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51

Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle tone

John E. Souness, Maria E. Villamil, Lisa C. Scott, Adrian Tomkinson, Mark A. Giembycz, David Raeburn

Journal:

British Journal of Pharmacology

Year:

1994

Language:

english

File:

PDF, 1.40 MB

english, 1994

52

Electrophysiological and other aspects of excitation-contraction coupling and uncoupling in mammalian airway smooth muscle

Mark A. Giembycz, Ian W. Rodger

Journal:

Year:

1987

Language:

english

File:

PDF, 1.46 MB

english, 1987

53

Forskolin inhibits leukotriene D4-induced thromboxane B2 release from guinea-pig lung parenchyma

Mark A. Giembycz, Ian W. Rodger

Journal:

Year:

1984

Language:

english

File:

PDF, 66 KB

english, 1984

54

Platelet-activating factor stimulates a rapid accumulation of inositol (1,4,5)trisphosphate in guinea pig eosinophils: Relationship to calcium mobilization and degranulation

Kroegel, Claus, Chilvers, Edwin R., Giembycz, Mark A., Challiss, R.A.John, Barnes, Peter J.

Journal:

Journal of Allergy and Clinical Immunology

Year:

1991

Language:

english

File:

PDF, 1.40 MB

english, 1991

55

Nitric oxide inhibits human rhinovirus-induced transcriptional activation of CXCL10 in airway epithelial cells

Koetzler, Rommy, Zaheer, Raza S., Wiehler, Shahina, Holden, Neil S., Giembycz, Mark A., Proud, David

Journal:

Journal of Allergy and Clinical Immunology

Year:

2009

Language:

english

File:

PDF, 815 KB

english, 2009

56

Identification of the protein kinase C isoenzymes in human lung and airways smooth muscle at the protein and mRNA level

Benjamin L.J. Webb, Mark A. Lindsay, Joachim Seybold, Nigel J. Brand, Magdi H. Yacoub, El-Bdaoui Haddad, Peter J. Barnes, Lan M. Adcock, Mark A. Giembycz

Journal:

Biochemical Pharmacology

Year:

1997

Language:

english

File:

PDF, 859 KB

english, 1997

57

Delayed eosinophil apoptosis in asthma

Kankaanranta, Hannu, Lindsay, Mark A., Giembycz, Mark A., Zhang, Xianzhi, Moilanen, Eeva, Barnes, Peter J.

Journal:

Journal of Allergy and Clinical Immunology

Year:

2000

Language:

english

File:

PDF, 78 KB

english, 2000

58

Selectivity profiling of the novel EP 2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP 2 receptor

Birrell, Mark A, Maher, Sarah A, Buckley, James, Dale, Nicole, Bonvini, Sara, Raemdonck, Kristof, Pullen, Nick, Giembycz, Mark A, Belvisi, Maria G

Journal:

British Journal of Pharmacology

Year:

2013

Language:

english

File:

PDF, 721 KB

english, 2013

59

Phosphodiesterase 4 Inhibitors and the Treatment of Asthma

Dr Mark A. Giembycz

Journal:

Year:

2000

Language:

english

File:

PDF, 312 KB

english, 2000

60

Mometasone furoate: an inhaled glucocorticoid for the management of asthma in adults and children

Cowie, Robert L, Giembycz, Mark A, Leigh, Richard

Journal:

Expert Opinion on Pharmacotherapy

Year:

2009

Language:

english

File:

PDF, 623 KB

english, 2009

61

Treatment of Chronic Obstructive Pulmonary Disease with Roflumilast, a New Phosphodiesterase 4 Inhibitor

Gross, Nicholas J., Giembycz, Mark A., Rennard, Stephen I.

