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51

Synthesis and biological evaluation of optically active Ki16425

Takanao Sato, Kenji Sugimoto, Asuka Inoue, Shinichi Okudaira, Junken Aoki, Hidetoshi Tokuyama

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 555 KB

english, 2012

52

Adiponectin suppresses tumorigenesis in ApcMin/+ mice

Kensuke Otani, Joji Kitayama, Koji Yasuda, Yasunori Nio, Masato Iwabu, Shinichi Okudaira, Junken Aoki, Toshimasa Yamauchi, Takashi Kadowaki, Hirokazu Nagawa

Journal:

Year:

2010

Language:

english

File:

PDF, 313 KB

english, 2010

53

A novel enzyme immunoassay for the determination of phosphatidylserine-specific phospholipase A1 in human serum samples

Kazuhiro Nakamura, Koji Igarashi, Ryunosuke Ohkawa, Naoya Saiki, Mika Nagasaki, Kansei Uno, Naoto Hayashi, Tetsuji Sawada, Kenichi Syukuya, Hiromitsu Yokota, Hiroyuki Arai, Hitoshi Ikeda, Junken Aoki,

Journal:

Clinica Chimica Acta

Year:

2010

Language:

english

File:

PDF, 283 KB

english, 2010

54

Serum autotaxin measurements in pregnant women: Application for the differentiation of normal pregnancy and pregnancy-induced hypertension

Akiko Masuda, Tomoyuki Fujii, Yuki Iwasawa, Kazuhiro Nakamura, Ryunosuke Ohkawa, Koji Igarashi, Shinichi Okudaira, Hitoshi Ikeda, Shiro Kozuma, Junken Aoki, Yutaka Yatomi

Journal:

Clinica Chimica Acta

Year:

2011

Language:

english

File:

PDF, 659 KB

english, 2011

55

Expression of NUDEL in manchette and its implication in spermatogenesis

Noritaka Yamaguchi, Yasukazu Takanezawa, Hiroyuki Koizumi, Makiko Umezu-Goto, Junken Aoki, Hiroyuki Arai

Journal:

Year:

2004

Language:

english

File:

PDF, 389 KB

english, 2004

56

Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma

Masayuki Tanaka, Yasuhiro Kishi, Yasukazu Takanezawa, Yoshiyuki Kakehi, Junken Aoki, Hiroyuki Arai

Journal:

Year:

2004

Language:

english

File:

PDF, 315 KB

english, 2004

57

Lysophosphatidic receptor, LPA3, is positively and negatively regulated by progesterone and estrogen in the mouse uterus

Kotaro Hama, Junken Aoki, Koji Bandoh, Asuka Inoue, Tomoko Endo, Tomokazu Amano, Hiroshi Suzuki, Hiroyuki Arai

Journal:

Year:

2006

Language:

english

File:

PDF, 211 KB

english, 2006

58

Peritoneal fluids from patients with certain gynecologic tumor contain elevated levels of bioactive lysophospholipase D activity

Akira Tokumura, Tetsuya Kume, Kenji Fukuzawa, Masahiro Tahara, Keiichi Tasaka, Junken Aoki, Hiroyuki Arai, Katsuhiko Yasuda, Hideharu Kanzaki

Journal:

Year:

2007

Language:

english

File:

PDF, 549 KB

english, 2007

59

Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity

Naoko Watanabe, Hitoshi Ikeda, Kazuhiro Nakamura, Ryunosuke Ohkawa, Yukio Kume, Tomoaki Tomiya, Kazuaki Tejima, Takako Nishikawa, Masahiro Arai, Mikio Yanase, Junken Aoki, Hiroyuki Arai, Masao Omata,

Journal:

Year:

2007

Language:

english

File:

PDF, 742 KB

english, 2007

60

LPA3, a unique G protein-coupled receptor for lysophosphatidic acid

Kotaro Hama, Junken Aoki

Journal:

Progress in Lipid Research

Year:

2010

Language:

english

File:

PDF, 746 KB

english, 2010

61

Mechanisms of lysophosphatidic acid production

Journal:

