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51

Chemistry and Pharmacology of Nicotinic Ligands Based on 6-[5-(Azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol (AMOP-H-OH) for Possible Use in Depression

Alan P. Kozikowski, J. Brek Eaton, Krishna Mohan Bajjuri, Sheela K. Chellappan, Yihua Chen, Sudhakar Karadi, Rong He, Barbara Caldarone, Michael Manzano, Po-Wai Yuen, Ronald J. Lukas

Journal:

Year:

2009

Language:

english

File:

PDF, 448 KB

english, 2009

52

Synthesis of (±)-10,10-dimethylhuperzine A — a huperzine analogue possessing a slower enzyme off-rate

Alan P. Kozikowski, Qingjie Ding, Ashima Saxena, Bhupendra P. Doctor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 284 KB

english, 1996

53

Chemical synthesis and biological evaluation of 1d-1,2,4,5-InsP4 and its 3-fluorinated counterpart 1d-3-F-1,2,4,5-InsP4 — potent 1d-1,4,5-InsP3-like calcium mobilizing analogues

Alan P. Kozikowski, Abdul H. Fauq, Robert A. Wilcox, Stefan R. Nahorski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 321 KB

english, 1995

54

Efficient Coupling reactions of β-Amino and β-Acetamido Radicals with Electron Deficient Alkenes - Aza-Carbofunctionalization of Olefins - A Promising New Tool for Alkaloid Synthesis.

Alan P. Kozikowski, James Scripko

Journal:

Tetrahedron Letters

Year:

1983

Language:

english

File:

PDF, 234 KB

english, 1983

55

Metalation of 2,2-dimethyl-5-methylene-1,3-dioxane---a functionalized allyloxy carbanion.

Alan P. Kozikowski, Kimiaki Isobe

Journal:

Tetrahedron Letters

Year:

1979

Language:

english

File:

PDF, 178 KB

english, 1979

56

Synthesis of cyclic sphingosine 1,3-phosphate (cSPP) through a photolytic reaction

Lixin Qiao, Alan P. Kozikowski

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 232 KB

english, 1998

57

Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

Butler, Kyle V., Kalin, Jay, Brochier, Camille, Vistoli, Guilio, Langley, Brett, Kozikowski, Alan P.

Journal:

Journal of the American Chemical Society

Year:

2010

Language:

english

File:

PDF, 252 KB

english, 2010

58

Further Structure−Activity Relationship Studies of Piperidine-Based Monoamine Transporter Inhibitors: Effects of Piperidine Ring Stereochemistry on Potency. Identification of Norepinephrine Transporter Selective Ligands and Broad-Spectrum Transporter Inhibitors

He, Rong, Kurome, Toru, Giberson, Kelly M., Johnson, Kenneth M., Kozikowski, Alan P.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 168 KB

english, 2005

59

A novel potassium hydride induced reorganization reaction. Synthesis of condensed heterocycles

Kozikowski, Alan P., Kuniak, Michael P.

Journal:

Journal of Organic Chemistry

Year:

1978

Language:

english

File:

PDF, 223 KB

english, 1978

60

Identification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, That Prolongs the Median Survival Time of Δ7 SMA KO Mouse Model of Spinal Muscular Atrophy

Chen, Po C., Gaisina, Irina N., El-Khodor, Bassem F., Ramboz, Sylvie, Makhortova, Nina R., Rubin, Lee L., Kozikowski, Alan P.

Journal:

ACS Chemical Neuroscience

Year:

2012

Language:

english

File:

PDF, 2.26 MB

english, 2012

61

Synthesis of an alleged constituent of New Brunswick cranberry leaves: the so-called cannivonine

Kozikowski, Alan P., Schmiesing, Richard J.

Journal:

Journal of Organic Chemistry

Year:

1983

Language:

english

File:

PDF, 4.81 MB

english, 1983

62

Lewis acid assisted condensations between a 5-methoxyisoxazolidine and silicon-based nucleophiles: .gamma.-amino alcohol building block in the synthesis of agroclavine I

Kozikowski, Alan P., Stein, Philip D.

Journal:

Journal of the American Chemical Society

Year:

1985

Language:

english

File:

PDF, 305 KB

english, 1985

63

Structure-Based Design of a New Class of Protein Kinase C Modulators

Qiao, Lixin, Wang, Shaomeng, George, Clifford, Lewin, Nancy E., Blumberg, Peter M., Kozikowski, Alan P.

