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51

Easy access to orthogonally protected α-alkyl aspartic acid and α-alkyl asparagine derivatives by controlled opening of β-lactams

Guillermo Gerona-Navarro, Ma̱ Teresa Garcı́a-López, Rosario González-Muñiz

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 120 KB

english, 2003

52

Memory of chirality in the stereoselective synthesis of β-lactams: importance of the starting amino acid derivative

Ma̱ Angeles Bonache, Guillermo Gerona-Navarro, Carlos Garcı́a-Aparicio, Miriam Alı́as, Mercedes Martı́n-Martı́nez, Ma̱ Teresa Garcı́a-López, Pilar López, Carlos Cativiela, Rosario González-Muñiz

Journal:

Tetrahedron: Asymmetry

Year:

2003

Language:

english

File:

PDF, 494 KB

english, 2003

53

Effects of the incorporation of IBTM β-turn mimetics into the dipeptoid CCK1 receptor agonist PD 170292

Mercedes Martı́n-Martı́nez, Miriam Latorre, M.Teresa Garcı́a-López, Edurne Cenarruzabeitia, Joaquı́n Del Rı́o, Rosario González-Muñiz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 122 KB

english, 2002

54

Pseudopeptide CCK-4 analogues incorporating the Ψ[CH(CN)NH] peptide bond surrogate

Susana Herrero, M.Luisa Suárez-Gea, Rosario González-Muñiz, M.Teresa García-López, Rosario Herranz, Santiago Ballaz, Ana Barber, Ana Fortuño, Joaquín Del Río

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 410 KB

english, 1997

55

Highly constrained dipeptoid analogues containing a type II′ β-turn mimic as novel and selective CCK-A receptor ligands

Natalia de la Figuera, Mercedes Martín-Martínez, Rosario Herranz, M. Teresa García-López, Miriam Latorre, Edurne Cenarruzabeitia, Joaquín del Río, Rosario González-Muñiz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 304 KB

english, 1999

56

Conformationally restricted PACAP27 analogues incorporating type II/II′ IBTM β-Turn Mimetics. Synthesis, NMR Structure Determination, and Binding Affinity

Rosario González-Muñiz, Mercedes Martı́n-Martı́nez, Cesare Granata, Eliandre de Oliveira, Clara M. Santiveri, Carlos González, Diana Frechilla, Rosario Herranz, M.Teresa Garcı́a-López, Joaquı́n Del Rı

Journal:

Bioorganic & Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 363 KB

english, 2001

57

Constrained C-terminal hexapeptide neurotensin analogues containing a 3-oxoindolizidine skeleton

M. Teresa García-López, Ibon Alkorta, M. José Domínguez, Rosario González-Muñiz, Rosario Herranz, Nils L. Johansen, Kjeld Madsen, Henning Thøgersen, Peter Suzdak

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1995

Language:

english

File:

PDF, 698 KB

english, 1995

58

Studies on the synthesis of β-keto esters derived from dipeptides: search for a low-epimerizing method

Rosario Patiño-Molina, Mercedes Martín-Martínez, Rosario Herranz, Maria Teresa García-López, Rosario González-Muñiz

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2000

Language:

english

File:

PDF, 548 KB

english, 2000

59

Exploring the binding pocket for pyridopyrimidine ligands at the CCK1 receptor by molecular docking

Amel Toumi-Maouche, Boubekeur Maouche, Safia Taïri-Kellou, Salima El-Aoufi, Mercedes Martín-Martínez, Rosario González-Muñiz, Daniel Fourmy, Bernard Maigret

Journal:

Journal of Molecular Modeling

Year:

2008

Language:

english

File:

PDF, 792 KB

english, 2008

60

Similarity Study on Peptide γ-turn Conformation Mimetics

Ibon Alkorta, MariaLuisa Suarez, Rosario Herranz, Rosario González-Muñiz, M.Teresa García-López

Journal:

Journal of Molecular Modeling

Year:

1996

Language:

english

File:

