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1

The effect of ABT-702, a novel adenosine kinase inhibitor, on the responses of spinal neurones following carrageenan inflammation and peripheral nerve injury

Rie Suzuki, Louise C Stanfa, Elizabeth A Kowaluk, Michael Williams, Michael F Jarvis, Anthony H Dickenson

Journal:

British Journal of Pharmacology

Year:

2001

Language:

english

File:

PDF, 162 KB

english, 2001

2

A-134974: a novel adenosine kinase inhibitor, relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats

Chang Z Zhu, Joe Mikusa, Katharine L Chu, Marlon Cowart, Elizabeth A Kowaluk, Michael F Jarvis, Steve McGaraughty

Journal:

Year:

2001

Language:

english

File:

PDF, 181 KB

english, 2001

3

Design, Synthesis, and Structure−Activity Relationship of 6-Alkynylpyrimidines as Potent Adenosine Kinase Inhibitors

Gomtsyan, Arthur, Didomenico, Stanley, Lee, Chih-Hung, Matulenko, Mark A., Kim, Ki, Kowaluk, Elizabeth A., Wismer, Carol T., Mikusa, Joe, Yu, Haixia, Kohlhaas, Kathy, Jarvis, Michael F., Bhagwat, Shri

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 149 KB

english, 2002

4

Lack of specificity of [35S]-ATPγS and [35S]-ADPβS as radioligands for ionotropic and metabotropic P2 receptor binding

Haixia Yu, Bruce Bianchi, Randy Metzger, Kevin J. Lynch, Elizabeth A. Kowaluk, Michael F. Jarvis, Tim van Biesen

Journal:

Drug Development Research

Year:

1999

Language:

english

File:

PDF, 316 KB

english, 1999

5

ChemInform Abstract: Emerging Molecular Approaches to Pain Therapy

Michael Williams, Elizabeth A. Kowaluk, Stephen P. Arneric

Journal:

Year:

1999

File:

PDF, 24 KB

1999

6

ChemInform Abstract: Synthesis and Biological Evaluation of Clitocine Analogues as Adenosine Kinase Inhibitors.

Chih-Hung Lee, Jerome F. Daanen, Meiqun Jiang, Haixia Yu, Kathy L. Kohlhaas, Karen Alexander, Michael F. Jarvis, Elizabeth L. Kowaluk, Shirpad S. Bhagwat

Journal:

Year:

2001

File:

PDF, 30 KB

2001

7

Synthesis and Structure—Activity Relationships of 5-Heteroatom-Substituted Pyridopyrimidines as Adenosine Kinase Inhibitors.

Gregory A. Gfesser, Erol K. Bayburt, Marlon Cowart, Stanley DiDomenico, Arthur Gomtsyan, Chih-Hung Lee, Andrew O. Stewart, Michael F. Jarvis, Elizabeth A. Kowaluk, Shripad S. Bhagwat

Journal:

Year:

2003

File:

PDF, 177 KB

2003

8

Synthesis and Biological Evaluation of Pteridine and Pyrazolopyrimidine Based Adenosine Kinase Inhibitors.

Arthur Gomtsyan, Stanley Didomenico, Chih-Hung Lee, Andrew O. Stewart, Shripad S. Bhagwat, Elizabeth A. Kowaluk, Michael F. Jarvis

Journal:

Year:

2004

File:

PDF, 34 KB

2004

9

Pharmacological characterization of P2X3 homomeric and heteromeric channels in nociceptive signaling and behavior

Michael F. Jarvis, Elizabeth A. Kowaluk

Journal:

Drug Development Research

Year:

2001

Language:

english

File:

PDF, 210 KB

english, 2001

10

Dynamics of clomethiazole edisylate interaction with plastic infusion systems

Elizabeth A. Kowaluk, Michael S. Roberts, Alan E. Polack

Journal:

Journal of Pharmaceutical Sciences

Year:

1984

Language:

english

File:

PDF, 588 KB

english, 1984

11

Comparison of models describing the sorption of nitroglycerin and diazepam by plastic infusion systems: Diffusion and compartment models

Elizabeth A. Kowaluk, Michael S. Roberts, Alan E. Polack

Journal:

