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51

Acetaminophen-induced hepatotoxicity

Jack A. Hinson, Lance R. Pohl, Terrence J. Monks, James R. Gillette

Journal:

Year:

1981

Language:

english

File:

PDF, 493 KB

english, 1981

52

Oxidation of carbon tetrachloride, bromotrichloromethane, and carbon tetrabromide by rat liver microsomes to electrophilic halogens

Bruce A. Mico, Richard V. Branchflower, Lance R. Pohl, Andrew T. Pudzianowski, Gilda H. Loew

Journal:

Year:

1982

Language:

english

File:

PDF, 378 KB

english, 1982

53

Carbon-13 nuclear magnetic resonance studies of spironolactone and several related steroids

Robert J. Highet, Terrence R. Burke, William F. Trager, Lance R. Pohl, Raymond H. Menard, Anne Marie Taburet, James R. Gillette

Journal:

Year:

1980

Language:

english

File:

PDF, 651 KB

english, 1980

54

Electrophilic halogens as potentially toxic metabolites of halogenated compounds

Lance R. Pohl, Bruce A. Mico

Journal:

Trends in Pharmacological Sciences

Year:

1984

Language:

english

File:

PDF, 535 KB

english, 1984

55

Drug Enterocyte Adducts: Possible Causal Factor for Diclofenac Enteropathy in Rats

Chessley R. Atchison*, A.Brian West‡, Arun Balakumaran*, Sally J. Hargus§, Lance R. Pohl‖, Davis H. Daiker*, Judith F. Aronson*, Walter E. Hoffmann¶, Bryan K. Shipp#, Mary Treinen-Moslen*

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 548 KB

english, 2000

56

An immunochemical approach of identifying and characterizing protein targets of toxic reactive metabolites

Journal:

Chemical Research in Toxicology

Year:

1993

Language:

english

File:

PDF, 1.11 MB

english, 1993

57

Eosinophils mediate the pathogenesis of halothane-induced liver injury in mice

Proctor, William R., Chakraborty, Mala, Chea, Lynette S., Morrison, Jeffrey C., Berkson, Julia D., Semple, Kenrick, Bourdi, Mohammed, Pohl, Lance R.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.44 MB

english, 2013

58

Cytochrome P4502C11 Is a Target of Diclofenac Covalent Binding in Rats

Shen, Sijiu, Hargus, Sally J., Martin, Brian M., Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

1997

Language:

english

File:

PDF, 134 KB

english, 1997

59

Covalent bonding of the prosthetic heme to protein: a potential mechanism for the suicide inactivation or activation of hemoproteins

Osawa, Yoichi, Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

1989

Language:

english

File:

PDF, 1.33 MB

english, 1989

60

Synthesis and thin-layer chromatographic, ultraviolet, and mass spectral properties of the anticoagulant phenprocoumon and its monohydroxylated derivatives

Pohl, Lance R., Haddock, Rodney, Garland, William A., Trager, William F.

Journal:

Journal of Medicinal Chemistry

Year:

1975

Language:

english

File:

PDF, 903 KB

english, 1975

61

Tolerogenic Role of Kupffer Cells in Allergic Reactions

Ju, Cynthia, McCoy, J. Philip, Chung, Christine J., Graf, Mary Louise M., Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

2003

Language:

english

File:

PDF, 239 KB

english, 2003

62

A Protective Role for Cyclooxygenase-2 in Drug-Induced Liver Injury in Mice †

Reilly, Timothy P., Brady, John N., Marchick, Michael R., Bourdi, Mohammed, George, John W., Radonovich, Michael F., Pise-Masison, Cynthia A., Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

2001

Language:

english

File:

PDF, 998 KB

english, 2001

63

Metabolic Activation of Diclofenac by Human Cytochrome P450 3A4: Role of 5-Hydroxydiclofenac

Shen, Sijiu, Marchick, Michael R., Davis, Margaret R., Doss, George A., Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

1999

Language:

english

File:

PDF, 178 KB

english, 1999

64

UDP-Glucose:Glycoprotein Glucosyltransferase Associates with Endoplasmic Reticulum Chaperones and Its Activity Is Decreased in Vivo by the Inhalation Anesthetic Halothane

