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1

Benzimidazole- and benzoxazole-based inhibitors of Rho kinase

E. Hampton Sessions, Yan Yin, Thomas D. Bannister, Amiee Weiser, Evelyn Griffin, Jennifer Pocas, Michael D. Cameron, Claudia Ruiz, Li Lin, Stephan C. Schürer, Thomas Schröter, Philip LoGrasso, Yangbo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 392 KB

english, 2008

2

The development of benzimidazoles as selective rho kinase inhibitors

E. Hampton Sessions, Michael Smolinski, Bo Wang, Bozena Frackowiak, Sarwat Chowdhury, Yan Yin, Yen Ting Chen, Claudia Ruiz, Li Lin, Jennifer Pocas, Thomas Schröter, Michael D. Cameron, Philip LoGrasso

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 440 KB

english, 2010

3

Time-resolved Forster resonance energy transfer assays for the binding of nucleotide and protein substrates to p38α protein kinase

Wen Xiao Zhang, Ruixiu Wang, Douglas Wisniewski, Alice I. Marcy, Philip LoGrasso, Jean-Marie Lisnock, Richard T. Cummings, James E. Thompson

Journal:

Analytical Biochemistry

Year:

2005

Language:

english

File:

PDF, 321 KB

english, 2005

4

Structure–activity relationships, and drug metabolism and pharmacokinetic properties for indazole piperazine and indazole piperidine inhibitors of ROCK-II

Yangbo Feng, Michael D. Cameron, Bozena Frackowiak, Evelyn Griffin, Li Lin, Claudia Ruiz, Thomas Schröter, Philip LoGrasso

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 169 KB

english, 2007

5

3,5-Disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors

Rong Jiang, Derek Duckett, Weiming Chen, Jeff Habel, Yuan Yuan Ling, Philip LoGrasso, Theodore M. Kamenecka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 232 KB

english, 2007

6

Chroman-3-amides as potent Rho kinase inhibitors

Yen Ting Chen, Thomas D. Bannister, Amiee Weiser, Evelyn Griffin, Li Lin, Claudia Ruiz, Michael D. Cameron, Stephan Schürer, Derek Duckett, Thomas Schröter, Philip LoGrasso, Yangbo Feng

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 426 KB

english, 2008

7

Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors

Youseung Shin, Weiming Chen, Jeff Habel, Derek Duckett, Yuan Yuan Ling, Marcel Koenig, Yuanjun He, Tomas Vojkovsky, Philip LoGrasso, Theodore M. Kamenecka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 493 KB

english, 2009

8

Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors

Yan Yin, Li Lin, Claudia Ruiz, Michael D. Cameron, Jennifer Pocas, Wayne Grant, Thomas Schröter, Weimin Chen, Derek Duckett, Stephan Schürer, Philip LoGrasso, Yangbo Feng

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 365 KB

english, 2009

9

Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors

Xingang Fang, Yen Ting Chen, E. Hampton Sessions, Sarwat Chowdhury, Tomas Vojkovsky, Yan Yin, Jennifer R. Pocas, Wayne Grant, Thomas Schröter, Li Lin, Claudia Ruiz, Michael D. Cameron, Philip LoGrasso

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 463 KB

english, 2011

10

The Structure of JNK3 in Complex with Small Molecule Inhibitors: Structural Basis for Potency and Selectivity

Giovanna Scapin, Sangita B. Patel, JeanMarie Lisnock, Joseph W. Becker, Philip V. LoGrasso

Journal:

Chemistry & Biology

Year:

2003

Language:

english

File:

PDF, 388 KB

english, 2003

11

Advances in pain therapeutics

Philip LoGrasso, Jeffrey McKelvy

Journal:

Current Opinion in Chemical Biology

Year:

2003

Language:

english

File:

PDF, 117 KB

english, 2003

12

Atmospheric Oxygen Inhibits Growth and Differentiation of Marrow-Derived Mouse Mesenchymal Stem Cells via a p53-Dependent Mechanism: Implications for Long-Term Culture Expansion

Siddaraju V. Boregowda, Veena Krishnappa, Jeremy W. Chambers, Philip V. Lograsso, Wen-Tzu Lai, Luis A. Ortiz, Donald G. Phinney

Journal:

Year:

2012

Language:

english

File:

PDF, 2.82 MB

english, 2012

13

Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (Part-II)

