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51

Glutathione Transferase M2-2 Catalyzes Conjugation of Dopamine and Dopa o-Quinones

Alexies Dagnino-Subiabre, Bruce K. Cassels, Sofia Baez, Ann-Sofie Johansson, Bengt Mannervik, Juan Segura-Aguilar

Journal:

Biochemical and Biophysical Research Communications

Year:

2000

Language:

english

File:

PDF, 67 KB

english, 2000

52

Possible Role of Salsolinol Quinone Methide in the Decrease of RCSN-3 Cell Survival

Pedro Martinez-Alvarado, Alexies Dagnino-Subiabre, Irmgard Paris, Diana Metodiewa, Christopher J. Welch, Claudio Olea-Azar, Pablo Caviedes, Raul Caviedes, Juan Segura-Aguilar

Journal:

Biochemical and Biophysical Research Communications

Year:

2001

Language:

english

File:

PDF, 176 KB

english, 2001

53

Dicoumarol-sensitive glucuronidation of benzo(a)pyrene metabolites in rat liver microsomes

Juan E. Segura-Aguilar, Virginia Barreiro, Christina Lind

Journal:

Archives of Biochemistry and Biophysics

Year:

1986

Language:

english

File:

PDF, 892 KB

english, 1986

54

Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity

Patricia Muñoz, Irmgard Paris, Laurie H. Sanders, J. Timothy Greenamyre, Juan Segura-Aguilar

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2012

Language:

english

File:

PDF, 1.98 MB

english, 2012

55

Effect of the knockdown of amyloid precursor protein on intracellular calcium increases in a neuronal cell line derived from the cerebral cortex of a trisomy 16 mouse

Guillermo Rojas, Ana María Cárdenas, Paola Fernández-Olivares, Takeshi Shimahara, Juan Segura-Aguilar, Raúl Caviedes, Pablo Caviedes

Journal:

Experimental Neurology

Year:

2008

Language:

english

File:

PDF, 570 KB

english, 2008

56

Quantitative structure activity relationships for the conversion of nitrobenzimidazolones and nitrobenzimidazoles by DT-diaphorase: implications for the kinetic mechanism

Zilvinas Anusevicius, Ans E.M.F Soffers, Narimantas Cénas, Jonas Sarlauskas, Juan Segura-Aguilar, Ivonne M.C.M Rietjens

Journal:

Year:

1998

Language:

english

File:

PDF, 111 KB

english, 1998

57

DT-diaphorase catalyzes N-denitration and redox cycling of tetryl

Žilvinas Anusevičius, Jonas Šarlauskas, Henrikas Nivinskas, Juan Segura-Aguilar, Narimantas Č≐nas

Journal:

Year:

1998

Language:

english

File:

PDF, 162 KB

english, 1998

58

The two-electron quinone reductase DT-diaphorase generates and maintains the antioxidant (reduced) form of coenzyme Q in membranes

Robert E. Beyer, Juan Segura-Aguilar, Salvatore di Bernardo, Marika Cavazzoni, Romana Fato, Diana Fiorentini, Maria Christina Galli, Massimo Setti, Laura Landi, Giorgio Lenaz

Journal:

Molecular Aspects of Medicine

Year:

1997

Language:

english

File:

PDF, 615 KB

english, 1997

59

Role of redox cycling and activation by DT-diaphorase in the cytotoxicity of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB-1954) and its analogs

Vanda Miŝkinien≐, Eglë̇ Sergedien≐, Auŝra Nemeikait≐, Juan Segura-Aguilar, Narimantas Ĉ≐nas

Journal:

Year:

1999

Language:

english

File:

PDF, 100 KB

english, 1999

60

Metabolic activation of dopamine o-quinones to o-semiquinones by NADPH cytochrome P450 reductase may play an important role in oxidative stress and apoptotic effects

Juan Segura-Aguilar, Diana Metodiewa, Christopher J Welch

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

1998

Language:

english

File:

PDF, 162 KB

english, 1998

61

Erratum to: Protective Effects of Nicotine Against Aminochrome-Induced Toxicity in Substantia Nigra Derived Cells: Implications for Parkinson’s Disease

Patricia Muñoz, Sandro Huenchuguala, Irmgard Paris, Carlos Cuevas, Monica Villa, Pablo Caviedes, Juan Segura-Aguilar, Yousef Tizabi

Journal:

Neurotoxicity Research

Year:

2012

Language:

english

File:

PDF, 94 KB

english, 2012

62

Studies on the mode of action of the herbicidal effect of 2,4,5-trichlorophenoxyacetic acid on germinating Norway spruce

Juan Segura-Aguilar, Inger Hakman, Jan Rydström

Journal:

Environmental and Experimental Botany

Year:

1995

Language:

english

File:

PDF, 955 KB

english, 1995

63

Regioselectivity and Reversibility of the Glutathione Conjugation of Quercetin Quinone Methide

Boersma, Marelle G., Vervoort, Jacques, Szymusiak, Henryk, Lemanska, Katarzyna, Tyrakowska, Bozena, Cenas, Narimantas, Segura-Aguilar, Juan, Rietjens, Ivonne M. C. M.