Seminars in Cell & Developmental Biology

Year:

2004

Language:

english

File:

PDF, 231 KB

english, 2004

62

A 3D view of autotaxin

Hiroshi Nishimasu, Ryuichiro Ishitani, Junken Aoki, Osamu Nureki

Journal:

Trends in Pharmacological Sciences

Year:

2012

Language:

english

File:

PDF, 2.48 MB

english, 2012

63

Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species: Structure–activity relationship of cloned LPA receptors

Koji Bandoh, Junken Aoki, Akitsu Taira, Masafumi Tsujimoto, Hiroyuki Arai, Keizo Inoue

Journal:

Year:

2000

Language:

english

File:

PDF, 290 KB

english, 2000

64

Direct association of LIS1, the lissencephaly gene product, with a mammalian homologue of a fungal nuclear distribution protein, rNUDE

Mayumi Kitagawa, Makiko Umezu, Junken Aoki, Hiroyuki Koizumi, Hiroyuki Arai, Keizo Inoue

Journal:

Year:

2000

Language:

english

File:

PDF, 436 KB

english, 2000

65

Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors

Kotaro Hama, Koji Bandoh, Yoshiyuki Kakehi, Junken Aoki, Hiroyuki Arai

Journal:

Year:

2002

Language:

english

File:

PDF, 148 KB

english, 2002

66

The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site

Rik Gijsbers, Junken Aoki, Hiroyuki Arai, Mathieu Bollen

Journal:

Year:

2003

Language:

english

File:

PDF, 357 KB

english, 2003

67

Molecular cloning of cDNAs encoding α1, α2, and β subunits of rat brain platelet-activating factor acetylhydrolase

Machiko Watanabe, Junken Aoki, Hiroshi Manya, Hiroyuki Arai, Keizo Inoue

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

1998

Language:

english

File:

PDF, 736 KB

english, 1998

68

PAF analogues capable of inhibiting PAF acetylhydrolase activity suppress migration of isolated rat cerebellar granule cells

Tomoya Adachi, Junken Aoki, Hiroshi Manya, Hiroaki Asou, Hiroyuki Arai, Keizo Inoue

Journal:

Neuroscience Letters

Year:

1997

Language:

english

File:

PDF, 214 KB

english, 1997

69

Localization of α-tocopherol transfer protein in rat brain

Akihiro Hosomi, Kaoru Goto, Hisatake Kondo, Takeshi Iwatsubo, Takanori Yokota, Masako Ogawa, Makoto Arita, Junken Aoki, Hiroyuki Arai, Keizo Inoue

Journal:

Neuroscience Letters

Year:

1998

Language:

english

File:

PDF, 232 KB

english, 1998

70

Structure and function of phosphatidylserine-specific phospholipase A1

Junken Aoki, Yuki Nagai, Hiroyuki Hosono, Keizo Inoue, Hiroyuki Arai

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Year:

2002

Language:

english

File:

PDF, 737 KB

english, 2002

71

cDNA cloning and expression of human lactosylceramide synthase

Minoru Takizawa, Tomoko Nomura, Etsuji Wakisaka, Naonobu Yoshizuka, Junken Aoki, Hiroyuki Arai, Keizo Inoue, Michihiro Hattori, Noboru Matsuo

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Year:

1999

Language:

english

File:

PDF, 547 KB

english, 1999

72

Structure−Activity Relationships of Fluorinated Lysophosphatidic Acid Analogues

Xu, Yong, Aoki, Junken, Shimizu, Kumiko, Umezu-Goto, Makiko, Hama, Kotaro, Takanezawa, Yasukazu, Yu, Shuangxing, Mills, Gordon B., Arai, Hiroyuki, Qian, Lian, Prestwich, Glenn D.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 348 KB

english, 2005

73

Decrease in circulating autotaxin by oral administration of prednisolone

Hayakazu Sumida, Kazuhiro Nakamura, Keisuke Yanagida, Ryunosuke Ohkawa, Yoshihide Asano, Takafumi Kadono, Kunihiko Tamaki, Koji Igarashi, Junken Aoki, Shinichi Sato, Satoshi Ishii, Takao Shimizu, Yuta