E. Hampton Sessions, Sarwat Chowdhury, Yan Yin, Jennifer R. Pocas, Wayne Grant, Thomas Schröter, Li Lin, Claudia Ruiz, Michael D. Cameron, Philip LoGrasso, Thomas D. Bannister, Yangbo Feng

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.90 MB

english, 2011

14

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)

Sarwat Chowdhury, E. Hampton Sessions, Jennifer R. Pocas, Wayne Grant, Thomas Schröter, Li Lin, Claudia Ruiz, Michael D. Cameron, Stephan Schürer, Philip LoGrasso, Thomas D. Bannister, Yangbo Feng

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 2.07 MB

english, 2011

15

Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38

Sarah J Harper, Philip LoGrasso

Journal:

Cellular Signalling

Year:

2001

Language:

english

File:

PDF, 408 KB

english, 2001

16

p38 Map Kinase Substrate Specificity Differs Greatly for Protein and Peptide Substrates

Julio Hawkins, Song Zheng, Betsy Frantz, Philip LoGrasso

Journal:

Archives of Biochemistry and Biophysics

Year:

2000

Language:

english

File:

PDF, 46 KB

english, 2000

17

Crystal Structures of Apolipoprotein(a) Kringle IV37 Free and Complexed with 6-Aminohexanoic Acid and withp-Aminomethylbenzoic Acid: Existence of Novel and Expected Binding Modes

Vincent Mikol, Philip V. LoGrasso, Brian R. Boettcher

Journal:

Journal of Molecular Biology

Year:

1996

Language:

english

File:

PDF, 1014 KB

english, 1996

18

Substituting c-Jun N-terminal kinase-3 (JNK3) ATP-binding site amino acid residues with their p38 counterparts affects binding of JNK- and p38-selective inhibitors

Michael Fricker, Philip LoGrasso, Semantha Ellis, Neil Wilkie, Peter Hunt, Scott J. Pollack

Journal:

Archives of Biochemistry and Biophysics

Year:

2005

Language:

english

File:

PDF, 732 KB

english, 2005

19

Mechanistic characterization for c-jun-N-Terminal Kinase 1α1

Brian Ember, Philip LoGrasso

Journal:

Archives of Biochemistry and Biophysics

Year:

2008

Language:

english

File:

PDF, 245 KB

english, 2008

20

Detection of myosin light chain phosphorylation—A cell-based assay for screening Rho-kinase inhibitors

Thomas Schröter, Evelyn Griffin, Amiee Weiser, Yangbo Feng, Philip LoGrasso

Journal:

Biochemical and Biophysical Research Communications

Year:

2008

Language:

english

File:

PDF, 426 KB

english, 2008

21

Characterization and purification of truncated human Rho-kinase II expressed in Sf-21 cells

Mary S Turner, Fen-Fen-Lin, John W Trauger, Jeffrey Stephens, Philip LoGrasso

Journal:

Archives of Biochemistry and Biophysics

Year:

2002

Language:

english

File:

PDF, 167 KB

english, 2002

22

Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases

John D. Laughlin, Jerome C. Nwachukwu, Mariana Figuera-Losada, Lisa Cherry, Kendall W. Nettles, Philip V. LoGrasso

Journal:

Year:

2012

Language:

english

File:

PDF, 1.41 MB

english, 2012

23

Selective Inhibition of Mitochondrial JNK Signaling Achieved Using Peptide Mimicry of the Sab Kinase Interacting Motif-1 (KIM1)

Chambers, Jeremy W., Cherry, Lisa, Laughlin, John D., Figuera-Losada, Mariana, LoGrasso, Philip V.

Journal:

ACS Chemical Biology

Year:

2011

Language:

english

File:

PDF, 1.05 MB

english, 2011

24

Activation of JNK3α1 Requires both MKK4 and MKK7: Kinetic Characterization of in Vitro Phosphorylated JNK3α1

Lisnock, JeanMarie, Griffin, Patrick, Calaycay, Jimmy, Frantz, Betsy, Parsons, Janey, O'Keefe, Stephen J., LoGrasso, Philip

Journal:

Year:

2000

Language:

english

File:

PDF, 156 KB

english, 2000

25

Synthesis of Benzoquinone Ansamycin-Inspired Macrocyclic Lactams from Shikimic Acid

Jeso, Valer, Iqbal, Sarah, Hernandez, Pamela, Cameron, Michael D., Park, HaJeung, LoGrasso, Philip V., Micalizio, Glenn C.

