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1

ChemInform Abstract: 5-Alkyl 1,2-Dihydrochromeno[3,4-f]quinolines: A Novel Class of Nonsteroidal Progesterone Receptor Modulators.

Lin Zhi, Christopher M. Tegley, James P. Edwards, Sarah J. West, Keith B. Marschke, Marco M. Gottardis, Dale E. Mais, Todd K. Jones

Journal:

Year:

1999

File:

PDF, 32 KB

1999

2

ChemInform Abstract: Switching Androgen Receptor Antagonists to Agonists by Modifying C-Ring Substituents on Piperidino[3,2-g]quinolinone.

Lin Zhi, Christopher M. Tegley, Keith B. Marschke, Todd K. Jones

Journal:

Year:

1999

File:

PDF, 30 KB

1999

3

ChemInform Abstract: Nonsteroidal Androgen Receptor Agonists Based on 4-(Trifluoromethyl)-2H-pyrano[3,2-g]quinolin-2-one.

James P. Edwards, Robert I. Higuchi, David T. Winn, Charlotte L. F. Pooley, Thomas R. Caferro, Lawrence G. Hamann, Lin Zhi, Keith B. Marschke, Mark E. Goldman, Todd K. Jones

Journal:

Year:

1999

File:

PDF, 34 KB

1999

4

ChemInform Abstract: Nonsteroidal Progesterone Receptor Antagonists Based on 6-Thiophenehydroquinolines.

Lin Zhi, Christopher M. Tegley, Barbara Pio, Sarah J. West, Keith B. Marschke, Dale E. Mais, Todd K. Jones

Journal:

Year:

2000

File:

PDF, 31 KB

2000

5

ChemInform Abstract: Synthesis and Progesterone Receptor Antagonist Activities of 6-Aryl Benzimidazolones and Benzothiazolones.

Puwen Zhang, Eugene A. Terefenko, Jay Wrobel, Zhiming Zhang, Yuan Zhu, Jeffrey Cohen, Keith B. Marschke, Dale Mais

Journal:

Year:

2002

File:

PDF, 31 KB

2002

6

Synthesis and Biological Activity of 5-Methylidene 1,2-Dihydrochromeno[3,4-f]quinoline Derivatives as Progesterone Receptor Modulators.

Lin Zhi, Christopher M. Tegley, Barbara Pio, James P. Edwards, Todd K. Jones, Keith B. Marschke, Dale E. Mais, Boris Risek, William T. Schrader

Journal:

Year:

2003

File:

PDF, 121 KB

2003

7

Structure—Activity Relationships and Sub-Type Selectivity in an Oxabicyclic Estrogen Receptor α/β Agonist Scaffold.

Lawrence G. Hamann, J. Hoyt Meyer, Daniel A. Ruppar, Keith B. Marschke, Francisco J. Lopez, Elizabeth A. Allegretto, Donald S. Karanewsky

Journal:

Year:

2005

File:

PDF, 16 KB

2005

8

Discovery of nonsteroidal glucocorticoid receptor ligands based on 6-indole-1,2,3,4-tetrahydroquinolines

Steven L. Roach, Robert I. Higuchi, Mark E. Adams, Yan Liu, Donald S. Karanewsky, Keith B. Marschke, Dale E. Mais, Jeffrey N. Miner, Lin Zhi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 200 KB

english, 2008

9

Structure–activity relationships and sub-type selectivity in an oxabicyclic estrogen receptor α/β agonist scaffold

Lawrence G. Hamann, J. Hoyt Meyer, Daniel A. Ruppar, Keith B. Marschke, Francisco J. Lopez, Elizabeth A. Allegretto, Donald S. Karanewsky

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 144 KB

english, 2005

10

Novel selective androgen receptor modulators: SAR studies on 6-bisalkylamino-2-quinolinones

Arjan van Oeveren, Mehrnoush Motamedi, Esther Martinborough, Shuo Zhao, Yixing Shen, Sarah West, William Chang, Adam Kallel, Keith B. Marschke, Francisco J. López, Andrés Negro-Vilar, Lin Zhi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 338 KB

english, 2007

11

Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones

Arjan van Oeveren, Barbara A. Pio, Christopher M. Tegley, Robert I. Higuchi, Min Wu, Todd K. Jones, Keith B. Marschke, Andrés Negro-Vilar, Lin Zhi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 145 KB

english, 2007

12

Selective androgen receptor modulators based on a series of 7H-[1,4]oxazino[3,2-g]quinolin-7-ones with improved in vivo activity

Yun Oliver Long, Robert I. Higuchi, Thomas R. Caferro, Thomas L.S. Lau, Min Wu, Marquis L. Cummings, Esther A. Martinborough, Keith B. Marschke, William Y. Chang, Francisco J. López, Donald S. Karanew