Journal:

Clinica Chimica Acta

Year:

2013

Language:

english

File:

PDF, 476 KB

english, 2013

74

Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells

Dai Shida, Joji Kitayama, Hironori Yamaguchi, Kotaro Hama, Junken Aoki, Hiroyuki Arai, Hiroharu Yamashita, Ken Mori, Akihiro Sako, Tsuyoshi Konishi, Toshiaki Watanabe, Teruyuki Sakai, Rika Suzuki, Hid

Journal:

Experimental Cell Research

Year:

2004

Language:

english

File:

PDF, 375 KB

english, 2004

75

Activation of Mitogen-Activated Protein Kinases by Lysophosphatidylcholine-Induced Mitochondrial Reactive Oxygen Species Generation in Endothelial Cells

Nobuo Watanabe, Jaroslaw W. Zmijewski, Wakako Takabe, Makiko Umezu-Goto, Claire Le Goffe, Azusa Sekine, Aimee Landar, Akira Watanabe, Junken Aoki, Hiroyuki Arai, Tatsuhiko Kodama, Michael P. Murphy, R

Journal:

The American Journal of Pathology

Year:

2006

Language:

english

File:

PDF, 1.81 MB

english, 2006

76

Structure and function of Zucchini endoribonuclease in piRNA biogenesis

Nishimasu, Hiroshi, Ishizu, Hirotsugu, Saito, Kuniaki, Fukuhara, Satoshi, Kamatani, Miharu K., Bonnefond, Luc, Matsumoto, Naoki, Nishizawa, Tomohiro, Nakanaga, Keita, Aoki, Junken, Ishitani, Ryuichiro

Journal:

Year:

2012

Language:

english

File:

PDF, 1.23 MB

english, 2012

77

Phosphorothioate analogs of sn-2 radyl lysophosphatidic acid (LPA): Metabolically stabilized LPA receptor agonists

Jiang, Guowei, Inoue, Asuka, Aoki, Junken, Prestwich, Glenn D.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 400 KB

english, 2013

78

Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain

Lin Ma, Hitoshi Uchida, Jun Nagai, Makoto Inoue, Jerold Chun, Junken Aoki…

Journal:

Year:

2009

Language:

english

File:

PDF, 1.04 MB

english, 2009

79

Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain

Makoto Inoue, Lin Ma, Junken Aoki, Jerold Chun, Hiroshi Ueda

Journal:

Year:

2008

Language:

english

File:

PDF, 518 KB

english, 2008

80

Platelet-Activating Factor Acetylhydrolases: Broad Substrate Specificity and Lipoprotein Binding Does Not Modulate the Catalytic Properties of the Plasma Enzyme

Min, Jung-Hyun, Wilder, Cheryl, Aoki, Junken, Arai, Hiroyuki, Inoue, Keizo, Paul, Leland, Gelb, Michael H.

Journal:

Year:

2001

Language:

english

File:

PDF, 235 KB

english, 2001

81

Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe

Kawaguchi, Mitsuyasu, Okabe, Takayoshi, Okudaira, Shinichi, Nishimasu, Hiroshi, Ishitani, Ryuichiro, Kojima, Hirotatsu, Nureki, Osamu, Aoki, Junken, Nagano, Tetsuo

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 3.42 MB

english, 2013

82

Mitochondria-type GPAT is required for mitochondrial fusion

Ohba, Yohsuke, Sakuragi, Takeshi, Kage-Nakadai, Eriko, Tomioka, Naoko H, Kono, Nozomu, Imae, Rieko, Inoue, Asuka, Aoki, Junken, Ishihara, Naotada, Inoue, Takao, Mitani, Shohei, Arai, Hiroyuki

Journal:

The EMBO Journal

Year:

2013

Language:

english

File:

PDF, 2.03 MB

english, 2013

83

Potentials of the Circulating Pruritogenic Mediator Lysophosphatidic Acid in Development of Allergic Skin Inflammation in Mice

