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1

Glutamate carboxypeptidase II is expressed by astrocytes in the adult rat nervous system

Berger, Urs V., Luthi-Carter, Ruth, Passani, Lucius A., Elkabes, Stella, Black, Ira, Konradi, Christine, Coyle, Joseph T.

Journal:

The Journal of Comparative Neurology

Year:

1999

Language:

english

File:

PDF, 1.01 MB

english, 1999

2

What have we learned from gene expression profiles in Huntington's disease?

Tamara Seredenina, Ruth Luthi-Carter

Journal:

Neurobiology of Disease

Year:

2012

Language:

english

File:

PDF, 744 KB

english, 2012

3

Synchrotron Infrared Microspectroscopy Detecting the Evolution of Huntington’s Disease Neuropathology and Suggesting Unique Correlates of Dysfunction in White versus Gray Brain Matter

Bonda, Markus, Perrin, Valérie, Vileno, Bertrand, Runne, Heike, Kretlow, Ariane, Forró, László, Luthi-Carter, Ruth, Miller, Lisa M., Jeney, Sylvia

Journal:

Analytical Chemistry

Year:

2011

Language:

english

File:

PDF, 3.16 MB

english, 2011

4

Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis

Becanovic, K., Pouladi, M. A., Lim, R. S., Kuhn, A., Pavlidis, P., Luthi-Carter, R., Hayden, M. R., Leavitt, B. R.

Journal:

Human Molecular Genetics

Year:

2010

Language:

english

File:

PDF, 470 KB

english, 2010

5

Sustained effects of nonallele-specific Huntingtin silencing

Valérie Drouet, Valérie Perrin, Raymonde Hassig, Noëlle Dufour, Gwennaelle Auregan, Sandro Alves, Gilles Bonvento, Emmanuel Brouillet, Ruth Luthi-Carter, Philippe Hantraye, Nicole Déglon

Journal:

Annals of Neurology

Year:

2009

Language:

english

File:

PDF, 809 KB

english, 2009

6

Biological and Potential Therapeutic Roles of Sirtuin Deacetylases

D. M. Taylor, M. M. Maxwell, R. Luthi-Carter, A. G. Kazantsev

Journal:

Cellular and Molecular Life Sciences

Year:

2008

Language:

english

File:

PDF, 3.19 MB

english, 2008

7

Diminished hippocalcin expression in Huntington’s disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons

Nikita Rudinskiy, Yoshio A. Kaneko, Ayshe Ana Beesen, Ozgun Gokce, Etienne Régulier, Nicole Déglon, Ruth Luthi-Carter

Journal:

Journal of Neurochemistry

Year:

2009

Language:

english

File:

PDF, 637 KB

english, 2009

8

Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo

Delphine Charvin, Emmanuel Roze, Valérie Perrin, Carole Deyts, Sandrine Betuing, Christiane Pagès, Etienne Régulier, Ruth Luthi-Carter, Emmanuel Brouillet, Nicole Déglon, Jocelyne Caboche

Journal:

Neurobiology of Disease

Year:

2008

Language:

english

File:

PDF, 947 KB

english, 2008

9

Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease

Bin Tang, Tamara Seredenina, Giovanni Coppola, Alexandre Kuhn, Daniel H. Geschwind, Ruth Luthi-Carter, Elizabeth A. Thomas

Journal:

Neurobiology of Disease

Year:

2011

Language:

english

File:

PDF, 1.30 MB

english, 2011

10

Hydrolysis of the neuropeptide N-acetylaspartylglutamate (NAAG) by cloned human glutamate carboxypeptidase II

Ruth Luthi-Carter, Amy K. Barczak, Henry Speno, Joseph T. Coyle

Journal:

Year:

1998

Language:

english

File:

PDF, 216 KB

english, 1998

11

Mechanisms of transcriptional dysregulation in Huntington's disease

Ruth Luthi-Carter, Jang-Ho J Cha

Journal:

Clinical Neuroscience Research

Year:

2003

Language:

english

File:

PDF, 475 KB

english, 2003

12

Cross-species and cross-platform gene expression studies with the Bioconductor-compliant R package 'annotationTools'

Alexandre Kuhn, Ruth Luthi-Carter, Mauro Delorenzi

Journal:

BMC Bioinformatics

Year:

2008

Language:

english

File:

PDF, 511 KB

english, 2008

13

Implication of the JNK pathway in a rat model of Huntington's disease

V. Perrin, N. Dufour, C. Raoul, R. Hassig, E. Brouillet, P. Aebischer, R. Luthi-Carter, N. Déglon

Journal:

Experimental Neurology

Year:

2009

Language:

english

File:

