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1

Ligand Bridging of the DNA Holliday Junction: Molecular Recognition of a Stacked-X Four-Way Junction by a Small Molecule

Anna L. Brogden, Nicholas H. Hopcroft, Mark Searcey, Christine J. Cardin

Journal:

Angewandte Chemie

Year:

2007

Language:

english

File:

PDF, 4.79 MB

english, 2007

2

Synthesis and evaluation of a novel bleomycin A2 analogue: continuing assessment of the linker domain

Dale L Boger, Brian M Aquila, Winston C Tse, Mark Searcey

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 743 KB

english, 2000

3

A convenient access to benzo-substituted phthalazines as potential precursors to DNA intercalators

Petros G Tsoungas, Mark Searcey

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 74 KB

english, 2001

4

Total Synthesis and Comparative Evaluation of Luzopeptin A−C and Quinoxapeptin A−C

Boger, Dale L., Ledeboer, Mark W., Kume, Masaharu, Searcey, Mark, Jin, Qing

Journal:

Journal of the American Chemical Society

Year:

1999

Language:

english

File:

PDF, 268 KB

english, 1999

5

A small molecule that induces assembly of a four way DNA junction at low temperature

Howell, Lesley A., Waller, Zoë A. E., Bowater, Richard, O'Connell, Maria, Searcey, Mark

Journal:

Chemical Communications

Year:

2011

Language:

english

File:

PDF, 1.39 MB

english, 2011

6

Ligand Bridging of the DNA Holliday Junction: Molecular Recognition of a Stacked-X Four-Way Junction by a Small Molecule

Anna L. Brogden, Nicholas H. Hopcroft, Mark Searcey, Christine J. Cardin

Journal:

Angewandte Chemie International Edition

Year:

2007

Language:

english

File:

PDF, 4.79 MB

english, 2007

7

Stereoselectivity, Sequence Specificity and Mechanism of Action of the Azinomycin Epoxide

Marie-Hélène David-Cordonnier, Maxwell Casely-Hayford, Mostafa Kouach, Gilbert Briand, Laurence H. Patterson, Christian Bailly, Mark Searcey

Journal:

Year:

2006

Language:

english

File:

PDF, 268 KB

english, 2006

8

Targeting Higher-Order DNA: Beyond the G-Quadruplex

Lesley A. Howell, Mark Searcey

Journal:

Year:

2009

Language:

english

File:

PDF, 178 KB

english, 2009

9

Rationally Engineered Total Biosynthesis of a Synthetic Analogue of a Natural Quinomycin Depsipeptide in Escherichia coli

Kenji Watanabe, Kinya Hotta, Alex P. Praseuth, Mark Searcey, Clay C. C. Wang, Hiroki Oguri, Hideaki Oikawa

Journal:

Year:

2009

Language:

english

File:

PDF, 267 KB

english, 2009

10

ChemInform Abstract: Synthesis and Evaluation of Duocarmycin and CC-1065 Analogues Containing Modifications in the Subunit Linking Amide.

Dale L. Boger, Alejandro Santillan Jr., Mark Searcey, Qing Jin

Journal:

Year:

1999

File:

PDF, 27 KB

1999

11

ChemInform Abstract: Total Synthesis and Comparative Evaluation of Luzopeptin A—C and Quinoxapeptin A—C.

Dale L. Boger, Mark W. Ledeboer, Masaharu Kume, Mark Searcey, Qing Jin

Journal:

Year:

2000

Language:

english

File:

PDF, 32 KB

english, 2000

12

ChemInform Abstract: Bifunctional Alkylating Agents Derived from Duocarmycin SA: Potent Antitumor Activity with Altered Sequence Selectivity.

Dale L. Boger, Mark Searcey, Winston C. Tse, Qing Jin

Journal:

Year:

2000

File:

PDF, 30 KB

2000

13

ChemInform Abstract: A Convenient Access to Benzo-Substituted Phthalazines as Potential Precursors to DNA Intercalators.