Journal of Pharmaceutical Sciences

Year:

1985

Language:

english

File:

PDF, 963 KB

english, 1985

12

Kinetics of sorption of lonizable solutes by plastic infusion bags

Elizabeth A. Kowaluk, Michael S. Roberts, Alan E. Polack

Journal:

Journal of Pharmaceutical Sciences

Year:

1986

Language:

english

File:

PDF, 870 KB

english, 1986

13

Prediction of solute sorption by polyvinyl chloride plastic infusion bags

Michael S. Roberts, Elizabeth A. Kowaluk, Alan E. Polack

Journal:

Journal of Pharmaceutical Sciences

Year:

1991

Language:

english

File:

PDF, 751 KB

english, 1991

14

Synthesis of phosphorus-containing amino acid analogs as inhibitors of nitric oxide synthase

Marlon Cowart, Elizabeth A. Kowaluk, Kathy L. Kohlhaas, Karen M. Alexander, James F. Kerwin Jr.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 190 KB

english, 1996

15

Synthesis and biological evaluation of clitocine analogues as adenosine kinase inhibitors

Chih-Hung Lee, Jerome F Daanen, Meiqun Jiang, Haixia Yu, Kathy L Kohlhaas, Karen Alexander, Michael F Jarvis, Elizabeth L Kowaluk, Shripad S Bhagwat

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 128 KB

english, 2001

16

Synthesis and biological evaluation of 6,7-disubstituted 4-aminopyrido[2,3-d]pyrimidines as adenosine kinase inhibitors

Richard J. Perner, Chih-Hung Lee, Meiqun Jiang, Yu-Gui Gu, Stanley DiDomenico, Erol K. Bayburt, Karen M. Alexander, Kathy L. Kohlhaas, Michael F. Jarvis, Elizabeth L. Kowaluk, Shripad S. Bhagwat

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 210 KB

english, 2005

17

Synthesis and structure-activity relationships of 5-heteroatom-substituted pyridopyrimidines as adenosine kinase inhibitors

Gregory A Gfesser, Erol K Bayburt, Marlon Cowart, Stanley DiDomenico, Arthur Gomtsyan, Chih-Hung Lee, Andrew O Stewart, Michael F Jarvis, Elizabeth A Kowaluk, Shripad S Bhagwat

Journal:

European Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 423 KB

english, 2003

18

Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X3 allosteric modulator, cibacron blue

Michael F Jarvis, Carol T Wismer, Edmund Schweitzer, Haixia Yu, Tim Van Biesen, Kevin J Lynch, Edward C Burgard, Elizabeth A Kowaluk

Journal:

British Journal of Pharmacology

Year:

2001

Language:

english

File:

PDF, 282 KB

english, 2001

19

Synthesis and biological evaluation of pteridine and pyrazolopyrimidine based adenosine kinase inhibitors

Arthur Gomtsyan, Stanley Didomenico, Chih-Hung Lee, Andrew O Stewart, Shripad S Bhagwat, Elizabeth A Kowaluk, Michael F Jarvis

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 262 KB

english, 2004

20

Biochemical mechanism of organic nitrate action

Ho-Leung Fung, Suk-Jae Chung, John Anthony Bauer, Saeho Chong, Elizabeth A. Kowaluk

Journal:

The American Journal of Cardiology

Year:

1992

Language:

english

File:

PDF, 833 KB

english, 1992

21

An adenosine kinase inhibitor attenuates tactile allodynia in a rat model of diabetic neuropathic pain

James J Lynch III, Michael F Jarvis, Elizabeth A Kowaluk

Journal:

European Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 126 KB

english, 1999

22

ABT-627, an endothelin ETA receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain

Michael F Jarvis, Jerry L Wessale, Chang Z Zhu, James J Lynch III, Brian D Dayton, Samuel V Calzadilla, Robert J Padley, Terry J Opgenorth, Elizabeth A Kowaluk

Journal:

European Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 237 KB

english, 2000

23

Comparison of the ability of adenosine kinase inhibitors and adenosine receptor agonists to attenuate thermal hyperalgesia and reduce motor performance in rats

Michael F Jarvis, Joe Mikusa, Katharine L Chu, Carol T Wismer, Prisca Honore, Elizabeth A Kowaluk, Steve McGaraughty