PDF, 2.74 MB

english, 2009

14

Comprehensive spatiotemporal transcriptomic analyses of the ganglionic eminences demonstrate the uniqueness of its caudal subdivision

Susan Willi-Monnerat, Eugenia Migliavacca, Didier Surdez, Mauro Delorenzi, Ruth Luthi-Carter, Alexey V. Terskikh

Journal:

Molecular and Cellular Neuroscience

Year:

2008

Language:

english

File:

PDF, 2.92 MB

english, 2008

15

Developmental expression of Synaptotagmin isoforms in single calyx of Held-generating neurons

Le Xiao, Yunyun Han, Heike Runne, Heather Murray, Olexiy Kochubey, Ruth Luthi-Carter, Ralf Schneggenburger

Journal:

Molecular and Cellular Neuroscience

Year:

2010

Language:

english

File:

PDF, 1.87 MB

english, 2010

16

Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation

Ruth Luthi-Carter, Barbara L Apostol, Anthone W Dunah, Molly M DeJohn, Laurie A Farrell, Gillian P Bates, Anne B Young, David G Standaert, Leslie M Thompson, Jang-Ho J Cha

Journal:

Neurobiology of Disease

Year:

2003

Language:

english

File:

PDF, 768 KB

english, 2003

17

Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease

Paolo Guidetti, Ruth E. Luthi-Carter, Sarah J. Augood, Robert Schwarcz

Journal:

Neurobiology of Disease

Year:

2004

Language:

english

File:

PDF, 432 KB

english, 2004

18

Capucin: A novel striatal marker down-regulated in rodent models of Huntington disease

M. de Chaldée, C. Brochier, A. Van de Vel, N. Caudy, R. Luthi-Carter, M.C. Gaillard, J.M. Elalouf

Journal:

Year:

2006

Language:

english

File:

PDF, 413 KB

english, 2006

19

Differential D1 and D2 receptor-mediated effects on immediate early gene induction in a transgenic mouse model of Huntington’s disease

Boris S. Spektor, David W. Miller, Zane R. Hollingsworth, Yoshio A. Kaneko, Steven M. Solano, Jennifer M. Johnson, John B. Penney Jr., Anne B. Young, Ruth Luthi-Carter

Journal:

Molecular Brain Research

Year:

2002

Language:

english

File:

PDF, 1.11 MB

english, 2002

20

N-Acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo

Lianna R. Orlando, Ruth Luthi-Carter, David G. Standaert, Joseph T. Coyle, John B. Penney Jr., Anne B. Young

Journal:

Neuroscience Letters

Year:

1997

Language:

english

File:

PDF, 158 KB

english, 1997

21

MAP Kinase Phosphatase 1 (MKP-1/DUSP1) Is Neuroprotective in Huntington's Disease via Additive Effects of JNK and p38 Inhibition

Taylor, D. M., Moser, R., Regulier, E., Breuillaud, L., Dixon, M., Beesen, A. A., Elliston, L., Silva Santos, M. d. F., Kim, J., Jones, L., Goldstein, D. R., Ferrante, R. J., Luthi-Carter, R.

Journal:

Journal of Neuroscience

Year:

2013

Language:

english

File:

PDF, 2.54 MB

english, 2013

22

Evolution Of Protein Misfolding And Cell Apoptosis In Huntington's Disease Studied By Synchrotron Infra-Red Microspectroscopy

Bonda, Markus, Runne, Heike, Vileno, Bertrand, Perrin, Valérie, Kretlow, Ariane, Miller, Lisa M., Forró, László, Lüthi-Carter, Ruth, Jeney, Sylvia

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 93 KB

english, 2009

23

Comparative analyses of Purkinje cell gene expression profiles reveal shared molecular abnormalities in models of different polyglutamine diseases

Friedrich, Bernd, Euler, Philipp, Ziegler, Ruhtraut, Kuhn, Alexandre, Landwehrmeyer, Bernhard G., Luthi-Carter, Ruth, Weiller, Cornelius, Hellwig, Sabine, Zucker, Birgit

Journal:

Year:

2012

Language:

english

File:

PDF, 827 KB

english, 2012

24

Huntington's and other polyglutamine diseases: many effects of single gene mutations

Ruth Luthi-Carter

Journal:

Drug Discovery Today: Disease Mechanisms

Year:

2007

Language:

english

File:

PDF, 1.05 MB

english, 2007

25

Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain

Kuhn, Alexandre, Thu, Doris, Waldvogel, Henry J, Faull, Richard L M, Luthi-Carter, Ruth

Journal:

Year:

2011

Language:

english

File:

PDF, 729 KB

english, 2011

26

Comprehensive Expression Analyses of Neural Cell-Type-Specific miRNAs Identify New Determinants of the Specification and Maintenance of Neuronal Phenotypes

Jovicic, A., Roshan, R., Moisoi, N., Pradervand, S., Moser, R., Pillai, B., Luthi-Carter, R.