Petros G. Tsoungas, Mark Searcey

Journal:

Year:

2002

File:

PDF, 31 KB

2002

14

A Mild Procedure for the Production of Secondary Amines from Oximes and Benzisoxazoles.

Mark Searcey, Sukhwant S. Grewal, Fiorenza Madeo, Petros G. Tsoungas

Journal:

Year:

2003

File:

PDF, 110 KB

2003

15

Truncated Azinomycin Analogues Intercalate into DNA.

Maxwell A. Casely-Hayford, Klaus Pors, Laurence H. Patterson, Clive Gerner, Stephen Neidle, Mark Searcey

Journal:

Year:

2005

File:

PDF, 9 KB

2005

16

ChemInform Abstract: The Isolation, Total Synthesis and Structure Elucidation of Chlorofusin, a Natural Product Inhibitor of the p53—MDM2 Protein—Protein Interaction

Ryan C. Clark, Sang Yeul Lee, Mark Searcey, Dale L. Boger

Journal:

Year:

2009

File:

PDF, 11 KB

2009

17

ChemInform Abstract: Targeting Higher-Order DNA: Beyond the G-Quadruplex

Lesley A. Howell, Mark Searcey

Journal:

Year:

2009

File:

PDF, 15 KB

2009

18

ChemInform Abstract: Synthesis and Evaluation of 9-Aminoacridines Derived from Benzyne Click Chemistry.

Lesley A. Howell, Aaron Howman, Maria A. O'Connell, Anja Mueller, Mark Searcey

Journal:

Year:

2010

File:

PDF, 40 KB

2010

19

DNA threading agents: effect of sidechain bulk on DNA binding and cytotoxicity of 9-anilinoacridine-4-carboxamides

Mark Searcey, P. Noel Martin, Nicola M. Howarth, Bernie Madden, Laurence P.G. Wakelin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 355 KB

english, 1996

20

Truncated azinomycin analogues intercalate into DNA

Maxwell A. Casely-Hayford, Klaus Pors, Laurence H. Patterson, Clive Gerner, Stephen Neidle, Mark Searcey

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 301 KB

english, 2005

21

Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry

Lesley A. Howell, Aaron Howman, Maria A. O’Connell, Anja Mueller, Mark Searcey

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 210 KB

english, 2009

22

Design and synthesis of threading intercalators to target DNA

Lesley A. Howell, Rosul Gulam, Anja Mueller, Maria A. O’Connell, Mark Searcey

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 452 KB

english, 2010

23

Evaluation of chlorofusin, its seven chromophore diastereomers, and key analogues

Ryan C. Clark, Sang Yeul Lee, Inkyu Hwang, Mark Searcey, Dale L. Boger

Journal:

Tetrahedron Letters

Year:

2009

Language:

english

File:

PDF, 256 KB

english, 2009

24

A mild procedure for the production of secondary amines from oximes and benzisoxazoles

Mark Searcey, Sukhwant S. Grewal, Fiorenza Madeo, Petros G. Tsoungas

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 156 KB

english, 2003

25

Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity

Dale L. Boger, Mark Searcey, Winston C. Tse, Qing Jin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 142 KB

english, 2000

26

Synthesis of CC-1065 and duocarmycin analogs via intramolecular aryl radical cyclization of a tethered vinyl chloride

Dale L. Boger, Christopher W. Boyce, Robert M. Garbaccio, Mark Searcey

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 295 KB

english, 1998

27

Synthesis of distamycin A polyamides targeting G-quadruplex DNA

Moore, Michael J. B., Cuenca, Francisco, Searcey, Mark, Neidle, Stephen

Journal:

Organic & Biomolecular Chemistry

Year:

2006

Language:

english

File:

PDF, 212 KB

english, 2006

28

Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity

Pors, Klaus, Loadman, Paul M., Shnyder, Steven D., Sutherland, Mark, Sheldrake, Helen M., Guino, Meritxell, Kiakos, Konstantinos, Hartley, John A., Searcey, Mark, Patterson, Laurence H.

