M. B. Tropak: search on Z-Library

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1

1-Deoxynojirimycins with dansyl capped N-substituents as probes for Morbus Gaucher affected cell lines

Richard F.G. Fröhlich, Richard H. Furneaux, Don J. Mahuran, Brigitte A. Rigat, Arnold E. Stütz, Michael B. Tropak, Jacqueline Wicki, Stephen G. Withers, Tanja M. Wrodnigg

Journal:

Carbohydrate Research

Year:

2010

Language:

english

File:

PDF, 480 KB

english, 2010

2

1-Deoxy-d-galactonojirimycins with dansyl capped N-substituents as β-galactosidase inhibitors and potential probes for GM1 gangliosidosis affected cell lines

Richard F.G. Fröhlich, Richard H. Furneaux, Don J. Mahuran, Robert Saf, Arnold E. Stütz, Michael B. Tropak, Jacqueline Wicki, Stephen G. Withers, Tanja M. Wrodnigg

Journal:

Carbohydrate Research

Year:

2011

Language:

english

File:

PDF, 598 KB

english, 2011

3

Identification of an altered splice site in Ashkenazi Tay-Sachs disease

Arpaia, E., Dumbrille-Ross, A., Maler, T., Neote, K., Tropak, M., Troxel, C., Stirling, J. L., Pitts, J. S., Bapat, B., Lamhonwah, A. M.

Journal:

Year:

1988

File:

PDF, 250 KB

1988

4

Exercise-induced cardioprotection is mediated by a bloodborne, transferable factor

M. M. Michelsen, N. B. Støttrup, M. R. Schmidt, B. Løfgren, R. V. Jensen, M. Tropak, E. Jean St-Michel, A. N. Redington, H. E. Bøtker

Journal:

Basic Research in Cardiology

Year:

2012

Language:

english

File:

PDF, 348 KB

english, 2012

5

Pharmacological Enhancement of -Hexosaminidase Activity in Fibroblasts from Adult Tay-Sachs and Sandhoff Patients

Journal:

Journal of Biological Chemistry

Year:

2004

Language:

english

File:

PDF, 1.05 MB

english, 2004

6

Remote Preconditioning Improves Maximal Performance in Highly Trained Athletes

JEAN-ST-MICHEL, EMILIE, MANLHIOT, CEDRIC, LI, JING, TROPAK, MICHAEL, MICHELSEN, MARIE M., SCHMIDT, MICHAEL R., MCCRINDLE, BRIAN W., WELLS, GREG D., REDINGTON, ANDREW N.

Journal:

Medicine & Science in Sports & Exercise

Year:

2011

Language:

english

File:

PDF, 7.58 MB

english, 2011

7

Tailoring the Specificity and Reactivity of a Mechanism-Based Inactivator of Glucocerebrosidase for Potential Therapeutic Applications

Brian P. Rempel, Dr. Michael B. Tropak, Dr. Don J. Mahuran, Prof. Stephen G. Withers

Journal:

Angewandte Chemie

Year:

2011

Language:

english

File:

PDF, 372 KB

english, 2011

8

Tailoring the Specificity and Reactivity of a Mechanism-Based Inactivator of Glucocerebrosidase for Potential Therapeutic Applications

Brian P. Rempel, Dr. Michael B. Tropak, Dr. Don J. Mahuran, Prof. Stephen G. Withers

Journal:

Angewandte Chemie International Edition

Year:

2011

Language:

english

File:

PDF, 355 KB

english, 2011

9

Isofagomine Induced Stabilization of Glucocerebrosidase

Gregory J. Kornhaber, Michael B. Tropak, Gustavo H. Maegawa, Steven J. Tuske, Stephen J. Coales, Don J. Mahuran, Yoshitomo Hamuro

Journal:

Year:

2008

Language:

english

File:

PDF, 892 KB

english, 2008

10

Identification of Pharmacological Chaperones for Gaucher Disease and Characterization of Their Effects on β-Glucocerebrosidase by Hydrogen/Deuterium Exchange Mass Spectrometry

