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1

Foundation review: Principles and applications of LC-MS in new drug discovery

Walter A. Korfmacher

Journal:

Drug Discovery Today

Year:

2005

Language:

english

File:

PDF, 800 KB

english, 2005

2

High-performance liquid chromatography-thermospray mass spectrometry of gibberellins

Eugene B. Hansen Jr., Joaquin Abian, Timothy A. Getek, John S. Choinski Jr., Walter A. Korfmacher

Journal:

Journal of Chromatography A

Year:

1992

Language:

english

File:

PDF, 622 KB

english, 1992

3

The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety

Ginny D. Ho, John Anthes, Ana Bercovici, John P. Caldwell, Kuo-Chi Cheng, Xiaoming Cui, Ahmad Fawzi, Xiomara Fernandez, William J. Greenlee, John Hey, Walter Korfmacher, Sherry X. Lu, Robbie L. McLeod

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.36 MB

english, 2009

4

Investigation of matrix effects in bioanalytical high-performance liquid chromatography/tandem mass spectrometric assays: application to drug discovery

Hong Mei, Yunsheng Hsieh, Cymbylene Nardo, Xiaoying Xu, Shiyong Wang, Kwokei Ng, Walter A. Korfmacher

Journal:

Rapid Communications in Mass Spectrometry

Year:

2003

Language:

english

File:

PDF, 254 KB

english, 2003

5

Effects of SCH 59228, an orally bioavailable farnesyl protein transferase inhibitor, on the growth of oncogene-transformed fibroblasts and a human colon carcinoma xenograft in nude mice

Ming Liu, Matthew S. Bryant, Jianping Chen, Suining Lee, Bohdan Yaremko, Zujun Li, Janet Dell, Phil Lipari, Michael Malkowski, Nicholas Prioli, Randall R. Rossman, Walter A. Korfmacher, Amin A. Nomeir

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1999

Language:

english

File:

PDF, 323 KB

english, 1999

6

Peer Reviewed: Systematic LC/MS Metabolite Identification in Drug Discovery

Clarke, Nigel J., Rindgen, Diane, Korfmacher, Walter A., Cox, Kathleen A.

Journal:

Analytical Chemistry

Year:

2001

Language:

english

File:

PDF, 9.93 MB

english, 2001

7

Mass Spectrometry for Drug Discovery and Drug Development (Korfmacher/Mass Spectrometry for Drug Discovery and Drug Development) || Index

Korfmacher, Walter A.

Year:

2013

Language:

english

File:

PDF, 870 KB

english, 2013

8

HPLC and FAB mass spectrometry analysis of fumonisins B1 and B2 produced by Fusarium moniliforme on food substrates

Holcomb, Manuel., Sutherland, John B., Chiarelli, M. Paul., Korfmacher, Walter A., Thompson, Harold C., Lay, Jack O., Hankins, Lacinda J., Cerniglia, Carl E.

Journal:

Journal of Agricultural and Food Chemistry

Year:

1993

Language:

english

File:

PDF, 444 KB

english, 1993

9

Microsample Determination of Lovastatin and its Hydroxy Acid Metabolite in Mouse and Rat Plasma by Liquid Chromatography/Ionspray Tandem Mass Spectrometry

Wu, Yunhui, Zhao, Jamie, Henion, Jack, Korfmacher, Walter A., Lapiguera, Amelia P., Lin, Chin-Chung

Journal:

Journal of Mass Spectrometry

Year:

1997

Language:

english

File:

PDF, 459 KB

english, 1997

10

Development of an automated mass spectrometry system for the quantitative analysis of liver microsomal incubation samples: a tool for rapid screening of new compounds for metabolic stability

Walter A. Korfmacher, Cynthia A. Palmer, Cymbelene Nardo, Kimberly Dunn-Meynell, Diane Grotz, Kathleen Cox, Chin-Chung Lin, Chris Elicone, Charles Liu, Eva Duchoslav

