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51

Differential Expression of Mouse Hepatic Transporter Genes in Response to Acetaminophen and Carbon Tetrachloride

Aleksunes, L. M.

Journal:

Toxicological Sciences

Year:

2004

Language:

english

File:

PDF, 278 KB

english, 2004

52

ANIT-Induced Intrahepatic Cholestasis Alters Hepatobiliary Transporter Expression via Nrf2-Dependent and Independent Signaling

Tanaka, Y., Aleksunes, L. M., Cui, Y. J., Klaassen, C. D.

Journal:

Toxicological Sciences

Year:

2009

Language:

english

File:

PDF, 926 KB

english, 2009

53

Regulation of Hepatic Phase II Metabolism in Pregnant Mice

Wen, X., Donepudi, A. C., Thomas, P. E., Slitt, A. L., King, R. S., Aleksunes, L. M.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2013

Language:

english

File:

PDF, 939 KB

english, 2013

54

Constitutive Androstane Receptor-Mediated Changes in Bile Acid Composition Contributes to Hepatoprotection from Lithocholic Acid-Induced Liver Injury in Mice

Beilke, L. D., Aleksunes, L. M., Holland, R. D., Besselsen, D. G., Beger, R. D., Klaassen, C. D., Cherrington, N. J.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 604 KB

english, 2009

55

Altered Disposition of Acetaminophen in Nrf2-null and Keap1-knockdown Mice

Reisman, S. A., Csanaky, I. L., Aleksunes, L. M., Klaassen, C. D.

Journal:

Toxicological Sciences

Year:

2009

Language:

english

File:

PDF, 726 KB

english, 2009

56

Expression of Organic Anion Transporter 2 in the Human Kidney and Its Potential Role in the Tubular Secretion of Guanine-Containing Antiviral Drugs

Cheng, Y., Vapurcuyan, A., Shahidullah, M., Aleksunes, L. M., Pelis, R. M.

Journal:

Drug Metabolism and Disposition

Year:

2012

Language:

english

File:

PDF, 1.05 MB

english, 2012

57

Emerging Role of Nrf2 in Protecting Against Hepatic and Gastrointestinal Disease

Aleksunes, Lauren M., Manautou, José E.

Journal:

Toxicologic Pathology

Year:

2007

Language:

english

File:

PDF, 3.70 MB

english, 2007

58

NF-E2-Related Factor 2 Inhibits Lipid Accumulation and Oxidative Stress in Mice Fed a High-Fat Diet

Tanaka, Y., Aleksunes, L. M., Yeager, R. L., Gyamfi, M. A., Esterly, N., Guo, G. L., Klaassen, C. D.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2008

Language:

english

File:

PDF, 399 KB

english, 2008

59

Down-Regulation of Brush Border Efflux Transporter Expression in the Kidneys of Pregnant Mice

Yacovino, L. L., Gibson, C. J., Aleksunes, L. M.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 612 KB

english, 2013

60

Characterization of Peroxisome Proliferator-Activated Receptor --Independent Effects of PPAR Activators in the Rodent Liver: Di-(2-ethylhexyl) phthalate also Activates the Constitutive-Activated Receptor

Ren, H., Aleksunes, L. M., Wood, C., Vallanat, B., George, M. H., Klaassen, C. D., Corton, J. C.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 662 KB

english, 2010

61

Acquired Resistance to Acetaminophen Hepatotoxicity is Associated with Induction of Multidrug Resistance-Associated Protein 4 (Mrp4) in Proliferating Hepatocytes

Aleksunes, L. M., Campion, S. N., Goedken, M. J., Manautou, J. E.

Journal:

Toxicological Sciences

Year:

2007

Language:

english

File:

PDF, 2.10 MB

english, 2007

62

Prominent Expression of Xenobiotic Efflux Transporters in Mouse Extraembryonic Fetal Membranes Compared with Placenta

Aleksunes, L. M., Cui, Y., Klaassen, C. D.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 689 KB

english, 2008

63

Antibacterial Spectrum of a Novel Des-Fluoro(6) Quinolone, BMS-284756

Fung-Tomc, J. C., Minassian, B., Kolek, B., Huczko, E., Aleksunes, L., Stickle, T., Washo, T., Gradelski, E., Valera, L., Bonner, D. P.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2000

Language:

english

File:

PDF, 79 KB

english, 2000

64

Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function

Campion, S. N., Johnson, R., Aleksunes, L. M., Goedken, M. J., van Rooijen, N., Scheffer, G. L., Cherrington, N. J., Manautou, J. E.

