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51

Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

Dohoon Kim, Christopher L. Frank, Matthew M. Dobbin, Rachel K. Tsunemoto, Weihong Tu, Peter L. Peng, Ji-Song Guan, Byung-Hoon Lee, Lily Y. Moy, Paola Giusti, Nisha Broodie, Ralph Mazitschek, Ivanna De

Journal:

Year:

2008

Language:

english

File:

PDF, 2.05 MB

english, 2008

52

Total Synthesis and Biological Evaluation of the Nakijiquinones

Stahl, Petra, Kissau, Lars, Mazitschek, Ralph, Huwe, Axel, Furet, Pascal, Giannis, Athanassios, Waldmann, Herbert

Journal:

Journal of the American Chemical Society

Year:

2001

Language:

english

File:

PDF, 242 KB

english, 2001

53

Halofuginone Inhibits TH17 Cell Differentiation by Activating the Amino Acid Starvation Response

Sundrud, M. S., Koralov, S. B., Feuerer, M., Calado, D. P., Kozhaya, A. E., Rhule-Smith, A., Lefebvre, R. E., Unutmaz, D., Mazitschek, R., Waldner, H., Whitman, M., Keller, T., Rao, A.

Journal:

Year:

2009

Language:

english

File:

PDF, 595 KB

english, 2009

54

Regulation of CD133 by HDAC6 Promotes β-Catenin Signaling to Suppress Cancer Cell Differentiation

Anthony B. Mak, Allison M.L. Nixon, Saranya Kittanakom, Jocelyn M. Stewart, Ginny I. Chen, Jasna Curak, Anne-Claude Gingras, Ralph Mazitschek, Benjamin G. Neel, Igor Stagljar, Jason Moffat

Journal:

Year:

2012

Language:

english

File:

PDF, 1.64 MB

english, 2012

55

208 Epigenetic Regulation of FOXP3+ Regulatory T Cells (Treg) By Small Molecule Targeting of a Single HDAC, Hdac6, Enhances Treg Function and Ameliorates Development of IBD in Murine Models

Edwin F. deZoeten, James E. Bradner, Ralph Mazitschek, Wayne W. Hancock

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 68 KB

english, 2008

56

Short-Chain HDAC Inhibitors Differentially Affect Vertebrate Development and Neuronal Chromatin

Fass, Daniel M., Shah, Rishita, Ghosh, Balaram, Hennig, Krista, Norton, Stephanie, Zhao, Wen-Ning, Reis, Surya A., Klein, Peter S., Mazitschek, Ralph, Maglathlin, Rebecca L., Lewis, Timothy A., Haggar

Journal:

ACS Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 2.24 MB

english, 2011

57

Synapse microarray identification of small molecules that enhance synaptogenesis

Shi, Peng, Scott, Mark A., Ghosh, Balaram, Wan, Dongpeng, Wissner-Gross, Zachary, Mazitschek, Ralph, Haggarty, Stephen J., Yanik, Mehmet Fatih

Journal:

Nature Communications

Year:

2011

Language:

english

File:

PDF, 1.22 MB

english, 2011

58

Histone deacetylase 3 as a novel therapeutic target in multiple myeloma

Minami, J, Suzuki, R, Mazitschek, R, Gorgun, G, Ghosh, B, Cirstea, D, Hu, Y, Mimura, N, Ohguchi, H, Cottini, F, Jakubikova, J, Munshi, N C, Haggarty, S J, Richardson, P G, Hideshima, T, Anderson, K C

Journal:

Year:

2014

Language:

english

File:

PDF, 1021 KB

english, 2014

59

Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity

McLellan, Catherine A., Whitesell, Luke, King, Oliver D., Lancaster, Alex K., Mazitschek, Ralph, Lindquist, Susan

Journal:

ACS Chemical Biology

Year:

2012

Language:

english

File:

PDF, 402 KB

english, 2012

60

Induction of differential apoptotic pathways in multiple myeloma cells by class-selective histone deacetylase inhibitors