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 231 KB

english, 2008

13

Discovery of a novel series of nonsteroidal androgen receptor modulators: 5- or 6-oxachrysen-2-ones

Shuo Zhao, Yixing Shen, Arjan van Oeveren, Keith B. Marschke, Lin Zhi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 134 KB

english, 2008

14

Tetrahydroquinoline glucocorticoid receptor agonists: Discovery of a 3-hydroxyl for improving receptor selectivity

Steven L. Roach, Robert I. Higuchi, Andrew R. Hudson, Mark E. Adams, Peter M. Syka, Dale E. Mais, Jeffrey N. Miner, Keith B. Marschke, Lin Zhi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1020 KB

english, 2011

15

Discovery of orally available tetrahydroquinoline-based glucocorticoid receptor agonists

Andrew R. Hudson, Robert I. Higuchi, Steven L. Roach, Mark E. Adams, Angela Vassar, Peter M. Syka, Dale E. Mais, Jeffrey N. Miner, Keith B. Marschke, Lin Zhi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 351 KB

english, 2011

16

Tetrahydroquinolin-3-yl carbamate glucocorticoid receptor agonists with reduced PEPCK activation

Steven L. Roach, Robert I. Higuchi, Andrew R. Hudson, Angie Vassar, Virginia H.S. Grant, Ryan Lamer, Charlene Hooper, Deepa Rungta, Peter M. Syka, Dale E. Mais, Keith B. Marschke, Lin Zhi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.30 MB

english, 2011

17

Nonsteroidal 2,3-dihydroquinoline glucocorticoid receptor agonists with reduced PEPCK activation

Andrew R. Hudson, Robert I. Higuchi, Steven L. Roach, Lino J. Valdez, Mark E. Adams, Angie Vassar, Deepa Rungta, Peter M. Syka, Dale E. Mais, Keith B. Marschke, Lin Zhi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 390 KB

english, 2011

18

Effects of isosteric pyridone replacements in androgen receptor antagonists based on 1,2-dihydro- and 1,2,3,4-tetrahydro-2,2-dimethyl-6-trifluoromethyl-8-pyridono[5,6-g]quinolines

James W Kong, Lawrence G Hamann, Daniel A Ruppar, James P Edwards, Keith B Marschke, Todd K Jones

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 166 KB

english, 2000

19

Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines

Lin Zhi, Christopher M Tegley, Barbara Pio, Sarah J West, Keith B Marschke, Dale E Mais, Todd K Jones

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 131 KB

english, 2000

20

Synthesis and progesterone receptor antagonist activities of 6-aryl benzimidazolones and benzothiazolones

Puwen Zhang, Eugene A. Terefenko, Jay Wrobel, Zhiming Zhang, Yuan Zhu, Jeffrey Cohen, Keith B. Marschke, Dale Mais

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 132 KB

english, 2001

21

Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators

Lin Zhi, Christopher M Tegley, Barbara Pio, James P Edwards, Todd K Jones, Keith B Marschke, Dale E Mais, Boris Risek, William T Schrader

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 215 KB

english, 2003

22

New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g]quinolinone

James P. Edwards, Sarah J. West, Charlotte L.F. Pooley, Keith B. Marschke, Luc J. Farmer, Todd K. Jones

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 347 KB

english, 1998

23

Nonsteroidal progesterone receptor antagonists based on a conformationally-restricted subseries of 6-aryl-1,2-dihydro-2,2,4-trimethylquinolines

Lawrence G. Hamann, David T. Winn, Charlotte L.F. Pooley, Christopher M. Tegley, Sarah J. West, Luc.J. Farmer, Lin Zhi, James P. Edwards, Keith B. Marschke, Dale E. Mais, Mark E. Goldman, Todd K. Jone

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 297 KB

english, 1998

24

5-Alkyl 1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal progesterone receptor modulators

Lin Zhi, Christopher M Tegley, James P Edwards, Sarah J West, Keith B Marschke, Marco M Gottardis, Dale E Mais, Todd K Jones

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 344 KB

english, 1998

25

Nonsteroidal androgen receptor agonists based on 4-(trifluoromethyl)-2H-pyrano[3,2-g]quinolin-2-one

James P. Edwards, Robert I. Higuchi, David T. Winn, Charlotte L.F. Pooley, Thomas R. Caferro, Lawrence G. Hamann, Lin Zhi, Keith B. Marschke, Mark E. Goldman, Todd K. Jones

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 351 KB

english, 1999

26

Switching androgen receptor antagonists to agonists by modifying C-ring substituents on piperidino[3,2-g]quinolinone

