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1

Synthesis of the staurosporine aglycone (K-252c) lactam regioisomer

Robert L. Hudkins, James L. Diebold

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 196 KB

english, 1997

2

Synthesis and Mixed Lineage Kinase Activity of Pyrrolocarbazole and Isoindolone Analogs of (+)K-252a

Hudkins, Robert L., Johnson, Neil W., Angeles, Thelma S., Gessner, George W., Mallamo, John P.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 156 KB

english, 2007

3

Pyrazole trk kinase inhibitors for the treatment of cancer

Hudkins, Robert L, Josef, Kurt A

Journal:

Expert Opinion on Therapeutic Patents

Year:

2007

Language:

english

File:

PDF, 145 KB

english, 2007

4

The Inflammatory Effect of Nucleus Pulposus

McCARRON, ROBERT F., WIMPEE, MARC W., HUDKINS, PHILIP G., LAROS, GERALD S.

Journal:

Year:

1987

File:

PDF, 502 KB

1987

5

Characterization of Opioid Receptors

DeHaven, Robert N., DeHaven-Hudkins, Diane L.

Journal:

Current Protocols in Pharmacology

Year:

2000

Language:

english

File:

PDF, 118 KB

english, 2000

6

ChemInform Abstract: Role of Neurotrophin-Trk Interactions in Oncology: The Antitumor Efficacy of Potent and Selective Trk Tyrosine Kinase Inhibitors in Pre-Clinical Tumor Models

Bruce A. Ruggeri, Shelia J. Miknyoczki, Jasbir Singh, Robert L. Hudkins

Journal:

Year:

1999

File:

PDF, 27 KB

1999

7

ChemInform Abstract: Synthesis of Benzo[b]thieno- and Benzo[b]furano[2,3-a]pyrrolo[3,4-c]carbazole-5-, -7- and -5,7-dione.

Robert L. Hudkins, Neil W. Johnson

Journal:

Year:

2001

File:

PDF, 30 KB

2001

8

ChemInform Abstract: Mixed Lineage Kinase Activity on Indolocarbazole Analogues.

Robert L. Hudkins, et al. et al.

Journal:

Year:

2002

File:

PDF, 34 KB

2002

9

A Simple Synthetic Protocol for the Protection of Amides, Lactams, Ureas, and Carbamates.

Dandu R. Reddy, Mohamed A. Iqbal, Robert L. Hudkins, Patricia A. Messina-McLaughlin, John P. Mallamo

Journal:

Year:

2003

File:

PDF, 119 KB

2003

10

Synthesis and Kinase Inhibitory Activity of 3′-(S)-epi-K-252a.

Diane E. Gingrich, Robert L. Hudkins

Journal:

Year:

2003

File:

PDF, 119 KB

2003

11

Synthesis of Indeno[2,1-a]pyrrolo[3,4-c]carbazole Lactam Regioisomers Using Ethyl cis-β-Cyanoacrylate as a Dienophile and Lactam Precursor.

Robert L. Hudkins, Chung Ho Park

Journal:

Year:

2003

File:

PDF, 196 KB

2003

12

ChemInform Abstract: Regioselective Synthesis of 2-Methyl-2,5,6,11,12,13-hexahydro 4H Indazolo[5,4-a]pyrrolo[3,4-c]carbazole-4-ones.

Ming Tao, Chung Ho Park, Kurt Josef, Robert L. Hudkins

Journal:

Year:

2010

File:

PDF, 45 KB

2010

13

ChemInform Abstract: 8-THP-DHI Analogues as Potent Type I Dual TIE-2/VEGF-R2 Receptor Tyrosine Kinase Inhibitors.

Robert L Hudkins, et al. et al.

Journal:

Year:

2010

File:

PDF, 19 KB

2010

14

ChemInform Abstract: A Facile and Efficient Synthesis of 3-Amino-5-bromopyridine Derivatives Using Microwave Irradiation.