Journal:

Chemical Research in Toxicology

Year:

2000

Language:

english

File:

PDF, 189 KB

english, 2000

64

Dopamine-Dependent Iron Toxicity in Cells Derived from Rat Hypothalamus

Paris, Irmgard, Martinez-Alvarado, Pedro, Cárdenas, Sergio, Perez-Pastene, Carolina, Graumann, Rebecca, Fuentes, Patricio, Olea-Azar, Claudio, Caviedes, Pablo, Segura-Aguilar, Juan

Journal:

Chemical Research in Toxicology

Year:

2005

Language:

english

File:

PDF, 215 KB

english, 2005

65

Effect of superoxide dismutase on the autoxidation of various hydroquinones—A possible role of superoxide dismutase as a superoxide: Semiquinone oxidoreductase

Cadenas, Enrique, Mira, Diego, Brunmark, Anders, Lind, Christina, Segura-Aguilar, Juan, Ernster, Lars

Journal:

Free Radical Biology and Medicine

Year:

1988

Language:

english

File:

PDF, 661 KB

english, 1988

66

The protective effect of superoxide dismutase and catalase against formation of reactive oxygen species during reduction of cyclized norepinephrine ortho-quinone of DT-diaphorase

Linderson, Ylva, Baez, Sofia, Segura-Aguilar, Juan

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

1994

Language:

english

File:

PDF, 684 KB

english, 1994

67

DT-diaphorase-catalyzed two electron reduction of quinone epoxides

Brunmark, Anders, Cadenas, Enrique, Lind, Christina, Segura-Aguilar, Juan, Ernster, Lars

Journal:

Free Radical Biology and Medicine

Year:

1987

Language:

english

File:

PDF, 568 KB

english, 1987

68

The Role of DT-Diaphorase in the Maintenance of the Reduced Antioxidant Form of Coenzyme Q in Membrane Systems

Robert E. Beyer, Juan Segura-Aguilar, Salvatore Di Bernardo, Marika Cavazzoni, Romana Fato, Diana Fiorentini, Maria Cristina Galli, Massimo Setti, Laura Landi and Giorgio Lenaz

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 994 KB

english, 1996

69

Activity and immunohistochemistry of DT-diaphorase in hamster and human kidney tumours

Segura-Aguilar, Juan, Cremades, Antonio, Llombart-Bosch, Antonio, Monsalve, Elena, Ernster, Lars, Romero, Francisco J.

Journal:

Year:

1994

Language:

english

File:

PDF, 1022 KB

english, 1994

70

Inhibition of VMAT-2 and DT-Diaphorase Induce Cell Death in a Substantia Nigra-Derived Cell LineAn Experimental Cell Model for Dopamine Toxicity Studies

Fuentes, Patricio, Paris, Irmgard, Nassif, Melissa, Caviedes, Pablo, Segura-Aguilar, Juan

Journal:

Chemical Research in Toxicology

Year:

2007

Language:

english

File:

PDF, 1.15 MB

english, 2007

71

Copper Neurotoxicity in Rat Substantia Nigra and Striatum Is Dependent on DT-Diaphorase Inhibition

Díaz-Véliz, Gabriela, Paris, Irmgard, Mora, Sergio, Raisman-Vozari, Rita, Segura-Aguilar, Juan

Journal:

Chemical Research in Toxicology

Year:

2008

Language:

english

File:

PDF, 7.52 MB

english, 2008

72

Protective and toxic roles of dopamine in Parkinson's disease

Segura-Aguilar, Juan, Paris, Irmgard, Muñoz, Patricia, Ferrari, Emanuele, Zecca, Luigi, Zucca, Fabio A.

Journal:

Journal of Neurochemistry

Year:

2014

Language:

english

File:

PDF, 714 KB

english, 2014

73

Neurotoxin Mechanisms and Processes Relevant to Parkinson’s Disease: An Update

Segura-Aguilar, Juan, Kostrzewa, Richard M.

Journal:

Neurotoxicity Research

Year:

2015

Language:

english

File:

PDF, 602 KB

english, 2015

74

Copper{middle dot}Dopamine Complex Induces Mitochondrial Autophagy Preceding Caspase-independent Apoptotic Cell Death

Paris, I., Perez-Pastene, C., Couve, E., Caviedes, P., LeDoux, S., Segura-Aguilar, J.