Journal:

COPD Journal of Chronic Obstructive Pulmonary Disease

Year:

2010

Language:

english

File:

PDF, 577 KB

english, 2010

62

How Phosphodiesterase 4 Inhibitors Work in Patients with Chronic Obstructive Pulmonary Disease of the Severe, Bronchitic, Frequent Exacerbator Phenotype

Giembycz, Mark A., Newton, Robert

Journal:

Clinics in Chest Medicine

Year:

2014

Language:

english

File:

PDF, 887 KB

english, 2014

63

Modulation of transcriptional responses by poly(I:C) and human rhinovirus: Effect of long-acting β2-adrenoceptor agonists

Rider, Christopher F., Miller-Larsson, Anna, Proud, David, Giembycz, Mark A., Newton, Robert

Journal:

European Journal of Pharmacology

Year:

2013

Language:

english

File:

PDF, 507 KB

english, 2013

64

Regulation of eosinophil apoptosis by nitric oxide: Role of c-Jun-N-terminal kinase and signal transducer and activator of transcription 5

Zhang, Xianzhi, Msc,, Moilanen, Eeva, Lahti, Aleksi, Hämäläinen, Mari, Giembycz, Mark A., Barnes, Peter J., Lindsay, Mark A., Kankaanranta, Hannu

Journal:

Journal of Allergy and Clinical Immunology

Year:

2003

Language:

english

File:

PDF, 274 KB

english, 2003

65

Selective Phosphodiesterase Inhibitors in the Therapy of Asthma

Gordon Dent,Dr Mark A. Giembycz

Journal:

Year:

1995

Language:

english

File:

PDF, 1.41 MB

english, 1995

66

Cilomilast: a second generation phosphodiesterase 4 inhibitor for asthma and chronic obstructive pulmonary disease

Giembycz, Mark A

Journal:

Expert Opinion on Investigational Drugs

Year:

2001

Language:

english

File:

PDF, 368 KB

english, 2001

67

Ketotifen Induces Primary Necrosis of Human Eosinophils

Hasela, Hannele, Malm-Erjefält, Monika, Erjefält, Jonas, Giembycz, Mark A., Zhang, Xianzhi, Moilanen, Eeva, Kankaanranta, Hannu

Journal:

Journal of Ocular Pharmacology and Therapeutics

Year:

2005

Language:

english

File:

PDF, 362 KB

english, 2005

68

Does thromboxane mediate the indirect contractile action of leukotriene D 4 in guinea-pig isolated lung parenchyma under equilibrium conditions?

Giembycz, Mark A., Rodger, Ian W.

Journal:

Canadian Journal of Physiology and Pharmacology

Year:

1987

Language:

english

File:

PDF, 1.22 MB

english, 1987

69

Cytokine-Induced Loss of Glucocorticoid Function: Effect of Kinase Inhibitors, Long-Acting β2-Adrenoceptor Agonist and Glucocorticoid Receptor Ligands

Rider, Christopher F., Shah, Suharsh, Miller-Larsson, Anna, Giembycz, Mark A., Newton, Robert, Wang, Zhengqi

Journal:

Year:

2015

Language:

english

File:

PDF, 75 KB

english, 2015

70

Airways Smooth Muscle: Neurotransmitters, Amines, Lipid Mediators and Signal Transduction || Histamine

Raeburn, David, Giembycz, Mark A.

Year:

1995

Language:

english

File:

PDF, 2.61 MB

english, 1995

71

Asthma: Epidemiology, Anti-Inflammatory Therapy and Future Trends || Epidemiology of Childhood Asthma

Giembycz, Mark A., O’Connor, Brian J.

Year:

2000

Language:

english

File:

PDF, 3.93 MB

english, 2000

72

Hydrogen Peroxide Reverses IL-5 Afforded Eosinophil Survival and Promotes Constitutive Human Eosinophil Apoptosis

Kankaanranta, Hannu, Giembycz, Mark A., Barnes, Peter J., Haddad, El-Bdaoui, Saarelainen, Seppo, Zhang, Xianzhi, Moilanen, Eeva, Lindsay, Mark A.