Journal:

Journal of the American Chemical Society

Year:

1998

Language:

english

File:

PDF, 90 KB

english, 1998

64

An approach to modified heterocyclic analogues of huperzine A and isohuperzine A. Synthesis of the pyrimidone and pyrazole analogues, and their anticholinesterase activity

Kozikowski, Alan P., Campiani, Giuseppe, Nacci, Vito, Sega, Alessandro, Saxena, Ashima, Doctor, Bhupendra P.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1996

Language:

english

File:

PDF, 1.61 MB

english, 1996

65

A total synthesis of actinobolin via the intermolecular Diels?Alder reaction of a threonine-derived diene

Kozikowski, Alan P., Konoike, Toshiro, Nieduzak, Thaddeus R.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1986

Language:

english

File:

PDF, 232 KB

english, 1986

66

Transition Metals in Organic Synthesis*

KOZIKOWSKI, Alan P., WETTER, Hansjürg F.

Journal:

Year:

1976

Language:

english

File:

PDF, 1.94 MB

english, 1976

67

Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51

Lv, Wei, Budke, Brian, Pawlowski, Michal, Connell, Philip P., Kozikowski, Alan P.

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.83 MB

english, 2016

68

Design and Synthesis of Mercaptoacetamides as Potent, Selective, and Brain Permeable Histone Deacetylase 6 Inhibitors

Lv, Wei, Zhang, Guangming, Barinka, Cyril, Eubanks, James H., Kozikowski, Alan P.

Journal:

ACS Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 575 KB

english, 2017

69

Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer

Suri, Amreena, Bailey, Anders W., Tavares, Maurício T., Gunosewoyo, Hendra, Dyer, Connor P., Grupenmacher, Alex T., Piper, David R., Horton, Robert A., Tomita, Tadanori, Kozikowski, Alan P., Roy, Sakt

Journal:

International Journal of Molecular Sciences

Year:

2019

Language:

english

File:

PDF, 2.56 MB

english, 2019

70

Active benzimidazole derivatives targeting the MmpL3 transporter in Mycobacterium abscessus

Raynaud, Clement, Daher, Wassim, Johansen, Matt, Roquet-Baneres, Françoise, Blaise, Mickael, Onajole, Oluseye K, Kozikowski, Alan, Herrmann, Jean-Louis, Dziadek, Jaroslaw, Gobis, Katarzyna, Kremer, La

Journal:

ACS Infectious Diseases

Year:

2019

Language:

english

File:

PDF, 1.36 MB

english, 2019

71

ChemInform Abstract: ORGANIC REACTIONS AT HIGH PRESSURE, CYCLOADDITIONS OF ENAMINES AND DIENAMINES

DAUBEN, WILLIAM G., KOZIKOWSKI, ALAN P.

Journal:

Chemischer Informationsdienst

Year:

1974

File:

PDF, 97 KB

1974

72

Synthesis of More Potent Analogues of the Acetylcholinesterase Inhibitor, Huperzine B.

V. Rajendran, Ashima Saxena, Bhupendra P. Doctor, Alan P. Kozikowski

Journal:

Year:

2002

File:

PDF, 33 KB

2002

73

Structural Remodeling of Cocaine: Design and Synthesis of Trisubstituted Cyclopropanes as Selective Serotonin Reuptake Inhibitors

Alan P. Kozikowski, Lianyun Zhao, Ao Zhang, Cheng Z. Wang, Judith Flippen-Anderson, Kenneth M. Johnson

Journal:

Year:

2006

Language:

english

File:

PDF, 210 KB

english, 2006

74

Palladium catalyzed synthesis of annelated indoles

Alan P. Kozikowski, Dawei Ma

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 218 KB

english, 1991

75

Synthesis, chiral chromatographic separation, and biological activities of the enantiomers of 10,10-dimethylhuperzine A

V Rajendran, K.R.C Prakash, Haresh S Ved, Ashima Saxena, Bhupendra P Doctor, Alan P Kozikowski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 129 KB

english, 2000

76

An enantioselective synthesis and biobehavioral evaluation of 7-fluoro-3-(p-fluorophenyl)-2-propyltropanes

K.R.C. Prakash, Monika Trzcinska, Kenneth M. Johnson, Alan P. Kozikowski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 149 KB

english, 2000

77

2,3-Disubstituted quinuclidines as a novel class of dopamine transporter inhibitors

