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1

The synthesis and the in vitro cytotoxicity studies of bisnaphthalimidopropyl polyamine derivatives against colon cancer cells and parasite Leishmania infantum

João Oliveira, Lynda Ralton, Joana Tavares, Anabela Codeiro-da-Silva, Charles S. Bestwick, Anne McPherson, Paul Kong Thoo Lin

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 152 KB

english, 2007

2

A review on comb-shaped amphiphilic polymers for hydrophobic drug solubilization

Hoskins, Clare, Thoo-Lin, Paul Kong, Cheng, Woei Ping

Journal:

Therapeutic Delivery

Year:

2012

Language:

english

File:

PDF, 2.29 MB

english, 2012

3

Caspase-independence and characterization of bisnaphthalimidopropyl spermidine induced cytotoxicity in HL60 cells

Bestwick, Charles S., Milne, Lesley, Dance, Anne-Marie, Cochennec, Gaela, Cruickshank, Gillian, Allain, Eflamm, Constable, Lynda, Duthie, Susan J., Thoo Lin, Paul Kong

Journal:

Toxicology in Vitro

Year:

2018

Language:

english

File:

PDF, 1.81 MB

english, 2018

4

The Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention/Treatment of Neurodegenerative Diseases: In Vitro, In Vivo and Clinical Trials

Pohl, Franziska, Kong Thoo Lin, Paul

Journal:

Year:

2018

Language:

english

File:

PDF, 3.35 MB

english, 2018

5

ChemInform Abstract: 5,8-Bis(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-1,4-dioxa-5,8- diazocane (V)

L. VAN MEERVELT, P. KONG THOO LIN

Journal:

Year:

1997

File:

PDF, 28 KB

1997

6

ChemInform Abstract: The Synthesis of Novel Oxa-azamacrocycles.

Vladimir Kuksa, Colin Marshall, Solange Wardell, Paul Kong Thoo Lin

Journal:

Year:

1999

File:

PDF, 24 KB

1999

7

ChemInform Abstract: Synthesis and in vitro Cytotoxic Studies of Novel Oxa-spermidine Derivatives and Homologues.

Vladimir A. Kuksa, Valentin A. Pavlov, Paul Kong Thoo Lin

Journal:

Year:

2000

File:

PDF, 31 KB

2000

8

ChemInform Abstract: Aminooxy Polyamine Analogues: Synthesis and Biological Activity

P. Kong Thoo Lin, V. Kuksa

Journal:

Year:

2000

File:

PDF, 23 KB

2000

9

ChemInform Abstract: Synthesis of Polyamines, Their Derivatives, Analogues, and Conjugates

Vladimir Kuksa, Robert Buchan, Paul Kong Thoo Lin

Journal:

Year:

2000

File:

PDF, 24 KB

2000

10

ChemInform Abstract: Synthesis and in vitro Cytotoxic Studies of Novel Bis-naphthalimidopropyl Polyamine Derivatives.

Paul Kong Thoo Lin, Valentin A. Pavlov

Journal:

Year:

2000

File:

PDF, 27 KB

2000

11

Isolation, Structure Elucidation and Bioactivity of Schischkiniin, a Unique Indole Alkaloid from the Seeds of Centaurea schischkinii.

Mohammad Shoeb, Sezgin Celik, Marcel Jaspars, Yashodharan Kumarasamy, Stephen M. MacManus, Lutfun Nahar, Paul K. Thoo-Lin, Satyajit D. Sarker

Journal:

Year:

2006

File:

PDF, 10 KB

2006

12

Bisnaphthalimidopropyl Derivatives as Inhibitors of Leishmania SIR2 Related Protein 1

Joana Tavares, Ali Ouaissi, Paul Kong Thoo Lin, Inês Loureiro, Simranjeet Kaur, Nilanjan Roy, Anabela Cordeiro-da-Silva

Journal:

Year:

2010

Language:

english

File:

PDF, 708 KB

english, 2010

13

Americanin, a bioactive dibenzylbutyrolactone lignan, from the seeds of Centaurea americana

Mohammad Shoeb, Stephen M. MacManus, Yashodharan Kumarasamy, Marcel Jaspars, Lutfun Nahar, Paul Kong Thoo-Lin, Hossein Nazemiyeh, Satyajit D. Sarker

Journal:

Year:

2006

Language:

english

File:

PDF, 162 KB

english, 2006

14

Isolation, structure elucidation and bioactivity of schischkiniin, a unique indole alkaloid from the seeds of Centaurea schischkinii

