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51

Prodrugs of Phosphates and Phosphonates

Hecker, Scott J., Erion, Mark D.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 347 KB

english, 2008

52

5-Aminopyrazoles as Dienophiles in the Inverse Electron Demand Diels−Alder Reactions of 2,4,6-Tris(ethoxy- carbonyl)-1,3,5-triazine: Syntheses of Pyrazolopyrimidines †

Dang, Qun, Brown, Brian S., Erion, Mark D.

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 73 KB

english, 1996

53

Relative Binding Affinities of Fructose-1,6-Bisphosphatase Inhibitors Calculated Using a Quantum Mechanics-Based Free Energy Perturbation Method

Reddy, M. Rami, Erion, Mark D.

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 41 KB

english, 2007

54

Efficient Synthesis of Purines and Purine Nucleosides via an Inverse Electron Demand Diels−Alder Reaction

Dang, Qun, Liu, Yan, Erion, Mark D.

Journal:

Journal of the American Chemical Society

Year:

1999

Language:

english

File:

PDF, 61 KB

english, 1999

55

Oxazole phosphonic acids as fructose 1,6-bisphosphatase inhibitors with potent glucose-lowering activity

Dang, Qun, Kasibthatla, Srinivas Rao, Jiang, Tao, Taplin, Frank, Gibson, Tony, Potter, Scott C., van Poelje, Paul D., Erion, Mark D.

Journal:

Year:

2011

Language:

english

File:

PDF, 210 KB

english, 2011

56

Adenosine Kinase Inhibitors. 2. Synthesis, Enzyme Inhibition, and Antiseizure Activity of Diaryltubercidin Analogues

Ugarkar, Bheemarao G., Castellino, Angelo J., DaRe, Jay M., Kopcho, Joseph J., Wiesner, James B., Schanzer, Juergen M., Erion, Mark D.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 267 KB

english, 2000

57

Purine Nucleoside Phosphorylase. 3. Reversal of Purine Base Specificity by Site-Directed Mutagenesis †

Stoeckler, Johanna D., Poirot, Anne F., Smith, Rose Marie, Parks,, Robert E., Ealick, Steven E., Takabayashi, Kenji, Erion, Mark D.

Journal:

Year:

1997

Language:

english

File:

PDF, 188 KB

english, 1997

58

AMP Deaminase Inhibitors. 2. Initial Discovery of a Non-Nucleotide Transition-State Inhibitor Series 1

Bookser, Brett C., Kasibhatla, Srinivas Rao, Appleman, James R., Erion, Mark D.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 424 KB

english, 2000

59

Fructose-1,6-bisphosphatase Inhibitors. 2. Design, Synthesis, and Structure−Activity Relationship of a Series of Phosphonic Acid Containing Benzimidazoles that Function as 5′-Adenosinemonophosphate (AMP) Mimics

Dang, Qun, Kasibhatla, Srinivas Rao, Xiao, Wei, Liu, Yan, DaRe, Jay, Taplin, Frank, Reddy, K. Raja, Scarlato, Gerard R., Gibson, Tony, van Poelje, Paul D., Potter, Scott C., Erion, Mark D.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.15 MB

english, 2010

60

Purine Nucleoside Phosphorylase. 1. Structure−Function Studies †

Erion, Mark D., Takabayashi, Kenji, Smith, Harry B., Kessi, Janine, Wagner, Sylvia, Hönger, Sybille, Shames, Spencer L., Ealick, Steven E.

Journal:

Year:

1997

Language:

english

File:

PDF, 262 KB

english, 1997

61

4-Substituted-5(3)-carbamoyl-3(5)-(2-deoxy-β- D -ribofuranosyl)pyrazoles. Application of Palladium Catalyzed Glycal Coupling Methodology to the Synthesis of Pyrazofurin Analogs

Erion, Mark D., Rydzewski†, Robert M.

Journal:

Nucleosides and Nucleotides

Year:

1997

Language:

english

File:

PDF, 932 KB

english, 1997

62

Design, Synthesis, and Characterization of a Series of Cytochrome P 450 3A-Activated Prodrugs (HepDirect Prodrugs) Useful for Targeting Phosph(on)ate-Based Drugs to the Liver §

Erion, Mark D., Reddy, K. Raja, Boyer, Serge H., Matelich, Michael C., Gomez-Galeno, Jorge, Lemus, Robert H., Ugarkar, Bheemarao G., Colby, Timothy J., Schanzer, Jürgen, van Poelje, Paul D.

Journal:

Journal of the American Chemical Society

Year:

2004

Language:

english

File:

PDF, 149 KB

english, 2004

63

Stereoselective total synthesis of the complement inhibitor K-76

McMurry, John E., Erion, Mark D.

