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1

Synthesis of multifunctional spirocyclic azetidines, and their application in drug discovery.

Kirichok, Alexander, Shton, Irina, Pishel, Irina, Zozulya, Sergey, Borysko, Petro, Kubyshkin, Vladimir, Zaporozhets, Olha, Tolmachev, Andrei, Mykhailiuk, Pavel

Journal:

Chemistry - A European Journal

Year:

2018

Language:

english

File:

PDF, 1.21 MB

english, 2018

2

Convenient synthesis of enantiopure (R-) and (S-)-3-fluoro-3-aminomethylpyrrolidines

Yarmolchuk, Vladimir S., Mykhalchuk, Vladimir L., Mykhailiuk, Pavel K.

Journal:

Year:

2014

Language:

english

File:

PDF, 638 KB

english, 2014

3

Functional features of dispatching control centre for automatic control system of agricultural enterprise

Lytvynov V. V.,Mykhailiuk I. V.,Posadska A. S.

Journal:

Математические машины и системы

Year:

2014

Language:

english

File:

PDF, 165 KB

english, 2014

4

Synthesis of Functionalized 2-Trifluoromethylquinolines and their Heteroaromatic Analogues

Khutoryanskiy, Viktor V., Biitseva, Angelina V., Mykhailiuk, Pavel K.

Journal:

Asian Journal of Organic Chemistry

Year:

2016

Language:

english

File:

PDF, 1.47 MB

english, 2016

5

Photochemical synthesis of 2-azabicyclo[3.2.0]heptanes: advanced building blocks for drug discovery. Synthesis of 2,3-ethanoproline.

Druzhenko, Tetiana, Skalenko, Yevhen, Samoilenko, Maryna, Denisenko, Aleksandr, Zozulya, Sergey, Borysko, Petro O., Sokolenko, Maria I., Tarasov, Alexandr, Mykhailiuk, Pavel K.

Journal:

Journal of Organic Chemistry

Year:

2018

Language:

english

File:

PDF, 617 KB

english, 2018

6

Synthesis of 2,2-disubstituted spirocyclic pyrrolidines by intramolecular Dieckmann condensation

Fominova, Kateryna, Diachuk, Taras, Sadkova, Iryna V., Mykhailiuk, Pavel

Journal:

European Journal of Organic Chemistry

Year:

2019

Language:

english

File:

PDF, 1.85 MB

english, 2019

7

Deoxofluorination of Aliphatic Carboxylic Acids: a Route to Trifluoromethyl-Substituted Derivatives

Bugera, Maksym, Trofymchuk, Serhii, Tarasenko, Karen, Zaporozhets, Olga, Pustovit, Yurii, Mykhailiuk, Pavel K.

Journal:

Journal of Organic Chemistry

Year:

2019

Language:

english

File:

PDF, 373 KB

english, 2019

8

(5S)-5-(Trifluoromethyl)pyrrolidin-2-one as a Promising Building Block for Fluoroorganic Chemistry

Andrii V. Bezdudny, Anatoliy N. Alekseenko, Pavel K. Mykhailiuk, Olga V. Manoilenko, Oleg V. Shishkin, Yurii M. Pustovit

Journal:

European Journal of Organic Chemistry

Year:

2011

Language:

english

File:

PDF, 175 KB

english, 2011

9

1-Amino-3,3-difluorocyclobutanecarboxylic acid

Pavel K. Mykhailiuk, Dmytro S. Radchenko, Igor V. Komarov

Journal:

Journal of Fluorine Chemistry

Year:

2010

Language:

english

File:

PDF, 202 KB

english, 2010

10

An optimized protocol for the multigram synthesis of 3-(trifluoromethyl)bicyclo[1.1.1]pent-1-ylglycine (CF3-Bpg)

Pavel K. Mykhailiuk, Nataliia M. Voievoda, Sergii Afonin, Anne S. Ulrich, Igor V. Komarov

Journal:

Journal of Fluorine Chemistry

Year:

2010

Language:

english

File:

PDF, 292 KB

english, 2010

11

Trifluoromethyl-substituted cyclopropanes

Oleksandr O. Grygorenko, Oleksiy S. Artamonov, Igor V. Komarov, Pavel K. Mykhailiuk

Journal:

Year:

2011

Language:

english

File:

PDF, 2.64 MB

english, 2011

12

Exploiting morph-DAST mediated ring-expansion of substituted cyclic β-amino alcohols for the preparation of cyclic fluorinated amino acids. Synthesis of 5-fluoromethylproline and 5-fluoropipecolic acid

Pavel K. Mykhailiuk, Svetlana V. Shishkina, Oleg V. Shishkin, Olga A. Zaporozhets, Igor V. Komarov

Journal:

Year:

2011

Language:

english

File:

PDF, 499 KB

english, 2011

13

Synthesis of β-fluoro-β-proline

Vladimir S. Yarmolchuk, Pavel K. Mykhailiuk, Igor V. Komarov

Journal:

Tetrahedron Letters

Year:

2011

Language:

english

File:

PDF, 415 KB

english, 2011

14

4-Fluoro-2,4-methanoproline

Tkachenko, Anton N., Radchenko, Dmytro S., Mykhailiuk, Pavel K., Grygorenko, Oleksandr O., Komarov, Igor V.

