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1

Rhizolutin, a novel 7/10/6âtricyclic dilactone, dissociates misfolded protein aggregates and reduces apoptosis/inflammation associated with Alzheimerâs disease

Kwon, Yun, Shin, Jisu, Nam, Kwangho, An, Joon Soo, Yang, Seung-Hoon, Hong, Seong-Heon, Bae, Munhyung, Moon, Kyuho, Cho, Yakdol, Woo, Jiwan, Park, Keunwan, Kim, Kyeonghwan, Shin, Jongheon, Kim, Byung-Y

Journal:

Angewandte Chemie

Year:

2020

File:

PDF, 1.84 MB

2020

2

Modeling allosteric signal propagation using protein structure networks

Keunwan Park, Dongsup Kim

Journal:

BMC Bioinformatics

Year:

2011

Language:

english

File:

PDF, 1.04 MB

english, 2011

3

Drug-drug relationship based on target information: application to drug target identification

Keunwan Park, Dongsup Kim

Journal:

BMC Systems Biology

Year:

2011

Language:

english

File:

PDF, 615 KB

english, 2011

4

Localized network centrality and essentiality in the yeast–protein interaction network

Keunwan Park, Dongsup Kim

Journal:

Year:

2009

Language:

english

File:

PDF, 422 KB

english, 2009

5

Binding similarity network of ligand

Keunwan Park, Dongsup Kim

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2008

Language:

english

File:

PDF, 748 KB

english, 2008

6

Analysis of the residue–residue coevolution network and the functionally important residues in proteins

Byung-Chul Lee, Keunwan Park, Dongsup Kim

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2008

Language:

english

File:

PDF, 428 KB

english, 2008

7

Importance of structural information in predicting human acute toxicity from in vitro cytotoxicity data

Soyoung Lee, Keunwan Park, Hee-Sung Ahn, Dongsup Kim

Journal:

Toxicology and Applied Pharmacology

Year:

2010

Language:

english

File:

PDF, 641 KB

english, 2010

8

Structure-based rebuilding of coevolutionary information reveals functional modules in rhodopsin structure

Keunwan Park, Dongsup Kim

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2012

Language:

english

File:

PDF, 793 KB

english, 2012

9

Interaction network among functional drug groups

Minho Lee,Keunwan Park,Dongsup Kim

Journal:

BMC Systems Biology

Year:

2013

Language:

english

File:

PDF, 1.84 MB

english, 2013

10

A High-Affinity Protein Binder that Blocks the IL-6/STAT3 Signaling Pathway Effectively Suppresses Non–Small Cell Lung Cancer

Lee, Joong-jae, Kim, Hyun Jung, Yang, Chul-Su, Kyeong, Hyun-Ho, Choi, Jung-Min, Hwang, Da-Eun, Yuk, Jae-Min, Park, Keunwan, Kim, Yu Jung, Lee, Seung-Goo, Kim, Dongsup, Jo, Eun-Kyeong, Cheong, Hae-Kap,

Journal:

Molecular Therapy

Year:

2014

Language:

english

File:

PDF, 2.36 MB

english, 2014

11

Soluble expression of human glycoprotein Ibα in Escherichia coli through replacement of the N-terminal capping domain

Ryou, Jeong-Hyun, Park, Keunwan, Lee, Joong-jae, Kim, Dongsup, Kim, Hak-Sung

Journal:

Protein Expression and Purification

Year:

2014

Language:

english

File:

PDF, 1.06 MB

english, 2014

12

Predicting the multi-modal binding propensity of small molecules: towards an understanding of drug promiscuity

Park, Keunwan, Lee, Soyoung, Ahn, Hee-Sung, Kim, Dongsup

Journal:

Molecular BioSystems

Year:

2009

Language:

english

File:

PDF, 641 KB

english, 2009

13

Building a drug–target network and its applications

Lee, Soyoung, Park, Keunwan, Kim, Dongsup

Journal:

Expert Opinion on Drug Discovery

Year:

2009

Language:

english

File:

PDF, 440 KB

english, 2009

14

A General Computational Approach for Repeat Protein Design

Parmeggiani, Fabio, Huang, Po-Ssu, Vorobiev, Sergey, Xiao, Rong, Park, Keunwan, Caprari, Silvia, Su, Min, Seetharaman, Jayaraman, Mao, Lei, Janjua, Haleema, Montelione, Gaetano T., Hunt, John, Baker,

Journal:

Journal of Molecular Biology

Year:

2015

Language:

english

File:

PDF, 2.86 MB

english, 2015

15

Control of repeat-protein curvature by computational protein design

Park, Keunwan, Shen, Betty W, Parmeggiani, Fabio, Huang, Po-Ssu, Stoddard, Barry L, Baker, David

Journal:

Nature Structural and Molecular Biology

Year:

2015

Language:

english

File:

PDF, 2.46 MB

english, 2015

16

Structure-Based Rational Design of a Toll-like Receptor 4 (TLR4) Decoy Receptor with High Binding Affinity for a Target Protein

Han, Jieun, Kim, Hyun Jung, Lee, Sang-Chul, Hong, Seungpyo, Park, Keunwan, Jeon, Young Ho, Kim, Dongsup, Cheong, Hae-Kap, Kim, Hak-Sung, Xu, Wenqing

Journal:

Year:

2012

Language:

english

File:

PDF, 1.03 MB

english, 2012

17

Dissecting the Critical Factors for Thermodynamic Stability of Modular Proteins Using Molecular Modeling Approach