Journal:

Journal of the American Chemical Society

Year:

1985

Language:

english

File:

PDF, 1.21 MB

english, 1985

64

AMP Deaminase Inhibitors. 5. Design, Synthesis, and SAR of a Highly Potent Inhibitor Series

Kasibhatla, Srinivas Rao, Bookser, Brett C., Xiao, Wei, Erion, Mark D.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 82 KB

english, 2001

65

N-Phosphonomethyl Dipeptides and Their Phosphonate Prodrugs, a New Generation of Neutral Endopeptidase (NEP, EC 3.4.24.11) Inhibitors

De Lombaert, Stephane, Erion, Mark D., Tan, Jenny, Blanchard, Louis, El-Chehabi, Lena, Ghai, R. D., Sakane, Yumi, Berry, Carol, Trapani, Angelo J.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 2.37 MB

english, 1994

66

Synthesis and Characterization of a Novel Liver-Targeted Prodrug of Cytosine-1-β- d -arabinofuranoside Monophosphate for the Treatment of Hepatocellular Carcinoma

Boyer, Serge H., Sun, Zhili, Jiang, Hongjian, Esterbrook, Julie, Gómez-Galeno, Jorge E., Craigo, William, Reddy, K. Raja, Ugarkar, Bheemarao G., MacKenna, Deidre A., Erion, Mark D.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 167 KB

english, 2006

67

Structure-based design of inhibitors of purine nucleoside phosphorylase. 2. 9-Alicyclic and 9-heteroalicyclic derivatives of 9-deazaguanine

Secrist, John A., Niwas, Shri, Rose, Jerry D., Babu, Y. Sudhakar, Bugg, Charles E., Erion, Mark D., Guida, Wayne C., Ealick, Steven E., Montgomery, John A.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 1.08 MB

english, 1993

68

Structure-based design of inhibitors of purine nucleoside phosphorylase. 3. 9-Arylmethyl derivatives of 9-deazaguanine substituted on the arylmethyl group. [Erratum to document cited in CA119(25):271601v]

Erion, Mark D., Niwas, Shri, Rose, Jerry D., Ananthan, Subramaniam, Allen, Mark, Secrist, John A., Babu, Y. Sudhakar, Bugg, Charles E., Guida, Wayne C.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 50 KB

english, 1994

69

Structure of Human Adenosine Kinase at 1.5 Å Resolution †,‡

Mathews, Irimpan I., Erion, Mark D., Ealick, Steven E.

Journal:

Year:

1998

Language:

english

File:

PDF, 365 KB

english, 1998

70

Synthetic intermediates potentially useful for the synthesis of tetrodotoxin and derivatives. 8. A series of highly functionalized pyrimidinones

Keana, John F. W., Boyle, Patrick J., Erion, Mark, Hartling, Ross, Husman, James R., Richman, Jack E., Roman, Richard B., Wah, Robert M.

Journal:

Journal of Organic Chemistry

Year:

1983

Language:

english

File:

PDF, 830 KB

english, 1983

71

Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 4. A Study of Phosphate Mimics

Guida, Wayne C., Elliott, Robert D., Thomas, H. Jeanette, Secrist, John A., Babu, Y. Sudhakar, Bugg, Charles E., Erion, Mark D., Ealick, Steven E., Montgomery, John A.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.85 MB

english, 1994

72

Chorismate aminations: partial purification of Escherichia coli PABA synthase and mechanistic comparison with anthranilate synthase

Walsh, Christopher T., Erion, Mark D., Walts, Alan E., Delany, John J., Berchtold, Glenn A.

Journal:

Year:

1987

Language:

english

File:

PDF, 2.16 MB

english, 1987

73

AMP Deaminase Inhibitors. 4. Further N3-Substituted Coformycin Aglycon Analogues: N3-Alkylmalonates as Ribose 5‘-Monophosphate Mimetics

Bookser, Brett C., Kasibhatla, Srinivas Rao, Erion, Mark D.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 123 KB

english, 2000

74

Inhibition of Peptidylglycine .alpha.-Amidating Monooxygenase by N-Substituted Homocysteine Analogs

Erion, Mark D., Tan, Jenny, Wong, Mary, Jeng, Arco Y.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.72 MB

english, 1994

75

Synthetic intermediates potentially useful for the synthesis of tetrodotoxin and derivatives. 9. Hydroquinazolines possessing the carbon skeleton of tetrodotoxin

Keana, John F. W., Bland, Jeffrey S., Boyle, Patrick J., Erion, Mark, Hartling, Ross, Husman, James R., Roman, Richard B., Ferguson, George, Parvez, Masood

Journal:

Journal of Organic Chemistry

Year:

1983

Language:

english

File:

PDF, 719 KB

english, 1983

76

1-Aminocyclopropanephosphonate: time-dependent inactivation of 1-aminocyclopropanecarboxylate deaminase and Bacillus stearothermophilus alanine racemase by slow dissociation behavior

Erion, Mark D., Walsh, Christopher T.

