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1

A convenient method for estimating the quantity of drug eliminated by the routes other than hepatic metabolism and renal excretion and the fraction of drug that reaches the “first pass” after oral administration

Leonid M. Berezhkovskiy

Journal:

Journal of Pharmaceutical Sciences

Year:

2006

Language:

english

File:

PDF, 117 KB

english, 2006

2

Some features of the kinetics and equilibrium of drug binding to plasma proteins

Berezhkovskiy, Leonid M

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2008

Language:

english

File:

PDF, 1.03 MB

english, 2008

3

Determination of Volume of Distribution at Steady State with Complete Consideration of the Kinetics of Protein and Tissue Binding in Linear Pharmacokinetics

Leonid M. Berezhkovskiy

Journal:

Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 140 KB

english, 2004

4

Volume of distribution at steady state for a linear pharmacokinetic system with peripheral elimination

Leonid M. Berezhkovskiy

Journal:

Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 156 KB

english, 2004

5

The influence of drug kinetics in blood on the calculation of oral bioavailability in linear pharmacokinetics: The traditional equation may considerably overestimate the true value

Leonid M. Berezhkovskiy

Journal:

Journal of Pharmaceutical Sciences

Year:

2006

Language:

english

File:

PDF, 202 KB

english, 2006

6

On the calculation of the concentration dependence of drug binding to plasma proteins with multiple binding sites of different affinities: Determination of the possible variation of the unbound drug fraction and calculation of the number of binding sites of the protein

Leonid M. Berezhkovskiy

Journal:

Journal of Pharmaceutical Sciences

Year:

2007

Language:

english

File:

PDF, 161 KB

english, 2007

7

The connection between the steady state (Vss) and terminal (Vβ) volumes of distribution in linear pharmacokinetics and the general proof that Vβ ≥ Vss

Leonid M. Berezhkovskiy

Journal:

Journal of Pharmaceutical Sciences

Year:

2007

Language:

english

File:

PDF, 217 KB

english, 2007

8

On the determination of the time delay in reaching the steady state drug concentration in the organ compared to plasma

Leonid M. Berezhkovskiy

Journal:

Journal of Pharmaceutical Sciences

Year:

2007

Language:

english

File:

PDF, 247 KB

english, 2007

9

Prediction of the possibility of the second peak of drug plasma concentration time curve after iv bolus administration from the standpoint of the traditional multi-compartmental linear pharmacokinetics

Leonid M. Berezhkovskiy

Journal:

Journal of Pharmaceutical Sciences

Year:

2008

Language:

english

File:

PDF, 143 KB

english, 2008

10

Determination of mean residence time of drug in plasma and the influence of the initial drug elimination and distribution on the calculation of pharmacokinetic parameters

Leonid M. Berezhkovskiy

Journal:

Journal of Pharmaceutical Sciences

Year:

2009

Language:

english

File:

PDF, 199 KB

english, 2009

11

Consideration of the linear concentration increase of the unbound drug fraction in plasma

Leonid M. Berezhkovskiy

Journal:

Journal of Pharmaceutical Sciences

Year:

2009

Language:

english

File:

PDF, 169 KB

english, 2009

12

On the prediction of hepatic clearance using the diluted plasma in metabolic stability assay

Leonid M. Berezhkovskiy, S. Cyrus Khojasteh, Jason S. Halladay, Cornelis E.C.A. Hop

Journal:

Journal of Pharmaceutical Sciences

Year:

2009

Language:

english

File:

PDF, 117 KB

english, 2009

13

Prediction of the possibility of the secondary peaks of iv bolus drug plasma concentration time curve by the model that directly takes into account the transit time through the organ

Leonid M. Berezhkovskiy

Journal:

Journal of Pharmaceutical Sciences

Year:

2009

Language:

english

File:

PDF, 206 KB

english, 2009

14

A valid equation for the well-stirred perfusion limited physiologically based pharmacokinetic model that consistently accounts for the blood–tissue drug distribution in the organ and the corresponding valid equation for the steady state volume of distribution

Leonid M. Berezhkovskiy

Journal:

Journal of Pharmaceutical Sciences

Year:

2010

Language:

english

File:

PDF, 165 KB

english, 2010

15

On the influence of protein binding on pharmacological activity of drugs

Leonid M. Berezhkovskiy

Journal:

Journal of Pharmaceutical Sciences

Year:

2010

Language:

english

File:

PDF, 204 KB

english, 2010

16

On the possibility of self-induction of drug protein binding

Leonid M. Berezhkovskiy

Journal:

Journal of Pharmaceutical Sciences

Year:

2010

Language:

english

File:

PDF, 139 KB

english, 2010

17

The corrected traditional equations for calculation of hepatic clearance that account for the difference in drug ionization in extracellular and intracellular tissue water and the corresponding corrected PBPK equation

Leonid M. Berezhkovskiy

Journal:

Journal of Pharmaceutical Sciences

Year:

2011

Language:

english

File:

PDF, 318 KB

english, 2011

18

On the accuracy of estimation of basic pharmacokinetic parameters by the traditional noncompartmental equations and the prediction of the steady-state volume of distribution in obese patients based upon data derived from normal subjects

Leonid M. Berezhkovskiy

Journal:

Journal of Pharmaceutical Sciences

Year:

2011

Language:

english

File:

PDF, 339 KB

english, 2011

19

The influence of hepatic transport on the distribution volumes and mean residence time of drug in the body and the accuracy of estimating these parameters by the traditional pharmacokinetic calculations

Leonid M. Berezhkovskiy

Journal:

Journal of Pharmaceutical Sciences

Year:

2011

Language:

english

File:

PDF, 426 KB

english, 2011

20

A convenient method to measure blood–plasma concentration ratio using routine plasma collection in in vivo pharmacokinetic studies

Leonid M. Berezhkovskiy, Xiaolin Zhang, Jonathan Cheong

Journal:

Journal of Pharmaceutical Sciences

Year:

2011

Language:

english

File:

PDF, 116 KB

english, 2011

21

Consistency of the novel equations for determination of hepatic clearance and drug time course in liver that account for the difference in drug ionization in extracellular and intracellular tissue water

Leonid M. Berezhkovskiy, Ning Liu, Jason S. Halladay

Journal:

Journal of Pharmaceutical Sciences

Year:

2012

Language:

english

File:

PDF, 58 KB

english, 2012

22

Analysis of peptide affinity to major histocompatibility complex proteins for the two-step binding mechanism

Leonid M Berezhkovskiy, Irina V Astafieva, Cristina Cardoso

Journal:

Analytical Biochemistry

Year:

2002

Language:

english

File:

PDF, 147 KB

english, 2002

23

On the requirement of oxidizing reagent for the formation of a disulfide bond

Leonid M. Berezhkovskiy, Shrikant V. Deshpande

Journal:

Biophysical Chemistry

Year:

2001

Language:

english

File:

PDF, 172 KB

english, 2001

24

On the kinetics of peptide binding to MHC proteins

Leonid M. Berezhkovskiy

Journal:

Biophysical Chemistry

Year:

1998

Language:

english

File:

PDF, 129 KB

english, 1998

25

The analysis of peptide affinity and its binding kinetics to DR1DW1 major histocompatibility complex protein

Leonid M. Berezhkovskiy

Journal:

Biophysical Chemistry

Year:

1999

Language:

english

File:

PDF, 171 KB

english, 1999

26

Determination of Drug Binding to Plasma Proteins Using Competitive Equilibrium Binding to Dextran-Coated Charcoal

Leonid M. Berezhkovskiy

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2006

Language:

english

File:

PDF, 145 KB

english, 2006

27

On the accuracy of determination of unbound drug fraction in tissue using diluted tissue homogenate

Leonid M. Berezhkovskiy

Journal:

Journal of Pharmaceutical Sciences

Year:

2012

Language:

english

File:

PDF, 209 KB

english, 2012

28

Determination of hepatic clearance with the account of drug–protein binding kinetics

Leonid M. Berezhkovskiy

Journal:

Journal of Pharmaceutical Sciences

Year:

2012

Language:

english

File:

PDF, 202 KB

english, 2012

29

Conceptual underestimation of the total body clearance by the sum of clearances of individual organs in physiologically based pharmacokinetics

Leonid M. Berezhkovskiy

Journal:

Journal of Pharmaceutical Sciences

Year:

2012

Language:

english

File:

PDF, 136 KB

english, 2012

30

An alternative approach for quantitative bioanalysis using diluted blood to profile oral exposure of small molecule anticancer drugs in mice

Liederer, Bianca M., Berezhkovskiy, Leonid M., Ubhayakar, Savita S., Deng, Yuzhong

Journal:

Journal of Pharmaceutical Sciences

Year:

2013

Language:

english

File:

PDF, 321 KB

english, 2013

31

Prediction of drug terminal half-life and terminal volume of distribution after intravenous dosing based on drug clearance, steady-state volume of distribution, and physiological parameters of the body

Berezhkovskiy, Leonid M.

Journal:

Journal of Pharmaceutical Sciences

Year:

2013

Language:

english

File:

PDF, 230 KB

english, 2013

32

On the accuracy of a one-compartment approach for determination of drug terminal half-life

Berezhkovskiy, Leonid M.

Journal:

Journal of Pharmaceutical Sciences

Year:

2013

Language:

english

File:

PDF, 248 KB

english, 2013

33

On the maintenance of hepatocyte intracellular pH 7.0 in the in-vitro metabolic stability assay

Berezhkovskiy, Leonid M., Wong, Susan, Halladay, Jason S.

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2013

Language:

english

File:

PDF, 233 KB

english, 2013

34

Evaluation of dried blood spot sampling following cassette dosing in drug discovery

Liang, Xiaorong, Yang, Lulu, Berezhkovskiy, Leonid, Liederer, Bianca, Nguyen, Trung, Jia, Wei, Schweiger, Michelle, Dean, Brian, Deng, Yuzhong

Journal:

Year:

2011

Language:

english

File:

PDF, 1.52 MB

english, 2011

35

Preclinical stereoselective disposition and toxicokinetics of two novel MET inhibitors

Liederer, Bianca M., Liu, Xingrong, Berezhkovskiy, Leonid M., Cain, Gary, Ding, Xiao, Gaudino, John, Kaus, Robert, Plise, Emile G., Sutherlin, Daniel P., Harstad, Eric B.

Journal:

Year:

2012

Language:

english

File:

PDF, 806 KB

english, 2012

36

Practical permeability-based hepatic clearance classification system (HepCCS) in drug discovery

Fan, Peter W, Song, Yang, Berezhkovskiy, Leonid M, Cheong, Jonathan, Plise, Emile G, Khojasteh, S Cyrus

Journal:

Future Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.51 MB

english, 2014

37

Exploration of PBPK Model—Calculation of Drug Time Course in Tissue Using IV Bolus Drug Plasma Concentration-Time Profile and the Physiological Parameters of the Organ

Berezhkovskiy, Leonid M.

Journal:

Journal of Pharmaceutical Sciences

Year:

2016

Language:

english

File:

PDF, 589 KB

english, 2016