Sukumar Sakamuri, Istvan J Enyedy, Wahiduz A Zaman, Srihari R Tella, Alan P Kozikowski, Judith L Flippen-Anderson, Tivadar Farkas, Kenneth M Johnson, Shaomeng Wang

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 481 KB

english, 2003

78

The intramolecular nitrile oxide cycloaddition (INOC) route to the ergot alkaloids: Use of the isoxazoline to γ-amino alcohol conversion in the total synthesis of (+)-paliclavine

Alan P. Kozikowski, Chen Yon-Yih, Wang B.C, Zhang-Bao Xu

Journal:

Year:

1984

Language:

english

File:

PDF, 1.06 MB

english, 1984

79

New synthesis and some selected reactions of the potential ergot alkaloid precursor indole-4-carboxaldehyde

Kozikowski, Alan P., Ishida, Hitoshi, Chen, Yon-Yih

Journal:

Journal of Organic Chemistry

Year:

1980

Language:

english

File:

PDF, 476 KB

english, 1980

80

Radiolabeling and biodistribution of methyl 2-(methoxycarbonyl)-2-(methylamino) bicyclo [2.1.1] - hexane -5-carboxylate, a potential neuroprotective drug

Meixiang Yu, Kjell Någren, Y.Iris Chen, Elijahu Livni, David Elmaleh, Alan Kozikowski, Xukui Wang, Kimmo Jokivarsi, Anna-Liisa Brownell

Journal:

Year:

2003

Language:

english

File:

PDF, 347 KB

english, 2003

81

A nitrile oxide based entry to 2,3-dihydropyran-4-ones. Synthesis of a protected version "compactin lactone" in racemic and optically active forms

Kozikowski, Alan P., Li, Chun Sing

Journal:

Journal of Organic Chemistry

Year:

1985

Language:

english

File:

PDF, 1.05 MB

english, 1985

82

Synthesis and Biology of the Conformationally Restricted ACPD Analogue, 2-Aminobicyclo[2.1.1]hexane-2,5-dicarboxylic Acid-I, a Potent mGluR Agonist

Kozikowski, Alan P., Steensma, Darryl, Araldi, Gian Luca, Tückmantel, Werner, Wang, Shaomeng, Pshenichkin, Sergey, Surina, Elena, Wroblewski, Jarda T.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 298 KB

english, 1998

83

Chemical Synthesis and Pharmacology of 6- and 7-Hydroxylated 2-Carbomethoxy-3-( p -tolyl)tropanes: Antagonism of Cocaine's Locomotor Stimulant Effects

Zhao, Lianyun, Johnson, Kenneth M., Zhang, Mei, Flippen-Anderson, Judith, Kozikowski, Alan P.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 289 KB

english, 2000

84

A Versatile Approach to PI(3,4)P 2 , PI(4,5)P 2 , and PI(3,4,5)P 3 from l -(−)-Quebrachitol

Qiao, Lixin, Hu, Youhong, Nan, Fajun, Powis, Garth, Kozikowski, Alan P.

Journal:

Organic Letters

Year:

2000

Language:

english

File:

PDF, 132 KB

english, 2000

85

Application of the Bivalent Ligand Approach to the Design of Novel Dimeric Serotonin Reuptake Inhibitors

Tamiz, Amir P., Zhang, Jianrong, Zhang, Mei, Wang, Cheng Z., Johnson, Kenneth M., Kozikowski, Alan P.

Journal:

Journal of the American Chemical Society

Year:

2000

Language:

english

File:

PDF, 93 KB

english, 2000

86

Synthetic Studies on the Stemona Alkaloids; Stereochemical Course of PhSe + -Induced Seven-Membered Ring Formation

Xiang, Li, Kozikowski, Alan P.

Journal:

Year:

1990

File:

PDF, 186 KB

1990

87

Synthesis of 4-Substituted Indoles and Their Elaboration to the Ergot Alkaloids

P. Kozikowski, Alan

Journal:

Year:

1981

Language:

english

File:

PDF, 407 KB

english, 1981

88

Identification of HDAC6-Selective Inhibitors of Low Cancer Cell Cytotoxicity

Gaisina, Irina N., Tueckmantel, Werner, Ugolkov, Andrey, Shen, Sida, Hoffen, Jessica, Dubrovskyi, Oleksii, Mazar, Andrew, Schoon, Renee A., Billadeau, Daniel, Kozikowski, Alan P.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.31 MB

english, 2016

89

Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus Infections

Kozikowski, Alan P., Onajole, Oluseye K, Stec, Jozef, Dupont, Christian, Viljoen, Albertus, Richard, Matthias, Chaira, Tridib, Lun, Shichun, Bishai, William R., Raj, V. Samuel, Ordway, Diane, Kremer,

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.63 MB

english, 2017

90

Novel TRH analog improves motor and cognitive recovery after traumatic brain injury in rodents

Faden, Alan I., Fox, Gerard B., Fan, Lei, Araldi, Gian Luca, Qiao, Lixin, Wang, Shaomeng, Kozikowski, Alan P.