Journal:

Year:

1987

Language:

english

File:

PDF, 1.07 MB

english, 1987

77

Discovery of AMP Mimetics that Exhibit High Inhibitory Potency and Specificity for AMP Deaminase

Erion, Mark D., Kasibhatla, Srinivas Rao, Bookser, Brett C., van Poelje, Paul D., Reddy, M. Rami, Gruber, Harry E., Appleman, James R.

Journal:

Journal of the American Chemical Society

Year:

1999

Language:

english

File:

PDF, 262 KB

english, 1999

78

Identifying regions of membrane proteins in contact with phospholipid head groups: covalent attachment of a new class of aldehyde lipid labels to cytochrome c oxidase

McMillen, Debra A., Volwerk, Johannes J., Ohishi, Junichi, Erion, Mark, Keana, John F. W., Jost, Patricia C., Griffith, O. Hayes

Journal:

Year:

1986

Language:

english

File:

PDF, 2.48 MB

english, 1986

79

Structure-based design of inhibitors of purine nucleoside phosphorylase. 3. 9-Arylmethyl derivatives of 9-deazaguanine substituted on the arylmethyl group

Erion, Mark D., Niwas, Shri, Rose, Jerry D., Ananthan, Subramaniam, Allen, Mark, Secrist, John A., Babu, Y. Sudhakar, Bugg, Charles E., Guida, Wayne C.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 3.25 MB

english, 1993

80

Dual Angiotensin Converting Enzyme/Thromboxane Synthase Inhibitors

Ksander, Gary M., Erion, Mark, Yuan, Andrew M., Diefenbacher, Clive G., El-Chehabi, Lena, Cote, Don, Levens, Nigel

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.21 MB

english, 1994

81

Structure-Based Drug Design Approaches for Predicting Binding Affinities of Hiv1 Protease Inhibitors

Reddy, M. Rami, Erion, Mark D.

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 754 KB

english, 1998

82

A New Regio-Defined Synthesis of PMEA

Dang, Qun, Liu, Van, Erion, Mark D.

Journal:

Nucleosides and Nucleotides

Year:

1998

Language:

english

File:

PDF, 325 KB

english, 1998

83

[IEEE 2012 IEEE 11th International Conference on Trust, Security and Privacy in Computing and Communications (TrustCom) - Liverpool, United Kingdom (2012.06.25-2012.06.27)] 2012 IEEE 11th International Conference on Trust, Security and Privacy in Computing and Communications - Anonymous Networking Meets Real-World Business Requirements

Vinkovits, Mark, Elmasllari, Erion, Pastrone, Claudio

Year:

2012

Language:

english

File:

PDF, 344 KB

english, 2012

84

The therapeutic potential of agents acting via purine receptors

Appleman, James R, Erion, Mark D

Journal:

Expert Opinion on Investigational Drugs

Year:

1998

Language:

english

File:

PDF, 338 KB

english, 1998

85

Design, Synthesis and Anticonvulsant Activity of the Potent Adenosine Kinase Inhibitor GP3269

Erion, Mark D., Ugarkar, Bheemarao G., DaRe, Jay, Castellino, Angelo J., Fujitaki, James M., Dixon, Ross, Appleman, James R., Wiesner, James B.

Journal:

Nucleosides and Nucleotides

Year:

1997

Language:

english

File:

PDF, 441 KB

english, 1997

86

LIVER TARGETING OF HEPATITIS-B ANTIVIRAL LAMIVUDINE USING THE HEPDIRECT™ PRODRUG TECHNOLOGY

Reddy, K. Raja, Colby, Timothy J., Fujitaki, James M., van Poelje, Paul D., Erion, Mark D.

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2005

Language:

english

File:

PDF, 231 KB

english, 2005

87

Synthesis of 3-Substituted 1-Acyloxy-1,3-butadienes via Thermolysis of the Corresponding Cyclobutenes

Keana, John F. W., Taneja, Hans R., Erion, Mark

Journal:

Synthetic Communications

Year:

1982

Language:

english

File:

PDF, 323 KB

english, 1982

88

Computer Aided Drug Design Strategies Used in the Discovery of Fructose 1, 6-Bisphosphatase Inhibitors

Reddy, M., Erion, Mark

Journal:

Current Pharmaceutical Design

Year:

2005

Language:

english

File:

PDF, 214 KB

english, 2005

89

Correction: Application of Crystallographic and Modeling Methods in the Design of Purine Nucleoside Phosphorylase Inhibitors

Steven E. Ealick, Y. Sudhakar Babu, Charles E. Bugg, Mark D. Erion, Wayne C. Guida, John A. Montgomery and John A. Secrist III

Journal:

Proceedings of the National Academy of Sciences

Year:

1992

Language:

english

File:

PDF, 381 KB

english, 1992

90

Application of Crystallographic and Modeling Methods in the Design of Purine Nucleoside Phosphorylase Inhibitors

Steven E. Ealick, Y. Sudhakar Babu, Charles E. Bugg, Mark D. Erion, Wayne C. Guida, John A. Montgomery and John A. Secrist III

Journal:

Proceedings of the National Academy of Sciences

Year:

1991

Language:

english

File:

PDF, 1.29 MB

english, 1991

91

[Annual Reports in Medicinal Chemistry] Volume 28 || Chapter 31. Adenosine Receptors as Pharmacological Targets

Year:

1993

Language:

english

File:

PDF, 890 KB

english, 1993

92

The pharmacology of CGS 25462

Trapani, Angelo J., Lombaert, Stephan?? De, Erion, Mark D., Ghai, Rajendra D., Peppard, Jane V., Lappe, Rodney W., Worcel, Manuel

Journal:

Journal of Hypertension

Year:

1993

File:

PDF, 168 KB

1993

93

Pharmacologic Profile of CGS 24128, a Potent, Long-Acting Inhibitor of Neutral Endopeptidase 24.11

Trapani, Angelo J., Beil, Michael E., Coté, Donald T., Lombaert, Stephane De, Erion, Mark D., Gerlock, Teresa E., Ghai, Rajendra D., Hopkins, Marlene F., Peppard, Jane V., Webb, Randy L., Lappe, Rodne

Journal:

Journal of Cardiovascular Pharmacology

Year:

1994

File:

PDF, 3.84 MB

1994

94

Pharmacologic Profile of CGS 24128, a Potent, Long-Acting Inhibitor of Neutral Endopeptidase 24.11

Trapani, Angelo J., Beil, Michael E., Coté, Donald T., Lombaert, Stephane De, Erion, Mark D., Gerlock, Teresa E., Ghai, Rajendra D., Hopkins, Marlene F., Peppard, Jane V., Webb, Randy L., Lappe, Rodne

Journal:

Journal of Cardiovascular Pharmacology

Year:

1994

File:

PDF, 3.84 MB

1994

95

Duodenal-jejunal bypass surgery induces hepatic lipidomic alterations associated with ameliorated hepatic steatosis in mice

Shang, Jin, Castro-Perez, Jose M., Shen, Xiaolan, Zhu, Yonghua, Liu, Haiying, Qian, Ying, Previs, Stephen, Howard, Andrew D., Erion, Mark, Kelley, David E., Wang, Liangsu

Journal:

Year:

2016

Language:

english

File:

PDF, 632 KB

english, 2016

96

Enhancing studies of pharmacodynamic mechanisms via measurements of metabolic flux.

Daurio, Natalie A, Wang, Sheng-Ping, Chen, Ying, Zhou, Haihong, McLaren, David G, Roddy, Thomas P, Johns, Douglas G., Milot, Denise, Kasumov, Takhar, Erion, Mark D, Kelley, David E, Previs, Stephen F

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2017

Language:

english

File:

PDF, 526 KB

english, 2017

97

GPR119 Agonism Increases Glucagon Secretion During Insulin-Induced Hypoglycemia

Li, Nina Xiaoyan, Brown, Stacey, Kowalski, Tim, Wu, Margaret, Yang, Liming, Dai, Ge, Petrov, Aleksandr, Ding, Yuyan, Dlugos, Tamara, Woods, H. Blair, Wang, Liangsu, Erion, Mark, Sherwin, Robert, Kelle

Journal:

Year:

2018

Language:

english

File:

PDF, 1.64 MB

english, 2018

98

Advances in Binding Free Energies Calculations: QM/MM-Based Free Energy Perturbation Method for Drug Design

Rathore, R.S., Sumakanth, M., Reddy, M., Reddanna, P., Rao, Allam, Erion, Mark, Reddy, M.R.

Journal:

Current Pharmaceutical Design

Year:

2013

Language:

english

File:

PDF, 697 KB

english, 2013

99

Nanoparticle-mediated lysosomal reacidification restores mitochondrial turnover and function in β cells under lipotoxicity

Assali, Essam A., Shlomo, Dovi, Zeng, Jialiu, Taddeo, Evan P., Trudeau, Kyle M., Erion, Karel A., Colby, Aaron H., Grinstaff, Mark W., Liesa, Marc, Las, Guy, Shirihai, Orian S.

Journal:

The FASEB Journal

Year:

2018

Language:

english

File:

PDF, 1.44 MB

english, 2018

100

Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Chung, Wendy K., Erion, Karel, Florez, Jose C., Hattersley, Andrew T., Hivert, Marie-France, Lee, Christine G., McCarthy, Mark I., Nolan, John J., Norris, Jill M., Pearson, Ewan R., Philipson, Louis,

Journal:

Year:

2020

File:

PDF, 1.32 MB

2020