Journal:

International Archives of Allergy and Immunology

Year:

2002

Language:

english

File:

PDF, 274 KB

english, 2002

73

Mitogen-Activated Protein Kinase Modulation of Nuclear Factor-κB–Induced Granulocyte Macrophage–Colony-Stimulating Factor Release from Human Alveolar Macrophages

Koch, Andrea, Giembycz, Mark, Ito, Kazuhiro, Lim, Sam, Jazrawi, Elen, Barnes, Peter J., Adcock, Ian, Erdmann, Erland, Chung, K. Fan

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2004

Language:

english

File:

PDF, 195 KB

english, 2004

74

Albuterol Does Not Antagonize the Inhibitory Effect of Dexamethasone on Monocyte Cytokine Release

SELDON, PAUL M., STEVENS, DAVID A., ADCOCK, IAN M., O'CONNOR, BRIAN J., BARNES, PETER J., GIEMBYCZ, MARK A.

Journal:

American Journal of Respiratory and Critical Care Medicine

Year:

1998

Language:

english

File:

PDF, 138 KB

english, 1998

75

β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids

Neil S. Holden, Matthew J. Bell, Christopher F. Rider, Elizabeth M. King, David D. Gaunt, Richard Leigh, Malcolm Johnson, David P. Siderovski, Scott P. Heximer, Mark A. Giembycz and Robert Newton

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 1.50 MB

english, 2011

76

First-generation antihistamines diphenhydramine and chlorpheniramine reverse cytokine-afforded eosinophil survival by enhancing apoptosis

Hasala, Hannele, Moilanen, Eeva, Janka-Junttila, Mirkka, Giembycz, Mark A., Kankaanranta, Hannu

Journal:

Allergy and Asthma Proceedings

Year:

2007

Language:

english

File:

PDF, 1.38 MB

english, 2007

77

[American Thoracic Society American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans - ()] D63. SIGNAL TRANSDUCTION: MEMBRANE RECEPTORS AND INTRACELLULAR PATHWAYS - Understanding Of The Enhancement Of Glucocorticoid-Dependent Transcription By ²2-Adrenoceptor Agonists

Rider, Christopher F., Giembycz, Mark, Newton, Robert

Year:

2010

Language:

english

File:

PDF, 18 KB

english, 2010

78

Bidirectional crosstalk via IL-6, PGE 2 and PGD 2 between murine myofibroblasts and alternatively activated macrophages enhances anti-inflammatory phenotype in both cells

Fernando, Maria R, Giembycz, Mark A, McKay, Derek M

Journal:

British Journal of Pharmacology

Year:

2016

Language:

english

File:

PDF, 1.14 MB

english, 2016

79

[American Thoracic Society American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans - ()] A65. GENE EXPRESSION, PHENOTYPE, AND FUNCTION IN AIRWAY SMOOTH MUSCLE: NEW INSIGHTS - Signalling Pathways Involved In ²2-adrenoceptor Agonist Induced Relaxation Of Airway Smooth Muscle

Clarke, Deborah L., Laroumanie, Fanny, Buckley, James, Giembycz, Mark, Birrell, Mark A., Belvisi, Maria G.

Year:

2010

Language:

english

File:

PDF, 21 KB

english, 2010

80

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California - ()] D73. RECEPTOR INPUT OF AIRWAY NETWORKING - TNF±-Induced Glucocorticoid Resistance: Inhibition Of Inflammatory Signalling And The Effect On Full And Partial GR Agonists

Rider, Christopher F., Shah, Suharsh, Gaunt, David D., Miller-Larsson, Anna, Johnson, Malcolm W., Giembycz, Mark A., Newton, Robert

Year:

2012

Language:

english

File:

PDF, 21 KB

english, 2012

81

Experimental design and analysis and their reporting: new guidance for publication in BJP

Curtis, Michael J, Bond, Richard A, Spina, Domenico, Ahluwalia, Amrita, Alexander, Stephen P A, Giembycz, Mark A, Gilchrist, Annette, Hoyer, Daniel, Insel, Paul A, Izzo, Angelo A, Lawrence, Andrew J,

Journal:

British Journal of Pharmacology

Year:

2015

Language:

english

File:

PDF, 499 KB

english, 2015

82

Phosphodiesterase 4 in macrophages: relationship between cAMP accumulation, suppression of cAMP hydrolysis and inhibition of [ 3 H] R -(—)-rolipram binding by selective inhibitors

KELLY, John J, BARNES, Peter J, GIEMBYCZ, Mark A

Journal:

Biochemical Journal

Year:

1996

Language:

english

File:

PDF, 943 KB

english, 1996

83

Protein kinase C isoenzymes in airway smooth muscle

WEBB, Benjamin L. J., LINDSAY, Mark A., BARNES, Peter J., GIEMBYCZ, Mark A.