Journal:

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology

Year:

1999

File:

PDF, 316 KB

1999

91

The preclinical candidate indole-2-carboxamide improves immune responses to Mycobacterium tuberculosis infection in healthy subjects and individuals with type 2 diabetes

Cao, Ruoqiong, Islamoglu, Hicret, Teskey, Garrett, Gyurjian, Karo, Abrahem, Rachel, Onajole, Oluseye K., Lun, Shichun, Bishai, William, Kozikowski, Alan P., Fraix, Marcel P., Sathananthan, Airani, Zho

Journal:

International Microbiology

Year:

2019

File:

PDF, 3.43 MB

2019

92

ChemInform Abstract: Enantioselective Deprotonation of the 8-Oxabicyclo[3.2.1]octan-3-one: Synthesis of 8-Oxa-norcocaines and 8-Oxa-pseudonorcocaines.

Daniele Simoni, Marinella Roberti, Riccardo Rondanin, Alan P. Kozikowski

Journal:

Year:

1999

File:

PDF, 35 KB

1999

93

ChemInform Abstract: Synthesis of 8-Oxa Analogues of Norcocaine Endowed with Interesting Cocaine-Like Activity.

Alan P. Kozikowski, Daniele Simoni, Marinella Roberti, Riccardo Rondanin, Shaomeng Wang, Pingfeng Du, Kenneth M. Johnson

Journal:

Year:

1999

Language:

english

File:

PDF, 32 KB

english, 1999

94

Synthesis and Pharmacological Evaluation of (Z)-9-(Heteroarylmethylene)-7-azatricyclo[4.3.1.03,7]decanes: Thiophene Analogues as Potent Norepinephrine Transporter Inhibitors.

Jia Zhou, Thomas Klaess, Ao Zhang, Kenneth M. Johnson, Cheng Z. Wang, Yanping Ye, Alan P. Kozikowski

Journal:

Year:

2004

File:

PDF, 104 KB

2004

95

Cover Picture: Design, Synthesis, and SAR Studies of Mefloquine-Based Ligands as Potential Antituberculosis Agents (ChemMedChem 6/2006)

Sarva Jayaprakash, Yasuyoshi Iso, Baojie Wan, Scott G. Franzblau, Alan P. Kozikowski

Journal:

Year:

2006

File:

PDF, 36 KB

2006

96

Synthesis of the Thiazolone Analogue of the Acetylcholinesterase Inhibitor, Huperzine A

Alan P. Kozikowski, Werner Tückmantel, Ashima Saxena, Bhupendra P. Doctor

Journal:

Helvetica Chimica Acta

Year:

1994

Language:

english

File:

PDF, 792 KB

english, 1994

97

Protection of alcohols as their (p-methoxybenzyloxy)methyl ethers.

Alan P. Kozikowski, Jiang-Ping Wu

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 180 KB

english, 1987

98

Use of the anomeric allylation reaction in natural products synthesis - a stereocontrolled synthesis of methyl deoxypseudomonate B.

Alan P. Kozikowski, Kirk L. Sorgi

Journal:

Tetrahedron Letters

Year:

1984

Language:

english

File:

PDF, 211 KB

english, 1984

99

Enantioselective deprotonation of the 8-oxabicyclo[3.2.1]octan-3-one: Synthesis of 8-oxa-norcocaines and 8-oxa-pseudonorcocaines

Daniele Simoni, Marinella Roberti, Riccardo Rondanin, Alan P. Kozikowski

Journal:

Tetrahedron Letters

Year:

1999

Language:

english

File:

PDF, 213 KB

english, 1999

100

Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine

Alexander Hoepping, John Babich, Jon A. Zubieta, Kenneth M. Johnson, Susanne Machill, Alan P. Kozikowski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 298 KB

english, 1999

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