity

Goodman, David W., Romero, Guillermo, Isakson, Peter

Journal:

Journal of Receptor and Signal Transduction Research

Year:

1994

Language:

english

File:

PDF, 802 KB

english, 1994

47

Anti-inflammatory and Upper Gastrointestinal Effects of Celecoxib in Rheumatoid Arthritis

Simon, Lee S., Weaver, Arthur L., Graham, David Y., Kivitz, Alan J., Lipsky, Peter E., Hubbard, Richard C., Isakson, Peter C., Verburg, Kenneth M., Yu, Shawn S., Zhao, William W., Geis, G. Steven

Journal:

JAMA The Journal of the American Medical Association

Year:

1999

Language:

english

File:

PDF, 130 KB

english, 1999

48

Effects of Celecoxib and Naproxen on Renal Function in the Elderly

Whelton, Andrew, Schulman, Gerald, Wallemark, Carl, Drower, Edward J., Isakson, Peter C., Verburg, Kenneth M., Geis, G. Steven

Journal:

Archives of Internal Medicine

Year:

2000

Language:

english

File:

PDF, 198 KB

english, 2000

49

B and T Cell Tumors || T CELL-DERIVED B CELL DIFFERENTIATION FACTORS: (BCDF) : DEFINITION OF BCDFμ AND BCDFγ11This work was supported by NIH grants AI-12789 and AI-11851.

Isakson, Peter C.

Year:

1982

Language:

english

File:

PDF, 454 KB

english, 1982

50

Endotoxin-Induced Release of Interleukin-6 from Rat Medial Basal Hypothalami*

SPANGELO, BRYAN L., JUDD, ALLAN M., MACLEOD, ROBERT M., GOODMAN, DAVID W., ISAKSON, PETER C.

Journal:

Year:

1990

Language:

english

File:

PDF, 1.00 MB

english, 1990