Reddeppa Reddy Dandu, Adam C. Rose, Robert L. Hudkins

Journal:

Year:

2011

File:

PDF, 24 KB

2011

15

Regioselective synthesis of 2-methyl-2,5,6,11,12,13-hexahydro 4H indazolo[5,4-a]pyrrolo[3,4-c]carbazole-4-ones

Ming Tao, Chung Ho Park, Kurt Josef, Robert L. Hudkins

Journal:

Journal of Heterocyclic Chemistry

Year:

2009

Language:

english

File:

PDF, 109 KB

english, 2009

16

Synthesis of benzo[b]thieno- and benzo[b]furano-[2,3-a]pyrrolo[3,4-c]carbazole-5-, -7- and -5,7-dione

Robert L. Hudkins, Neil W. Johnson

Journal:

Journal of Heterocyclic Chemistry

Year:

2001

Language:

english

File:

PDF, 47 KB

english, 2001

17

Synthesis of indeno[2,1-a]pyrrolo[3,4-c]carbazole lactam regioisomers using ethyl cis-β-cyanoacrylate as a dienophile and lactam precursor

Robert L. Hudkins, Chung Ho Park

Journal:

Journal of Heterocyclic Chemistry

Year:

2003

Language:

english

File:

PDF, 114 KB

english, 2003

18

Structure determination of N-methyl-tetrahydro-5H-indazol-5-ones

Kurt A. Josef, Reddeppareddy Dandu, Ming Tao, Robert L. Hudkins

Journal:

Journal of Heterocyclic Chemistry

Year:

2006

Language:

english

File:

PDF, 327 KB

english, 2006

19

Regiospecific synthesis of 5-(1H-indol-2-yl)-1- and 2-methyl-6,7-dihydro-2H-indazole isomers

Reddeppareddy Dandu, Ming Tao, Kurt A. Josef, Edward R. Bacon, Robert L. Hudkins

Journal:

Journal of Heterocyclic Chemistry

Year:

2007

Language:

english

File:

PDF, 286 KB

english, 2007

20

High specific activity tritium labeling of anti-tumor agent CEP-2563

Judith A. Egan, Crist N. Filer, Robert L. Hudkins

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

2005

Language:

english

File:

PDF, 94 KB

english, 2005

21

Synthesis and biological evaluation of iodine-125 iodocaramiphen. A potential M1 muscarinic imaging agent for SPECT

Daniel W. McPherson, F. F. (Russ) Knapp Jr., Robert L. Hudkins

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1994

Language:

english

File:

PDF, 376 KB

english, 1994

22

Tritiation of CEP-1347 at high specific activity using several methods

Judith A. Egan, Crist N. Filer, Scot Pounds, Thomas Connors, Ernest Knight Jr, Robert L. Hudkins

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

2005

Language:

english

File:

PDF, 88 KB

english, 2005

23

The selective mu-opioid receptor antagonist adl5510 reduces levodopa-induced dyskinesia without affecting antiparkinsonian action in mptp-lesioned macaque model of Parkinson's disease

James B. Koprich, Susan H. Fox, Tom H. Johnston, Allan Goodman, Bertrand Le Bourdonnec, Roland E. Dolle, Robert N. DeHaven, Diane L. DeHaven-Hudkins, Patrick J. Little, Jonathan M. Brotchie

Journal:

Movement Disorders

Year:

2011

Language:

english

File:

PDF, 486 KB

english, 2011

24

Enzyme-Linked Immunosorbent Assay for trkA Tyrosine Kinase Activity

Thelma S. Angeles, Catherine Steffler, Becky A. Bartlett, Robert L. Hudkins, Robert M. Stephens, David R. Kaplan, Craig A. Dionne

Journal:

Analytical Biochemistry

Year:

1996

Language:

english

File:

PDF, 151 KB

english, 1996

25

A Radioactive Binding Assay for Inhibitors of trkA Kinase

Ernest Knight Jr., Thomas J. Connors, Anna C. Maroney, Thelma S. Angeles, Robert L. Hudkins, Craig A. Dionne

Journal:

Analytical Biochemistry

Year:

1997

Language:

english

File:

PDF, 122 KB

english, 1997

26

Novel malonamide derivatives as potent κ opioid receptor agonists

Guo-Hua Chu, Minghua Gu, Joel A. Cassel, Serge Belanger, Thomas M. Graczyk, Robert N. DeHaven, Nathalie Conway-James, Michael Koblish, Patrick J. Little, Diane L. DeHaven-Hudkins, Roland E. Dolle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 150 KB

english, 2007

27

The effect of Pyrrolo[3,4-c]carbazole derivatives on spinal cord ChAT activity

David P. Rotella, Marcie A. Glicksman, J.Eric Prantner, Nicola T. Neff, Robert L. Hudkins

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 198 KB

english, 1995

28

Amino acid conjugates as κ opioid receptor agonists

Virendra Kumar, Deqi Guo, Jeffrey D. Daubert, Joel A. Cassel, Robert N. DeHaven, Erik Mansson, Diane L. DeHaven-Hudkins, Alan L. Maycock

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 115 KB

english, 2005

29

Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints

Guo-Hua Chu, Minghua Gu, Joel A. Cassel, Serge Belanger, Thomas M. Graczyk, Robert N. DeHaven, Nathalie Conway-James, Mike Koblish, Patrick J. Little, Diane L. DeHaven-Hudkins, Roland E. Dolle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 166 KB

english, 2005

30

Novel phenylamino acetamide derivatives as potent and selective κ opioid receptor agonists

Guo-Hua Chu, Minghua Gu, Joel A. Cassel, Serge Belanger, Gabriel. J. Stabley, Robert N. DeHaven, Nathalie Conway-James, Mike Koblish, Patrick J. Little, Diane L. DeHaven-Hudkins, Roland E. Dolle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 112 KB

english, 2006

31

Synthesis and structure–activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors

Ming Tao, Chung Ho Park, Ron Bihovsky, Gregory J. Wells, Jean Husten, Mark A. Ator, Robert L. Hudkins

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 158 KB

english, 2006

32

Synthesis and structure–activity relationships of novel pyrrolocarbazole lactam analogs as potent and cell-permeable inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)

Gregory J. Wells, Ron Bihovsky, Robert L. Hudkins, Mark A. Ator, Jean Husten

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 241 KB

english, 2006

33

Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as μ opioid receptor antagonists with improved opioid receptor selectivity profiles

Bertrand Le Bourdonnec, William M. Barker, Serge Belanger, Daniel D. Wiant, Nathalie C. Conway-James, Joel A. Cassel, Timothy J. O’Neill, Patrick J. Little, Robert N. DeHaven, Diane L. DeHaven-Hudkins

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 223 KB

english, 2008

34

TIE-2/VEGF-R2 SAR and in vitro activity of C3-acyl dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole analogs

Ted L. Underiner, Bruce Ruggeri, Lisa Aimone, Mark Albom, Thelma Angeles, Hong Chang, Robert L. Hudkins, Kathryn Hunter, Kurt Josef, Candy Robinson, Linda Weinberg, Shi Yang, Allison Zulli

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 597 KB

english, 2008

35

8-THP-DHI analogs as potent Type I dual TIE-2/VEGF-R2 receptor tyrosine kinase inhibitors

Robert L. Hudkins, Allison L. Zulli, Ted L. Underiner, Thelma S. Angeles, Lisa D. Aimone, Sheryl L. Meyer, Daniel Pauletti, Hong Chang, Elena V. Fedorov, Steven C. Almo, Alexander A. Fedorov, Bruce A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 346 KB

english, 2010

36

A simple synthetic protocol for the protection of amides, lactams, ureas, and carbamates

Dandu R Reddy, Mohamed A Iqbal, Robert L Hudkins, Patricia A Messina-McLaughlin, John P Mallamo

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 179 KB

english, 2002

37

Arylacetamides as peripherally restricted kappa opioid receptor agonists

Virendra Kumar, Michael A. Marella, Luz Cortes-Burgos, An-Chih Chang, Joel A. Cassel, Jeffrey D. Daubert, Robert N. DeHaven, Diane L. DeHaven-Hudkins, Susan L. Gottshall, Erik Mansson, Alan L. Maycock