Amouzadeh, Hamid R., Bourdi, Mohammed, Martin, Jackie L., Martin, Brian M., Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

1997

Language:

english

File:

PDF, 218 KB

english, 1997

65

Genomic Identification of Potential Risk Factors during Acetaminophen-Induced Liver Disease in Susceptible and Resistant Strains of Mice

Welch, Kevin D., Reilly, Timothy P., Bourdi, Mohammed, Hays, Thomas, Pise-Masison, Cynthia A., Radonovich, Michael F., Brady, John N., Dix, David J., Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

2006

Language:

english

File:

PDF, 439 KB

english, 2006

66

Role of IL-6 in an IL-10 and IL-4 Double Knockout Mouse Model Uniquely Susceptible to Acetaminophen-Induced Liver Injury †

Bourdi, Mohammed, Eiras, Daniel P., Holt, Michael P., Webster, Marie R., Reilly, Timothy P., Welch, Kevin D., Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

2007

Language:

english

File:

PDF, 507 KB

english, 2007

67

New chiral reagent for the determination of enantiomeric purity and absolute configuration of certain substituted .beta.-arylethylamines

Pohl, Lance R., Trager, William F.

Journal:

Journal of Medicinal Chemistry

Year:

1973

Language:

english

File:

PDF, 722 KB

english, 1973

68

Hepatoprotective Role of Endogenous Interleukin-13 in a Murine Model of Acetaminophen-Induced Liver Disease

Yee, Steven B., Bourdi, Mohammed, Masson, Mary Jane, Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

2007

Language:

english

File:

PDF, 1.16 MB

english, 2007

69

Pentahaloethane-based chlorofluorocarbon substitutes and halothane: correlation of in vivo hepatic protein trifluoroacetylation and urinary trifluoroacetic acid excretion with calculated enthalpies of activation

Harris, James W., Jones, Jeffrey P., Martin, Jackie L., LaRosa, Angela C., Olson, Michael J., Pohl, Lance R., Anders, M. W.

Journal:

Chemical Research in Toxicology

Year:

1992

Language:

english

File:

PDF, 1.16 MB

english, 1992

70

Proteomic Identification of Potential Susceptibility Factors in Drug-Induced Liver Disease

Welch, Kevin D., Wen, Bo, Goodlett, David R., Yi, Eugene C., Lee, Hookeun, Reilly, Timothy P., Nelson, Sidney D., Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

2005

Language:

english

File:

PDF, 549 KB

english, 2005

71

Nuclear magnetic resonance configuration correlation of primary amine derivatives of .alpha.-methyl-.alpha.-methoxy(pentafluorophenyl)acetic acid

Valente, Edward J., Pohl, Lance R., Trager, William F.

Journal:

Journal of Organic Chemistry

Year:

1980

Language:

english

File:

PDF, 553 KB

english, 1980

72

Covalent Modification of Rat Liver Dipeptidyl Peptidase IV (CD26) by the Nonsteroidal Anti-Inflammatory Drug Diclofenac

Hargus, Sally J., Martin, Brian M., George, John W., Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

1995

Language:

english

File:

PDF, 1.78 MB

english, 1995

73

Lymphocyte Loss and Immunosuppression Following Acetaminophen-Induced Hepatotoxicity in Mice as a Potential Mechanism of Tolerance

Masson, Mary Jane, Peterson, Richard A., Chung, Christine J., Graf, Mary L., Carpenter, Leah D., Ambroso, Jeffrey L., Krull, David L., Sciarrotta, Janeice, Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

2007

Language:

english

File:

PDF, 570 KB

english, 2007

74

Metabolic Activation and Immunochemical Localization of Liver Protein Adducts of the Nonsteroidal Anti-inflammatory Drug Diclofenac

Hargus, Sally J., Amouzedeh, Hamid R., Pumford, Neil R., Myers, Timothy G., McCoy, Stacie C., Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

1994

Language:

english

File:

PDF, 2.46 MB

english, 1994

75

Serum antibodies from halothane hepatitis patients react with the rat endoplasmic reticulum protein ERp72

Pumford, Neil R., Martin, Brian M., Thomassen, David, Burris, Jennifer A., Kenna, J. Gerald, Martin, Jackie L., Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