Mohammad Shoeb, Sezgin Celik, Marcel Jaspars, Yashodharan Kumarasamy, Stephen M. MacManus, Lutfun Nahar, Paul K. Thoo-Lin, Satyajit D. Sarker

Journal:

Year:

2005

Language:

english

File:

PDF, 155 KB

english, 2005

15

Montamine, a unique dimeric indole alkaloid, from the seeds of Centaurea montana (Asteraceae), and its in vitro cytotoxic activity against the CaCo2 colon cancer cells

Mohammad Shoeb, Stephen M. MacManus, Marcel Jaspars, Jioji Trevidu, Lutfun Nahar, Paul Kong-Thoo-Lin, Satyajit D. Sarker

Journal:

Year:

2006

Language:

english

File:

PDF, 202 KB

english, 2006

16

Synthesis of novel oxa-isosteres of spermidine and spermine

Paul Kong Thoo Lin, Nuala M. Maguire, Daniel M. Brown

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 287 KB

english, 1994

17

Cytotoxic and DNA binding properties of new bis-naphthalimido polyamine derivatives

V. Rodilla, V. Pavlov, D. Hion, P.Kong Thoo Lin

Journal:

Year:

2000

Language:

english

File:

PDF, 176 KB

english, 2000

18

The synthesis and in vitro cytotoxic studies of novel oxa-spermidine derivatives and homologues

Vladimir A Kuksa, Valentin A Pavlov, Paul Kong Thoo Lin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 113 KB

english, 2000

19

The synthesis and in vitro cytotoxic studies of novel bis-naphthalimidopropyl polyamine derivatives

Paul Kong Thoo Lin, Valentin A. Pavlov

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 142 KB

english, 2000

20

Novel oxa-spermine homologues: synthesis and cytotoxic properties

Vladimir A. Kuksa, Valentin A. Pavlov, Paul Kong Thoo Lin

Journal:

Bioorganic & Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 140 KB

english, 2002

21

Synthesis and X-ray structures of Ni and Zn complexes of a novel oxa-azamacrocyclic system

Vladimir A. Kuksa, Solange M.S.V. Wardell, Paul Kong Thoo Lin

Journal:

Inorganic Chemistry Communications

Year:

2000

Language:

english

File:

PDF, 142 KB

english, 2000

22

Novel fluorescent amphiphilic poly(allylamine) and their supramacromolecular self-assemblies in aqueous media

Clare Hoskins, Paul Kong Thoo Lin, Laurence Tetley, Woei Ping Cheng

Journal:

Polymers for Advanced Technologies

Year:

2012

Language:

english

File:

PDF, 775 KB

english, 2012

23

Biochemical effects and growth inhibition in MCF-7 cells caused by novel sulphonamido oxa-polyamine derivatives

V. Pavlov, P. Kong Thoo Lin, V. Rodilla

Journal:

Cellular and Molecular Life Sciences

Year:

2002

Language:

english

File:

PDF, 205 KB

english, 2002

24

The influence of bisnaphthalimidopropyl polyamines on DNA instability and repair in Caco-2 colon epithelial cells

Charles Stuart Bestwick, Lynda D. Ralton, Lesley Milne, Paul Kong Thoo Lin, Susan J. Duthie

Journal:

Cell Biology and Toxicology

Year:

2011

Language:

english

File:

PDF, 478 KB

english, 2011

25

In VitroandIn VivoAnticancer Activity of a Novel Nano-sized Formulation Based on Self-assembling Polymers Against Pancreatic Cancer

Clare Hoskins, Mehdi Ouaissi, Sofia Costa Lima, Woei Ping Cheng, Inês Loureirio, Eric Mas, Dominique Lombardo, Anabela Cordeiro-da-Silva, Ali Ouaissi, Paul Kong Thoo Lin

Journal:

Pharmaceutical Research

Year:

2010

Language:

english

File:

PDF, 436 KB

english, 2010

26

The Use of Nano Polymeric Self-Assemblies Based on Novel Amphiphilic Polymers for Oral Hydrophobic Drug Delivery

Hoskins Clare, Paul Kong Thoo Lin, Laurence Tetley, Woei Ping Cheng

Journal:

Pharmaceutical Research

Year:

2012

Language:

english

File:

PDF, 885 KB

english, 2012

27

Anti-colon cancer potential of phenolic compounds from the aerial parts ofCentaurea gigantea(Asteraceae)