Hideshima, T, Mazitschek, R, Santo, L, Mimura, N, Gorgun, G, Richardson, P G, Raje, N, Anderson, K C

Journal:

Year:

2014

Language:

english

File:

PDF, 731 KB

english, 2014

61

Efficient Acid-Catalyzed 18 F/ 19 F Fluoride Exchange of BODIPY Dyes

Keliher, Edmund J., Klubnick, Jenna A., Reiner, Thomas, Mazitschek, Ralph, Weissleder, Ralph

Journal:

Year:

2014

Language:

english

File:

PDF, 395 KB

english, 2014

62

In vivo imaging of specific drug–target binding at subcellular resolution

Dubach, J. M., Vinegoni, C., Mazitschek, R., Fumene Feruglio, P., Cameron, L. A., Weissleder, R.

Journal:

Nature Communications

Year:

2014

Language:

english

File:

PDF, 2.47 MB

english, 2014

63

Selective inhibition of histone deacetylase 6 alters the composition of circulating blood cells in a lethal septic model

Zhao, Ting, Li, Yongqing, Liu, Baoling, Halaweish, Ihab, Mazitschek, Ralph, Alam, Hasan B.

Journal:

Journal of Surgical Research

Year:

2014

Language:

english

File:

PDF, 921 KB

english, 2014

64

Selective Histone Deacetylase-6 Inhibition Attenuates Stress Responses and Prevents Immune Organ Atrophy in a Lethal Septic Model

Zhao, T., Li, Y., Bronson, R.T., Liu, B., Mazitschek, R., Velmahos, G.C., Alam, H.B.

Journal:

Journal of Surgical Research

Year:

2014

Language:

english

File:

PDF, 196 KB

english, 2014

65

Selective inhibition of histone deacetylase 6 attenuates inflammation and improves long-term survival in a lethal septic model

Zhao, Ting, Li, Yongqing, Liu, Baoling, Mazitschek, Ralph, Duan, Xiuzhen, Velmahos, George C., Alam, Hasan B.

Journal:

Journal of the American College of Surgeons

Year:

2013

Language:

english

File:

PDF, 48 KB

english, 2013

66

Monoalkoxy BODIPYs—A Fluorophore Class for Bioimaging

Courtis, Alexandra M., Santos, Sofia A., Guan, Yinghua, Hendricks, J. Adam, Ghosh, Balaram, Szantai-Kis, D. Miklos, Reis, Surya A., Shah, Jagesh V., Mazitschek, Ralph

Journal:

Bioconjugate Chemistry

Year:

2014

Language:

english

File:

PDF, 3.35 MB

english, 2014

67

A Concise Silylamine Approach to 2-Amino-3-hydroxy-indoles with Potent in vivo Antimalaria Activity

Urgaonkar, Sameer, Cortese, Joseph F., Barker, Robert H., Cromwell, Mandy, Serrano, Adelfa E., Wirth, Dyann F., Clardy, Jon, Mazitschek, Ralph

Journal:

Organic Letters

Year:

2010

Language:

english

File:

PDF, 254 KB

english, 2010

68

High-Throughput Screen for Novel Antimicrobials using a Whole Animal Infection Model

Moy, Terence I., Conery, Annie L., Larkins-Ford, Jonah, Wu, Gang, Mazitschek, Ralph, Casadei, Gabriele, Lewis, Kim, Carpenter, Anne E., Ausubel, Frederick M.

Journal:

ACS Chemical Biology

Year:

2009

Language:

english

File:

PDF, 2.57 MB

english, 2009

69

Correction to Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity

McLellan, Catherine A., Whitesell, Luke, King, Oliver D., Lancaster, Alex K., Mazitschek, Ralph, Lindquist, Susan

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 107 KB

english, 2014

70

In Vivo PET Imaging of Histone Deacetylases by 18 F-Suberoylanilide Hydroxamic Acid ( 18 F-SAHA)

Hendricks, J. Adam, Keliher, Edmund J., Marinelli, Brett, Reiner, Thomas, Weissleder, Ralph, Mazitschek, Ralph