Journal:

Rapid Communications in Mass Spectrometry

Year:

1999

Language:

english

File:

PDF, 162 KB

english, 1999

11

Demonstration of the capabilities of a parallel high performance liquid chromatography tandem mass spectrometry system for use in the analysis of drug discovery plasma samples

Walter A. Korfmacher, John Veals, Kimberly Dunn-Meynell, Xiping Zhang, Greg Tucker, Kathleen A. Cox, Chin-Chung Lin

Journal:

Rapid Communications in Mass Spectrometry

Year:

1999

Language:

english

File:

PDF, 102 KB

english, 1999

12

Direct analysis of plasma samples for drug discovery compounds using mixed-function column liquid chromatography tandem mass spectrometry

Yunsheng Hsieh, Matthew S. Bryant, Grace Gruela, Jean-Marc Brisson, Walter A. Korfmacher

Journal:

Rapid Communications in Mass Spectrometry

Year:

2000

Language:

english

File:

PDF, 92 KB

english, 2000

13

Relative retention times of 39 polychlorinated dibenzo-p-dioxins using SP2100 fused silica capillary chromatography

Walter A. Korfmacher, Ronald K. Mitchum

Journal:

Journal of Separation Science

Year:

1982

Language:

english

File:

PDF, 163 KB

english, 1982

14

Detection of 2-aminofluorene at femtogram levels via high resolution gas chromatography combined with negative ion atmospheric pressure ionization mass spectrometry

Takemi Kinouchi, Arleen T. López Miranda, Larry G. Rushing, Frederick A. Beland, Walter A. Korfmacher

Journal:

Journal of Separation Science

Year:

1990

Language:

english

File:

PDF, 422 KB

english, 1990

15

It is time for a paradigm shift in drug discovery bioanalysis: from SRM to HRMS

Ragu Ramanathan, Mohammed Jemal, Suma Ramagiri, Yuan-Qing Xia, W. Griffith Humpreys, Timothy Olah, Walter A. Korfmacher

Journal:

Journal of Mass Spectrometry

Year:

2011

Language:

english

File:

PDF, 326 KB

english, 2011

16

Direct analysis of drug candidates in tissue by matrix-assisted laser desorption/ionization mass spectrometry

Michelle L. Reyzer, Yunsheng Hsieh, Kwokei Ng, Walter A. Korfmacher, Richard M. Caprioli

Journal:

Journal of Mass Spectrometry

Year:

2003

Language:

english

File:

PDF, 409 KB

english, 2003

17

Estimation of the extent of oral absorption in animals from oral and intravenous pharmacokinetic data in drug discovery

Amin A. Nomeir, Richard Morrison, Daniel Prelusky, Walter Korfmacher, Lisa Broske, David Hesk, Paul McNamara, Hong Mei

Journal:

Journal of Pharmaceutical Sciences

Year:

2009

Language:

english

File:

PDF, 163 KB

english, 2009

18

Microbial transformation of the antihistaminic drug triprolidine hydrochloride

Eugene B. Hansen Jr., Robert H. Heflich, Walter A. Korfmacher, Dwight W. Miller, Carl E. Cerniglia

Journal:

Journal of Pharmaceutical Sciences

Year:

1988

Language:

english

File:

PDF, 604 KB

english, 1988

19

Mechanism for semiquinone formation in the oxygen negative chemical ionization mass spectrometry of 2,3,7,8-tetrachlorodibenzo-p-dioxin

Ronald K. Mitchum, Walter A. Korfmacher, James R. Althaus

Journal:

Journal of Mass Spectrometry

Year:

1984

Language:

english

File:

PDF, 367 KB

english, 1984

20

Atmospheric pressure ionization mass spectrometry of the polychlorinated dibenzo-p-dioxins

Walter A. Korfmacher, Ronald K. Mitchum

Journal:

Journal of Mass Spectrometry

Year:

1984

Language:

english

File:

PDF, 647 KB

english, 1984

21

Chemical ionization mass spectrometry of doxylamine and related compounds

Walter A. Korfmacher, Claude L. Holder, James P. Freeman, Ronald K. Mitchum, Aubrey B. Gosnell

Journal:

Journal of Mass Spectrometry

Year:

1985

Language:

english

File:

PDF, 413 KB

english, 1985

22

Formation of artifactual metabolites of doxylamine following acid hydrolysis

Claude L. Holder, Walter A. Korfmacher, Larry G. Rushing, Harold C. Thompson Jr., William Slikker Jr., Aubrey B. Gosnell

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1987

Language:

english

File:

PDF, 702 KB

english, 1987

23

Reduction of hERG inhibitory activity in the 4-piperidinyl urea series of H3 antagonists

Michael Berlin, Yoon Joo Lee, Christopher W. Boyce, Yi Wang, Robert Aslanian, Kevin D. McCormick, Steve Sorota, Shirley M. Williams, Robert E. West Jr., Walter Korfmacher

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.49 MB

english, 2010

24

The synthesis and structure–activity relationship of 4-benzimidazolyl-piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists

Pauline C. Ting, Joe F. Lee, Margaret M. Albanese, Jie Wu, Robert Aslanian, Leonard Favreau, Cymbelene Nardo, Walter A. Korfmacher, Robert E. West, Shirley M. Williams, John C. Anthes, Maria A. Rivell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 2.46 MB

english, 2010

25

Liquid chromatography-mass spectrometry

Walter A. Korfmacher

Journal:

Journal of the American Society for Mass Spectrometry

Year:

2007

Language:

english

File:

PDF, 30 KB

english, 2007

26

Chiral liquid chromatography-tandem mass spectrometric methods for stereoisomeric pharmaceutical determinations

Jiwen Chen, Walter A. Korfmacher, Yunsheng Hsieh

Journal:

Journal of Chromatography B

Year:

2005

Language:

english

File:

PDF, 311 KB

english, 2005

27

Ultra-performance liquid chromatography/tandem mass spectrometric determination of diastereomers of SCH 503034 in monkey plasma

Ganfeng Wang, Yunsheng Hsieh, Kuo-Chi Cheng, Richard A. Morrison, Srikanth Venkatraman, F. George Njoroge, Larry Heimark, Walter A. Korfmacher

Journal:

Journal of Chromatography B

Year:

2007

Language:

english

File:

PDF, 796 KB

english, 2007

28

High-performance liquid chromatography-atmospheric pressure photoionization/tandem mass spectrometry for the detection of 17alpha-ethinylestradiol in hepatocytes

Fangbiao Li, Yunsheng Hsieh, Walter A. Korfmacher

Journal:

Journal of Chromatography B

Year:

2008

Language:

english

File:

PDF, 453 KB

english, 2008

29

High-performance liquid chromatography–atmospheric pressure chemical ionization/tandem mass spectrometry for the determination of a thiol compound in plasma

Ganfeng Wang, Yunsheng Hsieh, Lydia Wang, Daniel Prelusky, Walter A Korfmacher, Richard Morrison

Journal:

Analytica Chimica Acta

Year:

2003

Language:

english

File:

PDF, 73 KB

english, 2003

30

Direct simultaneous determination of drug discovery compounds in monkey plasma using mixed-function column liquid chromatography/tandem mass spectrometry

Yunsheng Hsieh, Jean-Marc Brisson, Kwokei Ng, Walter A Korfmacher

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2002

Language:

english

File:

PDF, 252 KB

english, 2002

31

Simultaneous fast HPLC-MS/MS analysis of drug candidates and hydroxyl metabolites in plasma

Yunsheng Hsieh, Jean-Marc Brisson, Ganfeng Wang, Kwokei Ng, Walter A. Korfmacher

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2003

Language:

english

File:

PDF, 341 KB

english, 2003

32

Leptin induces inflammation-related genes in RINm5F insulinoma cells

Paul Hekerman, Julia Zeidler, Stefanie Korfmacher, Simone Bamberg-Lemper, Holger Knobelspies, Lennart Zabeau, Jan Tavernier, Walter Becker

Journal:

BMC Molecular Biology

Year:

2007

Language:

english

File:

PDF, 2.25 MB

english, 2007

33

A fully automated nanoelectrospray tandem mass spectrometric method for analysis of Caco-2 samples

Colleen K. Van Pelt, Sheng Zhang, Eliza Fung, Inhou Chu, Tongtong Liu, Cheng Li, Walter A. Korfmacher, Jack Henion

Journal:

Rapid Communications in Mass Spectrometry

Year:

2003

Language:

english

File:

PDF, 177 KB

english, 2003

34

Development of a low volume plasma sample precipitation procedure for liquid chromatography/tandem mass spectrometry assays used for drug discovery applications

Xiaoying Xu, Qiao Zhou, Walter A. Korfmacher

Journal:

Rapid Communications in Mass Spectrometry

Year:

2005

Language:

english

File:

PDF, 116 KB

english, 2005

35

A study of common discovery dosing formulation components and their potential for causing time-dependent matrix effects in high-performance liquid chromatography tandem mass spectrometry assays

Xiaoying Xu, Hong Mei, Shiyong Wang, Qiao Zhou, Ganfeng Wang, Lisa Broske, Adrienne Pena, Walter A. Korfmacher

Journal:

Rapid Communications in Mass Spectrometry

Year:

2005

Language:

english

File:

PDF, 224 KB

english, 2005

36

Optimizing an ultrafast generic high-performance liquid chromatography/tandem mass spectrometry method for faster discovery pharmacokinetic sample throughput

Kimberly W. Dunn-Meynell, Samuel Wainhaus, Walter A. Korfmacher

Journal:

Rapid Communications in Mass Spectrometry

Year:

2005

Language:

english

File:

PDF, 215 KB

english, 2005

37

Investigation of the profiling depth in matrix-assisted laser desorption/ionization imaging mass spectrometry

Lee Crossman, Nansie A. McHugh, Yunsheng Hsieh, Walter A. Korfmacher, Jiwen Chen

Journal:

Rapid Communications in Mass Spectrometry

Year:

2006

Language:

english

File:

PDF, 305 KB

english, 2006

38

Cassette-accelerated rapid rat screen: a systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery

Walter A. Korfmacher, Kathleen A. Cox, Kwokei J. Ng, John Veals, Yunsheng Hsieh, Sam Wainhaus, Lisa Broske, Dan Prelusky, Amin Nomeir, Ronald E. White

Journal:

Rapid Communications in Mass Spectrometry

Year:

2001

Language:

english

File:

PDF, 281 KB

english, 2001

39

Matrix-assisted laser desorption/ionization imaging mass spectrometry for direct measurement of clozapine in rat brain tissue

Yunsheng Hsieh, Roger Casale, Elaine Fukuda, Jiwen Chen, Ian Knemeyer, Julia Wingate, Richard Morrison, Walter Korfmacher

Journal:

Rapid Communications in Mass Spectrometry

Year:

2006

Language:

english

File:

PDF, 542 KB

english, 2006

40

Ultra-performance liquid chromatography/tandem mass spectrometric determination of testosterone and its metabolites in in vitro samples

Ganfeng Wang, Yunsheng Hsieh, Xiaoming Cui, Kuo-Chi Cheng, Walter A. Korfmacher

Journal:

Rapid Communications in Mass Spectrometry

Year:

2006

Language:

english

File:

PDF, 242 KB

english, 2006

41

Development of a biomarker assay for 3-indoxyl sulfate in mouse plasma and brain by liquid chromatography/tandem mass spectrometry