Lee, Yuno, Lee, Joong-jae, Kim, Songmi, Lee, Sang-Chul, Han, Jieun, Heu, Woosung, Park, Keunwan, Kim, Hyun Jung, Cheong, Hae-Kap, Kim, Dongsup, Kim, Hak-Sung, Lee, Keun Woo, Uversky, Vladimir N.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.58 MB

english, 2014

18

Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ

Lee, Jae Wook, Hirota, Tsuyoshi, Ono, Daisuke, Honma, Sato, Honma, Ken-ichi, Park, Keunwan, Kay, Steve

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 3.93 MB

english, 2019

19

A small molecule Nec-1 directly induces amyloid clearance in the brains of aged APP/PS1 mice

Yang, Seung-Hoon, Shin, Jisu, Shin, Naewoo Neo, Hwang, Ji-Hyun, Hong, Sung-Chul, Park, Keunwan, Lee, Jae Wook, Lee, Sejin, Baek, Seungyeop, Kim, Kyeonghwan, Cho, Illhwan, Kim, YoungSoo

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 6.25 MB

english, 2019

20

Fluorescent 1,4-Naphthoquinones To Visualize Diffuse and Dense-Core Amyloid Plaques in APP/PS1 Transgenic Mouse Brains

Neo Shin, Naewoo, Jeon, Hanna, Jung, Youngeun, Baek, Seungyeop, Lee, Sejin, Yoo, Hee Chan, Bae, Gi Hun, Park, Keunwan, Yang, Seung-Hoon, Han, Jung Min, Kim, Ikyon, Kim, YoungSoo

Journal:

ACS Chemical Neuroscience

Year:

2019

Language:

english

File:

PDF, 8.31 MB

english, 2019

21

Fluorescent 1,4-Naphthoquinones To Visualize Diffuse and Dense-Core Amyloid Plaques in APP/PS1 Transgenic Mouse Brains

Neo Shin, Naewoo, Jeon, Hanna, Jung, Youngeun, Baek, Seungyeop, Lee, Sejin, Yoo, Hee Chan, Bae, Gi Hun, Park, Keunwan, Yang, Seung-Hoon, Han, Jung Min, Kim, Ikyon, Kim, YoungSoo

Journal:

ACS Chemical Neuroscience

Year:

2019

File:

PDF, 8.31 MB

2019

22

Receptor subtype discrimination using extensive shape complementary designed interfaces

Dang, Luke T., Miao, Yi, Ha, Andrew, Yuki, Kanako, Park, Keunwan, Janda, Claudia Y., Jude, Kevin M., Mohan, Kritika, Ha, Nhi, Vallon, Mario, Yuan, Jenny, Vilches-Moure, José G., Kuo, Calvin J., Garcia

Journal:

Nature Structural and Molecular Biology

Year:

2019

Language:

english

File:

PDF, 5.82 MB

english, 2019

23

Multi-input chemical control of protein dimerization for programming graded cellular responses

Foight, Glenna Wink, Wang, Zhizhi, Wei, Cindy T., Jr Greisen, Per, Warner, Katrina M., Cunningham-Bryant, Daniel, Park, Keunwan, Brunette, T. J., Sheffler, William, Baker, David, Maly, Dustin J.

Journal:

Nature Biotechnology

Year:

2019

Language:

english

File:

PDF, 2.03 MB

english, 2019

24

Discovery of chemicals to clear or indicate amyloid aggregates by targeting memory-impairing anti-parallel AÎ² dimers

Lee, Jinny Claire, Kim, Hye Yun, Lee, Sejin, Shin, Jisu, Kim, Hyunjin Vincent, Kim, Kyeonghwan, Baek, Seungyeop, Lee, Donghee, Jeon, Hanna, Kim, DaWon, Yang, Seung-Hoon, Han, Gyoonhee, Park, Keunwan,

Journal:

Angewandte Chemie International Edition

Year:

2020

Language:

english

File:

PDF, 2.39 MB

english, 2020

25

Discovery of Chemicals to Either Clear or Indicate Amyloid Aggregates by Targeting MemoryâImpairing AntiâParallel AÎ² Dimers

Lee, Jinny Claire, Kim, Hye Yun, Lee, Sejin, Shin, Jisu, Kim, Hyunjin Vincent, Kim, Kyeonghwan, Baek, Seungyeop, Lee, Donghee, Jeon, Hanna, Kim, DaWon, Yang, SeungâHoon, Han, Gyoonhee, Park, Keunwan

Journal:

Angewandte Chemie

Year:

2020

File:

PDF, 2.39 MB

2020

26

Evolutionary chemical binding similarity approach integrated with 3D-QSAR method for effective virtual screening

Durai, Prasannavenkatesh, Ko, Young-Joon, Pan, Cheol-Ho, Park, Keunwan

Journal:

BMC Bioinformatics

Year:

2020

File:

PDF, 3.33 MB

2020

27

Rhizolutin, a novel 7/10/6âtricyclic dilactone, dissociates misfolded protein aggregates and reduces apoptosis/inflammation associated with Alzheimerâs disease

Kwon, Yun, Shin, Jisu, Nam, Kwangho, An, Joon Soo, Yang, Seung-Hoon, Hong, Seong-Heon, Bae, Munhyung, Moon, Kyuho, Cho, Yakdol, Woo, Jiwan, Park, Keunwan, Kim, Kyeonghwan, Shin, Jongheon, Kim, Byung-Y

Journal:

Angewandte Chemie International Edition

Year:

2020

File:

PDF, 1.84 MB

2020

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