1993

Language:

english

File:

PDF, 2.57 MB

english, 1993

76

Mispairing C57BL/6 Substrains of Genetically Engineered Mice and Wild-Type Controls Can Lead to Confounding Results as It Did in Studies of JNK2 in Acetaminophen and Concanavalin A Liver Injury

Bourdi, Mohammed, Davies, John S., Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

2011

Language:

english

File:

PDF, 1.15 MB

english, 2011

77

Halothane-Induced Liver Injury in Outbred Guinea Pigs: Role of Trifluoroacetylated Protein Adducts in Animal Susceptibility

Bourdi, Mohammed, Amouzadeh, Hamid R., Rushmore, Thomas H., Martin, Jackie L., Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

2001

Language:

english

File:

PDF, 721 KB

english, 2001

78

Immunohistochemical Detection of Protein Adducts of 2,4-Dinitrochlorobenzene in Antigen Presenting Cells and Lymphocytes after Oral Administration to Mice: Lack of a Role of Kupffer Cells in Oral Tolerance

Ju, Cynthia, Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

2001

Language:

english

File:

PDF, 2.30 MB

english, 2001

79

Biotransformation of phenprocoumon in the rat

Haddock, Rodney E., Trager, William F., Pohl, Lance R.

Journal:

Journal of Medicinal Chemistry

Year:

1975

Language:

english

File:

PDF, 645 KB

english, 1975

80

A molecular orbital study of model cytochrome P450 oxidation of tetrachloromethane and trichloromethane

Pudzianowski, Andrew T., Loew, Gilda H., Mico, Bruce A., Branchflower, Richard V., Pohl, Lance R.

Journal:

Journal of the American Chemical Society

Year:

1983

Language:

english

File:

PDF, 631 KB

english, 1983

81

Immunochemical Detection and Identification of Protein Adducts of Diclofenac in the Small Intestine of Rats: Possible Role in Allergic Reactions

Ware, Joseph A., Graf, Mary Louise M., Martin, Brian M., Lustberg, Lisa R., Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

1998

Language:

english

File:

PDF, 121 KB

english, 1998

82

Immunochemical detection of liver protein adducts of the nonsteroidal antiinflammatory drug diclofenac

Pumford, Neil R., Myers, Timothy G., Davila, Julio C., Highet, Robert J., Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

1993

Language:

english

File:

PDF, 1022 KB

english, 1993

83

Protective Role of Kupffer Cells in Acetaminophen-Induced Hepatic Injury in Mice

Ju, Cynthia, Reilly, Timothy P., Bourdi, Mohammed, Radonovich, Michael F., Brady, John N., George, John W., Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

2002

Language:

english

File:

PDF, 837 KB

english, 2002

84

Endogenous Interleukin-4 Regulates Glutathione Synthesis Following Acetaminophen-Induced Liver Injury in Mice

Ryan, Pauline M., Bourdi, Mohammed, Korrapati, Midhun C., Proctor, William R., Vasquez, Ronald A., Yee, Steven B., Quinn, Timothy D., Chakraborty, Mala, Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 3.73 MB

english, 2012

85

The calcium-binding protein calreticulin is covalently modified in rat liver by a reactive metabolite of the inhalation anesthetic halothane

Butler, Lynn E., Thomassen, David, Martin, Jackie L., Martin, Brian M., Kenna, J. Gerald, Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

1992

Language:

english

File:

PDF, 1.63 MB

english, 1992

86

Primary and .beta.-secondary deuterium isotope effects in N-deethylation reactions

Nelson, Sidney D., Pohl, Lance R., Trager, William F.

Journal:

Journal of Medicinal Chemistry

Year:

1975

Language:

english

File:

PDF, 535 KB

english, 1975

87

Human Cytochrome P450 2E1 Is a Major Autoantigen Associated with Halothane Hepatitis

Bourdi, Mohammed, Chen, Weiqiao, Peter, Raimund M., Martin, Jackie L., Buters, Jeroen T. M., Nelson, Sidney D., Pohl, Lance R.