PDF, 98 KB

english, 1996

61

CCK-4 restricted analogues containing a 3-oxoindolizidine skeleton

Rosario González-Muñiz, MaJosé Domínguez, Mercedes Martín-Martínez, Rosario Herranz, MaTeresa García-López, Ana Barber, Santiago Ballaz, Joaquín Del Río

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 331 KB

english, 1996

62

Synthesis and SAR studies on azetidine-containing dipeptides as HCMV inhibitors

Paula Pérez-Faginas, M. Teresa Aranda, M. Teresa García-López, Robert Snoeck, Graciela Andrei, Jan Balzarini, Rosario González-Muñiz

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.08 MB

english, 2011

63

Synthesis and anti-HCMV activity of 1-acyl-β-lactams and 1-acylazetidines derived from phenylalanine

Guillermo Gerona-Navarro, Ma Jesús Pérez de Vega, Ma Teresa Garcı́a-López, Graciela Andrei, Robert Snoeck, Jan Balzarini, Erik De Clercq, Rosario González-Muñiz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 278 KB

english, 2004

64

New Gly-Pro-Glu (GPE) analogues: Expedite solid-phase synthesis and biological activity

Sergio A. Alonso De Diego, Marta Gutiérrez-Rodríguez, M. Jesús Pérez de Vega, Diego Casabona, Carlos Cativiela, Rosario González-Muñiz, Rosario Herranz, Edurne Cenarruzabeitia, Diana Frechilla, Joaquí

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 151 KB

english, 2006

65

A simple and versatile route to ketomethylene dipeptide analogs

M. Teresa García-López, Rosario González-Muñíz, Juan R. Harto

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 218 KB

english, 1988

66

Pharmacological evaluation of IQM-95,333, a highly selective CCKA receptor antagonist with anxiolytic-like activity in animal models

Santiago Ballaz, Ana Barber, Ana Fortuño, Joaquín Del Río, Mercedes Martín-Martínez, Isabel Gómez-Monterrey, Rosario Herranz, Rosario González-Muñiz, Maria-Teresa García-López

Journal:

British Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 407 KB

english, 1997

67

Studies on the synthesis of β-keto esters derived from dipeptides: search for a low-epimerizing method

Rosario Patiño-Molina, Mercedes Martín-Martínez, Rosario Herranz, Maria Teresa García-López, Rosario González-Muñiz

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2000

Language:

english

File:

PDF, 79 KB

english, 2000

68

Exploring solid-phase approaches for the preparation of new β-lactams from amino acids

Guillermo Gerona-Navarro, Miriam Royo, Ma Teresa García-López, Fernando Albericio, Rosario González-Muñiz

Journal:

Molecular Diversity

Year:

2003

Language:

english

File:

PDF, 301 KB

english, 2003

69

5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-Based Potent and Selective CCK1 Receptor Antagonists: Structure−Activity Relationship Studies on the Central 1,3-Dioxoperhydropyrido[1,2-c]pyrimidine Scaffold

Bartolomé-Nebreda, José M., García-López, M. Teresa, González-Muñiz, Rosario, Cenarruzabeitia, Edurne, Latorre, Miriam, Del Río, Joaquín, Herranz, Rosario

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 127 KB

english, 2001

70

Factor J, an inhibitor of the classical and alternative complement pathway, does not inhibit esterolysis by factor D

Carolina González-Rubio, Rosario González-Mũniz, Miguel A. Jiménez-Clavero, Gumersindo Fontán, Margarita López-Trascasa

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1996

Language:

english

File:

PDF, 414 KB

english, 1996

71

Disulfide and amide-bridged cyclic peptide analogues of the VEGF81–91 fragment: Synthesis, conformational analysis and biological evaluation

María Isabel García-Aranda, Yasmina Mirassou, Benoit Gautier, Mercedes Martín-Martínez, Nicolas Inguimbert, Michel Vidal, María Teresa García-López, María Angeles Jiménez, Rosario González-Muñiz, Marí

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 582 KB

english, 2011

72

Optically active 1,3,4,4-tetrasubstituted β-lactams: Synthesis and evaluation as tumor cell growth inhibitors

Paula Pérez-Faginas, M. Teresa Aranda, M. Teresa García-López, Andrés Francesch, Carmen Cuevas, Rosario González-Muñiz