Journal:

Organic Letters

Year:

2009

Language:

english

File:

PDF, 105 KB

english, 2009

15

“Reported, but Still Unknown.” A Closer Look into 3,4-Bis- and 3,4,5-Tris(trifluoromethyl)pyrazoles

Gerus, Igor I., Mironetz, Roman X., Kondratov, Ivan S., Bezdudny, Andrei V., Dmytriv, Yurii V., Shishkin, Oleg V., Starova, Viktoriia S., Zaporozhets, Olga A., Tolmachev, Andrey A., Mykhailiuk, Pavel

Journal:

Journal of Organic Chemistry

Year:

2012

Language:

english

File:

PDF, 1.50 MB

english, 2012

16

Synthesis and Characterization of β-Trifluoromethyl-Substituted Pyrrolidines

Yarmolchuk, Vladimir S., Shishkin, Oleg V., Starova, Viktoriia S., Zaporozhets, Olga A., Kravchuk, Olga, Zozulya, Sergey, Komarov, Igor V., Mykhailiuk, Pavel K.

Journal:

European Journal of Organic Chemistry

Year:

2013

Language:

english

File:

PDF, 661 KB

english, 2013

17

Incorporation of labile trans-4,5-difluoromethanoproline into a peptide as a stable label for 19F NMR structure analysis

Kubyshkin, Vladimir S., Mykhailiuk, Pavel K., Afonin, Sergii, Grage, Stephan L., Komarov, Igor V., Ulrich, Anne S.

Journal:

Journal of Fluorine Chemistry

Year:

2013

Language:

english

File:

PDF, 1.16 MB

english, 2013

18

Generation of C 2 F 5 CHN 2 In Situ and Its First Reaction: [3+2] Cycloaddition with Alkenes

Mykhailiuk , Pavel K.

Journal:

Chemistry - A European Journal

Year:

2014

Language:

english

File:

PDF, 665 KB

english, 2014

19

Exploiting the Addition of Trimethyl(trifluoromethyl)silane to Functionalized N-Benzylimines for the Preparation of Two Novel x-Trifluoromethyl x-Amino Acids

Tkachenko, Anton, Radchenko, Dmytro, Mykhailiuk, Pavel, Shishkin, Oleg, Tolmachev, Andrei, Komarov, Igor

Journal:

Year:

2012

Language:

english

File:

PDF, 203 KB

english, 2012

20

Simple and Efficient Procedure for a Multigram Synthesis of Both trans- and cis-1-Amino-2-(trifluoromethyl)cyclopropane-1-carboxylic Acid

Artamonov, Olexiy, Mykhailiuk, Pavel, Voievoda, Nataliia, Volochnyuk, Dmitry, Komarov, Igor

Journal:

Year:

2010

Language:

english

File:

PDF, 99 KB

english, 2010

21

An Efficient and Safe Method for the Multigram Synthesis of trans-2-(Trifluoromethyl)cyclopropylamine

Yarmolchuk, Vladimir, Bezdudny, Andrii, Tolmacheva, Nataliya, Lukin, Oleg, Boyko, Alexander, Chekotylo, Alexey, Tolmachev, Andrei, Mykhailiuk, Pavel

Journal:

Year:

2012

Language:

english

File:

PDF, 152 KB

english, 2012

22

One-Pot Synthesis of CF 3 -Substituted Pyrazolines/Pyrazoles from Electron-Deficient Alkenes/Alkynes and CF 3 CHN 2 Generated in situ: Optimized Synthesis of Tris(trifluoromethyl)pyrazole

Slobodyanyuk, Evgeniy Y., Artamonov, Olexiy S., Shishkin, Oleg V., Mykhailiuk, Pavel K.

Journal:

European Journal of Organic Chemistry

Year:

2014

Language:

english

File:

PDF, 757 KB

english, 2014

23

Synthesis of Trifluoromethyl-Substituted 3-Azabicyclo[ n .1.0]alkanes: Advanced Building Blocks for Drug Discovery

Artamonov, Olexiy S., Slobodyanyuk, Evgeniy Y., Volochnyuk, Dmitriy M., Komarov, Igor V., Tolmachev, Andrey A., Mykhailiuk, Pavel K.