Lin Zhi, Christopher M. Tegley, Keith B. Marschke, Todd K. Jones

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 244 KB

english, 1999

27

4-Alkyl- and 3,4-dialkyl-1,2,3,4,-tetrahydro-8-pyridono[5,6-g]quinolines: Potent, nonsteroidal androgen receptor agonists

Robert I. Higuchi, James P. Edwards, Thomas R. Caferro, Josef D. Ringgenberg, James W. Kong, Lawrence G. Hamann, Kristen L. Arienti, Keith B. Marschke, Robert L. Davis, Luc J. Farmer, Todd K. Jones

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 360 KB

english, 1999

28

Lymphocyte stimulation by murine derived renal antigens: Lymphocyte response to renal antigens

Cheryl Speier Marschke, Keith Lance Stein, Neil Lempert

Journal:

Immunology Letters

Year:

1979

Language:

english

File:

PDF, 319 KB

english, 1979

29

Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore

Lin Zhi, Josef D Ringgenberg, James P Edwards, Christopher M Tegley, Sarah J West, Barbara Pio, Mehrnouch Motamedi, Todd K Jones, Keith B Marschke, Dale E Mais, William T Schrader

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 196 KB

english, 2003

30

Combination Treatment With a Selective Androgen Receptor Modulator q(SARM) and a Bisphosphonate Has Additive Effects in Osteopenic Female Rats

Eric G Vajda, Aimee Hogue, Kimberly N Griffiths, William Y Chang, Kelven Burnett, Yanling Chen, Keith Marschke, Dale E Mais, Bijan Pedram, Yixing Shen, Arjan van Oeveren, Lin Zhi, Francisco J López, M

Journal:

Journal of Bone and Mineral Research

Year:

2009

Language:

english

File:

PDF, 789 KB

english, 2009

31

Synthesis and Biological Activity of a Novel Series of Nonsteroidal, Peripherally Selective Androgen Receptor Antagonists Derived from 1,2-Dihydropyridono[5,6-g]quinolines

Hamann, Lawrence G., Higuchi, Robert I., Zhi, Lin, Edwards, James P., Wang, Xiao-Ning, Marschke, Keith B., Kong, James W., Farmer, Luc J., Jones, Todd K.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 479 KB

english, 1998

32

Specificity of simple hormone response elements in androgen regulated genes

Keith B. Marschke, Jiann-an Tan, Stuart R. Kupfer, Elizabeth M. Wilson, Frank S. French

Journal:

Endocrine (Springer)

Year:

1995

Language:

english

File:

PDF, 1.24 MB

english, 1995

33

Discovery of 6-N,N-Bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a Novel Selective Androgen Receptor Modulator#

van Oeveren, Arjan, Motamedi, Mehrnouch, Mani, Neelakandha S., Marschke, Keith B., López, Francisco J., Schrader, William T., Negro-Vilar, Andrés, Zhi, Lin

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 203 KB

english, 2006

34

Substituted 6-(1-Pyrrolidine)quinolin-2(1H)-ones as Novel Selective Androgen Receptor Modulators

Martinborough, Esther, Shen, Yixing, van Oeveren, Arjan, Long, Yun Oliver, Lau, Thomas L. S., Marschke, Keith B., Chang, William Y., López, Francisco J., Vajda, Eric G., Rix, Peter J.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 146 KB

english, 2007

35

Sex steroid hormone binding globulin levels and free 17β-estradiol and testosterone in cynomolgus monkeys during different reproductive states

Donald R. Koritnik, Keith B. Marschke

Journal:

Journal of Steroid Biochemistry

Year:

1986

Language:

english

File:

PDF, 948 KB

english, 1986

36

Contraceptive steroid treatment affects steroid binding proteins and the percentage of free 17β-estradiol and testosterone in the cynomolgus monkey (itmacaca fascicularis)

Donald R. Koritnik, Keith B. Marschke

Journal:

Journal of Steroid Biochemistry

Year:

1987

Language:

english

File:

PDF, 911 KB

english, 1987

37

Estrogen and androgen receptors in the liver of cynomolgus monkeys (Macaca fascicularis)

Keith B. Marschke, Donald R. Koritnik

Journal:

Journal of Steroid Biochemistry

Year:

1987

Language:

english

File:

PDF, 909 KB

english, 1987

38

Characterization of a hepatic protein in nonhuman primates that binds mibolerone but not dihydrotestosterone or methyltrienolone

Donald R. Koritnik, Keith B. Marschke, Alice Koshy

Journal:

Year:

1995

Language:

english

File:

PDF, 897 KB

english, 1995

39

5-Benzylidene-1,2-dihydrochromeno[3,4- f ]quinolines as Selective Progesterone Receptor Modulators

Zhi, Lin, Tegley, Christopher M., Pio, Barbara, Edwards, James P., Motamedi, Mehrnouch, Jones, Todd K., Marschke, Keith B., Mais, Dale E., Risek, Boris, Schrader, William T.

