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51

Structure–activity relationship and biological property of cortistatins, anti-angiogenic spongean steroidal alkaloids

Shunji Aoki, Yasuo Watanabe, Daiki Tanabe, Masayoshi Arai, Hideaki Suna, Katsushiro Miyamoto, Hiroshi Tsujibo, Kazutake Tsujikawa, Hiroshi Yamamoto, Motomasa Kobayashi

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 454 KB

english, 2007

52

Halicyclamine A, a marine spongean alkaloid as a lead for anti-tuberculosis agent

Masayoshi Arai, Mari Sobou, Catherine Vilchéze, Anthony Baughn, Hiroyuki Hashizume, Patamaporn Pruksakorn, Shunsuke Ishida, Makoto Matsumoto, William R. Jacobs Jr., Motomasa Kobayashi

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 314 KB

english, 2008

53

Dysideamine, a new sesquiterpene aminoquinone, protects hippocampal neuronal cells against iodoacetic acid-induced cell death

Hideaki Suna, Masayoshi Arai, Yoshie Tsubotani, Asami Hayashi, Andi Setiawan, Motomasa Kobayashi

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 506 KB

english, 2009

54

New anti-malarial peroxides with In vivo potency derived from spongean metabolites

Nobutoshi Murakami, Motoyuki Kawanishi, Huq Mohammad Mostaqul, Jie Li, Sawako Itagaki, Toshihiro Horii, Motomasa Kobayashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 149 KB

english, 2003

55

New analogue of arenastatin A, a potent cytotoxic spongean depsipeptide, with anti-tumor activity

Nobutoshi Murakami, Satoru Tamura, Kouhei Koyama, Masanori Sugimoto, Ryuji Maekawa, Motomasa Kobayashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 326 KB

english, 2004

56

Synthesis of a bioprobe for elucidation of target molecule of spongean anti-malarial peroxides

Nobutoshi Murakami, Motoyuki Kawanishi, Sawako Itagaki, Toshihiro Horii, Motomasa Kobayashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 269 KB

english, 2004

57

Synthesis of BC-ring model of globostellatic acid X methyl ester, an anti-angiogenic substance from marine sponge

Naoyuki Kotoku, Nao Tamada, Asami Hayashi, Motomasa Kobayashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 181 KB

english, 2008

58

New Rev-export inhibitor from Alpinia galanga and structure–activity relationship

Satoru Tamura, Atsushi Shiomi, Masafumi Kaneko, Ying Ye, Minoru Yoshida, Masayuki Yoshikawa, Tominori Kimura, Motomasa Kobayashi, Nobutoshi Murakami

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 262 KB

english, 2009

59

Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria

Patamaporn Pruksakorn, Masayoshi Arai, Naoyuki Kotoku, Catherine Vilchèze, Anthony D. Baughn, Prashini Moodley, William R. Jacobs Jr., Motomasa Kobayashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 360 KB

english, 2010

60

Probe molecule equipped with boronic acid moiety as a reversible cross-linking group improves its binding affinity

Naoyuki Kotoku, Xiu-Han Guo, Masayoshi Arai, Motomasa Kobayashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 379 KB

english, 2010

61

Kendarimide A, a novel peptide reversing P-glycoprotein-mediated multidrug resistance in tumor cells, from a marine sponge of Haliclona sp.

Shunji Aoki, Liwei Cao, Kouhei Matsui, Rachmaniar Rachmat, Shin-ichi Akiyama, Motomasa Kobayashi

Journal:

Year:

2004

Language:

english

File:

PDF, 153 KB

english, 2004

62

Efficient total synthesis of bastadin 6, an anti-angiogenic brominated tyrosine-derived metabolite from marine sponge

Naoyuki Kotoku, Hiroaki Tsujita, Atsushi Hiramatsu, Chinatsu Mori, Noriko Koizumi, Motomasa Kobayashi

Journal:

Year:

2005

Language:

english

File:

PDF, 234 KB

english, 2005

63

Shimalactone A, a novel polyketide, from marine-derived fungus Emericella variecolor GF10

Hong Wei, Takuya Itoh, Masahiro Kinoshita, Naoyuki Kotoku, Shunji Aoki, Motomasa Kobayashi