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.08 MB

english, 2011

73

Monitor – chemistry

Rosario González-Muñiz

Journal:

Drug Discovery Today

Year:

2004

Language:

english

File:

PDF, 207 KB

english, 2004

74

Monitor – New TRPV1-targeting agents for pain management

Rosario González-Muñiz

Journal:

Drug Discovery Today

Year:

2005

Language:

english

File:

PDF, 67 KB

english, 2005

75

Azepane Quaternary Amino Acids As Effective Inducers of 3 10 Helix Conformations

Núñez-Villanueva, Diego, Infantes, Lourdes, García-López, M. Teresa, González-Muñiz, Rosario, Martín-Martínez, Mercedes

Journal:

Journal of Organic Chemistry

Year:

2012

Language:

english

File:

PDF, 885 KB

english, 2012

76

Ketomethylene and Methyleneamino Pseudopeptide Analogues of Insect Allatostatins Inhibit Juvenile Hormone and Vitellogenin Production in the Cockroach Blattella germanica

Maria-Dolors Piulachs, Lluı̈sa Vilaplana, José-Manuel Bartolomé, Cristina Carreño, David Martı́n, Rosario González-Muñiz, Rosario Herranz, Marı́a-Teresa Garcı́a-López, David Andreu, Xavier Bellés

Journal:

Insect Biochemistry and Molecular Biology

Year:

1997

Language:

english

File:

PDF, 229 KB

english, 1997

77

Entry to New Conformationally Constrained Amino Acids. First Synthesis of 3-Unsubstituted 4-Alkyl-4-carboxy-2-azetidinone Derivatives via an Intramolecular N α-C α -Cyclization Strategy

Gerona-Navarro, Guillermo, Bonache, Maria Angeles, Herranz, Rosario, García-López, Maria Teresa, González-Muñiz, Rosario

Journal:

Journal of Organic Chemistry

Year:

2001

Language:

english

File:

PDF, 128 KB

english, 2001

78

Advances in modulating thermosensory TRP channels

Ferrer-Montiel, Antonio, Fernández-Carvajal, Asia, Planells-Cases, Rosa, Fernández-Ballester, Gregorio, González-Ros, José Manuel, Messeguer, Àngel, González-Muñiz, Rosario

Journal:

Expert Opinion on Therapeutic Patents

Year:

2012

Language:

english

File:

PDF, 576 KB

english, 2012

79

The Parkinson's disease-associated GPR37 receptor-mediated cytotoxicity is controlled by its intracellular cysteine-rich domain

Gandía, Jorge, Fernández-Dueñas, Víctor, Morató, Xavier, Caltabiano, Gianluigi, González-Muñiz, Rosario, Pardo, Leonardo, Stagljar, Igor, Ciruela, Francisco

Journal:

Journal of Neurochemistry

Year:

2013

Language:

english

File:

PDF, 895 KB

english, 2013

80

Ketomethylene and (Cyanomethylene)amino Pseudopeptide Analogs of the C-Terminal Hexapeptide of Neurotensin

Gonzalez-Muniz, Rosario, Garcia-Lopez, M. Teresa, Gomez-Monterrey, Isabel, Herranz, Rosario, Jimeno, M. Luisa, Suarez-Gea, M. Luisa, Johansen, Nils L., Madsen, Kjeld, Thogersen, Henning, Suzdak, Peter

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 925 KB

english, 1995

81

β-Turned Dipeptoids as Potent and Selective CCK 1 Receptor Antagonists

Martín-Martínez, Mercedes, De la Figuera, Natalia, Latorre, Miriam, Herranz, Rosario, García-López, M. Teresa, Cenarruzabeitia, Edurne, Del Río, Joaquín, González-Muñiz, Rosario

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 99 KB

english, 2000

82

Tetramic acids and indole derivatives from amino acid β-keto esters. Fine-tuning the conditions of the key Cu-catalyzed reaction

García-Aranda, M. Isabel, García-López, M. Teresa, Jesús Pérez de Vega, M., González-Muñiz, Rosario

Journal:

Tetrahedron Letters

Year:

2014

Language:

english

File:

PDF, 486 KB

english, 2014

83

From 1-Acyl-β-lactam Human Cytomegalovirus Protease Inhibitors to 1-Benzyloxycarbonylazetidines with Improved Antiviral Activity. A Straightforward Approach To Convert Covalent to Noncovalent Inhibitors

Gerona-Navarro, Guillermo, Pérez de Vega, M. Jesús, García-López, M. Teresa, Andrei, Graciela, Snoeck, Robert, De Clercq, Erik, Balzarini, Jan, González-Muñiz, Rosario

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 168 KB

english, 2005

84

Azetidine-Derived Amino Acids versus Proline Derivatives. Alternative Trends in Reverse Turn Induction

Baeza, José Luis, Gerona-Navarro, Guillermo, Pérez de Vega, Jesús, García-López, M. Teresa, González-Muñiz, Rosario, Martín-Martínez, Mercedes

Journal:

Journal of Organic Chemistry

Year:

2008

Language:

english

File:

PDF, 377 KB

english, 2008

85

General Approach for the Stereocontrolled Construction of the β-Lactam Ring in Amino Acid-Derived 4-Alkyl-4-carboxy-2-azetidinones

Gerona-Navarro, Guillermo, García-López, M. Teresa, González-Muñiz, Rosario

Journal:

Journal of Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 75 KB

english, 2002

86

Conformationally Constrained CCK4 Analogues Incorporating IBTM and BTD β-Turn Mimetics

Martín-Martínez, Mercedes, De la Figuera, Natalia, LaTorre, Miriam, García-López, M. Teresa, Cenarruzabeitia, Edurne, Del Río, Joaquín, González-Muñiz, Rosario

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 187 KB

english, 2005

87

Synthesis and Stereochemical Structure−Activity Relationships of 1,3-Dioxoperhydropyrido[1,2- c ]pyrimidine Derivatives: Potent and Selective Cholecystokinin-A Receptor Antagonists

Martín-Martínez, Mercedes, Bartolomé-Nebreda, José M., Gómez-Monterrey, Isabel, González-Muñiz, Rosario, García-López, M. Teresa, Ballaz, Santiago, Barber, Ana, Fortuño, Ana, Del Río, Joaquín, Herranz

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 216 KB

english, 1997

88

5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2- c ]pyrimidine-Based Potent and Selective CCK 1 Receptor Antagonists: Structure−Activity Relationship Studies on the Substituent at N2-Position

Bartolomé-Nebreda, José M., Patiño-Molina, Rosario, Martín-Martínez, Mercedes, Gómez-Monterrey, Isabel, García-López, M. Teresa, González-Muñiz, Rosario, Cenarruzabeitia, Edurne, Latorre, Miriam, Río,

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 115 KB

english, 2001

89

Exceptional Stereoselectivity in the Synthesis of 1,3,4-Trisubstituted 4-Carboxy β-Lactam Derivatives from Amino Acids

Pérez-Faginas, Paula, O'Reilly, Fran, O'Byrne, Aisling, García-Aparicio, Carlos, Martín-Martínez, Mercedes, Pérez de Vega, M. Jesús, García-López, M. Teresa, González-Muñiz, Rosario

Journal:

Organic Letters

Year:

2007

Language:

english

File:

PDF, 104 KB

english, 2007

90

IBTM-Containing Gramicidin S Analogues: Evidence for IBTM as a Suitable Type II‘ β-Turn Mimetic 1,2

Andreu, David, Ruiz, Sergi, Carreño, Cristina, Alsina, Jordi, Albericio, Fernando, Jiménez, María Ángeles, de la Figuera, Natalia, Herranz, Rosario, García-López, María Teresa, González-Muñiz, Rosario

Journal:

Journal of the American Chemical Society

Year:

1997

Language:

english

File:

PDF, 320 KB

english, 1997

91

Analgesic dipeptide derivatives. 4. Linear and cyclic analogs of the analgesic compounds arginyl-2-[(o-nitrophenyl)sulfenyl]tryptophan and lysyl-2-[(o-nitrophenyl)sulfenyl]tryptophan

