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51

A new era of GPCR structural and chemical biology

Granier, Sébastien, Kobilka, Brian

Journal:

Nature Chemical Biology

Year:

2012

Language:

english

File:

PDF, 965 KB

english, 2012

52

High-Resolution Crystal Structure of an Engineered Human 2-Adrenergic G Protein Coupled Receptor

Cherezov, V., Rosenbaum, D. M., Hanson, M. A., Rasmussen, S. G. F., Thian, F. S., Kobilka, T. S., Choi, H.-J., Kuhn, P., Weis, W. I., Kobilka, B. K.

Journal:

Year:

2007

Language:

english

File:

PDF, 752 KB

english, 2007

53

Synthesis of 3,7-diiodo-2,6-di(thiophen-2-yl)benzo[1,2-b:4,5-b′]difurans: functional building blocks for the design of new conjugated polymers

Kobilka, Brandon M., Dubrovskiy, Anton V., Ewan, Monique D., Tomlinson, Aimée L., Larock, Richard C., Chaudhary, Sumit, Jeffries-EL, Malika

Journal:

Chemical Communications

Year:

2012

Language:

english

File:

PDF, 1.22 MB

english, 2012

54

Molecular and cellular biology of adrenergic receptors

Journal:

Trends in Cardiovascular Medicine

Year:

1991

Language:

english

File:

PDF, 919 KB

english, 1991

55

Structural insights into G-protein-coupled receptor activation

William I Weis, Brian K Kobilka

Journal:

Current Opinion in Structural Biology

Year:

2008

Language:

english

File:

PDF, 936 KB

english, 2008

56

Nanobody stabilization of G protein-coupled receptor conformational states

Jan Steyaert, Brian K Kobilka

Journal:

Current Opinion in Structural Biology

Year:

2011

Language:

english

File:

PDF, 490 KB

english, 2011

57

Adrenergic Receptors From Molecular Structure to in vivo function

Lutz Hein, Brian K Kobilka

Journal:

Trends in Cardiovascular Medicine

Year:

1997

Language:

english

File:

PDF, 2.34 MB

english, 1997

58

Reconstitution of β2-adrenoceptor−GTP-binding-protein interaction in Sf9 cells : High coupling efficiency in a β2-adrenoceptor-Gsα fusion protein

Roland Seifert, Tae Weon Lee, Van T. Lam, Brian K. Kobilka

Journal:

Year:

1998

Language:

english

File:

PDF, 412 KB

english, 1998

59

Examining the efficiency of receptor/G-protein coupling with a cleavable β2-adrenoceptor–Gsα fusion protein

Roland Seifert, Katharina Wenzel-Seifert, Ulrik Gether, Van T. Lam, Brian K. Kobilka

Journal:

Year:

1999

Language:

english

File:

PDF, 472 KB

english, 1999

60

Role of Detergents in Conformational Exchange of a G Protein-coupled Receptor

Chung, K. Y., Kim, T. H., Manglik, A., Alvares, R., Kobilka, B. K., Prosser, R. S.

Journal:

Journal of Biological Chemistry

Year:

2012

Language:

english

File:

PDF, 1.34 MB

english, 2012

61

Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor

Kobilka, B., Matsui, H, Kobilka, T., Yang-Feng, T., Francke, U, Caron, M., Lefkowitz, R., Regan, J.

Journal:

Year:

1987

Language:

english

File:

PDF, 2.19 MB

english, 1987

62

Structure-based drug screening for G-protein-coupled receptors

Brian K. Shoichet, Brian K. Kobilka

Journal:

Trends in Pharmacological Sciences

Year:

2012

Language:

english

File:

PDF, 769 KB

english, 2012

63

The new biology of drug receptors

Robert J. Lefkowitz, Brian K. Kobilka, Marc G. Caron

Journal:

Biochemical Pharmacology

Year:

1989

Language:

english

File:

PDF, 876 KB

english, 1989

64

Adrenergic receptor signal transduction and regulation

L. Hein, B.K. Kobilka

Journal:

Neuropharmacology

Year:

1995

Language:

english

File:

PDF, 1.28 MB

english, 1995

65

G protein coupled receptor structure and activation

Brian K. Kobilka

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

2007

Language:

english

File:

PDF, 1.68 MB

english, 2007

66

Differential targeting and function of α2A and α2C adrenergic receptor subtypes in cultured sympathetic neurons

Patricia C. Brum, Carl M. Hurt, Olga G. Shcherbakova, Brian Kobilka, Timothy Angelotti

Journal:

Neuropharmacology

Year:

2006

Language:

english

File:

PDF, 4.40 MB

english, 2006

67

Ligand-Specific Interactions Modulate Kinetic, Energetic, and Mechanical Properties of the Human β2 Adrenergic Receptor

Michael Zocher, Juan J. Fung, Brian K. Kobilka, Daniel J. Müller

Journal:

Year:

2012

Language:

english

File:

PDF, 1.35 MB

english, 2012

68

Conformational complexity of G-protein-coupled receptors

Brian K. Kobilka, Xavier Deupi

Journal:

Trends in Pharmacological Sciences

Year:

2007

Language:

english

File:

PDF, 1.40 MB

english, 2007

69

New G-protein-coupled receptor crystal structures: insights and limitations

Brian Kobilka, Gebhard F.X. Schertler

Journal:

Trends in Pharmacological Sciences

Year:

2008

Language:

english

File:

PDF, 364 KB

english, 2008

70

Structural insights into adrenergic receptor function and pharmacology

Brian K. Kobilka

Journal:

Trends in Pharmacological Sciences

Year:

2011

Language:

english

File:

PDF, 843 KB

english, 2011

71

Efficient adenylyl cyclase activation by a β2-adrenoceptor-Giα2 fusion protein

Roland Seifert, Katharina Wenzel-Seifert, John M Arthur, Powell O Jose, Brian K Kobilka

Journal:

Biochemical and Biophysical Research Communications

Year:

2002

Language:

english

File:

PDF, 189 KB

english, 2002

72

Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome

Hiroyuki Sasamura, Lutz Hein, Jose E. Krieger, Richard E. Pratt, Brian K. Kobilka, Victor J. Dzau

Journal:

Biochemical and Biophysical Research Communications

Year:

1992

Language:

english

File:

PDF, 466 KB

english, 1992

73

Cloning and expression of the mouse homolog of the human α2-C2 adrenergic receptor

Andrzej J. Chruscinski, Richard E. Link, David A. Daunt, Greg S. Barsh, Brian K. Kobilka

Journal:

Biochemical and Biophysical Research Communications

Year:

1992

Language:

english

File:

PDF, 487 KB

english, 1992

74

Examination of ligand-induced conformational changes in the β2 adrenergic receptor

Brian Kobilka, Ulrik Gether, Roland Seifert, Sansan Lin, Pejman Ghanouni

Journal:

Year:

1998

Language:

english

File:

PDF, 354 KB

english, 1998

75

Neuropeptide Y receptor 1 (NPY-Y1) expression in human heart failure and heart transplantation

Lars Gullestad, Halfdan Aass, Heather Ross, Thor Ueland, Odd Geiran, John Kjekshus, Svein Simonsen, Michael Fowler, Brian Kobilka

Journal:

Journal of the Autonomic Nervous System

Year:

1998

Language:

english

File:

PDF, 165 KB

english, 1998

76

Gene targeting — homing in on α2-adrenoceptor-subtype function

E MacDonald, B.K Kobilka, M Scheinin

Journal:

Trends in Pharmacological Sciences

Year:

1997

Language:

english

File:

PDF, 381 KB

english, 1997

77

Gene targeting — homing in on α2-adrenoceptor-subtype function

Ewen MacDonald, Brian K. Kobilka, Mika Scheinin

Journal:

Trends in Pharmacological Sciences

Year:

1997

Language:

english

File:

PDF, 1.16 MB

english, 1997

78

Reply

Roland Seifert, Katharina Wenzel-Seifert, Brian K. Kobilka

Journal:

Trends in Pharmacological Sciences

Year:

2000

Language:

english

File:

PDF, 90 KB

english, 2000

79

GPCR–Gα fusion proteins: molecular analysis of receptor–G-protein coupling

Roland Seifert, Katharina Wenzel-Seifert, Brian K Kobilka

Journal:

Trends in Pharmacological Sciences

Year:

1999

Language:

english

File:

PDF, 199 KB

english, 1999

80

Behavioral and neurochemical characterization of α2A-adrenergic receptor knockout mice

J Lähdesmäki, J Sallinen, E MacDonald, B.K Kobilka, V Fagerholm, M Scheinin

Journal:

Year:

2002

Language:

english

File:

PDF, 388 KB

english, 2002

81

d-amphetamine and l-5-hydroxytryptophan-induced behaviours in mice with genetically-altered expression of the α2C-adrenergic receptor subtype

J Sallinen, A Haapalinna, T Viitamaa, B.K Kobilka, M Scheinin

Journal:

Year:

1998

Language:

english

File:

PDF, 225 KB

english, 1998

82

Alpha2C-adrenoceptor overexpression disrupts execution of spatial and non-spatial search patterns

M Björklund, J Sirviö, J Sallinen, M Scheinin, B.K Kobilka, P Riekkinen Jr

Journal:

Year:

1999

Language:

english

File:

PDF, 326 KB

english, 1999

83

ERK Plays a Regulatory Role in Induction of LTP by Theta Frequency Stimulation and Its Modulation by β-Adrenergic Receptors

Danny G Winder, Kelsey C Martin, Isabel A Muzzio, Daniel Rohrer, Andrzej Chruscinski, Brian Kobilka, Eric R Kandel

Journal:

Year:

1999

Language:

english

File:

PDF, 295 KB

english, 1999

84

Organization of -adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes

Shcherbakova, O. G., Hurt, C. M., Xiang, Y., Dell'Acqua, M. L., Zhang, Q., Tsien, R. W., Kobilka, B. K.

Journal:

The Journal of Cell Biology

Year:

2007

Language:

english

File:

PDF, 5.51 MB

english, 2007

85

Counting Low-Copy Number Proteins in a Single Cell

Huang, B., Wu, H., Bhaya, D., Grossman, A., Granier, S., Kobilka, B. K., Zare, R. N.

Journal:

Year:

2007

Language:

english

File:

PDF, 209 KB

english, 2007

86

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

Haga, Kazuko, Kruse, Andrew C., Asada, Hidetsugu, Yurugi-Kobayashi, Takami, Shiroishi, Mitsunori, Zhang, Cheng, Weis, William I., Okada, Tetsuji, Kobilka, Brian K., Haga, Tatsuya, Kobayashi, Takuya

Journal:

Year:

2012

Language:

english

File:

PDF, 1.18 MB

english, 2012

87

GPCR Engineering Yields High-Resolution Structural Insights into 2-Adrenergic Receptor Function

Rosenbaum, D. M., Cherezov, V., Hanson, M. A., Rasmussen, S. G. F., Thian, F. S., Kobilka, T. S., Choi, H.-J., Yao, X.-J., Weis, W. I., Stevens, R. C., Kobilka, B. K.

Journal:

Year:

2007

Language:

english

File:

PDF, 1.08 MB

english, 2007

88

Human β1- and β2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes

Thomas Frielle, Brian Kobilka, Robert J. Lefkowitz, Marc G. Caron

Journal:

Trends in Neurosciences

Year:

1988

Language:

english

File:

PDF, 522 KB

english, 1988

89

β-Adrenergic receptors and rhodopsin: shedding new light on an old subject

Robert J. Lefkowitz, Jeffrey L. Benovic, Brian Kobilka, Marc G. Caron

Journal:

Trends in Pharmacological Sciences

Year:

1986

Language:

english

File:

PDF, 625 KB

english, 1986

90

Primary structure of the mouse β1-adrenergic receptor gene

Jeffrey R. Jasper, Richard E. Link, Andrzej J. Chruscinski, Brian K. Kobilka, Daniel Bernstein

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

1993

Language:

english

File:

PDF, 194 KB

english, 1993

91

Disregulation of Akt associated with enhanced cardiotoxicity in β2-adrenergic receptor (AR) knockout mice: possible mechanism of crosstalk between β-receptors and HER2 in anthracycline cardiotoxicity