Journal:

Chemical Communications

Year:

2011

Language:

english

File:

PDF, 1.67 MB

english, 2011

29

Synthesis of Small Molecules Targeting Multiple DNA Structures using Click Chemistry

Dr. Lesley A. Howell, Dr. Richard A. Bowater, Dr. Maria A. O'Connell, Anthony P. Reszka, Prof. Stephen Neidle, Prof. Mark Searcey

Journal:

Year:

2012

Language:

english

File:

PDF, 690 KB

english, 2012

30

Catalytic antibody activity elicited by active immunisation : Evidence for natural variation involving preferential stabilization of the transition state

Gerard GALLACHER, Caroline S. JACKSON, Mark SEARCEY, Rajiv GOEL, Geoffrey W. MELLOR, Carmen Z. SMITH, Keith BROCKLEHURST

Journal:

Year:

1993

Language:

english

File:

PDF, 1.03 MB

english, 1993

31

Anti-inflammatory Effect of a Cell-Penetrating Peptide Targeting the Nrf2/Keap1 Interaction

Steel, Richard, Cowan, Jonathan, Payerne, Estelle, O'Connell, Maria A., Searcey, Mark

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.86 MB

english, 2012

32

Synthesis and Evaluation of 1,2,8,8a-Tetrahydrocyclopropa[ c ]pyrrolo[3,2- e ]indol-4(5 H )-one, the Parent Alkylation Subunit of CC-1065 and the Duocarmycins: Impact of the Alkylation Subunit Substituents and Its Implications for DNA Alkylation Catalysis

Boger, Dale L., Santillán, Alejandro, Searcey, Mark, Brunette, Steven R., Wolkenberg, Scott E., Hedrick, Michael P., Jin, Qing

Journal:

Journal of Organic Chemistry

Year:

2000

Language:

english

File:

PDF, 356 KB

english, 2000

33

Chemistry in Cancer Research: A Vital Partnership

Sturla, Shana J., Irwin, John J., Loeppky, Richard N., Mulvihill, Mark J., Searcey, Mark

Journal:

ACS Chemical Biology

Year:

2007

Language:

english

File:

PDF, 261 KB

english, 2007

34

Design and synthesis of a DNA-crosslinking azinomycin analogue

Casely-Hayford, Maxwell A., Pors, Klaus, James, Colin H., Patterson, Laurence H., Hartley, John A., Searcey, Mark

Journal:

Organic & Biomolecular Chemistry

Year:

2005

Language:

english

File:

PDF, 152 KB

english, 2005

35

Design, Synthesis, and Evaluation of an α-Helix Mimetic Library Targeting Protein−Protein Interactions

Shaginian, Alex, Whitby, Landon R., Hong, Sukwon, Hwang, Inkyu, Farooqi, Bilal, Searcey, Mark, Chen, Jiandong, Vogt, Peter K., Boger, Dale L.

Journal:

Journal of the American Chemical Society

Year:

2009

Language:

english

File:

PDF, 1.19 MB

english, 2009

36

Efficient Solid-Phase-Based Total Synthesis of the Bisintercalator TANDEM

Malkinson, John P., Anim, Michael K., Zloh, Mire, Searcey, Mark, Hampshire, Andrew J., Fox, Keith R.

Journal:

Journal of Organic Chemistry

Year:

2005

Language:

english

File:

PDF, 414 KB

english, 2005

37

The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53–MDM2 protein–protein interaction

Clark, Ryan C., Lee, Sang Yeul, Searcey, Mark, Boger, Dale L.

Journal:

Natural Product Reports

Year:

2009

Language:

english

File:

PDF, 1.36 MB

english, 2009

38

Solid-Phase Synthesis of the Cyclic Peptide Portion of Chlorofusin, an Inhibitor of p53-MDM2 Interactions

Malkinson, John P., Zloh, Mire, Kadom, Mohanad, Errington, Rachel, Smith, Paul J., Searcey, Mark

Journal:

Organic Letters

Year:

2003

Language:

english

File:

PDF, 128 KB

english, 2003

39

Identification and characterisation of a G-quadruplex forming sequence in the promoter region of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)

Waller, Zoë A.E., Howell, Lesley A., MacDonald, Colin J., O’Connell, Maria A., Searcey, Mark

Journal:

Biochemical and Biophysical Research Communications

Year:

2014

Language:

english

File:

PDF, 503 KB

english, 2014

40

DNA Binding by Analogues of the Bifunctional Intercalator TANDEM

Hampshire, Andrew J., Rusling, David A., Bryan, Stephanie, Paumier, David, Dawson, Simon J., Malkinson, John P., Searcey, Mark, Fox, Keith R.

