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51

A Novel Series of 2-Pyridyl-Containing Compounds as Lysophosphatidic Acid Receptor Antagonists: Development of a Nonhydrolyzable LPA3 Receptor-Selective Antagonists (Id).

Brian H. Heasley, Renata Jarosz, Karen M. Carter, Jenny Van, Kevin R. Lynch, Timothy L. Macdonald

Journal:

Year:

2004

File:

PDF, 12 KB

2004

52

Synthesis of Benzimidazole Based Analogues of Sphingosine-1-phosphate: Discovery of Potent, Subtype-Selective S1P4 Receptor Agonists.

Jeremy J. Clemens, Michael D. Davis, Kevin R. Lynch, Timothy L. Macdonald

Journal:

Year:

2005

Language:

english

File:

PDF, 168 KB

english, 2005

53

Synthesis and Antimicrobial Evaluation of Nitazoxanide-Based Analogues: Identification of Selective and Broad Spectrum Activity

Dr. T. Eric Ballard, Xia Wang, Dr. Igor Olekhnovich, Taylor Koerner, Craig Seymour, Joseph Salamoun, Michelle Warthan, Prof. Paul S. Hoffman, Prof. Timothy L. Macdonald

Journal:

Year:

2011

Language:

english

File:

PDF, 361 KB

english, 2011

54

Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cells

Cristoforo G. Gaetano, Nasser Samadi, Jose L. Tomsig, Timothy L. Macdonald, Kevin R. Lynch, David N. Brindley

Journal:

Molecular Carcinogenesis

Year:

2009

Language:

english

File:

PDF, 240 KB

english, 2009

55

Blood lead by furnace-Zeeman atomic absorption spectrophotometry

Shane S. Que Hee, Timothy J. Macdonald, Robert L. Bornschein

Journal:

Microchemical Journal

Year:

1985

Language:

english

File:

PDF, 634 KB

english, 1985

56

A novel synthesis of piperidin-3-ones via an intramolecular Amadori-type reaction

Timothy J. Guzi, Timothy L. Macdonald

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 188 KB

english, 1996

57

Facile synthesis of lysophospholipids containing unsaturated fatty acid chains

Darrin W. Hopper, John G. Catalano, Timothy L. Macdonald

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 237 KB

english, 1996

58

Synthesis and biological evaluation of γ-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists

Frank W. Foss Jr., Ashley H. Snyder, Michael D. Davis, Michael Rouse, Mark D. Okusa, Kevin R. Lynch, Timothy L. Macdonald

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 535 KB

english, 2007

59

Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists

Jeremy J. Clemens, Michael D. Davis, Kevin R. Lynch, Timothy L. Macdonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 350 KB

english, 2004

60

A rapid assay for assessment of sphingosine kinase inhibitors and substrates

Yugesh Kharel, Thomas P. Mathews, Andrew J. Kennedy, Joseph D. Houck, Timothy L. Macdonald, Kevin R. Lynch

Journal:

Analytical Biochemistry

Year:

2011

Language:

english

File:

PDF, 505 KB

english, 2011

61

α- and β-Substituted phosphonate analogs of LPA as autotaxin inhibitors

Peng Cui, William F. McCalmont, Jose L. Tomsig, Kevin R. Lynch, Timothy L. Macdonald

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 270 KB

english, 2008

62

Synthesis and structure–activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein

Hiteshkumar D. Jain, Chunchun Zhang, Shuo Zhou, Hao Zhou, Jun Ma, Xiaoxiang Liu, Xuebin Liao, Amy M. Deveau, Christine M. Dieckhaus, Michael A. Johnson, Kirsten S. Smith, Timothy L. Macdonald, Hideaki

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 810 KB

english, 2008

63

Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs

Frank W. Foss Jr., Thomas P. Mathews, Yugesh Kharel, Perry C. Kennedy, Ashley H. Snyder, Michael D. Davis, Kevin R. Lynch, Timothy L. Macdonald

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 555 KB

english, 2009

64

Regioselective oxidation of 2-amino-3-aroyl-4,5-dialkylthiophenes by DMSO

Elizabeth Joshi, Mahendra D. Chordia, Timothy L. Macdonald, Joel Linden, Ray Olsson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 193 KB

english, 2004

65

Initial structure–activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist

Brian H. Heasley, Renata Jarosz, Kevin R. Lynch, Timothy L. Macdonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 297 KB

english, 2004

66

Design, synthesis, and biological evaluation of novel T-Type calcium channel antagonists

William F McCalmont, Tiffany N Heady, Jaclyn R Patterson, Michael A Lindenmuth, Doris M Haverstick, Lloyd S Gray, Timothy L Macdonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 273 KB

english, 2004

67

A novel series of 2-pyridyl-containing compounds as lysophosphatidic acid receptor antagonists: development of a nonhydrolyzable LPA3 receptor-selective antagonist