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.94 MB

english, 2011

71

Chemical Interrogation of the Malaria Kinome

Derbyshire, Emily R., Zuzarte-Luís, Vanessa, Magalhães, Andreia D., Kato, Nobutaka, Sanschagrin, Paul C., Wang, Jinhua, Zhou, Wenjun, Miduturu, Chandrasekhar V., Mazitschek, Ralph, Sliz, Piotr, Mota,

Journal:

Year:

2014

Language:

english

File:

PDF, 1.25 MB

english, 2014

72

Development of Natural Product-Derived Receptor Tyrosine Kinase Inhibitors Based on Conservation of Protein Domain Fold

Kissau, Lars, Stahl, Petra, Mazitschek, Ralph, Giannis, Athannasios, Waldmann, Herbert

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 579 KB

english, 2003

73

Structural Origin of Selectivity in Class II-Selective Histone Deacetylase Inhibitors

Estiu, Guillermina, Greenberg, Edward, Harrison, Christopher B., Kwiatkowski, Nicholas P., Mazitschek, Ralph, Bradner, James E., Wiest, Olaf

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.82 MB

english, 2008

74

Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase Inhibitors by Multimodality Molecular Imaging in Living Subjects

Chan, C. T., Qi, J., Smith, W., Paranol, R., Mazitschek, R., West, N., Reeves, R., Chiosis, G., Schreiber, S. L., Bradner, J. E., Paulmurugan, R., Gambhir, S. S.

Journal:

Cancer Research

Year:

2014

Language:

english

File:

PDF, 1.51 MB

english, 2014

75

Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells

Aldana-Masangkay, Grace I., Rodriguez-Gonzalez, Agustin, Lin, Tara, Ikeda, Alan K., Hsieh, Yao-Te, Kim, Yong-Mi, Lomenick, Brett, Okemoto, Kazuo, Landaw, Elliot M., Wang, Dongpeng, Mazitschek, Ralph,

Journal:

Leukemia and Lymphoma

Year:

2011

Language:

english

File:

PDF, 1.87 MB

english, 2011

76

Comprehensive Genetic Counseling for Families At Risk for HNPCC: Impact on Distress and Perceptions

Keller, M., Jost, R., Haunstetter, C. Mastromarino, Kienle, P., Knaebel, H.-P., Gebert, J., Sutter, C., Knebel-Doeberitz, M. V., Cremer, F., Mazitschek, U.

Journal:

Genetic Testing

Year:

2002

Language:

english

File:

PDF, 184 KB

english, 2002

77

Cover Picture: Chemical Interrogation of the Malaria Kinome (ChemBioChem 13/2014)

Derbyshire, Emily R., Zuzarte-Luís, Vanessa, Magalhães, Andreia D., Kato, Nobutaka, Sanschagrin, Paul C., Wang, Jinhua, Zhou, Wenjun, Miduturu, Chandrasekhar V., Mazitschek, Ralph, Sliz, Piotr, Mota,

Journal:

Year:

2014

Language:

english

File:

PDF, 512 KB

english, 2014

78

HDAC6 Inhibitors Modulate Lys49 Acetylation and Membrane Localization of β-Catenin in Human iPSC-Derived Neuronal Cells

Iaconelli, Jonathan, Huang, Joanne H., Berkovitch, Shaunna S., Chattopadhyay, Shrikanta, Mazitschek, Ralph, Schreiber, Stuart L., Haggarty, Stephen J., Karmacharya, Rakesh

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 4.00 MB

english, 2015

79

Protective effect of suberoylanilide hydroxamic acid against lipopolysaccharide-induced liver damage in rodents

Zhao, Yili, Zhou, Peter, Liu, Baoling, Bambakidis, Ted, Mazitschek, Ralph, Alam, Hasan B., Li, Yongqing

Journal:

Journal of Surgical Research

Year:

2015

Language:

english

File:

PDF, 859 KB

english, 2015

80

Colorimetric High-Throughput Screen for Detection of Heme Crystallization Inhibitors

Rush, M. A., Baniecki, M. L., Mazitschek, R., Cortese, J. F., Wiegand, R., Clardy, J., Wirth, D. F.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2009

Language:

english

File:

PDF, 132 KB

english, 2009

81

Ubiquitin Proteasome System Stress Underlies Synergistic Killing of Ovarian Cancer Cells by Bortezomib and a Novel HDAC6 Inhibitor

Bazzaro, M., Lin, Z., Santillan, A., Lee, M. K., Wang, M.-C., Chan, K. C., Bristow, R. E., Mazitschek, R., Bradner, J., Roden, R. B.S.

