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51

134 HIV DNA Integration

Bushman, Frederic D., Brady, Troy, Malani, Nirav, Leboulch, Philippe, Hacein-Bey, Salima, Cavazzana-Calvo, Marina, Ocwieja, Karen, Roth, Shoshannah, Berry, Charles C.

Journal:

JAIDS Journal of Acquired Immune Deficiency Syndromes

Year:

2012

Language:

english

File:

PDF, 1.53 MB

english, 2012

52

10. High-Efficiency Transduction of Primary Human CD34+ Hematopoietic Stem/Progenitor Cells by AAV6 Serotype Vectors: Strategies for Overcoming Donor Variation and Implications in Genome Editing

Yin, Zifei, Bukhai, Kanit, Aslanidi, George, Ling, Chen, Tan, Mengqun, Yoder, Mervin, Leboulch, Philippe, Payen, Emmanuel, Srivastava, Arun

Journal:

Molecular Therapy

Year:

2016

Language:

english

File:

PDF, 1.12 MB

english, 2016

53

Enhanced transduction of Macaca fascicularis hematopoietic cells with chimeric lentiviral vectors

Sii-Felice, Karine, Castillo Padilla, Javier, Relouzat, Francis, Cheuzeville, Joëlle, Tantawet, Siriporn, Maouche-Chretien, Leila, Le Grand, Roger, Leboulch, Philippe, Payen, Emmanuel

Journal:

Human Gene Therapy

Year:

2019

Language:

english

File:

PDF, 1.80 MB

english, 2019

54

A Phase I/II Clinical Trial of β-Globin Gene Therapy for β-Thalassemia

ARTHUR BANK, RONALD DORAZIO, PHILIPPE LEBOULCH

Journal:

Annals of the New York Academy of Sciences

Year:

2005

Language:

english

File:

PDF, 3.16 MB

english, 2005

55

Lack of Antitumor Activity of Recombinant Endostatin in a Human Neuroblastoma Xenograft Model

Emmanuel Jouanneau, Laurent Alberti, Mimoun Nejjari, Isabelle Treilleux, Isabelle Vilgrain, Adeline Duc, Valérie Combaret, Marie Favrot, Philippe Leboulch, Thomas Bachelot

Journal:

Journal of Neuro-Oncology

Year:

2001

Language:

english

File:

PDF, 73 KB

english, 2001

56

Arrayed lentiviral barcoding for quantification analysis of hematopoietic dynamics

Grosselin, Jeanne, Sii-Felice, Karine, Payen, Emmanuel, Chretien, Stany, Roux, Diana Tronik-Le, Leboulch, Philippe

Journal:

Year:

2013

Language:

english

File:

PDF, 1.35 MB

english, 2013

57

Retroviral transfer of a human beta-globin/delta-globin hybrid gene linked to beta locus control region hypersensitive site 2 aimed at the gene therapy of sickle cell disease.

Takekoshi, K. J., Oh, Y. H., Westerman, K. W., London, I. M., Leboulch, P.

Journal:

Proceedings of the National Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 1.24 MB

english, 1995

58

Direct Binding of pRb/E2F-2 to GATA-1 Regulates Maturation and Terminal Cell Division during Erythropoiesis

Kadri, Zahra, Shimizu, Ritsuko, Ohneda, Osamu, Maouche-Chretien, Leila, Gisselbrecht, Sylvie, Yamamoto, Masayuki, Romeo, Paul-Henri, Leboulch, Philippe, Chretien, Stany, Goodell, Margaret A.

Journal:

Year:

2009

Language:

english

File:

PDF, 2.71 MB

english, 2009

59

LentiGlobin gene therapy for transfusion-dependent β-Thalassemia: Update from the northstar HGB-204 phase 1/2 clinical study

Rasko, J., Thompson, A., Kwiatkowski, J., Hongeng, S., Schiller, G.J., Anurathapan, U., Cavazzana-Calvo, M., Ho, P., von Kalle, C., Kletzel, M., Leboulch, P., Vichinsky, E., Petrusich, A., Asmal, M.,

Journal:

Year:

2017

Language:

english

File:

PDF, 79 KB

english, 2017

60

Improving gene replacement by intracellular formation of linear homologous DNA

G. de Piédoue, R. Maurisse, I. Kuzniak, B. Lopez, A. Perrin, O. Nègre, P. Leboulch, J.-P. Feugeas

Journal:

The Journal of Gene Medicine

Year:

2005

Language:

english

File:

PDF, 203 KB

english, 2005

61

A reversibly immortalized human hepatocyte cell line as a source of hepatocyte-based biological support