Journal:

Biochemical Journal

Year:

1997

Language:

english

File:

PDF, 574 KB

english, 1997

84

Neutrophil Chemotactic Activity of Sputum From Patients With COPD

Beeh, Kai M., Kornmann, Oliver, Buhl, Roland, Culpitt, Sarah V., Giembycz, Mark A., Barnes, Peter J.

Journal:

Year:

2003

Language:

english

File:

PDF, 1.03 MB

english, 2003

85

GS-5759, a Bifunctional β 2 -Adrenoceptor Agonist and Phosphodiesterase 4 Inhibitor for Chronic Obstructive Pulmonary Disease with a Unique Mode of Action: Effects on Gene Expression in Human Airway Epithelial Cells

Joshi, Taruna, Yan, Dong, Hamed, Omar, Tannheimer, Stacey L., Phillips, Gary B., Wright, Clifford D., Kim, Musong, Salmon, Michael, Newton, Robert, Giembycz, Mark A.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2017

Language:

english

File:

PDF, 1.49 MB

english, 2017

86

Updating the guidelines for data transparency in the British Journal of Pharmacology - data sharing and the use of scatter plots instead of bar charts

George, Christopher H, Stanford, S Clare, Alexander, Steve, Cirino, Giuseppe, Docherty, James R, Giembycz, Mark A, Hoyer, Daniel, Insel, Paul A, Izzo, Angelo A, Ji, Yong, MacEwan, David J, Sobey, Chri

Journal:

British Journal of Pharmacology

Year:

2017

Language:

english

File:

PDF, 260 KB

english, 2017

87

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California - ()] D35. PHOSPHODIESTERASE INHIBITORS AS THERAPEUTICS FOR LUNG DISEASES - GS-5759, A Novel Bi-Functional Phosphodiesterase 4 Inhibitor And Long-Acting ²2-Adrenoceptor Agonist, Augments GRE-Dependent Transcription In Human Airway Epithelial Cells

Joshi, Taruna, Wilson, Sylvia M., Wright, Clifford D., Tannheimer, Stacey L., Salmon, Michael, Newton, Robert, Giembycz, Mark A.

Year:

2012

Language:

english

File:

PDF, 20 KB

english, 2012

88

Inhibition of ABCC4 potentiates combination beta agonist and glucocorticoid responses in human airway epithelial cells

Huff, Ryan D., Rider, Christopher F., Yan, Dong, Newton, Robert, Giembycz, Mark A., Carlsten, Chris, Hirota, Jeremy A.

Journal:

Journal of Allergy and Clinical Immunology

Year:

2017

Language:

english

File:

PDF, 1.21 MB

english, 2017

89

Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology

Alexander, Steve P H, Roberts, Richard E, Broughton, Brad R S, Sobey, Christopher G, George, Christopher H, Stanford, S Clare, Cirino, Giuseppe, Docherty, James R, Giembycz, Mark A, Hoyer, Daniel, Ins

Journal:

British Journal of Pharmacology

Year:

2018

Language:

english

File:

PDF, 245 KB

english, 2018

90

Dual Transmembrane Signalling Mechanisms in Eosinophils: Evidence for Two Functionally Distinct Receptors for Platelet-Activating Factor

Kroegel, Claus, Warner, Jane A., Giembycz, Mark A., Matthys, Heinrich, Lichtenstein, Larry M., Barnes, Peter J.