Journal:

Journal of Neuroscience

Year:

2013

Language:

english

File:

PDF, 1.59 MB

english, 2013

27

Isolation and Expression of a Rat Brain cDNA Encoding Glutamate Carboxypeptidase II

Ruth Luthi-Carter, Urs V. Berger, Amy K. Barczak, Matthew Enna and Joseph T. Coyle

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.62 MB

english, 1998

28

A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase

Taylor, David M., Balabadra, Uma, Xiang, Zhongmin, Woodman, Ben, Meade, Sarah, Amore, Allison, Maxwell, Michele M., Reeves, Steven, Bates, Gillian P., Luthi-Carter, Ruth, Lowden, Philip A. S., Kazants

Journal:

ACS Chemical Biology

Year:

2011

Language:

english

File:

PDF, 2.02 MB

english, 2011

29

Involvement of autophagy in hypoxic-excitotoxic neuronal death

Ginet, Vanessa, Spiehlmann, Amélie, Rummel, Coralie, Rudinskiy, Nikita, Grishchuk, Yulia, Luthi-Carter, Ruth, Clarke, Peter GH, Truttmann, Anita C, Puyal, Julien

Journal:

Year:

2014

Language:

english

File:

PDF, 7.89 MB

english, 2014

30

Neuroprotection by Hsp104 and Hsp27 in Lentiviral-based Rat Models of Huntington's Disease

Perrin, Valérie, Régulier, Etienne, Abbas-Terki, Toufik, Hassig, Raymonde, Brouillet, Emmanuel, Aebischer, Patrick, Luthi-Carter, Ruth, Déglon, Nicole

Journal:

Molecular Therapy

Year:

2007

Language:

english

File:

PDF, 649 KB

english, 2007

31

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

Luthi-Carter, Ruth, Taylor, David M., Pallos, Judit, Lambert, Emmanuel, Amore, Allison, Parker, Alex, Moffitt, Hilary, Smith, Donna L., Runne, Heike, Gokce, Ozgun, Kuhn, Alexandre, Xiang, Zhongmin, Ma

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 755 KB

english, 2010

32

Diminished Activity-Dependent Brain-Derived Neurotrophic Factor Expression Underlies Cortical Neuron Microcircuit Hypoconnectivity Resulting from Exposure to Mutant Huntingtin Fragments

Gambazzi, L., Gokce, O., Seredenina, T., Katsyuba, E., Runne, H., Markram, H., Giugliano, M., Luthi-Carter, R.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2010

Language:

english

File:

PDF, 1.39 MB

english, 2010

33

Neuroprotective Effects of Synaptic Modulation in Huntington's Disease R6/2 Mice

Stack, E. C., Dedeoglu, A., Smith, K. M., Cormier, K., Kubilus, J. K., Bogdanov, M., Matson, W. R., Yang, L., Jenkins, B. G., Luthi-Carter, R., Kowall, N. W., Hersch, S. M., Beal, M. F., Ferrante, R.

Journal:

Journal of Neuroscience

Year:

2007

Language:

english

File:

PDF, 782 KB

english, 2007

34

Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects

Luthi-Carter, R.

Journal:

Human Molecular Genetics

Year:

2002

Language:

english

File:

PDF, 4.25 MB

english, 2002

35

Dysregulation of Gene Expression in Primary Neuron Models of Huntington's Disease Shows That Polyglutamine-Related Effects on the Striatal Transcriptome May Not Be Dependent on Brain Circuitry

Runne, H., Regulier, E., Kuhn, A., Zala, D., Gokce, O., Perrin, V., Sick, B., Aebischer, P., Deglon, N., Luthi-Carter, R.

Journal:

Journal of Neuroscience

Year:

2008

Language:

english

File:

PDF, 431 KB

english, 2008

36

Expression analysis of novel striatal-enriched genes in Huntington disease

Mazarei, G., Neal, S. J., Becanovic, K., Luthi-Carter, R., Simpson, E. M., Leavitt, B. R.

Journal:

Human Molecular Genetics

Year:

2010

Language:

english

File:

PDF, 351 KB

english, 2010

37

The Ratio of Monomeric to Aggregated Forms of A 40 and A 42 Is an Important Determinant of Amyloid- Aggregation, Fibrillogenesis, and Toxicity

Jan, A., Gokce, O., Luthi-Carter, R., Lashuel, H. A.