Garcia-Lopez, M. Teresa, Gonzalez-Muniz, Rosario, Molinero, M. Teresa, Del Rio, Joaquin

Journal:

Journal of Medicinal Chemistry

Year:

1988

Language:

english

File:

PDF, 915 KB

english, 1988

92

Combination of Molecular Modeling, Site-Directed Mutagenesis, and SAR Studies To Delineate the Binding Site of Pyridopyrimidine Antagonists on the Human CCK1 Receptor

Martín-Martínez, Mercedes, Marty, Anne, Jourdan, Maud, Escrieut, Chantal, Archer, Elodie, González-Muñiz, Rosario, García-López, M. Teresa, Maigret, Bernard, Herranz, Rosario, Fourmy, Daniel

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 267 KB

english, 2005

93

5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2- c ]pyrimidine-Based Potent and Selective CCK 1 Receptor Antagonists: Structural Modifications at the Tryptophan Domain

Bartolomé-Nebreda, José M., Gómez-Monterrey, Isabel, García-López, M. Teresa, González-Muñiz, Rosario, Martín-Martínez, Mercedes, Ballaz, Santiago, Cenarruzabeitia, Edurne, LaTorre, Miriam, Del Río, J

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 163 KB

english, 1999

94

Analgesic dipeptide derivatives. 3. Synthesis and structure-activity relationships of o-nitrophenyl-modified analogs of the analgesic compound H-Lys-Trp(NPS)-OMe

Garcia-Lopez, M. Teresa, Gonzalez-Muniz, Rosario, Molinero, M. Teresa, Naranjo, Jose R., Del Rio, J.

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 840 KB

english, 1987

95

Trp-Trp pairs as β-hairpin stabilisers: Hydrogen-bonded versus non-hydrogen-bonded sites

Santiveri, Clara M., Pérez de Vega, María Jesús, González-Muñiz, Rosario, Jiménez, M. Angeles

Journal:

Organic & Biomolecular Chemistry

Year:

2011

Language:

english

File:

PDF, 505 KB

english, 2011

96

Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding

Bonache, M. Angeles, Alaimo, Alessandro, Malo, Covadonga, Millet, Oscar, Villarroel, Alvaro, González-Muñiz, Rosario

Journal:

Organic & Biomolecular Chemistry

Year:

2014

Language:

english

File:

PDF, 2.00 MB

english, 2014

97

Experimental and Theoretical Studies on the Rearrangement of 2-Oxoazepane α,α-Amino Acids into 2′-Oxopiperidine β 2,3,3 -Amino Acids: An Example of Intramolecular Catalysis

Núñez-Villanueva, Diego, Bonache, M. Ángeles, Lozano, Laura, Infantes, Lourdes, Elguero, José, Alkorta, Ibon, García-López, M. Teresa, González-Muñiz, Rosario, Martín-Martínez, Mercedes

Journal:

Chemistry - A European Journal

Year:

2015

Language:

english

File:

PDF, 1.32 MB

english, 2015

98

Divergent, stereoselective access to heterocyclic α,α-quaternary- and β 2,3,3 -amino acid derivatives from a N-Pmp-protected Orn-derived β-lactam

Núñez-Villanueva, Diego, García-López, M. Teresa, Martín-Martínez, Mercedes, González-Muñiz, Rosario

Journal:

Organic & Biomolecular Chemistry

Year:

2015

Language:

english

File:

PDF, 239 KB

english, 2015

99

Strategies for Design of Non Peptide CCK1R Agonist/Antagonist Ligands

M. Teresa Garcia-Lopez, Bentham Science Publisher, Rosario Gonzalez-Muniz, Bentham Science Publisher, Mercedes Martin-Martinez, Bentham Science Publisher, Rosario Herranz, Bentham Science Publisher

Journal:

Current Topics in Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 320 KB

english, 2007

100

Editorial [Hot Topic: Emerging Therapeutic Opportunities by Targeting Protein – Protein Interactions (Guest Editor: Dr. Rosario Gonzalez-Muniz)]

Gonzalez-Muniz, Rosario

Journal:

Current Topics in Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 18 KB

english, 2007