Journal:

International Archives of Allergy and Immunology

Year:

1992

Language:

english

File:

PDF, 680 KB

english, 1992

91

Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers

Curtis, Michael J, Alexander, Steve, Cirino, Giuseppe, Docherty, James R, George, Christopher H, Giembycz, Mark A, Hoyer, Daniel, Insel, Paul A, Izzo, Angelo A, Ji, Yong, MacEwan, David J, Sobey, Chri

Journal:

British Journal of Pharmacology

Year:

2018

Language:

english

File:

PDF, 662 KB

english, 2018

92

Role of the mitogen-activated protein kinases and tyrosine kinases during leukotriene B 4 -induced eosinophil activation

Lindsay, Mark A., Haddad, El-Bdaoui, Rousell, Jonathan, Teixeira, Mauro M., Hellewell, Paul G., Barnes, Peter J., Giembycz, Mark A.

Journal:

Journal of Leukocyte Biology

Year:

1998

Language:

english

File:

PDF, 148 KB

english, 1998

93

Analysis of the Indacaterol-Regulated Transcriptome in Human Airway Epithelial Cells Implicates Gene Expression Changes in the Adverse and Therapeutic Effects of β 2 -Adrenoceptor Agonists

Yan, Dong, Hamed, Omar, Joshi, Taruna, Mostafa, Mahmoud M., Jamieson, Kyla C., Joshi, Radhika, Newton, Robert, Giembycz, Mark A.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2018

Language:

english

File:

PDF, 11.88 MB

english, 2018

94

Glucocorticoid Repression of Inflammatory Gene Expression Shows Differential Responsiveness by Transactivation- and Transrepression-Dependent Mechanisms

King, Elizabeth M., Chivers, Joanna E., Rider, Christopher F., Minnich, Anne, Giembycz, Mark A., Newton, Robert, Ito, Kazuhiro

Journal:

Year:

2013

Language:

english

File:

PDF, 1.76 MB

english, 2013

95

Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells

Smith, Susan J., Brookes-Fazakerley, Steven, Donnelly, Louise E., Barnes, Peter J., Barnette, Mary S., Giembycz, Mark A.

Journal:

American journal of physiology. Lung cellular and molecular physiology

Year:

2003

Language:

english

File:

PDF, 462 KB

english, 2003

96

A bronchoprotective role for Rgs2 in a murine model of lipopolysaccharide-induced airways inflammation

George, Tresa, Chakraborty, Mainak, Giembycz, Mark A., Newton, Robert

Journal:

Allergy, Asthma & Clinical Immunology

Year:

2018

Language:

english

File:

PDF, 2.34 MB

english, 2018

97

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California - ()] C98. NOVEL AIRWAY EPITHELIAL BARRIER AND IMMUNE RESPONSES - Novel Anti-Inflammatory Mechanisms Of Corticosteroid/Long-Acting ²2-Adrenoceptor Agonist Combination Treatment In Pulmonary Epithelial Cells: Roles For Regulator Of G-Protein Signalling (RGS) 2

Holden, Neil S., Rider, Christopher F., Kaur, Manminder, George, Tresa, Leigh, Richard, Johnson, Malcolm, Giembycz, Mark A., Newton, Robert

Year:

2012

Language:

english

File:

PDF, 19 KB

english, 2012

98

[American Thoracic Society American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado - ()] B34. EPITHELIAL CELL ACTIVITY - Evidence For A Second Receptor For Prostacyclin In Human Airway Epithelial Cells That Mediates Inhibition Of CXCL9 And CXCL10 Release

Giembycz, Mark, Sheddan, Neil, Wilson, Sylvia, Newton, Robert

Year:

2011

Language:

english

File:

PDF, 20 KB

english, 2011

99

Pertussis Toxin Shows Distinct Early Signalling Events in Platelet-Activating Factorâ, Leukotriene B4â, and C5a-Induced Eosinophil Homotypic Aggregation In Vitro and Recruitment In Vivo

Teixeira, Mauro M., Giembycz, Mark A., Lindsay, Mark A., Hellewell, Paul G.

Journal:

Year:

1997

File:

PDF, 236 KB

1997

100

Pleiotropic role of lyn kinase in leukotriene B4âinduced eosinophil activation

Lynch, Oonagh T., Giembycz, Mark A., Daniels, Ian, Barnes, Peter J., Lindsay, Mark A.

Journal:

Year:

2000

File:

PDF, 236 KB

2000