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 130 KB

english, 2000

38

Phenytoin derivatives as potent σ ligands

Robert L. Hudkins, Diane L. DeHaven-Hudkins

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 239 KB

english, 1994

39

Synthesis and kinase inhibitory activity of 3′-(S)-epi-K-252a

Diane E. Gingrich, Robert L. Hudkins

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 112 KB

english, 2002

40

Design of dual acting anticonvulsant-antimuscarinic succinimide and hydantoin derivatives

Robert L. Hudkins, Diane L. DeHaven-Hudkins, Peter Doukas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 339 KB

english, 1997

41

Prodrug esters of the indolocarbazole CEP-751 (KT-6587)

Robert L. Hudkins, Mohamed Iqbal, Chung-Ho Park, Joel Goldstein, Joseph L. Herman, Efraim Shek, Chikara Murakata, John P. Mallamo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 212 KB

english, 1998

42

Histiocytoid hemangioma of bone: A benign lesion which may mimic angiosarcoma

Robert O. Cone, Phillip Hudkins, Vung Nguyen, W. A. Merriwether

Journal:

Skeletal Radiology

Year:

1983

Language:

english

File:

PDF, 1.56 MB

english, 1983

43

Azepinone as a conformational constraint in the design of κ-opioid receptor agonists

Paul A. Tuthill, Pamela R. Seida, William Barker, Joel A. Cassel, Serge Belanger, Robert N. DeHaven, Michael Koblish, Susan L. Gottshall, Patrick J. Little, Diane L. DeHaven-Hudkins, Roland E. Dolle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 371 KB

english, 2004

44

Synthesis and evaluation of novel peripherally restricted κ-opioid receptor agonists

Virendra Kumar, Deqi Guo, Joel A. Cassel, Jeffrey D. Daubert, Robert N. DeHaven, Diane L. DeHaven-Hudkins, Erin K. Gauntner, Susan L. Gottshall, Susan L. Greiner, Michael Koblish, Patrick J. Little, E

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 128 KB

english, 2005

45

Arylacetamide κ opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity

Bertrand Le Bourdonnec, Christopher W. Ajello, Pamela R. Seida, Roberta G. Susnow, Joel A. Cassel, Serge Belanger, Gabriel J. Stabley, Robert N. DeHaven, Diane L. DeHaven-Hudkins, Roland E. Dolle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 182 KB

english, 2005

46

Novel C-3 N-urea, amide, and carbamate dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole analogs as potent TIE-2 and VEGF-R2 dual inhibitors

Nadine C. Becknell, Allison L. Zulli, Thelma S. Angeles, Shi Yang, Mark S. Albom, Lisa D. Aimone, Candy Robinson, Hong Chang, Robert L. Hudkins

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 125 KB

english, 2006

47

Muscarinic receptor binding profile of para-substituted caramiphen analogs

Hudkins, Robert L., DeHaven-Hudkins, Diane L., Stubbins, James F.

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 893 KB

english, 1991

48

ChemInform Abstract: 4-Phenoxypiperidine Pyridazin-3-one Histamine H3 Receptor Inverse Agonists Demonstrating Potent and Robust Wake Promoting Activity.

Robert L. Hudkins, et al. et al.

Journal:

Year:

2012

File:

PDF, 30 KB

2012

49

ChemInform Abstract: Synthesis and Evaluation of a New Series of 1′-Cyclobutyl-6-(4-piperidyloxy)spiro[benzopyran-2,4′-piperidine] Derivatives as High Affinity and Selective Histamine-3 Receptor (H3R) Antagonists.

Reddeppa Reddy Dandu, Jacquelyn A. Lyons, Rita Raddatz, Zeqi Huang, Lisa D. Aimone, Robert L. Hudkins

Journal:

Year:

2012

File:

PDF, 28 KB

2012

50

High specific activity tritiation of the pyridazin-3-one histamine H3 receptor inverse agonist CEP-27088

Joseph R. Andrews, Crist N. Filer, Mario Maniscalco, Nadine C. Becknell, Robert L. Hudkins

Journal:

Applied Radiation and Isotopes

Year:

2012

Language:

english

File:

PDF, 238 KB

english, 2012

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