Naoya Kobayashi, Karen A. Westerman, Noriaki Tanaka, Ira J. Fox, Philippe Leboulch

Journal:

Addiction Biology

Year:

2001

Language:

english

File:

PDF, 171 KB

english, 2001

62

An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia

Dussiot, Michael, Maciel, Thiago T, Fricot, Aurélie, Chartier, Céline, Negre, Olivier, Veiga, Joel, Grapton, Damien, Paubelle, Etienne, Payen, Emmanuel, Beuzard, Yves, Leboulch, Philippe, Ribeil, Jean

Journal:

Nature Medicine

Year:

2014

Language:

english

File:

PDF, 2.35 MB

english, 2014

63

Permanent and panerythroid correction of murine thalassemia by multiple lentiviral integration in hematopoietic stem cells

Imren, S., Payen, E., Westerman, K. A., Pawliuk, R., Fabry, M. E., Eaves, C. J., Cavilla, B., Wadsworth, L. D., Beuzard, Y., Bouhassira, E. E., Russell, R., London, I. M., Nagel, R. L., Leboulch, P.,

Journal:

Proceedings of the National Academy of Sciences

Year:

2002

Language:

english

File:

PDF, 417 KB

english, 2002

64

Establishment of a highly differentiated immortalized adult human hepatocyte cell line by retroviral gene transfer

N Kobayashi, H Noguchi, T Fujiwara, K.A Westerman, P Leboulch, N Tanaka

Journal:

Transplantation Proceedings

Year:

2000

Language:

english

File:

PDF, 129 KB

english, 2000

65

Targeted Gene Correction with 5′ Acridine-Oligonucleotide Conjugates

de Piédoue, G., Andrieu-Soler, C., Concordet, J.P., Maurisse, R., Sun, J.-S., Lopez, B., Kuzniak, I., Leboulch, P., Feugeas, J.-P.

Journal:

Oligonucleotides

Year:

2007

Language:

english

File:

PDF, 108 KB

english, 2007

66

Mutagenesis of retroviral vectors transducing human beta-globin gene and beta-globin locus control region derivatives results in stable transmission of an active transcriptional structure.

Leboulch, P., Huang, G.M., Humphries, R.K., Oh, Y.H., Eaves, C.J., Tuan, D.Y., London, I.M.

Journal:

The EMBO Journal

Year:

1994

Language:

english

File:

PDF, 2.61 MB

english, 1994

67

Gene Therapy of the Î² Hemoglobinopathies: Success and Challenges

Payen, Emmanuel, Leboulch, Philippe

Journal:

Year:

2019

File:

PDF, 490 KB

2019

68

Prevention of Murine Erythropoietic Protoporphyria-Associated Skin Photosensitivity and Liver Disease by Dermal and Hepatic Ferrochelatase

Pawliuk, Robert, Tighe, Robert, Wise, Robert J., Mathews-Roth, Micheline M., Leboulch, Philippe

Journal:

The Journal of Investigative Dermatology

Year:

2005

Language:

english

File:

PDF, 2.68 MB

english, 2005

69

Early Results of a Phase I/ II Study of Gene Therapy for β-Thalassemia Major Via Transplantation of Autologous Hematopoietic Stem Cells Transduced Ex-Vivo with a Lentiviral βAT87Q -Globin Vector

Soni, Sandeep, Thompson, Alexis A., Walters, Mark, Leboulch, Philippe, Cavazzana, Marina

Journal:

Biology of Blood and Marrow Transplantation

Year:

2015

Language:

english

File:

PDF, 163 KB

english, 2015

70

Immortalization of a primate bipotent epithelial liver stem cell

Allain, J.-E., Dagher, I., Mahieu-Caputo, D., Loux, N., Andreoletti, M., Westerman, K., Briand, P., Franco, D., Leboulch, P., Weber, A.