Journal:

Pharmacology Biochemistry and Behavior

Year:

2002

Language:

english

File:

PDF, 203 KB

english, 2002

24

Characterization of the Effects of Adenosine Kinase Inhibitors on Acute Thermal Nociception in Mice

Elizabeth A Kowaluk, Kathy L Kohlhaas, Anthony Bannon, Karen Gunther, James J Lynch III, Michael F Jarvis

Journal:

Pharmacology Biochemistry and Behavior

Year:

1999

Language:

english

File:

PDF, 246 KB

english, 1999

25

Discovery of 4-Amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine, an Orally Active, Non-Nucleoside Adenosine Kinase Inhibitor

Lee, Chih-Hung, Jiang, Meiqun, Cowart, Marlon, Gfesser, Greg, Perner, Richard, Kim, Ki Hwan, Gu, Yu Gui, Williams, Michael, Jarvis, Michael F., Kowaluk, Elizabeth A.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 156 KB

english, 2001

26

Cloning and Expression of the Adenosine Kinase Gene from Rat and Human Tissues

Teresa McNally, Rosalind J. Helfrich, Marlon Cowart, Sarah A. Dorwin, Joseph L. Meuth, Kenneth B. Idler, Kimberly A. Klute, Robert L. Simmer, Elizabeth A. Kowaluk, Donald N. Halbert

Journal:

Biochemical and Biophysical Research Communications

Year:

1997

Language:

english

File:

PDF, 226 KB

english, 1997

27

Tolerance to relaxation in rat aorta: comparison of an S-nitrpsothiol with nitroglycerin

Elizabeth A. Kowaluk, Roman Poliszczuk, Ho-Leung Fung

Journal:

European Journal of Pharmacology

Year:

1987

Language:

english

File:

PDF, 409 KB

english, 1987

28

Dissociation of nitrovasodilator-induced relaxation from cyclic GMP levels during in vitro nitrate tolerance

Elizabeth A. Kowaluk, Ho-Leung Fung

Journal:

European Journal of Pharmacology

Year:

1990

Language:

english

File:

PDF, 398 KB

english, 1990

29

Adenosine kinase inhibition protects brain against transient focal ischemia in rats

Ning Jiang, Elizabeth A Kowaluk, Chi-Hung Lee, Hormoz Mazdiyasni, Michael Chopp

Journal:

European Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 203 KB

english, 1997

30

Inhibition of adenosine kinase during oxygen-glucose deprivation in rat cortical neuronal cultures

James J Lynch III, Karen M Alexander, Michael F Jarvis, Elizabeth A Kowaluk

Journal:

Neuroscience Letters

Year:

1998

Language:

english

File:

PDF, 146 KB

english, 1998

31

Site and event specific increase of striatal adenosine release by adenosine kinase inhibition in rats

Donald R. Britton, Joe Mikusa, Chih-Hung Lee, Michael F. Jarvis, Michael Williams, Elizabeth A. Kowaluk

Journal:

Neuroscience Letters

Year:

1999

Language:

english

File:

PDF, 133 KB

english, 1999

32

Effect of intermittent exposure and drug-free intervals on the in vitro vascular tolerance to nitroglycerin

Elizabeth Kowaluk, Keith Hough, Ho-Leung Fung

Journal:

Year:

1989

Language:

english

File:

PDF, 452 KB

english, 1989

33

Pharmacological characterization of recombinant human and rat P2X receptor subtypes

Bruce R Bianchi, Kevin J Lynch, Edward Touma, Wende Niforatos, Edward C Burgard, Karen M Alexander, Helen S Park, Haixia Yu, Randy Metzger, Elizabeth Kowaluk, Michael F Jarvis, Tim van Biesen

Journal:

European Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 320 KB

english, 1999

34

Emerging Molecular Approaches to Pain Therapy

Williams, Michael, Kowaluk, Elizabeth A., Arneric, Stephen P.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 931 KB

english, 1999

35

5,6,7-Trisubstituted 4-Aminopyrido[2,3- d ]pyrimidines as Novel Inhibitors of Adenosine Kinase