Shimizu, Yoshibumi, Morikawa, Yoshiyuki, Okudaira, Shinichi, Kimoto, Shigenobu, Tanaka, Tamotsu, Aoki, Junken, Tokumura, Akira

Journal:

The American Journal of Pathology

Year:

2014

Language:

english

File:

PDF, 1.42 MB

english, 2014

84

Tissue tropism and species specificity of poliovirus infection

Nomoto, Akio, Koike, Satoshi, Aoki, Junken

Journal:

Trends in Microbiology

Year:

1994

Language:

english

File:

PDF, 1.04 MB

english, 1994

85

Synthesis of Migration-Resistant Hydroxyethoxy Analogues of Lysophosphatidic Acid

Qian, Lian, Xu, Yong, Arai, Hiroyuki, Aoki, Junken, McIntyre, Thomas M., Prestwich, Glenn D.

Journal:

Organic Letters

Year:

2003

Language:

english

File:

PDF, 88 KB

english, 2003

86

Nectin/PRR: An Immunoglobulin-Like Cell Adhesion Molecule Recruited to Cadherin-Based Adherens Junctions through Interaction with Afadin, a PDZ Domain-Containing Protein

Kenichi Takahashi, Hiroyuki Nakanishi, Masako Miyahara, Kenji Mandai, Keiko Satoh, Ayako Satoh, Hideo Nishioka, Junken Aoki, Akio Nomoto, Akira Mizoguchi and Yoshimi Takai

Journal:

The Journal of Cell Biology

Year:

1999

Language:

english

File:

PDF, 3.79 MB

english, 1999

87

Neural Cell Adhesion Molecule Mediates Contact-Dependent Inhibition of Growth of Near-Diploid Mouse Fibroblast Cell Line m5S/1M

Junken Aoki, Masato Umeda, Koji Takio, Koiti Titani, Hiroshi Utsumi, Masao Sasaki and Keizo Inoue

Journal:

The Journal of Cell Biology

Year:

1991

Language:

english

File:

PDF, 2.54 MB

english, 1991

88

A novel mutation, c.699C>G (p.C233W), in the LIPH gene leads to a loss of the hydrolytic activity and the LPA6 activation ability of PA-PLA1α in autosomal recessive wooly hair/hypotrichosis

Yoshizawa, Mayuko, Nakamura, Motonobu, Farooq, Muhammad, Inoue, Asuka, Aoki, Junken, Shimomura, Yutaka

Journal:

Journal of Dermatological Science

Year:

2013

Language:

english

File:

PDF, 1.46 MB

english, 2013

89

Fluorescence Probe for Lysophospholipase C/NPP6 Activity and a Potent NPP6 Inhibitor

Kawaguchi, Mitsuyasu, Okabe, Takayoshi, Okudaira, Shinichi, Hanaoka, Kenjiro, Fujikawa, Yuuta, Terai, Takuya, Komatsu, Toru, Kojima, Hirotatsu, Aoki, Junken, Nagano, Tetsuo

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 1.64 MB

english, 2011

90

Enantioselective Responses to a Phosphorothioate Analogue of Lysophosphatidic Acid with LPA 3 Receptor-Selective Agonist Activity

Qian, Lian, Xu, Yong, Hasegawa, Yutaka, Aoki, Junken, Mills, Gordon B., Prestwich, Glenn D.

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 78 KB

english, 2003

91

A Missense Mutation within the Helix Initiation Motif of the Keratin K71 Gene Underlies Autosomal Dominant Woolly Hair/Hypotrichosis

Fujimoto, Atsushi, Farooq, Muhammad, Fujikawa, Hiroki, Inoue, Asuka, Ohyama, Manabu, Ehama, Ritsuko, Nakanishi, Jotaro, Hagihara, Motofumi, Iwabuchi, Tokuro, Aoki, Junken, Ito, Masaaki, Shimomura, Yut

Journal:

The Journal of Investigative Dermatology

Year:

2012

Language:

english

File:

PDF, 2.50 MB

english, 2012

92

Synthesis and Evaluation of Lysophosphatidylserine Analogues as Inducers of Mast Cell Degranulation. Potent Activities of Lysophosphatidylthreonine and Its 2-Deoxy Derivative

Iwashita, Masazumi, Makide, Kumiko, Nonomura, Taro, Misumi, Yoshimasa, Otani, Yuko, Ishida, Mayuko, Taguchi, Ryo, Tsujimoto, Masafumi, Aoki, Junken, Arai, Hiroyuki, Ohwada, Tomohiko

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 2.83 MB

english, 2009

93

Detection of Physiological Activities of G Protein-Coupled Receptor-Acting Pharmaceuticals in Wastewater

Ihara, Masaru, Inoue, Asuka, Hanamoto, Seiya, Zhang, Han, Aoki, Junken, Tanaka, Hiroaki

Journal:

Environmental Science & Technology

Year:

2015

Language:

english

File:

PDF, 1.54 MB

english, 2015

94

Analysis of unique mutations in the LPAR6 gene identified in a Japanese family with autosomal recessive woolly hair/hypotrichosis: Establishment of a useful assay system for LPA6

Hayashi, Ryota, Inoue, Asuka, Suga, Yasushi, Aoki, Junken, Shimomura, Yutaka

Journal:

Journal of Dermatological Science

Year:

2015

Language:

english

File:

PDF, 2.19 MB

english, 2015

95

LIS1 Missense Mutations

Caspi, Michal, Coquelle, Frédéric M., Koifman, Cynthia, Levy, Talia, Arai, Hiroyuki, Aoki, Junken, De Mey, Jan R., Reiner, Orly

Journal:

Journal of Biological Chemistry

Year:

2003

Language:

english

File:

PDF, 1.26 MB

english, 2003

96

Analysis of serum and urinary lysophospholipase D/autotaxin in nephrotic syndrome

Nakamura, Kazuhiro, Nangaku, Masaomi, Ohkawa, Ryunosuke, Okubo, Shigeo, Yokota, Hiromitsu, Ikeda, Hitoshi, Aoki, Junken, Yatomi, Yutaka

Journal:

Clinical Chemistry and Laboratory Medicine

Year:

2008

Language:

english

File:

PDF, 108 KB

english, 2008

97

Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp6

Morita, Junko, Kato, Kazuki, Mihara, Emiko, Ishitani, Ryuichiro, Takagi, Junichi, Nishimasu, Hiroshi, Aoki, Junken, Nureki, Osamu

Journal:

Acta Crystallographica Section F Structural Biology Communications

Year:

2014

Language:

english

File:

PDF, 1.14 MB

english, 2014

98

Serum lysophospholipase D/autotaxin may be a new nutritional assessment marker: study on prostate cancer patients

Nakamura, Kazuhiro, Takeuchi, Takumi, Ohkawa, Ryunosuke, Okubo, Shigeo, Yokota, Hiromitsu, Tozuka, Minoru, Aoki, Junken, Arai, Hiroyuki, Ikeda, Hitoshi, Ohshima, Noriko, Kitamura, Tadaichi, Yatomi, Yu

Journal:

Annals of Clinical Biochemistry

Year:

2007

Language:

english

File:

PDF, 254 KB

english, 2007

99

LPA-producing enzyme PA-PLA 1 α regulates hair follicle development by modulating EGFR signalling

Inoue, Asuka, Arima, Naoaki, Ishiguro, Jun, Prestwich, Glenn D, Arai, Hiroyuki, Aoki, Junken

Journal:

The EMBO Journal

Year:

2011

Language:

english

File:

PDF, 1.19 MB

english, 2011

100

Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation

Van, Bo, Nishi, Miyuki, Komazaki, Shinji, Ichimura, Atsuhiko, Kakizawa, Sho, Nakanaga, Keita, Aoki, Junken, Park, Ki-Ho, Ma, Jianjie, Ueyama, Tomomi, Ogata, Takehiro, Maruyama, Naoki, Takeshima, Hiros

Journal:

Year:

2015

Language:

english

File:

PDF, 2.87 MB

english, 2015