Journal:

Angewandte Chemie International Edition

Year:

2013

Language:

english

File:

PDF, 961 KB

english, 2013

26

Synthesis of Potent Bicyclic Bisarylimidazole c-Jun N-Terminal Kinase Inhibitors by Catalytic C−H Bond Activation

Rech, Jason C., Yato, Michihisa, Duckett, Derek, Ember, Brian, LoGrasso, Philip V., Bergman, Robert G., Ellman, Jonathan A.

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 41 KB

english, 2007

27

Synthesis and Biological Evaluation of Urea Derivatives as Highly Potent and Selective Rho Kinase Inhibitors

Yin, Yan, Lin, Li, Ruiz, Claudia, Khan, Susan, Cameron, Michael D., Grant, Wayne, Pocas, Jennifer, Eid, Nibal, Park, HaJeung, Schröter, Thomas, LoGrasso, Philip V., Feng, Yangbo

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.96 MB

english, 2013

28

A Small Molecule Bidentate-Binding Dual Inhibitor Probe of the LRRK2 and JNK Kinases

Feng, Yangbo, Chambers, Jeremy W., Iqbal, Sarah, Koenig, Marcel, Park, HaJeung, Cherry, Lisa, Hernandez, Pamela, Figuera-Losada, Mariana, LoGrasso, Philip V.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.92 MB

english, 2013

29

Convergent Synthesis and Discovery of a Natural Product-Inspired Paralog-Selective Hsp90 Inhibitor

Jeso, Valer, Cherry, Lisa, Macklin, Todd K., Pan, Subhas Chandra, LoGrasso, Philip V., Micalizio, Glenn C.

Journal:

Organic Letters

Year:

2011

Language:

english

File:

PDF, 1.57 MB

english, 2011

30

Kinetic Mechanism for p38 MAP Kinase

LoGrasso, Philip V., Frantz, Betsy, Rolando, Anna M., O'Keefe, Stephen J., Hermes, Jeffery D., O'Neill, Edward A.

Journal:

Year:

1997

Language:

english

File:

PDF, 231 KB

english, 1997

31

Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors

He, Yuanjun, Duckett, Derek, Chen, Weimin, Ling, Yuan Yuan, Cameron, Michael D., Lin, Li, Ruiz, Claudia H., LoGrasso, Philip V., Kamenecka, Theodore M., Koenig, Marcel

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.73 MB

english, 2014

32

Amino acid derived quinazolines as Rock/PKA inhibitors

Chowdhury, Sarwat, Chen, Yen Ting, Fang, Xingang, Grant, Wayne, Pocas, Jennifer, Cameron, Michael D., Ruiz, Claudia, Lin, Li, Park, HaJeung, Schröter, Thomas, Bannister, Thomas D., LoGrasso, Philip V.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.68 MB

english, 2013

33

Mechanism of Activation for Zap-70 Catalytic Activity

Philip V. LoGrasso, Julio Hawkins, Lori J. Frank, Douglas Wisniewski and Alice Marcy

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.46 MB

english, 1996

34

Kinetic Mechanism and Inhibitor Characterization for c-jun-N-Terminal Kinase 3α1

Ember, Brian, Kamenecka, Ted, LoGrasso, Philip

Journal:

Year:

2008

Language:

english

File:

PDF, 291 KB

english, 2008

35

Buffer enhancement of proton transfer in catalysis by human carbonic anhydrase III

Tu, Chingkuang, Paranawithana, Shanthi R., Jewell, David A., Tanhauser, Susan M., LoGrasso, Philip V., Wynns, George C., Laipis, Philip J., Silverman, David N.

Journal:

Year:

1990

Language:

english

File:

PDF, 750 KB

english, 1990

36

Influence of amino acid replacement at position 198 on catalytic properties of zinc-bound water in human carbonic anhydrase III

LoGrasso, Philip V., Tu, Chingkuang, Chen, Xian, Taoka, Shinichi, Laipis, Philip J., Silverman, David N.