Mohammad Shoeb, Marcel Jaspars, Stephen M. MacManus, Sezgin Celik, Lutfun Nahar, Paul Kong-Thoo-Lin, Satyajit D. Sarker

Journal:

Journal of Natural Medicines

Year:

2007

Language:

english

File:

PDF, 181 KB

english, 2007

28

Synthesis and duplex stability of oligonucleotides containing adenine-guanine analogues

Daniel M. Brown, Paul Kong Thoo Lin

Journal:

Carbohydrate Research

Year:

1992

Language:

english

File:

PDF, 704 KB

english, 1992

29

Synthesis, cytotoxicity and DNA-binding of novel bisnaphthalimidopropyl derivatives in breast cancer MDA-MB-231 cells

Gemma A. Barron, Giovanna Bermano, Amanda Gordon, Paul Kong Thoo Lin

Journal:

European Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 238 KB

english, 2010

30

Synthesis and structure of 1,12-bis-(N-naphthalamido)-4,9-bis-(2,4,6-trimethylbenzenesulfonyl)-4,9-diaza-dodecane

Solange M. S. V. Wardell, Paul Kong Thoo Lin

Journal:

Journal of Chemical Crystallography

Year:

1998

Language:

english

File:

PDF, 457 KB

english, 1998

31

Synthesis and biological activities of bisnaphthalimido polyamines derivatives: cytotoxicity, DNA binding, DNA damage and drug localization in breast cancer MCF 7 cells

Anne-Marie Dance, Lynda Ralton, Zoe Fuller, Lesley Milne, Susan Duthie, Charles S. Bestwick, Paul Kong Thoo Lin

Journal:

Biochemical Pharmacology

Year:

2005

Language:

english

File:

PDF, 252 KB

english, 2005

32

Bisnaphthalimidopropyl spermidine induces apoptosis within colon carcinoma cells

Lynda D. Ralton, Charles S. Bestwick, Lesley Milne, Susan Duthie, Paul Kong Thoo Lin

Journal:

Chemico-Biological Interactions

Year:

2009

Language:

english

File:

PDF, 752 KB

english, 2009

33

Cytotoxicity, DNA binding and localisation of novel bis-naphthalimidopropyl polyamine derivatives

Valentin Pavlov, Paul Kong Thoo Lin, Vicente Rodilla

Journal:

Chemico-Biological Interactions

Year:

2001

Language:

english

File:

PDF, 132 KB

english, 2001

34

Molecular Basis for Methoxyamine-initiated Mutagenesis: 1H Nuclear Magnetic Resonance Studies of Oligonucleotide Duplexes Containing Base-modified Cytosine Residues

Angus N.R. Nedderman, Martin J. Stone, Dudley H. Williams, Paul Kong Thoo Lin, Daniel M. Brown

Journal:

Journal of Molecular Biology

Year:

1993

File:

PDF, 509 KB

1993

35

Direct Observation of Two Base-pairing Modes of a Cytosine-Thymine Analogue with Guanine in a DNAZ-form Duplex: Significance for Base Analogue Mutagenesis

Madeleine H. Moore, Luc Van Meervelt, Stephen A. Salisbury, Paul Kong Thoo Lin, Daniel M. Brown

Journal:

Journal of Molecular Biology

Year:

1995

Language:

english

File:

PDF, 2.69 MB

english, 1995

36

A thymine-like base analogue forms wobble pairs with adenine in a Z-DNA duplex

Geertrui S Schuerman, Luc Van Meervelt, David Loakes, Daniel M Brown, Paul Kong Thoo Lin, Madeleine H Moore, Stephen A Salisbury

Journal:

Journal of Molecular Biology

Year:

1998

Language:

english

File:

PDF, 318 KB

english, 1998

37

Molecular basis for methoxyamine initiated mutagenesis: 1H Nuclear magnetic resonance studies of base-modified oligodeoxynucleotides

Martin J. Stone, Angus N.R. Nedderman, Dudley H. Williams, Paul Kong Thoo Lin, Daniel M. Brown

Journal:

Journal of Molecular Biology

Year:

1991

Language:

english

File:

PDF, 1.41 MB

english, 1991

38

Effect of three novel polyamine oxa-analogues (MTR-OSPD, DIP-SPN and APPO-TFA) on the growth and proliferation of Swiss 3T3 cells

Susan Bardocz, Mohamed Sakhri, Arpad Pusztai, Nuala M. Maguire, Paul Kong Thoo Lin