Journal:

AJP Gastrointestinal and Liver Physiology

Year:

2008

Language:

english

File:

PDF, 1.99 MB

english, 2008

65

Nrf2- and PPAR -Mediated Regulation of Hepatic Mrp Transporters after Exposure to Perfluorooctanoic Acid and Perfluorodecanoic Acid

Maher, J. M., Aleksunes, L. M., Dieter, M. Z., Tanaka, Y., Peters, J. M., Manautou, J. E., Klaassen, C. D.

Journal:

Toxicological Sciences

Year:

2008

Language:

english

File:

PDF, 573 KB

english, 2008

66

Coordinated Expression of Multidrug Resistance-Associated Proteins (Mrps) in Mouse Liver during Toxicant-Induced Injury

Aleksunes, L. M.

Journal:

Toxicological Sciences

Year:

2006

Language:

english

File:

PDF, 1.56 MB

english, 2006

67

Compensatory Induction of Liver Efflux Transporters in Response to ANIT-Induced Liver Injury Is Impaired in FXR-Null Mice

Cui, Y. J., Aleksunes, L. M., Tanaka, Y., Goedken, M. J., Klaassen, C. D.

Journal:

Toxicological Sciences

Year:

2009

Language:

english

File:

PDF, 1.36 MB

english, 2009

68

Establishment of Metabolism and Transport Pathways in the Rodent and Human Fetal Liver

Moscovitz, Jamie, Aleksunes, Lauren

Journal:

International Journal of Molecular Sciences

Year:

2013

Language:

english

File:

PDF, 504 KB

english, 2013

69

Influence of Acetaminophen Vehicle on Regulation of Transporter Gene Expression During Hepatotoxicity

Aleksunes, Lauren M., Augustine, Lisa M., Cherrington, Nathan J., Manautou, José E.

Journal:

Journal of Toxicology and Environmental Health

Year:

2007

Language:

english

File:

PDF, 105 KB

english, 2007

70

Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers

Aleksunes, L. M., Yeager, R. L., Klaassen, C. D.

Journal:

Year:

2009

Language:

english

File:

PDF, 814 KB

english, 2009

71

Introducing the "TCDD-Inducible AhR-Nrf2 Gene Battery"

Yeager, R. L., Reisman, S. A., Aleksunes, L. M., Klaassen, C. D.

Journal:

Toxicological Sciences

Year:

2009

Language:

english

File:

PDF, 628 KB

english, 2009

72

Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice

Cui, J. Y., Aleksunes, L. M., Tanaka, Y., Fu, Z. D., Guo, Y., Guo, G. L., Lu, H., Zhong, X.-b., Klaassen, C. D.

Journal:

AJP Gastrointestinal and Liver Physiology

Year:

2012

Language:

english

File:

PDF, 7.92 MB

english, 2012

73

Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice

Csanaky, I. L., Aleksunes, L. M., Tanaka, Y., Klaassen, C. D.

Journal:

AJP Gastrointestinal and Liver Physiology

Year:

2009

Language:

english

File:

PDF, 1.96 MB

english, 2009

74

Repression of Hepatobiliary Transporters and Differential Regulation of Classic and Alternative Bile Acid Pathways in Mice During Pregnancy

Aleksunes, L. M., Yeager, R. L., Wen, X., Cui, J. Y., Klaassen, C. D.

Journal:

Toxicological Sciences

Year:

2012

Language:

english

File:

PDF, 17.04 MB

english, 2012

75

In vitro screening of environmental chemicals identifies zearalenone as a novel substrate of the placental BCRP/ABCG2 transporter

Xiao, Jingcheng, Wang, Qi, Bircsak, Kristin M., Wen, Xia, Aleksunes, Lauren M.

Journal:

Toxicology Research

Year:

2015

Language:

english

File:

PDF, 1.40 MB

english, 2015

76

Screening a Mouse Liver Gene Expression Compendium Identifies Modulators of the Aryl Hydrocarbon Receptor (AhR)

K. Oshida, N. Vasani, R. S. Thomas, D. Applegate, F. J. Gonzalez, L. M. Aleksunes, C. D. Klaassen, J. C. Corton

Year:

2015

Language:

english

File:

PDF, 2.55 MB

english, 2015

77

Renal and Hepatic Transporter Expression in Type 2 Diabetic Rats

Manautou, Jose, Nowicki, Michael, Aleksunes, Lauren, Sawant, Sharmilee, Dnyanmote, Ankur, Mehendale, Harihara

Journal:

Drug Metabolism Letters

Year:

2008

File:

PDF, 661 KB

2008

78

Inherited Disorders of Bilirubin Clearance

Memon, Naureen, Weinberger, Barry I, Hegyi, Thomas, Aleksunes, Lauren M

Journal:

Pediatric Research

Year:

2015

Language:

english

File:

PDF, 2.44 MB

english, 2015

79

Nrf2 Regulates the Sensitivity of Mouse Keratinocytes to Nitrogen Mustard via Multidrug Resistance-Associated Protein 1 (Mrp1)

Udasin, Ronald G., Wen, Xia, Bircsak, Kristin M., Aleksunes, Lauren M., Shakarjian, Michael P., Kong, Ah-Ng Tony, Heck, Diane E., Laskin, Debra L., Laskin, Jeffrey D.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 650 KB

english, 2015

80

Correlation between Conjugated Bisphenol A Concentrations and Efflux Transporter Expression in Human Fetal Livers

Moscovitz, J. E., Nahar, M. S., Shalat, S. L., Slitt, A. L., Dolinoy, D. C., Aleksunes, L. M.

Journal:

Drug Metabolism and Disposition

Year:

2016

Language:

english

File:

PDF, 324 KB

english, 2016

81

Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium

Szilagyi, John T., Mishin, Vladimir, Heck, Diane E., Jan, Yi-Hua, Aleksunes, Lauren M., Richardson, Jason R., Heindel, Ned D., Laskin, Debra L., Laskin, Jeffrey D.

Journal:

Toxicological Sciences

Year:

2016

Language:

english

File:

PDF, 1.19 MB

english, 2016

82

Nrf2 activators as potential modulators of injury in human kidney cells

Atilano-Roque, Amandla, Wen, Xia, Aleksunes, Lauren M., Joy, Melanie S.

Journal:

Toxicology Reports

Year:

2016

Language:

english

File:

PDF, 2.13 MB

english, 2016

83

Genetic and Dietary Regulation of Glyburide Efflux by the Human Placental Breast Cancer Resistance Protein Transporter

Bircsak, K. M., Gupta, V., Yuen, P. Y. S., Gorczyca, L., Weinberger, B. I., Vetrano, A. M., Aleksunes, L. M.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2016

Language:

english

File:

PDF, 844 KB

english, 2016

84

Cefoxitin Plasma and Subcutaneous Adipose Tissue Concentration in Patients Undergoing Sleeve Gastrectomy

Brunetti, Luigi, Kagan, Leonid, Forrester, Glenn, Aleksunes, Lauren M., Lin, Hongxia, Buyske, Steven, Nahass, Ronald G.

Journal:

Clinical Therapeutics

Year:

2016

Language:

english

File:

PDF, 259 KB

english, 2016

85

Evaluation of the chromogenic anti-factor IIa assay to assess dabigatran exposure in geriatric patients with atrial fibrillation in an outpatient setting

Brunetti, Luigi, Sanchez-Catanese, Betty, Kagan, Leonid, Wen, Xia, Liu, Min, Buckley, Brian, Luyendyk, James P., Aleksunes, Lauren M.

Journal:

Thrombosis Journal

Year:

2016

Language:

english

File:

PDF, 682 KB

english, 2016

86

Environmentally Relevant Concentrations of Arsenite Induce Dose-Dependent Differential Genotoxicity Through Poly(ADP-Ribose) Polymerase Inhibition and Oxidative Stress in Mouse Thymus Cells

Xu, Huan, Zhou, Xixi, Wen, Xia, Lauer, Fredine T., Liu, Ke Jian, Hudson, Laurie G., Aleksunes, Lauren M., Burchiel, Scott W.

Journal:

Toxicological Sciences

Year:

2016

Language:

english

File:

PDF, 1.17 MB

english, 2016

87

Isoform-Specific Regulation of Mouse Carboxylesterase Expression and Activity by Prototypical Transcriptional Activators

Baker, Angela A., Guo, Grace L., Aleksunes, Lauren M., Richardson, Jason R.

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

2015

Language:

english

File:

PDF, 280 KB

english, 2015

88

Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group

Brouwer, KLR, Aleksunes, LM, Brandys, B, Giacoia, GP, Knipp, G, Lukacova, V, Meibohm, B, Nigam, SK, Rieder, M, de Wildt, SN

Journal:

Clinical Pharmacology & Therapeutics

Year:

2015

Language:

english

File:

PDF, 334 KB

english, 2015

89

Bardoxolone methyl modulates efflux transporter and detoxifying enzyme expression in cisplatin-induced kidney cell injury

Atilano-Roque, Amandla, Aleksunes, Lauren M., Joy, Melanie S.