Journal:

Proceedings of the National Academy of Sciences

Year:

2002

Language:

english

File:

PDF, 629 KB

english, 2002

71

Long-Term Transfer and Expression of the Human Î²-Globin Gene in a Mouse Transplant Model

Raftopoulos, Harry, Ward, Maureen, Leboulch, Philippe, Bank, Arthur

Journal:

Year:

1997

File:

PDF, 393 KB

1997

72

Distribution of Lentiviral Vector Integration Sites in Mice Following Therapeutic Gene Transfer to Treat β-thalassemia

Ronen, Keshet, Negre, Olivier, Roth, Shannah, Colomb, Charlotte, Malani, Nirav, Denaro, Maria, Brady, Troy, Fusil, Floriane, Gillet-Legrand, Beatrix, Hehir, Kathleen, Beuzard, Yves, Leboulch, Philippe

Journal:

Molecular Therapy

Year:

2011

Language:

english

File:

PDF, 611 KB

english, 2011

73

The integrity of the FOG‐2 LXCXE pRb‐binding motif is required for small intestine homeostasis

Goupille, Olivier, Kadri, Zahra, Langelé, Amandine, Luccantoni, Sophie, Badoual, Cécile, Leboulch, Philippe, Chrétien, Stany

Journal:

Experimental Physiology

Year:

2019

Language:

english

File:

PDF, 2.51 MB

english, 2019

74

Site-specific chromosomal integration in mammalian cells: highly efficient CRE recombinase-mediated cassette exchange

Yong-Qing Feng, Jost Seibler, Raouf Alami, Andrew Eisen, Karen A Westerman, Philippe Leboulch, Steven Fiering, Eric E Bouhassira

Journal:

Journal of Molecular Biology

Year:

1999

Language:

english

File:

PDF, 305 KB

english, 1999

75

Five year outcome of lentiviral gene therapy for human beta-thalassemia, lessons and prospects

Leboulch, Philippe

Journal:

Thalassemia Reports

Year:

2013

Language:

english

File:

PDF, 494 KB

english, 2013

76

REVERSIBLY IMMORTALIZED HUMAN ENDOTHELIAL SCAVENGER CELLS TO DEVELOP A BIOARTIFICIAL ORGAN

Noguchi, H., Kobayashi, N., Totsugawa, T., Watanabe, T., Matsumura, T., Fujiwara, T., Tanaka, N., Westerman, K. A., Leboulch, P.

Journal:

Year:

2001

Language:

english

File:

PDF, 2.19 MB

english, 2001

77

Construction of a Differentiated Human Hepatocyte Cell Line Expressing the Herpes Simplex Virus-Thymidine Kinase Gene

Kobayashi, Naoya, Miyazaki, Masahiro, Westerman, Karen A., Noguchi, Hirofumi, Sakaguchi, Masakiyo, Totsugawa, Toshinori, Watanabe, Takamasa, Matsumura, Toshihisa, Fujiwara, Toshiyoshi, Leboulch, Phili

Journal:

Year:

2001

Language:

english

File:

PDF, 1.04 MB

english, 2001

78

Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2

Cao, Renhai, Bråkenhielm, Ebba, Pawliuk, Robert, Wariaro, David, Post, Mark J., Wahlberg, Eric, Leboulch, Philippe, Cao, Yihai

Journal:

Nature Medicine

Year:

2003

Language:

english

File:

PDF, 5.41 MB

english, 2003

79

Retroviral Transfer of a Human β-Globin/δ-Globin Hybrid Gene Linked to β Locus Control Region Hypersensitive Site 2 Aimed at the Gene Therapy of Sickle Cell Disease

Ken J. Takekoshi, Young H. Oh, Karen W. Westerman, Irving M. London and Philippe Leboulch

Journal:

Proceedings of the National Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 1.19 MB

english, 1995

80

Eukaryotic Translation Initiation Factor 4E Regulates Expression of Cyclin D1 at Transcriptional and Post-transcriptional Levels

Rosenwald, Igor B., Kaspar, Roger, Rousseau, Dennis, Gehrke, Lee, Leboulch, Philippe, Chen, Jane-Jane, Schmidt, Emmett V., Sonenberg, Nahum, London, Irving M.

Journal:

Journal of Biological Chemistry

Year:

1995

Language:

english

File:

PDF, 127 KB

english, 1995

81

Reversible immortalization of mammalian cells mediated by retroviral transfer and site-specific recombination.

Westerman, K. A., Leboulch, P.

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.60 MB

english, 1996

82

ENHANCED LIVER-SPECIFIC FUNCTIONS BY COCULTIVATION OF IMMORTALIZED HUMAN HEPATOCYTES AND LIVER FAT-STORING CELLS

Watanabe, T., Kobayashi, N., Noguchi, H., Totsugawa, T., Matsumura, T., Fujiwara, T., Tanaka, N., Hikida, M., Ohmori, A., Westerman, K. A., Leboulch, P.

