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1

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

Lovén, Jakob, Hoke, Heather A., Lin, Charles Y., Lau, Ashley, Orlando, David A., Vakoc, Christopher R., Bradner, James E., Lee, Tong Ihn, Young, Richard A.

Journal:

Year:

2013

Language:

english

File:

PDF, 2.06 MB

english, 2013

2

Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation

Gaub, Aline, Sheikh, Bilal N., Basilicata, M. Felicia, Vincent, Marie, Nizon, Mathilde, Colson, Cindy, Bird, Matthew J., Bradner, James E., Thevenon, Julien, Boutros, Michael, Akhtar, Asifa

Journal:

Nature Communications

Year:

2020

File:

PDF, 4.41 MB

2020

3

Small-Molecule Inhibition of BRDT for Male Contraception

Matzuk, Martin M., McKeown, Michael R., Filippakopoulos, Panagis, Li, Qinglei, Ma, Lang, Agno, Julio E., Lemieux, Madeleine E., Picaud, Sarah, Yu, Richard N., Qi, Jun, Knapp, Stefan, Bradner, James E.

Journal:

Year:

2012

Language:

english

File:

PDF, 2.61 MB

english, 2012

4

Genome-wide localization of small molecules

Anders, Lars, Guenther, Matthew G, Qi, Jun, Fan, Zi Peng, Marineau, Jason J, Rahl, Peter B, Lovén, Jakob, Sigova, Alla A, Smith, William B, Lee, Tong Ihn, Bradner, James E, Young, Richard A

Journal:

Nature Biotechnology

Year:

2013

Language:

english

File:

PDF, 1.03 MB

english, 2013

5

Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions

Ji, Xiong, Dadon, Daniel B., Abraham, Brian J., Lee, Tong Ihn, Jaenisch, Rudolf, Bradner, James E., Young, Richard A.

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 1.90 MB

english, 2015

6

RNA Exosome-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer Activity

Pefanis, Evangelos, Wang, Jiguang, Rothschild, Gerson, Lim, Junghyun, Kazadi, David, Sun, Jianbo, Federation, Alexander, Chao, Jaime, Elliott, Oliver, Liu, Zhi-Ping, Economides, Aris N., Bradner, Jame

Journal:

Year:

2015

Language:

english

File:

PDF, 3.10 MB

english, 2015

7

Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance

Marcotte, Richard, Sayad, Azin, Brown, Kevin R., Sanchez-Garcia, Felix, Reimand, Jüri, Haider, Maliha, Virtanen, Carl, Bradner, James E., Bader, Gary D., Mills, Gordon B., Pe’er, Dana, Moffat, Jason,

Journal:

Year:

2016

Language:

english

File:

PDF, 6.14 MB

english, 2016

8

Ligand-Promoted Meta-C–H Arylation of Anilines, Phenols, and Heterocycles

Wang, Peng, Farmer, Marcus E., Huo, Xing, Jain, Pankaj, Shen, Peng-Xiang, Ishoey, Mette, Bradner, James E., Wisniewski, Steven R., Eastgate, Martin D., Yu, Jin-Quan

Journal:

Journal of the American Chemical Society

Year:

2016

Language:

english

File:

PDF, 1.90 MB

english, 2016

9

Relative Binding Free Energy Calculations Applied to Protein Homology Models

Cappel, Daniel, Hall, Michelle Lynn, Lenselink, Eelke B., Beuming, Thijs, Qi, Jun, Bradner, James E., Sherman, Woody

Journal:

Journal of Chemical Information and Modeling

Year:

2016

Language:

english

File:

PDF, 1.20 MB

english, 2016

10

Transcriptional Addiction in Cancer

Bradner, James E., Hnisz, Denes, Young, Richard A.

Journal:

Year:

2017

Language:

english

File:

PDF, 2.80 MB

english, 2017

11

Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression

Min Shi, Joshua Bradner, Aneeka M. Hancock, Kathryn A. Chung, Joseph F. Quinn, Elaine R. Peskind, Douglas Galasko, Joseph Jankovic, Cyrus P. Zabetian, Hojoong M. Kim, James B. Leverenz, Thomas J. Mont

Journal:

Annals of Neurology

Year:

2011

Language:

english

File:

PDF, 254 KB

english, 2011

12

Fluorous-Based Small-Molecule Microarrays for the Discovery of Histone Deacetylase Inhibitors

Arturo J. Vegas, James E. Bradner, Weiping Tang, Olivia M. McPherson, Edward F. Greenberg, Angela N. Koehler, Stuart L. Schreiber

Journal:

Angewandte Chemie

Year:

2007

Language:

english

File:

PDF, 784 KB

english, 2007

13

Fluorous-Based Small-Molecule Microarrays for the Discovery of Histone Deacetylase Inhibitors

Arturo J. Vegas, James E. Bradner, Weiping Tang, Olivia M. McPherson, Edward F. Greenberg, Angela N. Koehler, Stuart L. Schreiber

Journal:

Angewandte Chemie International Edition

Year:

2007

Language:

english

File:

PDF, 784 KB

english, 2007

14

ChemInform Abstract: Discovery of Histone Deacetylase 8 Selective Inhibitors.