Michael B. Tropak, Gregory J. Kornhaber, Brigitte A. Rigat, Gustavo H. Maegawa, Justin D. Buttner, Jan E. Blanchard, Cecilia Murphy, Steven J. Tuske, Stephen J. Coales, Yoshitomo Hamuro, Eric D. Brown

Journal:

Year:

2008

Language:

english

File:

PDF, 1.28 MB

english, 2008

11

Cover Picture: Identification of Pharmacological Chaperones for Gaucher Disease and Characterization of Their Effects on β-Glucocerebrosidase by Hydrogen/Deuterium Exchange Mass Spectrometry (ChemBioChem 16/2008)

Michael B. Tropak, Gregory J. Kornhaber, Brigitte A. Rigat, Gustavo H. Maegawa, Justin D. Buttner, Jan E. Blanchard, Cecilia Murphy, Steven J. Tuske, Stephen J. Coales, Yoshitomo Hamuro, Eric D. Brown

Journal:

Year:

2008

Language:

english

File:

PDF, 1.07 MB

english, 2008

12

Synthesis, Kinetic Evaluation and Cell-Based Analysis of C-Alkylated Isofagomines as Chaperones of β-Glucocerebrosidase

Tara Hill, Dr. Michael B. Tropak, Dr. Don Mahuran, Dr. Stephen G. Withers

Journal:

Year:

2011

Language:

english

File:

PDF, 256 KB

english, 2011

13

Functional topography of myelin-associated glycoprotein. II. Mapping of domains on molecular fragments

A. Meyer-Franke, M. B. Tropak, J. C. Roder, P. Fischer, K. Beyreuther, R. Probstmeier, M. Schachner

Journal:

Journal of Neuroscience Research

Year:

1995

Language:

english

File:

PDF, 1.27 MB

english, 1995

14

Identification of drug candidates which increase cytochrome c oxidase activity in deficient patient fibroblasts

Mary Maj, Niroshan Sriskandarajah, Vinci Hung, Ikennah Browne, Bhavank Shah, Anita Weadge, Nicola L. Jamieson, Michael Tropak, Jessie M. Cameron, Jane B. Addis, Brian H. Robinson

Journal:

Year:

2011

Language:

english

File:

PDF, 1.01 MB

english, 2011

15

1-Deoxygalactonojirimycin-lysine hybrids as potent d-galactosidase inhibitors

Andreas J. Steiner, Georg Schitter, Arnold E. Stütz, Tanja M. Wrodnigg, Chris A. Tarling, Stephen G. Withers, Katrin Fantur, Don Mahuran, Eduard Paschke, Michael Tropak

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 191 KB

english, 2008

16

High-Throughput Screening for Human Lysosomal β-N-Acetyl Hexosaminidase Inhibitors Acting as Pharmacological Chaperones

Michael B. Tropak, Jan E. Blanchard, Stephen G. Withers, Eric D. Brown, Don Mahuran

Journal:

Chemistry & Biology

Year:

2007

Language:

english

File:

PDF, 714 KB

english, 2007

17

2-Acetamino-1,2-dideoxynojirimycin—lysine hybrids as hexosaminidase inhibitors

Andreas J. Steiner, Georg Schitter, Arnold E. Stütz, Tanja M. Wrodnigg, Chris A. Tarling, Stephen G. Withers, Don J. Mahuran, Michael B. Tropak

Journal:

Tetrahedron: Asymmetry

Year:

2009

Language:

english

File:

PDF, 342 KB

english, 2009

18

High-Resolution Mapping of GenS3 and B11F7 Epitopes on Myelin-Associated Glycoprotein by Expression PCR

Michael B. Tropak, John C. Roder

Journal:

Journal of Neurochemistry

Year:

1994

Language:

english

File:

PDF, 1.02 MB

english, 1994

19

Regulation of Myelin-Associated Glycoprotein Binding by Sialylated Cis-Ligands

M. B. Tropak, J. C. Roder

Journal:

Journal of Neurochemistry

Year:

1997

Language:

english

File:

PDF, 1.70 MB

english, 1997

20

Comparison of HCMV IE and EF-1 Promoters for the Stable Expression of β-Subunit of Hexosaminidase in CHO Cell Lines