Journal:

Chemical Research in Toxicology

Year:

1996

Language:

english

File:

PDF, 199 KB

english, 1996

88

Formation of heme-derived products by the reaction of ferrous deoxymyoglobin with bromotrichloromethane

Osawa, Yoichi, Highet, Robert J., Murphy, Constance M., Cotter, Robert J., Pohl, Lance R.

Journal:

Journal of the American Chemical Society

Year:

1989

Language:

english

File:

PDF, 693 KB

english, 1989

89

Neoantigens Associated with Halothane Hepatitis

Pohl, Lance R., Kenna, J. G., Satoh, Hiroko, Christ, David, Martin, Jackie L.

Journal:

Drug Metabolism Reviews

Year:

1989

Language:

english

File:

PDF, 1.14 MB

english, 1989

90

A prospective on covalent binding and toxicity

Gillette, James R., Pohl, Lance R.

Journal:

Journal of Toxicology and Environmental Health

Year:

1977

Language:

english

File:

PDF, 1.29 MB

english, 1977

91

Determination of Toxic Pathways of Metabolism by Deuterium Substitution

Pohl, Lance R., Gillette, James R.

Journal:

Drug Metabolism Reviews

Year:

1984

Language:

english

File:

PDF, 707 KB

english, 1984

92

Characteristics of a purified dog hepatic microsomal N , O -acyltransferase

Sone, Tomomichi, Zukowski, Kim, Land, Susan J., King, Charles M., Martin, Brian M., Pohl, Lance R., Wang, Ching Y.

Journal:

Year:

1994

Language:

english

File:

PDF, 3.89 MB

english, 1994

93

Drug-Induced Allergic Hepatitis

Journal:

Seminars in Liver Disease

Year:

1990

Language:

english

File:

PDF, 898 KB

english, 1990

94

Stereoselective Metabolism of Halothane Enantiomers to Trifluoroacetylated Liver Proteins

Martin, Jackie L., Meinwald, Jerrold, Radford, Peter, Liu, Zhi, Graf, Mary Louise M., Pohl, Lance R.

Journal:

Drug Metabolism Reviews

Year:

1995

Language:

english

File:

PDF, 1014 KB

english, 1995

95

Tissue Acylation by the Chlorofluorocarbon Substitute 2,2-Dichloro-1,1,1- Trifluoroethane

James W. Harris, Lance R. Pohl, Jackie L. Martin and M. W. Anders

Journal:

Proceedings of the National Academy of Sciences

Year:

1991

Language:

english

File:

PDF, 702 KB

english, 1991

96

SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity

Lu, Zhongping, Bourdi, Mohammed, Li, Jian H, Aponte, Angel M, Chen, Yong, Lombard, David B, Gucek, Marjan, Pohl, Lance R, Sack, Michael N

Journal:

Year:

2011

Language:

english

File:

PDF, 636 KB

english, 2011

97

Cell Ultrastructure and Distribution of Trifluoroacetylated Protein-Adducts in Early Hepatic Injury in Mice Induced by Inhalation Anesthetic, Halothane.

Brantner, Christine A., Bourdi, Mohammed, Chakraborty, Mala, Pohl, Lance R., Daniels, Mathew P.

Journal:

Microscopy and Microanalysis

Year:

2014

Language:

english

File:

PDF, 6.96 MB

english, 2014

98

Renal Cysteine Conjugate β-lyase and Compound A Nephrotoxicity

Njoku, Dolores B., Martin, Jackie L., Pohl, Lance R.

Journal:

Year:

1999

File:

PDF, 729 KB

1999

99

Hepatotoxicity after Desflurane Anesthesia

Martin, Jackie L., Plevak, David J., Flannery, Kathleen D., Charlton, Michael, Poterucha, John J., Humphreys, Chris E., Derfus, Gregory, Pohl, Lance R.

Journal:

Year:

1995

File:

PDF, 3.57 MB

1995

100

Autoantibodies Associated with Volatile Anesthetic Hepatitis Found in the Sera of a Large Cohort of Pediatric Anesthesiologists

Njoku, Dolores B., Greenberg, Robert S., Bourdi, Mohammed, Borkowf, Craig B., Dake, Elizabeth M., Martin, Jackie L., Pohl, Lance R.

Journal:

Anesthesia & Analgesia

Year:

2002

Language:

english

File:

PDF, 122 KB

english, 2002