Perner, Richard J., Gu, Yu-Gui, Lee, Chih-Hung, Bayburt, Erol K., McKie, Jeffery, Alexander, Karen M., Kohlhaas, Kathy L., Wismer, Carol T., Mikusa, Joe, Jarvis, Michael F., Kowaluk, Elizabeth A., Bha

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 151 KB

english, 2003

36

Nitroaromatic Amino Acids as Inhibitors of Neuronal Nitric Oxide Synthase

Cowart, Marlon, Kowaluk, Elizabeth A., Daanen, Jerome F., Kohlhaas, Kathy L., Alexander, Karen M., Wagenaar, Frank L., Kerwin, James F.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 186 KB

english, 1998

37

Adenosine modulation: a novel approach to analgesia and inflammation

Kowaluk, Elizabeth A

Journal:

Expert Opinion on Investigational Drugs

Year:

1998

Language:

english

File:

PDF, 123 KB

english, 1998

38

Therapeutic potential of adenosine kinase inhibitors

Kowaluk, Elizabeth A, Jarvis, Michael F

Journal:

Expert Opinion on Investigational Drugs

Year:

2000

Language:

english

File:

PDF, 209 KB

english, 2000

39

Opportunities in pain therapy:beyond the opioids and NSAIDs

Kowaluk, Elizabeth A, Arneric, Stephen P, Williams, Michael

Journal:

Expert Opinion on Emerging Drugs

Year:

1998

File:

PDF, 1.49 MB

1998

40

Opportunities in pain therapy:beyond the opioids and NSAIDs

Kowaluk, Elizabeth A, Arneric, Stephen P, Williams, Michael

Journal:

Expert Opinion on Emerging Drugs

Year:

1998

Language:

english

File:

PDF, 1.49 MB

english, 1998

41

[Annual Reports in Medicinal Chemistry] Volume 33 || Novel Molecular Approaches to Analgesia

Kowaluk, Elizabeth A.

Year:

1998

Language:

english

File:

PDF, 830 KB

english, 1998

42

[Annual Reports in Medicinal Chemistry] Volume 35 || Chapter 3. Recent advances in development of novel analgesics

Kowaluk, Elizabeth A.

Year:

2000

Language:

english

File:

PDF, 731 KB

english, 2000

43

Molecular and Functional Characterization of Human P2X 2 Receptors

Lynch, Kevin J., Touma, Edward, Niforatos, Wende, Kage, Karen L., Burgard, Edward C., van Biesen, Tim, Kowaluk, Elizabeth A., Jarvis, Michael F.

Journal:

Molecular Pharmacology

Year:

1999

Language:

english

File:

PDF, 445 KB

english, 1999

44

Interactions between drugs and intravenous delivery systems

Kowaluk, Elizabeth A., Roberts, Michael S., Polack, Alan E.

Journal:

American Journal of Health-System Pharmacy

Year:

1982

Language:

english

File:

PDF, 984 KB

english, 1982

45

P2X Receptor–Mediated Ionic Currents in Dorsal Root Ganglion Neurons

Burgard, Edward C., Niforatos, Wende, van Biesen, Tim, Lynch, Kevin J., Touma, Edward, Metzger, Randy E., Kowaluk, Elizabeth A., Jarvis, Michael F.

Journal:

Journal of Neurophysiology

Year:

1999

Language:

english

File:

PDF, 215 KB

english, 1999

46

Factors Affecting the Availability of Diazepam Stored in Plastic Bags and Administered Through Intravenous Sets

Kowaluk, Elizabeth A., Roberts, Michael S., Polack, Alan E.

Journal:

American Journal of Health-System Pharmacy

Year:

1983

File:

PDF, 832 KB

1983

47

Drug Loss in Polyolefin Infusion Systems

Kowaluk, Elizabeth A., Roberts, Michael S., Polack, Alan E.

Journal:

American Journal of Health-System Pharmacy

Year:

1983

Language:

english

File:

PDF, 174 KB

english, 1983

48

Drug Loss in Polyolefin Infusion Systems

Kowaluk, Elizabeth A., Roberts, Michael S., Polack, Alan E.

Journal:

American Journal of Health-System Pharmacy

Year:

1983

File:

PDF, 174 KB

1983