Journal:

Journal of Biological Chemistry

Year:

2008

Language:

english

File:

PDF, 1.28 MB

english, 2008

38

Folylpoly- -glutamate Carboxypeptidase from Pig Jejunum: MOLECULAR CHARACTERIZATION AND RELATION TO GLUTAMATE CARBOXYPEPTIDASE II

Halsted, C. H., Ling, E.-h., Luthi-Carter, R., Villanueva, J. A., Gardner, J. M., Coyle, J. T.

Journal:

Journal of Biological Chemistry

Year:

1998

Language:

english

File:

PDF, 333 KB

english, 1998

39

Reply to Valenza and Cattaneo: SIRT2-mediated neuroprotection and cholesterol dyshomeostasis in Huntington's disease

Luthi-Carter, R., Kazantsev, A. G.

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 433 KB

english, 2010

40

A Large Number of Protein Expression Changes Occur Early in Life and Precede Phenotype Onset in a Mouse Model for Huntington Disease

Zabel, C., Mao, L., Woodman, B., Rohe, M., Wacker, M. A., Klare, Y., Koppelstatter, A., Nebrich, G., Klein, O., Grams, S., Strand, A., Luthi-Carter, R., Hartl, D., Klose, J., Bates, G. P.

Journal:

Molecular & Cellular Proteomics

Year:

2009

Language:

english

File:

PDF, 409 KB

english, 2009

41

Calpain Hydrolysis of - and 2-Adaptins Decreases Clathrin-dependent Endocytosis and May Promote Neurodegeneration

Rudinskiy, N., Grishchuk, Y., Vaslin, A., Puyal, J., Delacourte, A., Hirling, H., Clarke, P. G. H., Luthi-Carter, R.

Journal:

Journal of Biological Chemistry

Year:

2009

Language:

english

File:

PDF, 1.79 MB

english, 2009

42

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

Luthi-Carter, R.

Journal:

Human Molecular Genetics

Year:

2000

Language:

english

File:

PDF, 1.83 MB

english, 2000

43

Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood

Runne, H., Kuhn, A., Wild, E. J., Pratyaksha, W., Kristiansen, M., Isaacs, J. D., Regulier, E., Delorenzi, M., Tabrizi, S. J., Luthi-Carter, R.

Journal:

Proceedings of the National Academy of Sciences

Year:

2007

Language:

english

File:

PDF, 491 KB

english, 2007

44

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

Labbadia, John, Cunliffe, Helen, Weiss, Andreas, Katsyuba, Elena, Sathasivam, Kirupa, Seredenina, Tamara, Woodman, Ben, Moussaoui, Saliha, Frentzel, Stefan, Luthi-Carter, Ruth, Paganetti, Paolo, Bates

Journal:

Journal of Clinical Investigation

Year:

2011

Language:

english

File:

PDF, 2.40 MB

english, 2011

45

Novel -secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1

Wu, F., Schweizer, C., Rudinskiy, N., Taylor, D. M., Kazantsev, A., Luthi-Carter, R., Fraering, P. C.

Journal:

The FASEB Journal

Year:

2010

Language:

english

File:

PDF, 715 KB

english, 2010

46

Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

Luthi-Carter, R.

Journal:

Human Molecular Genetics

Year:

2002

Language:

english

File:

PDF, 2.86 MB

english, 2002

47

Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington's disease

Thu, D. C. V., Oorschot, D. E., Tippett, L. J., Nana, A. L., Hogg, V. M., Synek, B. J., Luthi-Carter, R., Waldvogel, H. J., Faull, R. L. M.

Journal:

Year:

2010

Language:

english

File:

PDF, 920 KB

english, 2010

48

In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons

Thomas, E. A., Coppola, G., Tang, B., Kuhn, A., Kim, S., Geschwind, D. H., Brown, T. B., Luthi-Carter, R., Ehrlich, M. E.

Journal:

Human Molecular Genetics

Year:

2011

Language:

english

File:

PDF, 510 KB

english, 2011

49

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

Ruth Luthi-Carter, David M. Taylor, Judit Pallos, Emmanuel Lambert, Allison Amore, Alex Parker, Hilary Moffitt, Donna L. Smith, Heike Runne, Ozgun Gokce, Alexandre Kuhn, Zhongmin Xiang, Michele M. Max

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.49 MB

english, 2010

50

Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington’s disease models

Smalley, Joshua L., Breda, Carlo, Mason, Robert P., Kooner, Gurdeep, Luthi-Carter, Ruth, Gant, Timothy W., Giorgini, Flaviano

Journal:

Journal of Molecular Medicine

Year:

2016

Language:

english

File:

PDF, 1.34 MB

english, 2016

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