Journal:

Toxicology Letters

Year:

2016

Language:

english

File:

PDF, 660 KB

english, 2016

90

Nuclear Factor-E2-Related Factor 2 Expression in Liver Is Critical for Induction of NAD(P)H:quinone Oxidoreductase 1 during Cholestasis

Lauren M. Aleksunes, Angela L. Slitt, Jonathan M. Maher, Matthew Z. Dieter, Tamara R. Knight, Michael Goedken, Nathan J. Cherrington, Jefferson Y. Chan, Curtis D. Klaassen and José E. Manautou

Journal:

Cell Stress and Chaperones

Year:

2006

Language:

english

File:

PDF, 701 KB

english, 2006

91

Drug Metabolism in Diseases || Contributors

Aleksunes, L.M.

Year:

2017

Language:

english

File:

PDF, 23 KB

english, 2017

92

Regulation of the placental BCRP transporter by PPAR gamma

Lin, Yixin, Bircsak, Kristin M., Gorczyca, Ludwik, Wen, Xia, Aleksunes, Lauren M.

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

2016

Language:

english

File:

PDF, 535 KB

english, 2016

93

Profiling of Kidney Injury Biomarkers in Patients Receiving Cisplatin: Time-dependent Changes in the Absence of Clinical Nephrotoxicity

George, B, Wen, X, Mercke, N, Gomez, M, O'Bryant, C, Bowles, DW, Hu, Y, Hogan, SL, Joy, MS, Aleksunes, LM

Journal:

Clinical Pharmacology & Therapeutics

Year:

2017

Language:

english

File:

PDF, 2.26 MB

english, 2017

94

Differential regulation of intestinal efflux transporters by pregnancy in mice

Moscovitz, Jamie E., Yarmush, Gabriel, Herrera-Garcia, Guadalupe, Guo, Grace L., Aleksunes, Lauren M.

Journal:

Year:

2017

Language:

english

File:

PDF, 739 KB

english, 2017

95

Xenobiotic transporters and kidney injury

George, Blessy, You, Dahea, Joy, Melanie S., Aleksunes, Lauren M.

Journal:

Advanced Drug Delivery Reviews

Year:

2017

Language:

english

File:

PDF, 1.96 MB

english, 2017

96

Down-regulation of the placental BCRP/ ABCG2 transporter in response to hypoxia signaling

Francois, Lissa N., Gorczyca, Ludwik, Du, Jianyao, Bircsak, Kristin M., Yen, Elizabeth, Wen, Xia, Tu, Mei-Juan, Yu, Ai-Ming, Illsley, Nicholas P., Zamudio, Stacy, Aleksunes, Lauren M.

Journal:

Year:

2017

Language:

english

File:

PDF, 980 KB

english, 2017

97

Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21 st International Symposium on Microsomes and Drug Oxidations (MDO)

Yu, Ai-Ming, Ingelman-Sundberg, Magnus, Cherrington, Nathan J., Aleksunes, Lauren M., Zanger, Ulrich M., Xie, Wen, Jeong, Hyunyoung, Morgan, Edward M., Turnbaugh, Peter J., Klaassen, Curtis D., Bhatt,

Journal:

Acta Pharmaceutica Sinica B

Year:

2017

Language:

english

File:

PDF, 310 KB

english, 2017

98

Localization of the placental BCRP/ ABCG2 transporter to lipid rafts: Role for cholesterol in mediating efflux activity

Szilagyi, John T., Vetrano, Anna M., Laskin, Jeffrey D., Aleksunes, Lauren M.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.82 MB

english, 2017

99

In Vitro Transport Activity and Trafficking of MRP2/ABCC2 Polymorphic Variants

Wen, Xia, Joy, Melanie S., Aleksunes, Lauren M.

Journal:

Pharmaceutical Research

Year:

2017

Language:

english

File:

PDF, 1.88 MB

english, 2017

100

Efflux Transporters Regulate Arsenite Induced Genotoxicity in Double Negative and Double Positive T Cells

Xu, Huan, Medina, Sebastian, Lauer, Fredine T., Douillet, Christelle, Jian Liu, Ke, Hudson, Laurie G., Stýblo, Miroslav, Aleksunes, Lauren M., Burchiel, Scott W.

Journal:

Toxicological Sciences

Year:

2017

Language:

english

File:

PDF, 1.44 MB

english, 2017