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 154 KB

english, 2003

40

5-Benzylidene 1,2-Dihydrochromeno[3,4- f ]quinolines, A Novel Class of Nonsteroidal Human Progesterone Receptor Agonists

Tegley, Christopher M., Zhi, Lin, Marschke, Keith B., Gottardis, Marco M., Yang, Qinchuan, Jones, Todd K.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 137 KB

english, 1998

41

5-Aryl-1,2-dihydro-5 H -chromeno[3,4- f ]quinolines as Potent, Orally Active, Nonsteroidal Progesterone Receptor Agonists: The Effect of D-Ring Substituents

Edwards, James P., West, Sarah J., Marschke, Keith B., Mais, Dale E., Gottardis, Marco M., Jones, Todd K.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 164 KB

english, 1998

42

5-Aryl-1,2-dihydrochromeno[3,4- f ]quinolines: A Novel Class of Nonsteroidal Human Progesterone Receptor Agonists

Zhi, Lin, Tegley, Christopher M., Kallel, E. Adam, Marschke, Keith B., Mais, Dale E., Gottardis, Marco M., Jones, Todd K.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 321 KB

english, 1998

43

A Tissue-Selective Nonsteroidal Progesterone Receptor Modulator: 7,9-Difluoro-5-(3-methylcyclohex-2-enyl)-2,2,4-trimethyl-1,2-dihydrochromeno[3,4- f ]quinoline

Pedram, Bijan, Oeveren, Arjan van, Mais, Dale E., Marschke, Keith B., Verbost, Pieter M., Groen, Marinus B., Zhi, Lin

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 117 KB

english, 2008

44

Discovery of a Potent, Orally Active, Nonsteroidal Androgen Receptor Agonist: 4-Ethyl-1,2,3,4-tetrahydro-6- (trifluoromethyl)-8-pyridono[5,6- g ]- quinoline (LG121071)

Hamann, Lawrence G., Mani, Neelakandha S., Davis, Robert L., Wang, Xiao-Ning, Marschke, Keith B., Jones, Todd K.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 62 KB

english, 1999

45

5-Aryl-1,2,3,4-tetrahydrochromeno[3,4- f ]quinolin-3-ones as a Novel Class of Nonsteroidal Progesterone Receptor Agonists: Effect of A-Ring Modification

Zhi, Lin, Tegley, Christopher M., Marschke, Keith B., Mais, Dale E., Jones, Todd K.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 157 KB

english, 1999

46

Discovery and Preliminary SAR Studies of a Novel, Nonsteroidal Progesterone Receptor Antagonist Pharmacophore

Pooley, Charlotte L. F., Edwards, James P., Goldman, Mark E., Wang, Ming-Wei, Marschke, Keith B., Crombie, Diane L., Jones, Todd K.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 123 KB

english, 1998

47

6-Aryl-1,4-dihydro-benzo[ d ][1,3]oxazin- 2-ones: A Novel Class of Potent, Selective, and Orally Active Nonsteroidal Progesterone Receptor Antagonists †

Zhang, Puwen, Terefenko, Eugene A., Fensome, Andrew, Wrobel, Jay, Winneker, Richard, Lundeen, Scott, Marschke, Keith B., Zhang, Zhiming

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 61 KB

english, 2002

48

Novel class of non-steroidal progesterone receptor antagonists

Zhi, Lin, Marschke, Keith B

Journal:

Expert Opinion on Therapeutic Patents

Year:

1999

Language:

english

File:

PDF, 84 KB

english, 1999

49

LGD-5552, an Antiinflammatory Glucocorticoid Receptor Ligand with Reduced Side Effects, in Vivo

López, Francisco J., Ardecky, Robert J., Bebo, Bruce, Benbatoul, Khalid, De Grandpre, Louise, Liu, Sha, Leibowitz, Mark D., Marschke, Keith, Rosen, Jon, Rungta, Deepa, Viveros, Humberto O., Yen, Wan-C

Journal:

Year:

2008

Language:

english

File:

PDF, 786 KB

english, 2008

50

An Orally Active Selective Androgen Receptor Modulator Is Efficacious on Bone, Muscle, and Sex Function with Reduced Impact on Prostate

Miner, Jeffrey N., Chang, William, Chapman, Mark S., Finn, Patricia D., Hong, Mei Hua, López, Francisco J., Marschke, Keith B., Rosen, Jon, Schrader, William, Turner, Russell, van Oeveren, Arjan, Vive

Journal:

Year:

2007

File:

PDF, 410 KB

2007