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

1996

Language:

english

File:

PDF, 728 KB

english, 1996

39

Immunological alterations induced by polyamine derivatives on murine splenocytes and human mononuclear cells

Anabela Cordeiro-da-Silva, Joana Tavares, Natália Araújo, Fátima Cerqueira, Ana Tomás, Paul Kong Thoo Lin, Ali Ouaissi

Journal:

International Immunopharmacology

Year:

2004

Language:

english

File:

PDF, 398 KB

english, 2004

40

Growth, morphological and biochemical changes in oxa-spermine derivative-treated MCF-7 human breast cancer cells

V Pavlov, V Rodilla, P Kong Thoo Lin

Journal:

Year:

2002

Language:

english

File:

PDF, 193 KB

english, 2002

41

In vitro evaluation of bisnaphthalimidopropyl derivatives loaded into pegylated nanoparticles against Leishmania infantum protozoa

Sofia Costa Lima, Vasco Rodrigues, Jorge Garrido, Fernanda Borges, Paul Kong Thoo Lin, Anabela Cordeiro da Silva

Journal:

International Journal of Antimicrobial Agents

Year:

2012

Language:

english

File:

PDF, 734 KB

english, 2012

42

Molecular and crystal structure of d(CGCGmo4CG): N4-methoxycytosine · guanine base-pairs in Z-DNA

Luc Van Meervelt, Madeleine H. Moore, Paul Kong Thoo Lin, Daniel M. Brown, Olga Kennard

Journal:

Journal of Molecular Biology

Year:

1990

Language:

english

File:

PDF, 791 KB

english, 1990

43

Anti-leishmanial activity of the bisnaphthalimidopropyl derivatives

Joana Tavares, Ali Ouaissi, Ana Marta Silva, Paul Kong Thoo Lin, Nilanjan Roy, Anabela Cordeiro-da-Silva

Journal:

Parasitology International

Year:

2012

Language:

english

File:

PDF, 466 KB

english, 2012

44

Azaindolizines. 6. The synthesis of 7-azaindolizines from methylpyrazines

Buchan, Robert, Fraser, Martin, Lin, Paul V. S. Kong Thoo

Journal:

Journal of Organic Chemistry

Year:

1985

Language:

english

File:

PDF, 1.05 MB

english, 1985

45

Synthesis, cytotoxicity and DNA binding of oxoazabenzo[de]anthracenes derivatives in colon cancer Caco-2 cells

Di Salvo, Alberto, Dugois, Pauline, Tandeo, Delphine, Peltekian, Marie, Kong Thoo Lin, Paul

Journal:

European Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.12 MB

english, 2013

46

New PVC Nitrate-Selective Electrode: Application to Vegetables and Mineral Waters

Kong Thoo Lin, P., Araujo, A. N., Montenegro, M. C. B. S. M., Pérez-Olmos, R.

Journal:

Journal of Agricultural and Food Chemistry

Year:

2005

Language:

english

File:

PDF, 48 KB

english, 2005

47

Synthesis of Derivatives of 3,4-Dihydro-6H,8H-pyrimido[4,5-c][1,2]oxazin-7-one

Kong Thoo Lin, P., M. Brown, D.

Journal:

Year:

1989

Language:

english

File:

PDF, 177 KB

english, 1989

48

Azaindolizines. 7. 7-Azaindolizines, their reactivity and reaction with dimethyl acetylenedicarboxylate

Buchan, Robert, Fraser, Martin, Lin, Paul V. S. Kong Thoo

Journal:

Journal of Organic Chemistry

Year:

1989

Language:

english

File:

PDF, 441 KB

english, 1989

49

Base pairing of cytosine analogues with adenine and guanine in oligonucleotide duplexes: evidence for exchange between Watson?Crick and wobble base pairs using 1H NMR spectroscopy

Nedderman, Angus N. R., Stone, Martin J., Lin, Paul Kong Thoo, Brown, Daniel M., Williams, Dudley H.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1991

Language:

english

File:

PDF, 252 KB

english, 1991

50

Characterization and evaluation of BNIPDaoct-loaded PLGA nanoparticles for visceral leishmaniasis: in vitro and in vivo studies

Costa Lima, Sofia A, Resende, Mariana, Silvestre, Ricardo, Tavares, Joana, Ouaissi, Ali, Lin, Paul Kong Thoo, Cordeiro-da-Silva, Anabela

Journal:

Year:

2012

Language:

english

File:

PDF, 1.46 MB

english, 2012

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