Brian H Heasley, Renata Jarosz, Karen M Carter, S Jenny Van, Kevin R Lynch, Timothy L Macdonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 303 KB

english, 2004

68

Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: Discovery of potent S1P1 receptor agonists

Jeremy J. Clemens, Michael D. Davis, Kevin R. Lynch, Timothy L. Macdonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 317 KB

english, 2005

69

N6-Ethyl-2-alkynyl NECAs, selective human A3 adenosine receptor agonists

Ran Zhu, Cynthia R. Frazier, Joel Linden, Timothy L. Macdonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 116 KB

english, 2006

70

Synthesis and biological evaluation of lisofylline (LSF) analogs as a potential treatment for Type 1 diabetes

Peng Cui, Timothy L. Macdonald, Meng Chen, Jerry L. Nadler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 126 KB

english, 2006

71

Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors

Peng Cui, Jose L. Tomsig, William F. McCalmont, Sangderk Lee, Christopher J. Becker, Kevin R. Lynch, Timothy L. Macdonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 164 KB

english, 2007

72

Mechanisms of trovafloxacin hepatotoxicity: Studies of a model cyclopropylamine-containing system

Qin Sun, Ran Zhu, Frank W. Foss Jr., Timothy L. Macdonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 197 KB

english, 2007

73

Stereochemistry–activity relationship of orally active tetralin S1P agonist prodrugs

Bin Ma, Kevin M. Guckian, Edward Yin-Shiang Lin, Wen-Cherng Lee, Daniel Scott, Gnanasambandam Kumaravel, Timothy L. Macdonald, Kevin R. Lynch, Cheryl Black, Sowmya Chollate, Kyungmin Hahm, Gregg Hetu,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 588 KB

english, 2010

74

Biological activity of modified and exchanged 2-amino-5-nitrothiazole amide analogues of nitazoxanide

T. Eric Ballard, Xia Wang, Igor Olekhnovich, Taylor Koerner, Craig Seymour, Paul S. Hoffman, Timothy L. Macdonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 243 KB

english, 2010

75

Synthesis and structure–activity relationships of tyrosine-based inhibitors of autotaxin (ATX)

James E. East, Andrew J. Kennedy, Jose L. Tomsig, Alexandra R. De Leon, Kevin R. Lynch, Timothy L. Macdonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 844 KB

english, 2010

76

Influence of calcium and silica on hydraulic properties of sodium montmorillonite assemblages under alkaline conditions

Andrew S. Kinsela, Alice Tjitradjaja, Richard N. Collins, T. David Waite, Timothy E. Payne, Bennett C.T. Macdonald, Ian White

Journal:

Journal of Colloid and Interface Science

Year:

2010

Language:

english

File:

PDF, 623 KB

english, 2010

77

The supply and preservation of ancient and modern components of organic carbon in the Canadian Beaufort Shelf of the Arctic Ocean

Miguel A. Goñi, Mark B. Yunker, Robie W. Macdonald, Timothy I. Eglinton

Journal:

Marine Chemistry

Year:

2005

Language:

english

File:

PDF, 664 KB

english, 2005

78

Constraints on the origin of sedimentary organic carbon in the Beaufort Sea from coupled molecular 13C and 14C measurements

Nicholas J. Drenzek, Daniel B. Montluçon, Mark B. Yunker, Robie W. Macdonald, Timothy I. Eglinton

Journal:

Marine Chemistry

Year:

2007

Language:

english

File:

PDF, 853 KB

english, 2007

79

Practical synthesis of biaryl colchicinoids containing 3′,4′-catechol ether-based A-rings via Suzuki cross-coupling with ligandless palladium in water

Amy Morin Deveau, Timothy L. Macdonald

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 294 KB

english, 2004

80

Synthesis of tetrahydrofurocarbazolones via intramolecular Diels-Alder reactions

Jose S. Madalengoitia, Timothy L. Macdonald

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 246 KB

english, 1993

81

Total Synthesis of (±)-N-Acetylcolchinol

J.Scott Sawyer, Timothy L. Macdonald

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 258 KB

english, 1988

82

Carbonyl-initiated cyclization of tetraalkylstannanes

Timothy L. Macdonald, Claire M. Delahunty, Keith Mead, Dale E. O'Dell

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 225 KB

english, 1989

83

The allylic alcohol function in alkyltin (IV)-mediated carbocyclization. Regiospecific octalin and hydrindene synthesis.