Journal:

Year:

2008

Language:

english

File:

PDF, 9.43 MB

english, 2008

41

Solid-Phase Synthesis of Chlorofusin Analogues

Woon, Esther C. Y., Arcieri, Mariangela, Wilderspin, Andrew F., Malkinson, John P., Searcey, Mark

Journal:

Journal of Organic Chemistry

Year:

2007

Language:

english

File:

PDF, 378 KB

english, 2007

42

Synthesis and Evaluation of Duocarmycin and CC-1065 Analogues Containing Modifications in the Subunit Linking Amide

Boger, Dale L., Santillán, Alejandro, Searcey, Mark, Jin, Qing

Journal:

Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 148 KB

english, 1999

43

Development of Nonsymmetrical 1,4-Disubstituted Anthraquinones That Are Potently Active against Cisplatin-Resistant Ovarian Cancer Cells

Pors, Klaus, Plumb, Jane A., Brown, Robert, Teesdale-Spittle, Paul, Searcey, Mark, Smith, Paul J., Patterson, Laurence H.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 172 KB

english, 2005

44

Synthesis of DNA-Directed Pyrrolidinyl and Piperidinyl Confined Alkylating Chloroalkylaminoanthraquinones: Potential for Development of Tumor-Selective N -Oxides

Pors, Klaus, Shnyder, Steven D., Teesdale-Spittle, Paul H., Hartley, John A., Zloh, Mire, Searcey, Mark, Patterson, Laurence H.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 503 KB

english, 2006

45

Critical Role of the Linking Amide in CC-1065 and the Duocarmycins: Implications on the Source of DNA Alkylation Catalysis

Boger, Dale L., Santillán, Alejandro, Searcey, Mark, Jin, Qing

Journal:

Journal of the American Chemical Society

Year:

1998

Language:

english

File:

PDF, 152 KB

english, 1998

46

Non-covalent duplex to duplex crosslinking of DNA in solution revealed by single molecule force spectroscopy

Rackham, Benjamin D., Howell, Lesley A., Round, Andrew N., Searcey, Mark

Journal:

Organic & Biomolecular Chemistry

Year:

2013

Language:

english

File:

PDF, 1.96 MB

english, 2013

47

A rapid screen for molecules that form duplex to duplex crosslinks in DNA

Marín, María J., Rackham, Benjamin D., Round, Andrew N., Howell, Lesley A., Russell, David A., Searcey, Mark

Journal:

Chemical Communications

Year:

2013

Language:

english

File:

PDF, 1.58 MB

english, 2013

48

Bleomycin mimics. Design and synthesis of an acridine derivative which cleaves DNA in a sequence-neutral manner

Searcey, Mark, McClean, Siobhán, Madden, Bernie, Wakelin, Laurence P. G.

Journal:

Journal of the Chemical Society Perkin Transactions 2

Year:

1997

Language:

english

File:

PDF, 716 KB

english, 1997

49

Probing cytochrome P450-mediated activation with a truncated azinomycin analogue

Vinader, Victoria, Sadiq, Maria, Sutherland, Mark, Huang, Mengying, Loadman, Paul M., Elsalem, Lina, Shnyder, Steven D., Cui, Hongjuan, Afarinkia, Kamyar, Searcey, Mark, Patterson, Laurence H., Pors,

Journal:

Year:

2015

Language:

english

File:

PDF, 689 KB

english, 2015

50

Duocarmycins - Natures Prodrugs?

Journal:

Current Pharmaceutical Design

Year:

2002

Language:

english

File:

PDF, 87 KB

english, 2002