Weiping Tang, Tuoping Luo, Edward F. Greenberg, James E. Bradner, Stuart L. Schreiber

Journal:

Year:

2012

File:

PDF, 30 KB

2012

15

On the inhibition of histone deacetylase 8

Guillermina Estiu, Nathan West, Ralph Mazitschek, Edward Greenberg, James E. Bradner, Olaf Wiest

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.27 MB

english, 2010

16

Discovery of histone deacetylase 8 selective inhibitors

Weiping Tang, Tuoping Luo, Edward F. Greenberg, James E. Bradner, Stuart L. Schreiber

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 503 KB

english, 2011

17

A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold

Melissa M. Kemp, Qiu Wang, Jason H. Fuller, Nathan West, Nicole M. Martinez, Elizabeth M. Morse, Michel Weïwer, Stuart L. Schreiber, James E. Bradner, Angela N. Koehler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.70 MB

english, 2011

18

A Robust Small-Molecule Microarray Platform for Screening Cell Lysates

James E. Bradner, Olivia M. McPherson, Ralph Mazitschek, David Barnes-Seeman, John P. Shen, Jasmeet Dhaliwal, Kristen E. Stevenson, Jay L. Duffner, Seung Bum Park, Donna S. Neuberg, Paul Nghiem, Stuar

Journal:

Chemistry & Biology

Year:

2006

Language:

english

File:

PDF, 741 KB

english, 2006

19

Tallysomycin S10b: Experimental antitumor activity and toxicity

John E. Schurig, William C. Rose, Robert S. Hirth, Abraham Schlein, James B. Huftalen, Alexander P. Florczyk, William T. Bradner

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1984

Language:

english

File:

PDF, 730 KB

english, 1984

20

DNA-bend modulation in a repressor-to-activator switching mechanism

Ansari, Aseem Z., Bradner, James E., O'Halloran, Thomas V.

Journal:

Year:

1995

File:

PDF, 640 KB

1995

21

Direct inhibition of the NOTCH transcription factor complex

Moellering, Raymond E., Cornejo, Melanie, Davis, Tina N., Bianco, Cristina Del, Aster, Jon C., Blacklow, Stephen C., Kung, Andrew L., Gilliland, D. Gary, Verdine, Gregory L., Bradner, James E.

Journal:

Year:

2009

Language:

english

File:

PDF, 1.27 MB

english, 2009

22

Direct inhibition of the NOTCH transcription factor complex

Moellering, Raymond E., Cornejo, Melanie, Davis, Tina N., Bianco, Cristina Del, Aster, Jon C., Blacklow, Stephen C., Kung, Andrew L., Gilliland, D. Gary, Verdine, Gregory L., Bradner, James E.

Journal:

Year:

2010

File:

PDF, 31 KB

2010

23

Chemical phylogenetics of histone deacetylases

Bradner, James E, West, Nathan, Grachan, Melissa L, Greenberg, Edward F, Haggarty, Stephen J, Warnow, Tandy, Mazitschek, Ralph

Journal:

Nature Chemical Biology

Year:

2010

Language:

english

File:

PDF, 536 KB

english, 2010

24

A pulse at the heart of targeted therapy

Bradner, James E

Journal:

Nature Chemical Biology

Year:

2009

Language:

english

File:

PDF, 1.49 MB

english, 2009

25

Donor-recipient mismatch for common gene deletion polymorphisms in graft-versus-host disease

McCarroll, Steven A, Bradner, James E, Turpeinen, Hannu, Volin, Liisa, Martin, Paul J, Chilewski, Shannon D, Antin, Joseph H, Lee, Stephanie J, Ruutu, Tapani, Storer, Barry

Journal:

Nature Genetics

Year:

2009

Language:

english

File:

PDF, 279 KB

english, 2009

26

Effect of Thrombocytopenia on Outcomes Following Treatment With Either Enoxaparin or Unfractionated Heparin in Patients Presenting With Acute Coronary Syndromes