Timothy L Macdonald, Sankaran Mahalingam

Journal:

Tetrahedron Letters

Year:

1981

Language:

english

File:

PDF, 220 KB

english, 1981

84

Synthesis of 3-hydroxy and 3-amino 2-substitutedN-heterocyclesvia enamine oxidation and aziridination

Mihiro Sunose, Kirsty M. Anderson, A. Guy Orpen, Timothy Gallagher, Simon J.F. Macdonald

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 257 KB

english, 1998

85

Distribution and sources of organic biomarkers in arctic sediments from the Mackenzie River and Beaufort Shelf

Miguel A Goñi, Mark B Yunker, Robie W Macdonald, Timothy I Eglinton

Journal:

Marine Chemistry

Year:

2000

Language:

english

File:

PDF, 889 KB

english, 2000

86

5-HETE congeners as modulators of cell proliferation

Thomas A Miller, Jagadananda Ghosh, Charles E Myers, Timothy L Macdonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 125 KB

english, 2000

87

The synthesis of amino-acid functionalized β-Carbolines as topoisomerase II inhibitors

Amy Morin Deveau, Marc A Labroli, Christine M Dieckhaus, Mary T Barthen, Kirsten S Smith, Timothy L Macdonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 820 KB

english, 2001

88

DNA topoisomerase II inhibition by substituted 1,2,3,4-tetrahydro-β-carboline derivatives

Erich K. Lehnert, Kelli E. Miller, Jose S. Madalengoitia, Timothy J. Guzi, Timothy L. Macdonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 818 KB

english, 1994

89

Synthesis of para-Alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists

Jeremy J. Clemens, Michael D. Davis, Kevin R. Lynch, Timothy L. Macdonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 175 KB

english, 2003

90

The synthesis and evaluation of functionalized estratropones: Potent inhibitors of tubulin polymerization

Thomas A. Miller, Amanda L. Bulman, Charles D. Thompson, Michael E. Garst, Timothy L. Macdonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 313 KB

english, 1997

91

The synthesis and evaluation of benzannelated-azatoxins: The benzazatoxins

Thomas A. Miller, Prakash R. Vachaspati, Marc A. Labroli, Charles D. Thompson, Amanda L. Bulman, Timothy L. Macdonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 315 KB

english, 1998

92

The synthesis and evaluation of temperature sensitive tubulin toxins

Thomas A. Miller, Amanda L. Bulman, Charles D. Thompson, Timothy L. Macdonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 366 KB

english, 1999

93

Comparative molecular field analysis of colchicine inhibition and tubulin polymerization for combretastatins binding to the colchicine binding site on β-tubulin

Milton L Brown, Jayson M Rieger, Timothy L Macdonald

Journal:

Bioorganic & Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 392 KB

english, 2000

94

Comparative molecular field analysis and QSAR on substrates binding to cytochrome P450 2D6

Shahriar Haji-Momenian, Jayson M Rieger, Timothy L Macdonald, Milton L Brown

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 522 KB

english, 2003

95

Structure-activity relationship for DNA topoisomerase II-induced DNA cleavage by azatoxin analogues

Jose S. Madalengoitia, Jetze J. Tepe, Karl A. Werbovetz, Erich K. Lehnert, Timothy L. Macdonald

Journal:

Bioorganic & Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 1.01 MB

english, 1997

96

The relationship between antenatal risk characteristics, place of delivery and adverse delivery outcome in rural Malawi

TEIJA KULMALA, MERIMAARIA VAAHTERA, JUHA RANNIKKO, MACDONALD NDEKHA, TIMOTHY CULLINAN, MARJA-LEENA SALIN, PER ASHORN

Journal:

Acta Obstetricia et Gynecologica Scandinavica

Year:

2000

Language:

english

File:

PDF, 71 KB

english, 2000

97

The assessment of poorly performing doctors: the development of the assessment programmes for the General Medical Council’s Performance Procedures

Lesley Southgate, Jim Cox, Timothy David, David Hatch, Alan Howes, Neil Johnson, Brian Jolly, Ewan Macdonald, Pauline McAvoy, Peter McCrorie, Joanne Turner

Journal:

Medical Education

Year:

2001

Language:

english

File:

PDF, 323 KB

english, 2001

98

The General Medical Council’s Performance Procedures: peer review of performance in the workplace

Lesley Southgate, Jim Cox, Timothy David, David Hatch, Alan Howes, Neil Johnson, Brian Jolly, Ewan Macdonald, Pauline McAvoy, Peter McCrorie, Joanne Turner

Journal:

Medical Education

Year:

2001

Language:

english

File:

PDF, 343 KB

english, 2001

99

Novel computed tomographic chest metrics to detect pulmonary hypertension

Andrew L Chan, Maya M Juarez, David K Shelton, Taylor MacDonald, Chin-Shang Li, Tzu-Chun Lin, Timothy E Albertson

Journal:

BMC Medical Imaging

Year:

2011

Language:

english

File:

PDF, 406 KB

english, 2011

100

Inhibition of topoisomerases by fredericamycin A

Michael D. Latham, Charles K. King, Peter Gorycki, Timothy L. Macdonald, Warren E. Ross

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1989

Language:

english

File:

PDF, 528 KB

english, 1989