Journal:

Year:

2001

Language:

english

File:

PDF, 2.19 MB

english, 2001

83

Induced pluripotent stem cell generation from a man carrying a complex chromosomal rearrangement as a genetic model for infertility studies

Mouka, Aurélie, Izard, Vincent, Tachdjian, Gérard, Brisset, Sophie, Yates, Frank, Mayeur, Anne, Drévillon, Loïc, Jarray, Rafika, Leboulch, Philippe, Maouche-Chrétien, Leila, Tosca, Lucie

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 1.68 MB

english, 2017

84

UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells

Ngom, Mor, Imren, Suzan, Maetzig, Tobias, Adair, Jennifer E., Knapp, David J.H.F., Chagraoui, Jalila, Fares, Iman, Bordeleau, Marie-Eve, Sauvageau, Guy, Leboulch, Philippe, Eaves, Connie, Humphries, R

Journal:

Molecular Therapy — Methods & Clinical Development

Year:

2018

Language:

english

File:

PDF, 1.67 MB

english, 2018

85

CLINICAL OUTCOMES OF LENTIGLOBIN GENE THERAPY FOR TRANSFUSION-DEPENDENT β-THALASSAEMIA (TDT) FOLLOWING COMPLETION OF THE NORTHSTAR (HGB-204) STUDY

Walters, M. C., Kwiatkowski, J. L., Rasko, J. E.J., Hongeng, S., Schiller, G. J., Anurathapan, U., Cavazzana, M., Ho, P. J., Schmidt, M., Kletzel, M., Leboulch, P., Vichinsky, E., Deary, B., Chen, Y.,

Journal:

Year:

2019

File:

PDF, 334 KB

2019

86

Retroviral Vectors Aimed at the Gene Therapy of Human β-Globin Gene Disorders

ROBERT PAWLIUK, THOMAS BACHELOT, HARRY RAFTOPOULOS, CHRISTIAN KALBERER, R. KEITH HUMPHRIES, ARTHUR BANK, PHILIPPE LEBOULCH

Journal:

Annals of the New York Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 554 KB

english, 1998

87

10.1038/10488

Mathews-Roth, Micheline M., Leboulch, Philippe, Pawliuk, Robert, Bachelot, Thomas, Wise, Robert J.

Journal:

Nature Medicine

Year:

1999

Language:

english

File:

PDF, 381 KB

english, 1999

88

Treatment of liver failure in rats with end-stage cirrhosis by transplantation of immortalized hepatocytes

Jin Cai, Masahiro Ito, Hideo Nagata, Karen A. Westerman, Daryl LaFleur, Jayanta Roy Chowdhury, Philippe Leboulch, Ira J. Fox

Journal:

Year:

2002

Language:

english

File:

PDF, 453 KB

english, 2002

89

ESTABLISHMENT OF AN IMMORTALIZED HUMAN PANCREATIC BETA CELL LINE

Narushima, M, Kobayashi, N, Westerman, K A, Fukazawa, T, Sakaguchi, M, Tanaka, Y, Lakey, Jonathan RT., Leboulch, Philippe, Tanaka, N

Journal:

Transplantation Journal

Year:

2004

Language:

english

File:

PDF, 327 KB

english, 2004

90

Mutagenesis of retroviral vectors transducing human beta-globin gene and beta-globin locus control region derivatives results in stable transmission of an active transcriptional structure.

Leboulch, P, Huang, G M, Humphries, R K, Oh, Y H, Eaves, C J, Tuan, D Y, London, I M

Journal:

The EMBO Journal

Year:

1994

Language:

english

File:

PDF, 2.60 MB

english, 1994

91

TAL-1 and GATA-1 coupled cell proliferation and differentiation during terminal erythroid differentiation

Zahra Kadri, Nicolas Goardon, Ritsuko Shimizu, Osamu Ohneda, Tran Hoang, Philippe Leboulch, Sylvie Gisselbrecht, Masayuki Yamamoto, Stany Chretien, Paul Henri Romeo

Journal:

Blood Cells, Molecules, and Diseases

Year:

2007

Language:

english

File:

PDF, 65 KB

english, 2007

92

Reversible Immortalization of Mammalian Cells Mediated by Retroviral Transfer and Site-Specific Recombination

Karen A. Westerman and Philippe Leboulch

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.16 MB

english, 1996

93

The LXCXE Retinoblastoma Protein-Binding Motif of FOG-2 Regulates Adipogenesis

Goupille, Olivier, Penglong, Tipparat, Kadri, Zahra, Granger-Locatelli, Marine, Denis, Raphaël, Luquet, Serge, Badoual, Cécile, Fucharoen, Suthat, Maouche-Chrétien, Leila, Leboulch, Philippe, Chrétien

Journal:

Year:

2017

Language:

english

File:

PDF, 3.93 MB

english, 2017

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