Journal:

Journal of Biological Chemistry

Year:

2009

Language:

english

File:

PDF, 1.58 MB

english, 2009

75

DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity

Munoz, P., Cardenas, S., Huenchuguala, S., Briceno, A., Couve, E., Paris, I., Segura-Aguilar, J.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 725 KB

english, 2015

76

Glutathione Transferase-M2-2 Secreted from Glioblastoma Cell Protects SH-SY5Y Cells from Aminochrome Neurotoxicity

Cuevas, Carlos, Huenchuguala, Sandro, Muñoz, Patricia, Villa, Monica, Paris, Irmgard, Mannervik, Bengt, Segura-Aguilar, Juan

Journal:

Neurotoxicity Research

Year:

2015

Language:

english

File:

PDF, 519 KB

english, 2015

77

Human Class Mu Glutathione Transferases, in Particular Isoenzyme M2-2, Catalyze Detoxication of the Dopamine Metabolite Aminochrome

Segura-Aguilar, J., Baez, S., Widersten, M., Welch, C. J., Mannervik, B.

Journal:

Journal of Biological Chemistry

Year:

1997

Language:

english

File:

PDF, 722 KB

english, 1997

78

The Effect of 5OH-1,4-Naphthoquinone on Norway Spruce Seeds during Germination

Segura-Aguilar, J., Hakman, I., Rydstrom, J.

Journal:

PLANT PHYSIOLOGY

Year:

1992

Language:

english

File:

PDF, 1.14 MB

english, 1992

79

The levels of quinone reductases, superoxide dismutase and glutathione-related enzymatic activities in diethylstilbestrol-induced carcinogenesis in the kidney of male Syrian golden hamsters

Segura-Aguilar, Juan, Cortés-Vizcaino, Virginia, Llombart-Bosch, Antonio, Ernster, Lars, Monsalve, Elena, Romero, Francisco J.

Journal:

Year:

1990

Language:

english

File:

PDF, 3.56 MB

english, 1990

80

Autophagy Protects Against Aminochrome-Induced Cell Death in Substantia Nigra-Derived Cell Line

Paris, I., Munoz, P., Huenchuguala, S., Couve, E., Sanders, L. H., Greenamyre, J. T., Caviedes, P., Segura-Aguilar, J.

Journal:

Toxicological Sciences

Year:

2011

Language:

english

File:

PDF, 763 KB

english, 2011

81

Aminochrome Toxicity is Mediated by Inhibition of Microtubules Polymerization Through the Formation of Adducts with Tubulin

Briceño, Andrea, Muñoz, Patricia, Brito, Patricia, Huenchuguala, Sandro, Segura-Aguilar, Juan, Paris, Irmgard B.

Journal:

Neurotoxicity Research

Year:

2016

Language:

english

File:

PDF, 1.11 MB

english, 2016

82

Interactions of iron, dopamine and neuromelanin pathways in brain aging and parkinson's disease

F. A. Zucca, J. Segura-aguilar, E. Ferrari, P. Muñoz, I. Paris, D. Sulzer, T. Sarna, L. Casella, L. Zecca

Year:

2015

Language:

english

File:

PDF, 682 KB

english, 2015

83

The Effect of 5OH-1,4-Naphthoquinone on Norway Spruce Seeds during Germination

Juan Segura-Aguilar, Inger Hakman and Jan Rydström

Journal:

PLANT PHYSIOLOGY

Year:

1992

Language:

english

File:

PDF, 970 KB

english, 1992

84

Frequency of the D620N Mutation in VPS35 in Parkinson Disease

Kumar, Kishore R., Weissbach, Anne, Heldmann, Marcus, Kasten, Meike, Tunc, Sinem, Sue, Carolyn M., Svetel, Marina, Kostić, Vladimir S., Segura-Aguilar, Juan, Ramirez, Alfredo, Simon, David K., Vieregg

Journal:

Archives of Neurology

Year:

2012

Language:

english

File:

PDF, 173 KB

english, 2012

85

The need of a new and more physiological preclinical model for Parkinson’s disease

Segura-Aguilar, Juan, Paris, Irmgard, Muñoz, Patricia

Journal:

Cellular and Molecular Life Sciences

Year:

2016

Language:

english

File:

PDF, 320 KB

english, 2016

86

DT-diaphorase protects astrocytes from aminochrome-induced toxicity

Huenchuguala, Sandro, Muñoz, Patricia, Graumann, Rebecca, Paris, Irmgard, Segura-Aguilar, Juan

Journal:

NeuroToxicology

Year:

2016

Language:

english

File:

PDF, 326 KB

english, 2016

87

Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes

BAEZ, Sofia, SEGURA-AGUILAR, Juan, WIDERSTEN, Mikael, JOHANSSON, Ann-Sofie, MANNERVIK, Bengt

Journal:

Biochemical Journal

Year:

1997

Language:

english

File:

PDF, 225 KB

english, 1997

88

New preclinical model are required to discover neuroprotective compound in Parkinson’s disease

Segura-Aguilar, Juan

Journal:

Pharmacological Research

Year:

2017

Language:

english

File:

PDF, 186 KB

english, 2017

89

Are Dopamine Oxidation Metabolites Involved in the Loss of Dopaminergic Neurons in the Nigrostriatal System in Parkinson’s Disease?