Incilay Sinici, Maryam Zarghooni, Michael B. Tropak, Don J. Mahuran, H. Asuman Özkara

Journal:

Biochemical Genetics

Year:

2006

Language:

english

File:

PDF, 214 KB

english, 2006

21

Lending a helping hand, screening chemical libraries for compounds that enhance β-hexosaminidase A activity in GM2 gangliosidosis cells

Michael B. Tropak, Don Mahuran

Journal:

Year:

2007

Language:

english

File:

PDF, 516 KB

english, 2007

22

MyeliN-associated Glycoprotein Binding to Gangliosides: Structural Specificity and Functional Implications

RONALD L. SCHNAAR, BRIAN E. COLLINS, LATASHA P. WRIGHT, MAKOTO KISO, MICHAEL B. TROPAK, JOHN C. RODER, PAUL R. CROCKER

Journal:

Annals of the New York Academy of Sciences

Year:

1998

File:

PDF, 2.16 MB

1998

23

Myelination in the absence of myelin-associated glycoprotein

Li, Chumei, Tropak, Michael B., Gerlai, Robert, Clapoff, Susan, Abramow-Newerly, Wanda, Trapp, Bruce, Peterson, Alan, Roder, John

Journal:

Year:

1994

File:

PDF, 700 KB

1994

24

Isolation and characterization of the human catalase gene

Quan, F., Korneluk, R.G., Tropak, M.B., Gravel, R.A.

Journal:

Nucleic Acids Research

Year:

1986

Language:

english

File:

PDF, 1.38 MB

english, 1986

25

Remote cardioprotection by direct peripheral nerve stimulation and topical capsaicin is mediated by circulating humoral factors

Kathrine L. Redington, Tara Disenhouse, Samuel C. Strantzas, Rachel Gladstone, Can Wei, Michael B. Tropak, Xiaojing Dai, Cedric Manlhiot, Jing Li, Andrew N. Redington

Journal:

Basic Research in Cardiology

Year:

2012

Language:

english

File:

PDF, 632 KB

english, 2012

26

Remote ischemic preconditioning elaborates a transferable blood-borne effector that protects mitochondrial structure and function and preserves myocardial performance after neonatal cardioplegic arrest

Lixing Wang, Norihiko Oka, Michael Tropak, John Callahan, John Lee, Greg Wilson, Andrew Redington, Christopher A. Caldarone

Journal:

The Journal of Thoracic and Cardiovascular Surgery

Year:

2008

Language:

english

File:

PDF, 742 KB

english, 2008

27

Potent neuroprotection induced by remote preconditioning in a rat model of neonatal cerebral hypoxic–ischemic injury

Michael B. Tropak, Hui Shi, Jing Li, XiaoJing Dai, Andrew N. Redington, Rand Askalan

Journal:

The Journal of Thoracic and Cardiovascular Surgery

Year:

2011

Language:

english

File:

PDF, 392 KB

english, 2011

28

Cloning of cDNA encoding the membrane-bound form of bovine β1,4-galactosyltransferase

Giacomo D'AGOSTARO, Brad BENDIAK, Michael TROPAK

Journal:

Year:

1989

Language:

english

File:

PDF, 828 KB

english, 1989

29

Cloning and Molecular Characterization of Two Splice Variants of a New Putative Member of the Siglec-3-like Subgroup of Siglecs

George Foussias, Steve M. Taylor, George M. Yousef, Michael B. Tropak, Michael H. Ordon, Eleftherios P. Diamandis

Journal:

Biochemical and Biophysical Research Communications

Year:

2001

Language:

english

File:

PDF, 376 KB

english, 2001

30

Cytotoxicity of B72.3XOKT3 Bispecific Antibody Recognizing Human Colon Cancer

Baruch Shpitz, Hartley Stern, Jas S. Sandhu, Raymond M. Reilley, Michael B. Tropak, Gwen Jansz, Jennis Xu, Steven Gallinger

Journal:

Journal of Surgical Research

Year:

1996

Language:

english

File:

PDF, 119 KB

english, 1996

31

Conservation of functionally important epitopes on myelin associated glycoprotein (MAG)