Journal:

Clinical Cancer Research

Year:

2008

Language:

english

File:

PDF, 579 KB

english, 2008

82

Tubacin Kills Epstein-Barr Virus (EBV)-Burkitt Lymphoma Cells by Inducing Reactive Oxygen Species and EBV Lymphoblastoid Cells by Inducing Apoptosis

Kawada, J., Zou, P., Mazitschek, R., Bradner, J. E., Cohen, J. I.

Journal:

Journal of Biological Chemistry

Year:

2009

Language:

english

File:

PDF, 2.08 MB

english, 2009

83

8-Benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic Acid (SD-1008), a Novel Janus Kinase 2 Inhibitor, Increases Chemotherapy Sensitivity in Human Ovarian Cancer Cells

Duan, Z., Bradner, J., Greenberg, E., Mazitschek, R., Foster, R., Mahoney, J., Seiden, M. V.

Journal:

Molecular Pharmacology

Year:

2007

Language:

english

File:

PDF, 597 KB

english, 2007

84

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

Bradner, James E., Mak, Raymond, Tanguturi, Shyam K., Mazitschek, Ralph, Haggarty, Stephen J., Ross, Kenneth, Chang, Cindy Y., Bosco, Jocelyn, West, Nathan, Morse, Elizabeth, Lin, Katherine, Shen, Joh

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 686 KB

english, 2010

85

Aminoindoles, a Novel Scaffold with Potent Activity against Plasmodium falciparum

Barker, R. H., Urgaonkar, S., Mazitschek, R., Celatka, C., Skerlj, R., Cortese, J. F., Tyndall, E., Liu, H., Cromwell, M., Sidhu, A. B., Guerrero-Bravo, J. E., Crespo-Llado, K. N., Serrano, A. E., Lin

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2011

Language:

english

File:

PDF, 755 KB

english, 2011

86

Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

Schuetz, A., Min, J., Allali-Hassani, A., Schapira, M., Shuen, M., Loppnau, P., Mazitschek, R., Kwiatkowski, N. P., Lewis, T. A., Maglathin, R. L., McLean, T. H., Bochkarev, A., Plotnikov, A. N., Veda

Journal:

Journal of Biological Chemistry

Year:

2008

Language:

english

File:

PDF, 1.05 MB

english, 2008

87

Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6

Zilberman, Y., Ballestrem, C., Carramusa, L., Mazitschek, R., Khochbin, S., Bershadsky, A.

Journal:

Journal of Cell Science

Year:

2009

Language:

english

File:

PDF, 1.60 MB

english, 2009

88

HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions

Tran, A. D.-A., Marmo, T. P., Salam, A. A., Che, S., Finkelstein, E., Kabarriti, R., Xenias, H. S., Mazitschek, R., Hubbert, C., Kawaguchi, Y., Sheetz, M. P., Yao, T.-P., Bulinski, J. C.

Journal:

Journal of Cell Science

Year:

2007

Language:

english

File:

PDF, 1.06 MB

english, 2007

89

A genomic and evolutionary approach reveals non-genetic drug resistance in malaria

Herman, Jonathan D, Rice, Daniel P, Ribacke, Ulf, Silterra, Jacob, Deik, Amy A, Moss, Eli L, Broadbent, Kate M, Neafsey, Daniel E, Desai, Michael M, Clish, Clary B, Mazitschek, Ralph, Wirth, Dyann F

Journal:

Year:

2014

Language:

english

File:

PDF, 2.37 MB

english, 2014

90

Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma

Ecker, Jonas, Oehme, Ina, Mazitschek, Ralph, Korshunov, Andrey, Kool, Marcel, Hielscher, Thomas, Kiss, Judit, Selt, Florian, Konrad, Carina, Lodrini, Marco, Deubzer, Hedwig E, von Deimling, Andreas, K

Journal:

Acta Neuropathologica Communications

Year:

2015

Language:

english

File:

PDF, 1.39 MB

english, 2015

91

Live-cell multiphoton fluorescence correlation spectroscopy with an improved large Stokes shift fluorescent protein

Guan, Y., Meurer, M., Raghavan, S., Rebane, A., Lindquist, J. R., Santos, S., Kats, I., Davidson, M. W., Mazitschek, R., Hughes, T. E., Drobizhev, M., Knop, M., Shah, J. V.

Journal:

Molecular Biology of the Cell

Year:

2015

Language:

english

File:

PDF, 1.95 MB

english, 2015

92

A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly

Groen, A. C., Needleman, D., Brangwynne, C., Gradinaru, C., Fowler, B., Mazitschek, R., Mitchison, T. J.

Journal:

Journal of Cell Science

Year:

2008

Language:

english

File:

PDF, 1.71 MB

english, 2008

93

Histone Deacetylase 6 and Heat Shock Protein 90 Control the Functions of Foxp3+ T-Regulatory Cells

de Zoeten, E. F., Wang, L., Butler, K., Beier, U. H., Akimova, T., Sai, H., Bradner, J. E., Mazitschek, R., Kozikowski, A. P., Matthias, P., Hancock, W. W.

Journal:

Molecular and Cellular Biology

Year:

2011

Language:

english

File:

PDF, 4.69 MB

english, 2011

94

Advances in measuring single-cell pharmacology in vivo

Vinegoni, Claudio, Dubach, J. Matthew, Thurber, Greg M., Miller, Miles A., Mazitschek, Ralph, Weissleder, Ralph

Journal:

Drug Discovery Today

Year:

2015

Language:

english

File:

PDF, 1.01 MB

english, 2015

95

Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation

Hahn, C. K., Ross, K. N., Warrington, I. M., Mazitschek, R., Kanegai, C. M., Wright, R. D., Kung, A. L., Golub, T. R., Stegmaier, K.

Journal:

Proceedings of the National Academy of Sciences

Year:

2008

Language:

english

File:

PDF, 1010 KB

english, 2008

96

Antidepressant-Like Properties of Novel HDAC6-Selective Inhibitors with Improved Brain Bioavailability

Jochems, Jeanine, Boulden, Janette, Lee, Bridgin G, Blendy, Julie A, Jarpe, Matthew, Mazitschek, Ralph, Van Duzer, John H, Jones, Simon, Berton, Olivier

Journal:

Neuropsychopharmacology

Year:

2014

Language:

english

File:

PDF, 798 KB

english, 2014

97

Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype

Santos, Sofia A., Lukens, Amanda K., Coelho, Lis, Nogueira, Fátima, Wirth, Dyann F., Mazitschek, Ralph, Moreira, Rui, Paulo, Alexandra

Journal:

European Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 6.87 MB

english, 2015

98

Turn-On Labeling in Living Cells

Devaraj, N., Hilderbrand, S., Upadhyay, R., Mazitschek, R., Weissleder, R.

Journal:

Year:

2010

Language:

english

File:

PDF, 171 KB

english, 2010

99

Peptidomimetics and Angiogenesis

Mazitschek, Ralph, Baumhof, Patrick, Giannis, Athanassios

Journal:

Mini Reviews in Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 308 KB

english, 2002

100

Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation

Ageta-Ishihara, Natsumi, Miyata, Takaki, Ohshima, Chika, Watanabe, Masahiko, Sato, Yoshikatsu, Hamamura, Yuki, Higashiyama, Tetsuya, Mazitschek, Ralph, Bito, Haruhiko, Kinoshita, Makoto

Journal:

Nature Communications

Year:

2013

Language:

english

File:

PDF, 2.40 MB

english, 2013