Journal:

Year:

1993

Language:

english

File:

PDF, 806 KB

english, 1993

37

Discovery of Potent and Selective Urea-Based ROCK Inhibitors and Their Effects on Intraocular Pressure in Rats

Yin, Yan, Cameron, Michael D., Lin, Li, Khan, Susan, Schröter, Thomas, Grant, Wayne, Pocas, Jennifer, Chen, Yen Ting, Schürer, Stephan, Pachori, Alok, LoGrasso, Philip, Feng, Yangbo

Journal:

ACS Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.44 MB

english, 2010

38

JNK Inhibition Protects Dopamine Neurons and Provides Behavioral Improvement in a Rat 6-Hydroxydopamine Model of Parkinson’s Disease

Crocker, Candice E., Khan, Susan, Cameron, Michael D., Robertson, Harold A., Robertson, George S., LoGrasso, Philip

Journal:

ACS Chemical Neuroscience

Year:

2011

Language:

english

File:

PDF, 1.93 MB

english, 2011

39

Enhancement of the catalytic properties of human carbonic anhydrase III by site-directed mutagenesis

Jewell, David A., Tu, Chingkuang, Paranawithana, Shanthi R., Tanhauser, Susan M., LoGrasso, Philip V., Laipis, Philip J., Silverman, David N.

Journal:

Year:

1991

Language:

english

File:

PDF, 870 KB

english, 1991

40

Discovery of Substituted 4-(Pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as Potent and Highly Selective Rho Kinase (ROCK-II) Inhibitors

Feng, Yangbo, Yin, Yan, Weiser, Amiee, Griffin, Evelyn, Cameron, Michael D., Lin, Li, Ruiz, Claudia, Schürer, Stephan C., Inoue, Toshihiro, Rao, P. Vasanth, Schröter, Thomas, LoGrasso, Philip

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 427 KB

english, 2008

41

Interaction and influence of phenylalanine-198 and threonine-199 on catalysis by human carbonic anhydrase III

Chen, Xian, Tu, Chingkuang, LoGrasso, Philip V., Laipis, Philip J., Silverman, David N.

Journal:

Year:

1993

Language:

english

File:

PDF, 625 KB

english, 1993

42

Catalytic enhancement of human carbonic anhydrase III by replacement of phenylalanine-198 with leucine

LoGrasso, Philip V., Tu, Chingkuang, Jewell, David A., Wynns, George C., Laipis, Philip J., Silverman, David N.

Journal:

Year:

1991

Language:

english

File:

PDF, 993 KB

english, 1991

43

Kinetic Mechanism for Human Rho-Kinase II (ROCK-II)

Trauger, John W., Lin, Fen-Fen, Turner, Mary S., Stephens, Jeffrey, LoGrasso, Philip V.

Journal:

Year:

2002

Language:

english

File:

PDF, 73 KB

english, 2002

44

Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives

Zheng, Ke, Iqbal, Sarah, Hernandez, Pamela, Park, HaJeung, LoGrasso, Philip V., Feng, Yangbo

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 3.99 MB

english, 2014

45

Rho kinase inhibitors: a patent review (2012 – 2013)

Feng, Yangbo, LoGrasso, Philip V

Journal:

Expert Opinion on Therapeutic Patents

Year:

2014

Language:

english

File:

PDF, 743 KB

english, 2014

46

Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors

Zheng, Ke, Park, Chul Min, Iqbal, Sarah, Hernandez, Pamela, Park, HaJeung, LoGrasso, Philip V., Feng, Yangbo

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.39 MB

english, 2015

47

Serum- and Glucocorticoid-Inducible Kinase 1 Confers Protection in Cell-Based and in In Vivo Neurotoxin Models via the c-Jun N-Terminal Kinase Signaling Pathway

Iqbal, Sarah, Howard, Shannon, LoGrasso, Philip V.

Journal:

Molecular and Cellular Biology

Year:

2015

Language:

english

File:

PDF, 3.29 MB

english, 2015

48

Rho Kinase (ROCK) Inhibitors and Their Application to Inflammatory Disorders

LoGrasso, Philip, Feng, Yangbo

Journal:

Current Topics in Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 424 KB

english, 2009

49

Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential

Feng, Yangbo, LoGrasso, Philip V., Defert, Olivier, Li, Rongshi

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.31 MB

english, 2015

50

Inhibitors of c-jun-N-Terminal Kinase (JNK)

LoGrasso, Philip, Kamenecka, Theodore

Journal:

Mini Reviews in Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 259 KB

english, 2008