Michael B. Tropak, Gwenderlyn F. Jansz, Wanda Abramow-Newerly, John C. Roder

Journal:

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology

Year:

1995

Language:

english

File:

PDF, 1.30 MB

english, 1995

32

An α-subunit loop structure is required for GM2 activator protein binding by β-hexosaminidase A

Maryam Zarghooni, Scott Bukovac, Michael Tropak, John Callahan, Don Mahuran

Journal:

Biochemical and Biophysical Research Communications

Year:

2004

Language:

english

File:

PDF, 284 KB

english, 2004

33

7 Identification of the gene encoding the enzyme deficient in MPS IIIC (Sanfilippo disease type C)

Xiaolian Fan, Huiwen Zhang, Sunqu Zhang, Richard Bagshaw, Michael Tropak, John Callahan, Don Mahuran

Journal:

Molecular Genetics and Metabolism

Year:

2007

Language:

english

File:

PDF, 57 KB

english, 2007

34

19 Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis

Don Mahuran, Gustavo Maegawa, Michael Tropak, Joe Clarke

Journal:

Molecular Genetics and Metabolism

Year:

2007

Language:

english

File:

PDF, 56 KB

english, 2007

35

65. Identification of Ambroxol as a potential enzyme enhancement-agent for Gaucher disease

Don Mahuran, Gustavo Maegawa, Michael Tropak, Justin Butner, Gregory Kornhaber, Brigitte Rigat, Joe Clarke

Journal:

Molecular Genetics and Metabolism

Year:

2008

Language:

english

File:

PDF, 43 KB

english, 2008

36

100. Effects of novel β-glucocerebrosidase enhancers and pharmacological chaperones on protein stability/dynamics probed by hydrogen–deuterium exchange mass spectrometry

Michael Tropak, Greg Kornhaber, Gustavo Maegawa, Justin Buttner, Jan Blancharrd, Brigitte Rigat, Eric Brown, Don Mahuran

Journal:

Molecular Genetics and Metabolism

Year:

2008

Language:

english

File:

PDF, 44 KB

english, 2008

37

116. Identification of pharmacological chaperones for feline and human GM1 gangliosidosis

Brigitte Rigat, Tropak Michael, Ellen Crushell, Benedict Daphne, Douglas Martin, Arnold Stuetz, John Callahan, Don Mahuran

Journal:

Molecular Genetics and Metabolism

Year:

2009

Language:

english

File:

PDF, 55 KB

english, 2009

38

30. Open-label Phase I/II clinical trial of pyrimethamine for the treatment of chronic GM2 gangliosidosis

Joe Clarke, Edwin Kolodny, Don Mahuran, Maria Fuller, Michael Tropak, Jack Keimel, Swati Sathe, Sophia Pesotchinsky, Brigette Rigat

Journal:

Molecular Genetics and Metabolism

Year:

2010

Language:

english

File:

PDF, 43 KB

english, 2010

39

119. Widening of in vitro spectrum of activity for pyrimethamine and its most active derivative in adult Tay-Sachs disease

Brigitte Rigat, Michael Tropak, Sayuri Yonekawa, Marco Ciufolini, Don Mahuran

Journal:

Molecular Genetics and Metabolism

Year:

2010

Language:

english

File:

PDF, 44 KB

english, 2010

40

89. Demonstration of the in cellulo efficacy of pyrimethamine as a pharmacological chaperone for late onset Tay-Sachs Disease using a fluorescent GM2 ganglioside analogue

Don Mahuran, Michael Tropak, Scott Bukovac, Brigitte Rigat, Sayuri Yonekawa, Warren Wakarchuk

Journal:

Molecular Genetics and Metabolism

Year:

2010

Language:

english

File:

PDF, 42 KB

english, 2010

41

135. Identification of pyrimethamine derivatives showing improved enzyme enhancement efficacy towards mutant Hex A

Michael Tropak, Sayuri Yonekawa, Jianmin Zhang, Kam Ho, Virender Aulakh, Marco Ciufolini, Don Mahuran

Journal:

Molecular Genetics and Metabolism

Year:

2010

Language:

english

File:

PDF, 42 KB

english, 2010

42

An open-label Phase I/II clinical trial of pyrimethamine for the treatment of patients affected with chronic GM2 gangliosidosis (Tay–Sachs or Sandhoff variants)

Joe T.R. Clarke, Don J. Mahuran, Swati Sathe, Edwin H. Kolodny, Brigitte A. Rigat, Julian A. Raiman, Michael B. Tropak

Journal:

Molecular Genetics and Metabolism

Year:

2011

Language:

english

File:

PDF, 340 KB

english, 2011

43

An open-label phase I/II clinical trial of pyrimethamine for the treatment of patients affected with chronic GM2 Gangliosidosis (Tay-Sachs or Sandhoff variants)

Joe Clarke, Don Mahuran, Swati Sathe, Edwin Kolodny, Brigitte Rigat, Julian Raiman, Michael Tropak

Journal:

Molecular Genetics and Metabolism

Year:

2011

Language:

english

File:

PDF, 56 KB

english, 2011

44

Pharmacological chaperones facilitate the post-ER transport of recombinant N370S mutant β-glucocerebrosidase in plant cells: Evidence that N370S is a folding mutant

Gholamreza Babajani, Michael B. Tropak, Don J. Mahuran, Allison R. Kermode

Journal:

Molecular Genetics and Metabolism

Year:

2012

Language:

english

File:

PDF, 493 KB

english, 2012

45

Identification of the Gene Encoding the Enzyme Deficient in Mucopolysaccharidosis IIIC (Sanfilippo Disease Type C)

Xiaolian Fan, Huiwen Zhang, Sunqu Zhang, Richard D. Bagshaw, Michael B. Tropak, John W. Callahan, Don J. Mahuran

Journal:

The American Journal of Human Genetics

Year:

2006

Language:

english

File:

PDF, 1.91 MB

english, 2006

46

Evaluation of N-nonyl-deoxygalactonojirimycin as a pharmacological chaperone for human GM1 gangliosidosis leads to identification of a feline model suitable for testing enzyme enhancement therapy

Brigitte A. Rigat, Michael B. Tropak, Justin Buttner, Ellen Crushell, Daphne Benedict, John W. Callahan, Douglas R. Martin, Don J. Mahuran

Journal:

Molecular Genetics and Metabolism

Year:

2012

Language:

english

File:

PDF, 1.11 MB

english, 2012

47

Rapid Assembly of a Library of Lipophilic Iminosugars via the Thiol–Ene Reaction Yields Promising Pharmacological Chaperones for the Treatment of Gaucher Disease

Goddard-Borger, Ethan D., Tropak, Michael B., Yonekawa, Sayuri, Tysoe, Christina, Mahuran, Don J., Withers, Stephen G.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.37 MB

english, 2012

48

Interaction of δ and κ opioid receptors with adenosine A1 receptors mediates cardioprotection by remote ischemic preconditioning

Surendra, Harinee, Diaz, Roberto J., Harvey, Kordan, Tropak, Michael, Callahan, John, Hinek, Alina, Hossain, Taneya, Redington, Andrew, Wilson, Gregory J.

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2013

Language:

english

File:

PDF, 686 KB

english, 2013

49

Remote Cardioprotection by Transfer of Coronary Effluent from Ischemic Preconditioned Rabbit Heart Preserves Mitochondrial Integrity and Function via Adenosine Receptor Activation

Leung, Chung Ho, Wang, Lixing, Nielsen, Jan M., Tropak, Michael B., Fu, Yana Y., Kato, Hideyuki, Callahan, John, Redington, Andrew N., Caldarone, Christopher A.

Journal:

Cardiovascular Drugs and Therapy

Year:

2014

Language:

english

File:

PDF, 341 KB

english, 2014

50

Production of active human glucocerebrosidase in seeds of Arabidopsis thaliana complex-glycan-deficient (cgl) plants

He, X., Galpin, J. D., Tropak, M. B., Mahuran, D., Haselhorst, T., von Itzstein, M., Kolarich, D., Packer, N. H., Miao, Y., Jiang, L., Grabowski, G. A., Clarke, L. A., Kermode, A. R.

Journal:

Year:

2012

Language:

english

File:

PDF, 341 KB

english, 2012