Journal:

Year:

2005

Language:

english

File:

PDF, 222 KB

english, 2005

64

Cortistatins E, F, G, and H, four novel steroidal alkaloids from marine sponge Corticium simplex

Yasuo Watanabe, Shunji Aoki, Daiki Tanabe, Andi Setiawan, Motomasa Kobayashi

Journal:

Year:

2007

Language:

english

File:

PDF, 299 KB

english, 2007

65

Cortistatins J, K, L, novel abeo-9(10-19)-androstane-type steroidal alkaloids with isoquinoline unit, from marine sponge Corticium simplex

Shunji Aoki, Yasuo Watanabe, Daiki Tanabe, Andi Setiawan, Masayoshi Arai, Motomasa Kobayashi

Journal:

Tetrahedron Letters

Year:

2007

Language:

english

File:

PDF, 163 KB

english, 2007

66

Stereoselective total synthesis of arenastatin A, a spongean cytotoxic depsipeptide

Naoyuki Kotoku, Fuminori Narumi, Tomoya Kato, Miho Yamaguchi, Motomasa Kobayashi

Journal:

Tetrahedron Letters

Year:

2007

Language:

english

File:

PDF, 155 KB

english, 2007

67

Synthesis of CD-ring structure of cortistatin A, an anti-angiogenic steroidal alkaloid from marine sponge

Naoyuki Kotoku, Yuji Sumii, Takeshi Hayashi, Motomasa Kobayashi

Journal:

Tetrahedron Letters

Year:

2008

Language:

english

File:

PDF, 187 KB

english, 2008

68

Lembehyne A, a Novel Neuritogenic Polyacetylene, from a Marine Sponge of Haliclona sp.

Shunji Aoki, Kouhei Matsui, Kazuhiro Tanaka, Rachmaniar Satari, Motomasa Kobayashi

Journal:

Year:

2000

Language:

english

File:

PDF, 88 KB

english, 2000

69

Molecular modeling of 5-desacetylaltohyrtin A, a spongean cytotoxic macrolide

Shunji Aoki, Nobuaki Nemoto, Yuji Kobayashi, Motomasa Kobayashi, Isao Kitagawa

Journal:

Year:

2001

Language:

english

File:

PDF, 100 KB

english, 2001

70

Synthesis of stable analogs in blood and conformational analysis of arenastatin A, a potent cytotoxic spongean depsipeptide

Nobutoshi Murakami, Satoru Tamura, Weiqi Wang, Tatsuya Takagi, Motomasa Kobayashi

Journal:

Year:

2001

Language:

english

File:

PDF, 426 KB

english, 2001

71

Brianthein A, a novel briarane-type diterpene reversing multidrug resistance in human carcinoma cell line, from the gorgonian Briareum excavatum

Shunji Aoki, Masanori Okano, Kouhei Matsui, Takuya Itoh, Rachmaniar Satari, Shin-ichi Akiyama, Motomasa Kobayashi

Journal:

Year:

2001

Language:

english

File:

PDF, 235 KB

english, 2001

72

Marine natural products. XXV. Biologically active tridecapeptide lactones from the Okinawan marine sponge Theonella swinhoei (Theonellidae). Structure of theonellapeptolide Id

Isao Kitagawa, Nam Kyung Lee, Motomasa Kobayashi, Hirotaka Shibuya

Journal:

Year:

1991

Language:

english

File:

PDF, 869 KB

english, 1991

73

Structure–activity relationship of neuritogenic spongean acetylene alcohols, lembehynes

Shunji Aoki, Kouhei Matsui, Hong Wei, Nobutoshi Murakami, Motomasa Kobayashi

Journal:

Year:

2002

Language:

english

File:

PDF, 186 KB

english, 2002

74

Reversal of multidrug resistance in human carcinoma cell line by agosterols, marine spongean sterols

Shunji Aoki, Andi Setiawan, Yasuhiro Yoshioka, Kouichi Higuchi, Ritsuko Fudetani, Zhe-Sheng Chen, Tomoyuki Sumizawa, Shin-ichi Akiyama, Motomasa Kobayashi

Journal:

Year:

1999

Language:

english

File:

PDF, 531 KB

english, 1999

75

Myrmekiosides a and b, novel mono-o-alkyl-diglycosylglycerols reversing tumor cell morphology of ras-transformed cells from a marine sponge of myrmekioderma sp

Shunji Aoki, Kouichi Higuchi, Ai Kato, Nobutoshi Murakami, Motomasa Kobayashi

Journal:

Year:

1999

Language:

english

File:

PDF, 445 KB

english, 1999

76

Trichoharzin, a new polyketide produced by the imperfect fungus Trichoderma harzianum separated from the marine sponge Micale cecilia

Motomasa Kobayashi, Hideto Uehara, Katsuyoshi Matsunami, Shunji Aoki, Isao Kitagawa

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 306 KB

english, 1993

77

Thornasterol A and B, two genuine sapogenols from the starfish acanthaster planci

Isao Kitagawa, Motomasa Kobayashi, Tamio Sugawara, Itiro Yosioka

Journal:

Tetrahedron Letters

Year:

1975

Language:

english

File:

PDF, 216 KB

english, 1975

78

Altohyrtin A, a potent anti-tumor macrolide from the Okinawan marine sponge Hyrtios altum

Motomasa Kobayashi, Shunji Aoki, Haruhiko Sakai, Kazuyoshi Kawazoe, Noriaki Kihara, Takuma Sasaki, Isao Kitagawa

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 257 KB

english, 1993

79

Four new prostanoids: Claviridenone-A, -B, -C, and -D from the okinawan soft coral Clavularia viridis

Motomasa Kobayashi, Tohru Yasuzawa, Minoru Yoshihara, Hideo Akutsu, Yoshimasa Kyogoku, Isao Kitagawa

Journal:

Tetrahedron Letters

Year:

1982

Language:

english

File:

PDF, 291 KB

english, 1982

80

Absolute stereostructures of halenaquinol and halenaquinol sulfate, pentacyclic hydroquinones from the okinawan marine sponge xestospongia sapra, as determined by theoretical calculation of CD spectra

Motomasa Kobayashi, Nobuyoshi Shimizu, Isao Kitagawa, Yoshimasa Kyogoku, Nobuyuki Harada, Hisashi Uda

Journal:

Tetrahedron Letters

Year:

1985

Language:

english

File:

PDF, 273 KB

english, 1985

81

Structure of swinholide A, a potent cytotoxic macrolide from the Okinawan marine sponge Theonella Swinhoei

Motomasa Kobayashi, Jun-ichi Tanaka, Taketo Katori, Miki Matsuura, Isao Kitagawa

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 270 KB

english, 1989

82

Aragupetrosine a, a new vasodilative macrocyclic quinolizidine alkaloid from an Okinawan marine sponge Xestospongia sp

Motomasa Kobayashi, Kazuyoshi Kawazoe, Isao Kitagawa

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 265 KB

english, 1989

83

Total synthesis of lembehyne A, a neuritogenic spongean polyacetylene

Nobutoshi Murakami, Tatsuo Nakajima, Motomasa Kobayashi

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 75 KB

english, 2001

84

Facile construction of 6-carbomethoxymethyl-3-methoxy-1,2-dioxane, a core structure of spongean anti-malarial peroxides

Nobutoshi Murakami, Motoyuki Kawanishi, Sawako Itagaki, Toshihiro Horii, Motomasa Kobayashi

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 93 KB

english, 2001

85

Neodolabelline, a methyl migrated dolabellane-type diterpene from the okinawan soft coral clavularia koellikeri

Motomasa Kobayashi, Byeng Wha Son, Takaji Fujiwara, Yoshimasa Kyogoku, Isao Kitagawa

Journal:

Tetrahedron Letters

Year:

1984

Language:

english

File:

PDF, 289 KB

english, 1984

86

Stoloniferone-a, -b, -c, and -d, four new cytotoxic steroids from the okinawan soft coral clavularia viridis

Motomasa Kobayashi, Nam Kyung Lee, Byeng Wha Son, Kazunori Yanag, Yoshimasa Kyogoku, Isao Kitagawa

Journal:

Tetrahedron Letters

Year:

1984

Language:

english

File:

PDF, 298 KB

english, 1984

87

Alcyonolide, a novel diterpenoid from a soft coral

Motomasa Kobayashi, Tohru Yasuzawa, Yuji Kobayashi, Yoshimasa Kyogoku, Isao Kitagawa

Journal:

Tetrahedron Letters

Year:

1981

Language:

english

File:

PDF, 207 KB

english, 1981

88

On the structure of the major saponin from the starfish acanthaster planci

Isao Kitagawa, Motomasa Kobayashi

Journal:

Tetrahedron Letters

Year:

1977

Language:

english

File:

PDF, 233 KB

english, 1977

89

Callystatin A, a potent cytotoxic polyketide from the marine sponge, Callyspongia truncata

Motomasa Kobayashi, Kouichi Higuchi, Nobutoshi Murakami, Hisashi Tajima, Shunji Aoki

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 205 KB

english, 1997

90

Absolute stereostructure of callystatin A, a potent cytotoxic polyketide from the marine sponge, Callyspongia truncata

Nobutoshi Murakami, Weiqi Wang, Masashi Aoki, Yasuhiro Tsutsui, Kouichi Higuchi, Shunji Aoki, Motomasa Kobayashi

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 223 KB

english, 1997

91

Total synthesis of callystatin A, a potent cytotoxic polyketide from the marine sponge, Callyspongia truncata

Nobutoshi Murakami, Weiqi Wang, Masashi Aoki, Yasuhiro Tsutsui, Masanori Sugimoto, Motomasa Kobayashi

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 308 KB

english, 1998

92

Agosterol A, a novel polyhydroxylated sterol acetate reversing multidrug resistance from a marine sponge of Spongia sp.

Shunji Aoki, Yasuhiro Yoshioka, Yasuhisa Miyamoto, Kouichi Higuchi, Andi Setiawan, Nobutoshi Murakami, Zhe-Sheng Chen, Tomoyuki Sumizawa, Shin-ichi Akiyama, Motomasa Kobayashi

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 228 KB

english, 1998

93

Absolute stereostructure and total synthesis of leptomycin B

Motomasa Kobayashi, Weiqi Wang, Yasuhiro Tsutsui, Masanori Sugimoto, Nobutoshi Murakami

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 248 KB

english, 1998

94

Synthesis and biological property of carba and 20-Deoxo analogues of arenastatin A

Nobutoshi Murakami, Weiqi Wang, Satoru Tamura, Motomasa Kobayashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 198 KB

english, 2000

95

Synthesis and evaluation of 4-deacetoxyagosterol A as an MDR-modulator

Nobutoshi Murakami, Masanori Sugimoto, Mari Morita, Shin-ichi Akiyama, Motomasa Kobayashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 155 KB

english, 2000

96

New multidrug resistance modulators from atractylodis lanceae rhizoma

Nobutoshi Murakami, Etsuko Iwata, Satoru Tamura, Shin-ichi Akiyama, Motomasa Kobayashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 138 KB

english, 2000

97

New anti-malarial flavonol glycoside from hydrangeae dulcis folium

Nobutoshi Murakami, Huq Mohammad Mostaqul, Satoru Tamura, Sawako Itagaki, Toshihiro Horii, Motomasa Kobayashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 100 KB

english, 2001

98

New readily accessible peroxides with High Anti-malarial Potency

Nobutoshi Murakami, Motoyuki Kawanishi, Sawako Itagaki, Toshihiro Horii, Motomasa Kobayashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 115 KB

english, 2002

99

New Rev-transport inhibitor with anti-HIV activity from Valerianae Radix

Nobutoshi Murakami, Ying Ye, Motoyuki Kawanishi, Shunji Aoki, Nobuaki Kudo, Minoru Yoshida, Emi E. Nakayama, Tatsuo Shioda, Motomasa Kobayashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 137 KB

english, 2002

100

Facilely accessible multidrug resistance modulator derived from sucrose

Nobutoshi Murakami, Satoru Tamura, Etsuko Iwata, Shunji Aoki, Shin-ichi Akiyama, Motomasa Kobayashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 122 KB

english, 2002

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