Robert W. Yeh, Stephen D. Wiviott, Robert P. Giugliano, David A. Morrow, Amy Shui, Jie Qin, Benjamin Scirica, James E. Bradner, Ik-Kyung Jang, C. Michael Gibson, Elliott M. Antman

Journal:

The American Journal of Cardiology

Year:

2007

Language:

english

File:

PDF, 136 KB

english, 2007

27

Identification and Characterization of Small Molecule Inhibitors of a Class I Histone Deacetylase from Plasmodium falciparum

Tang, Weiping, Bradner, James E., Patel, Vishal, Mazitschek, Ralph, Coleman, Bradley, Nguyen, Cokey, Urgaonkar, Sameer, Cortese, Joseph, Barker, Robert H., Greenberg, Edward

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 60 KB

english, 2009

28

Complement 3 and Factor H in Human Cerebrospinal Fluid in Parkinson's Disease, Alzheimer's Disease, and Multiple-System Atrophy

Yu Wang, Aneeka M. Hancock, Joshua Bradner, Kathryn A. Chung, Joseph F. Quinn, Elaine R. Peskind, Douglas Galasko, Joseph Jankovic, Cyrus P. Zabetian, Hojoong M. Kim, James B. Leverenz, Thomas J. Mont

Journal:

The American Journal of Pathology

Year:

2011

Language:

english

File:

PDF, 1.01 MB

english, 2011

29

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

Lin, Charles Y., Lovén, Jakob, Rahl, Peter B., Paranal, Ronald M., Burge, Christopher B., Bradner, James E., Lee, Tong Ihn, Young, Richard A.

Journal:

Year:

2012

Language:

english

File:

PDF, 3.02 MB

english, 2012

30

Chromatin modifications as therapeutic targets in MLL-rearranged leukemia

Aniruddha J. Deshpande, James Bradner, Scott A. Armstrong

Journal:

Trends in Immunology

Year:

2012

Language:

english

File:

PDF, 752 KB

english, 2012

31

208 Epigenetic Regulation of FOXP3+ Regulatory T Cells (Treg) By Small Molecule Targeting of a Single HDAC, Hdac6, Enhances Treg Function and Ameliorates Development of IBD in Murine Models

Edwin F. deZoeten, James E. Bradner, Ralph Mazitschek, Wayne W. Hancock

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 68 KB

english, 2008

32

Comparative seismic noise on the ocean bottom and on land

Bradner, Hugh, Dodds, James G.

Journal:

Journal of Geophysical Research

Year:

1964

Language:

english

File:

PDF, 744 KB

english, 1964

33

Modulation of Signaling Cascades by Inhibitors of Histone Deacetylase and Akt

Hideshima, Teru, Ikeda, Hiroshi, Mitsiades, Constantine C., Chauhan, Darminder, Bradner, James E., Munshi, Nikhil C., Richardson, Paul G., Anderson, Kenneth C.

Journal:

Clinical Lymphoma & Myeloma

Year:

2009

Language:

english

File:

PDF, 95 KB

english, 2009

34

Synthesis and Biological Evaluation of JAHAs: Ferrocene-Based Histone Deacetylase Inhibitors

Spencer, John, Amin, Jahangir, Wang, Minghua, Packham, Graham, Alwi, Sharifah S. Syed, Tizzard, Graham J., Coles, Simon J., Paranal, Ronald M., Bradner, James E., Heightman, Tom D.

Journal:

ACS Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 808 KB

english, 2011

35

BET acetyl-lysine binding proteins control pathological cardiac hypertrophy

Spiltoir, Jessica I., Stratton, Matthew S., Cavasin, Maria A., Demos-Davies, Kim, Reid, Brian G., Qi, Jun, Bradner, James E., McKinsey, Timothy A.

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2013

Language:

english

File:

PDF, 1.33 MB

english, 2013

36

A cyclodextrin-capped histone deacetylase inhibitor

Amin, Jahangir, Puglisi, Antonino, Clarke, James, Milton, John, Wang, Minghua, Paranal, Ronald M., Bradner, James E., Spencer, John

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 476 KB

english, 2013

37

Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs

Guerra-Bubb, Jennifer M., Bowers, Albert A., Smith, William B., Paranal, Ronald, Estiu, Guillermina, Wiest, Olaf, Bradner, James E., Williams, Robert M.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 849 KB

english, 2013

38

The use of small molecules in somatic-cell reprogramming

Federation, Alexander J., Bradner, James E., Meissner, Alexander

Journal:

Trends in Cell Biology

Year:

2014

Language:

english

File:

PDF, 1.53 MB

english, 2014

39

MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia

Chen, Chong, Liu, Yu, Rappaport, Amy R., Kitzing, Thomas, Schultz, Nikolaus, Zhao, Zhen, Shroff, Aditya S., Dickins, Ross A., Vakoc, Christopher R., Bradner, James E., Stock, Wendy, LeBeau, Michelle M

Journal:

Year:

2014

Language:

english

File:

PDF, 3.79 MB

english, 2014

40

Selective inhibition of BET bromodomain epigenetic signalling interferes with the bone-associated tumour vicious cycle

Lamoureux, François, Baud’huin, Marc, Rodriguez Calleja, Lidia, Jacques, Camille, Berreur, Martine, Rédini, Françoise, Lecanda, Fernando, Bradner, James E., Heymann, Dominique, Ory, Benjamin

Journal:

Nature Communications

Year:

2014

Language:

english

File:

PDF, 1.63 MB

english, 2014

41

A general framework for interoperability with applications to healthcare

Gaynor, Mark, Yu, Feliciano, Andrus, Charles H., Bradner, Scott, Rawn, James

Journal:

Health Policy and Technology

Year:

2014

Language:

english

File:

PDF, 789 KB

english, 2014

42

Molecular Dynamics of DOT1L and Modeling of EZH2

Pineda, Javier, Marineau, Jason, Estiu, Guille, Bradner, James

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 69 KB

english, 2013

43

An epigenomic approach to therapy for tamoxifen-resistant breast cancer

Feng, Qin, Zhang, Zheng, Shea, Martin J, Creighton, Chad J, Coarfa, Cristian, Hilsenbeck, Susan G, Lanz, Rainer, He, Bin, Wang, Lei, Fu, Xiaoyong, Nardone, Agostina, Song, Yongcheng, Bradner, James, M

Journal:

Year:

2014

Language:

english

File:

PDF, 1.04 MB

english, 2014

44

Synthesis and Histone Deacetylase Inhibitory Activity of Largazole Analogs: Alteration of the Zinc-Binding Domain and Macrocyclic Scaffold

Bowers, Albert A., West, Nathan, Newkirk, Tenaya L., Troutman-Youngman, Annie E., Schreiber, Stuart L., Wiest, Olaf, Bradner, James E., Williams, Robert M.

Journal:

Organic Letters

Year:

2009

Language:

english

File:

PDF, 1.24 MB

english, 2009

45

Regulation of HOX gene expression by AF10-mediated conversion of H3K79me1 to H3K79me2

Deshpande, Aniruddha, Deshpande, Anagha, Sinha, Amit, Chen, Liying, Chang, Jenny, Chen, David, Koche, Richard, Krivtsov, Andrei, Luo, Minkui, Bradner, James, Bernt, Kathrin, Armstrong, Scott

Journal:

Experimental Hematology

Year:

2014

Language:

english

File:

PDF, 59 KB

english, 2014

46

7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones: Readily accessible and highly potent anticancer compounds

D’Erasmo, Michael P., Smith, William B., Munoz, Alberto, Mohandas, Poornima, Au, Andrew S., Marineau, Jason J., Quadri, Luis E.N., Bradner, James E., Murelli, Ryan P.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 580 KB

english, 2014

47

Total Synthesis and Biological Mode of Action of Largazole: A Potent Class I Histone Deacetylase Inhibitor

Bowers, Albert, West, Nathan, Taunton, Jack, Schreiber, Stuart L., Bradner, James E., Williams, Robert M.

Journal:

Journal of the American Chemical Society

Year:

2008

Language:

english

File:

PDF, 451 KB

english, 2008

48

Antitumor and DNA-binding properties of a group of oligomeric complexes of platinum(II) and platinum(IV)

Peritz, Adam, Al-Baker, Salaam, Vollano, Jean F., Dabrowiak, James C., Schurig, John E., Bradner, William T.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 2.47 MB

english, 1990

49

Synthesis and Conformation−Activity Relationships of the Peptide Isosteres of FK228 and Largazole

Bowers, Albert A., Greshock, Thomas J., West, Nathan, Estiu, Guillermina, Schreiber, Stuart L., Wiest, Olaf, Williams, Robert M., Bradner, James E.

Journal:

Journal of the American Chemical Society

Year:

2009

Language:

english

File:

PDF, 606 KB

english, 2009

50

Structural Origin of Selectivity in Class II-Selective Histone Deacetylase Inhibitors

Estiu, Guillermina, Greenberg, Edward, Harrison, Christopher B., Kwiatkowski, Nicholas P., Mazitschek, Ralph, Bradner, James E., Wiest, Olaf

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.82 MB

english, 2008