Daniel Bernstein, Mingming Zhao, Jennifer Powers, Giovanni Fajardo, Brian Kobilka

Journal:

Journal of Cardiac Failure

Year:

2003

Language:

english

File:

PDF, 50 KB

english, 2003

92

Identification of GPCR-Interacting Cytosolic Proteins Using HDL Particles and Mass Spectrometry-Based Proteomic Approach

Chung, Ka Young, Day, Peter W., Vélez-Ruiz, Gisselle, Sunahara, Roger K., Kobilka, Brian K., Marchese, Adriano

Journal:

Year:

2013

Language:

english

File:

PDF, 553 KB

english, 2013

93

The Structural Basis of G-Protein-Coupled Receptor Signaling (Nobel Lecture)

Journal:

Angewandte Chemie International Edition

Year:

2013

Language:

english

File:

PDF, 2.51 MB

english, 2013

94

Influence of heteroatoms on photovoltaic performance of donor–acceptor copolymers based on 2,6-di(thiophen-2-yl)benzo[1,2-b:4,5-b′]difurans and diketopyrrolopyrrole

Kobilka, Brandon M., Hale, Benjamin J., Ewan, Monique D., Dubrovskiy, Anton V., Nelson, Toby L., Duzhko, Volodimyr, Jeffries-EL, Malika

Journal:

Polymer Chemistry

Year:

2013

Language:

english

File:

PDF, 2.67 MB

english, 2013

95

The Role of Ligands on the Equilibria Between Functional States of a G Protein-Coupled Receptor

Kim, Tae Hun, Chung, Ka Young, Manglik, Aashish, Hansen, Alexandar L., Dror, Ron O., Mildorf, Thomas J., Shaw, David E., Kobilka, Brian K., Prosser, R. Scott

Journal:

Journal of the American Chemical Society

Year:

2013

Language:

english

File:

PDF, 2.59 MB

english, 2013

96

Analysis of Biomolecular Interactions Using a Miniaturized Surface Plasmon Resonance Sensor

Whelan, Rebecca J., Wohland, Thorsten, Neumann, Lars, Huang, Bo, Kobilka, Brian K., Zare, Richard N.

Journal:

Analytical Chemistry

Year:

2002

Language:

english

File:

PDF, 134 KB

english, 2002

97

Correction to “Tandem Facial Amphiphiles for Membrane Protein Stabilization”

Chae, Pil Seok, Gotfryd, Kamil, Pacyna, Jennifer, Miercke, Larry J. W., Rasmussen, Søren G. F., Robbins, Rebecca A., Rana, Rohini R., Loland, Claus J., Kobilka, Brian, Stroud, Robert, Byrne, Bernadett

Journal:

Journal of the American Chemical Society

Year:

2013

Language:

english

File:

PDF, 424 KB

english, 2013

98

Tandem Facial Amphiphiles for Membrane Protein Stabilization

Chae, Pil Seok, Gotfryd, Kamil, Pacyna, Jennifer, Miercke, Larry J. W., Rasmussen, Søren G. F., Robbins, Rebecca A., Rana, Rohini R., Loland, Claus J., Kobilka, Brian, Stroud, Robert, Byrne, Bernadett

Journal:

Journal of the American Chemical Society

Year:

2010

Language:

english

File:

PDF, 422 KB

english, 2010

99

Ligand Stabilization of the β 2 Adrenergic Receptor: Effect of DTT on Receptor Conformation Monitored by Circular Dichroism and Fluorescence Spectroscopy †

Lin, Sansan, Gether, Ulrik, Kobilka, Brian K.

Journal:

Year:

1996

Language:

english

File:

PDF, 482 KB

english, 1996

100

Cardiovascular Regulation in Mice Lacking alpha 2-Adrenergic Receptor Subtypes b and c

Link, R. E., Desai, K., Hein, L., Stevens, M. E., Chruscinski, A., Bernstein, D., Barsh, G. S., Kobilka, B. K.

Journal:

Year:

1996

Language:

english

File:

PDF, 634 KB

english, 1996