Herrera, Andrea, Muñoz, Patricia, Steinbusch, Harry W. M., Segura-Aguilar, Juan

Journal:

ACS Chemical Neuroscience

Year:

2017

Language:

english

File:

PDF, 1.20 MB

english, 2017

90

On the Role of DT-Diaphorase Inhibition in Aminochrome-Induced Neurotoxicity In Vivo

Herrera-Soto, Andrea, Díaz-Veliz, Gabriela, Mora, Sergio, Muñoz, Patricia, Henny, Pablo, Steinbusch, Harry W. M., Segura-Aguilar, Juan

Journal:

Neurotoxicity Research

Year:

2017

Language:

english

File:

PDF, 820 KB

english, 2017

91

On the Role of Mining Exposure in Epigenetic Effects in Parkinson’s Disease

Castillo, Sebastian, Muñoz, Patricia, Behrens, Maria Isabel, Diaz-Grez, Fernando, Segura-Aguilar, Juan

Journal:

Neurotoxicity Research

Year:

2017

Language:

english

File:

PDF, 288 KB

english, 2017

92

DT-diaphorase Protects Against Autophagy Induced by Aminochrome-Dependent Alpha-Synuclein Oligomers

Muñoz, Patricia S., Segura-Aguilar, Juan

Journal:

Neurotoxicity Research

Year:

2017

Language:

english

File:

PDF, 366 KB

english, 2017

93

The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems.

Beyer, R. E., Segura-Aguilar, J., Di Bernardo, S., Cavazzoni, M., Fato, R., Fiorentini, D., Galli, M. C., Setti, M., Landi, L., Lenaz, G.

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.00 MB

english, 1996

94

THE IMPORTANCE OF MITOPHAGY IN MAINTAINING MITOCHONDRIAL FUNCTION IN U373MG CELLS. BAFILOMYCIN A1 RESTORES AMINOCHROME-INDUCED MITOCHONDRIAL DAMAGE

Huenchuguala, Sandro, Muñoz, Patricia, Segura-Aguilar, Juan

Journal:

ACS Chemical Neuroscience

Year:

2017

Language:

english

File:

PDF, 1.44 MB

english, 2017

95

Knockdown of Myo-Inositol Transporter SMIT1 Normalizes Cholinergic and Glutamatergic Function in an Immortalized Cell Line Established from the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Human Trisomy 21 (Down Syndrome)

Cárdenas, Ana María, Fernández-Olivares, Paola, Díaz-Franulic, Ignacio, González-Jamett, Arlek M., Shimahara, Takeshi, Segura-Aguilar, Juan, Caviedes, Raúl, Caviedes, Pablo

Journal:

Neurotoxicity Research

Year:

2017

Language:

english

File:

PDF, 639 KB

english, 2017

96

Neurotoxins as Preclinical Models for Parkinson’s Disease

Segura-Aguilar, Juan

Journal:

Neurotoxicity Research

Year:

2018

Language:

english

File:

PDF, 524 KB

english, 2018

97

Formation of reactive oxygen species during one-electron reduction of noradrenochrome catalyzed by NADPH-cytochrome P-450 reductase

Baez, S., Segura-Aguilar, J.

Journal:

Year:

1994

Language:

english

File:

PDF, 717 KB

english, 1994

98

Comment on: “Activating Autophagy as a Therapeutic Strategy for Parkinson’s Disease”

Segura-Aguilar, Juan

Journal:

Year:

2018

Language:

english

File:

PDF, 370 KB

english, 2018

99

Can we conclude a potential therapeutic action for Parkinson’s disease by using postmortem tissue and a preclinical model based on an exogenous neurotoxin?

Segura-Aguilar, Juan

Journal:

Cell Death and Disease

Year:

2018

Language:

english

File:

PDF, 662 KB

english, 2018

100

Commentary: Gene Therapy: A Promising Approach for Neuroprotection in Parkinson's Disease?

Segura-Aguilar, Juan

Journal:

Frontiers in Neuroanatomy

Year:

2017

Language:

english

File:

PDF, 498 KB

english, 2017