Ganfeng Wang, Walter A. Korfmacher

Journal:

Rapid Communications in Mass Spectrometry

Year:

2009

Language:

english

File:

PDF, 274 KB

english, 2009

42

Quantitative screening and matrix effect studies of drug discovery compounds in monkey plasma using fast-gradient liquid chromatography/tandem mass spectrometry

Yunsheng Hsieh, Madhu Chintala, Hong Mei, Jacqueline Agans, Jean-Marc Brisson, Kwokei Ng, Walter A. Korfmacher

Journal:

Rapid Communications in Mass Spectrometry

Year:

2001

Language:

english

File:

PDF, 147 KB

english, 2001

43

Liquid extraction surface analysis mass spectrometry (LESA-MS) as a novel profiling tool for drug distribution and metabolism analysis: the terfenadine example

Daniel Eikel, Marissa Vavrek, Sheri Smith, Carol Bason, Suzie Yeh, Walter A. Korfmacher, Jack D. Henion

Journal:

Rapid Communications in Mass Spectrometry

Year:

2011

Language:

english

File:

PDF, 918 KB

english, 2011

44

Simultaneous determination of a drug candidate and its metabolite in rat plasma samples using ultrafast monolithic column high-performance liquid chromatography/tandem mass spectrometry

Yunsheng Hsieh, Gangfeng Wang, Yuguang Wang, Samuel Chackalamannil, Jean-Marc Brisson, Kwokei Ng, Walter A. Korfmacher

Journal:

Rapid Communications in Mass Spectrometry

Year:

2002

Language:

english

File:

PDF, 143 KB

english, 2002

45

Comparison of conventional and enhanced mass resolution triple-quadrupole mass spectrometers for discovery bioanalytical applications

Xiaoying Xu, John Veals, Walter A. Korfmacher

Journal:

Rapid Communications in Mass Spectrometry

Year:

2003

Language:

english

File:

PDF, 273 KB

english, 2003

46

Pharmacokinetic screening for the selection of new drug discovery candidates is greatly enhanced through the use of liquid chromatography–atmospheric pressure ionization tandem mass spectrometry

Matthew S Bryant, Walter A Korfmacher, Shiyong Wang, Cymbelene Nardo, Amin A Nomeir, Chin-Chung Lin

Journal:

Journal of Chromatography A

Year:

1997

Language:

english

File:

PDF, 490 KB

english, 1997

47

Direct cocktail analysis of drug discovery compounds in pooled plasma samples using liquid chromatography–tandem mass spectrometry

Yunsheng Hsieh, Matthew S Bryant, Jean-Marc Brisson, Kwokei Ng, Walter A Korfmacher

Journal:

Journal of Chromatography B

Year:

2002

Language:

english

File:

PDF, 1.04 MB

english, 2002

48

Semi-automated determination of plasma stability of drug discovery compounds using liquid chromatography–tandem mass spectrometry

Gangfeng Wang, Yunsheng Hsieh, YauYi Lau, K.-C Cheng, Kwokei Ng, Walter A Korfmacher, Ronald E White

Journal:

Journal of Chromatography B

Year:

2002

Language:

english

File:

PDF, 395 KB

english, 2002

49

Fused bicycles as arylketone bioisosteres leading to potent, orally active thiadiazole H3 antagonists

Dong Xiao, Anandan Palani, Michael Sofolarides, Robert Aslanian, Robert E. West Jr., Shirley M. Williams, Ren-Long Wu, Joyce Hwa, Christopher Sondey, Jean Lachowicz, Walter A. Korfmacher

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.32 MB

english, 2012

50

Mapping pharmaceuticals in tissues using MALDI imaging mass spectrometry

Yunsheng Hsieh, Jiwen Chen, Walter A. Korfmacher

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2007

Language:

english

File:

PDF, 842 KB

english, 2007