Journal:

European Journal of Organic Chemistry

Year:

2014

Language:

english

File:

PDF, 682 KB

english, 2014

24

Sulfonyl Fluorides as Alternative to Sulfonyl Chlorides in Parallel Synthesis of Aliphatic Sulfonamides

Bogolubsky, Andrey V., Moroz, Yurii S., Mykhailiuk, Pavel K., Pipko, Sergey E., Konovets, Anzhelika I., Sadkova, Irina V., Tolmachev, Andrey

Journal:

ACS Combinatorial Science

Year:

2014

Language:

english

File:

PDF, 516 KB

english, 2014

25

Bis(2,2,2-trifluoroethyl) Carbonate as a Condensing Agent in One-Pot Parallel Synthesis of Unsymmetrical Aliphatic Ureas

Bogolubsky, Andrey V., Moroz, Yurii S., Mykhailiuk, Pavel K., Granat, Dmitry S., Pipko, Sergey E., Konovets, Anzhelika I., Doroschuk, Roman, Tolmachev, Andrey

Journal:

ACS Combinatorial Science

Year:

2014

Language:

english

File:

PDF, 709 KB

english, 2014

26

Synthesis of isomeric (3,3,3-trifluoropropyl)anilines

Trofymchuk, Sergii, Bezdudny, Andrii, Pustovit, Yurii, Mykhailiuk, Pavel K.

Journal:

Journal of Fluorine Chemistry

Year:

2015

Language:

english

File:

PDF, 237 KB

english, 2015

27

Enzyme-Catalyzed Kinetic Resolution of 2,2,2-Trifluoro-1-(heteroaryl)ethanols: Experimental and Docking Studies

Kucher, Olexandr V., Kolodiazhnaya, Anastasiya O., Smolii, Oleg B., Prisuazhnyk, Dmytro V., Tolmacheva, Katerina A., Zaporozhets, Olga A., Moroz, Yurii S., Mykhailiuk, Pavel K., Tolmachev, Andrey A.

Journal:

European Journal of Organic Chemistry

Year:

2014

Language:

english

File:

PDF, 1.59 MB

english, 2014

28

Facile one-pot synthesis of 4-substituted semicarbazides

Bogolubsky, Andrey V., Moroz, Yurii S., Mykhailiuk, Pavel K., Dmytriv, Yurii V., Pipko, Sergey E., Babichenko, Liudmyla N., Konovets, Anzhelika I., Tolmachev, Andrey

Journal:

Year:

2015

Language:

english

File:

PDF, 384 KB

english, 2015

29

Multigram Synthesis of Fluoroalkyl-Substituted Pyrazole-4-carboxylic Acids

Iminov, Rustam T., Mashkov, Alexander V., Vyzir, Ivan I., Chalyk, Bohdan A., Tverdokhlebov, Anton V., Mykhailiuk, Pavel K., Babichenko, Ludmila N., Tolmachev, Andrey A., Volovenko, Yulian M., Biitseva

Journal:

European Journal of Organic Chemistry

Year:

2015

Language:

english

File:

PDF, 956 KB

english, 2015

30

Three-component synthesis of fluorinated pyrazoles from fluoroalkylamines, NaNO 2 and electron-deficient alkynes

Mykhailiuk, Pavel K.

Journal:

Organic & Biomolecular Chemistry

Year:

2015

Language:

english

File:

PDF, 884 KB

english, 2015

31

In Situ Generation of Difluoromethyl Diazomethane for [3+2] Cycloadditions with Alkynes

Mykhailiuk, Pavel K.

Journal:

Angewandte Chemie International Edition

Year:

2015

Language:

english

File:

PDF, 622 KB

english, 2015

32

Synthesis and studies on gem-fluorinated 2-azabicyclo[n.1.0]alkanes

Kubyshkin, Vladimir, Kheylik, Yurii, Mykhailiuk, Pavel K.

Journal:

Journal of Fluorine Chemistry

Year:

2015

Language:

english

File:

PDF, 885 KB

english, 2015

33

One-Pot Parallel Synthesis of Alkyl Sulfides, Sulfoxides, and Sulfones

Bogolubsky, Andrey V., Moroz, Yurii S., Mykhailiuk, Pavel K., Ostapchuk, Eugeniy N., Rudnichenko, Alexander V., Dmytriv, Yurii V., Bondar, Anna N., Zaporozhets, Olga A., Pipko, Sergey E., Doroschuk, R

Journal:

ACS Combinatorial Science

Year:

2015

Language:

english

File:

PDF, 329 KB

english, 2015

34

2,2,2-Trifluoroethyl Chlorooxoacetate—Universal Reagent for One-Pot Parallel Synthesis of N 1 -Aryl- N 2 -alkyl-Substituted Oxamides

Bogolubsky, Andrey V., Moroz, Yurii S., Mykhailiuk, Pavel K., Pipko, Sergey E., Zhemera, Anton V., Konovets, Anzhelika I., Stepaniuk, Olena O., Myronchuk, Inna S., Dmitriv, Yurii V., Doroschuk, Roman

Journal:

ACS Combinatorial Science

Year:

2015

Language:

english

File:

PDF, 848 KB

english, 2015

35

Multigram Synthesis of 1-(Difluoromethyl)imidazoles and -benzimidazoles

Levterov, Vadym, Grygorenko, Oleksandr, Mykhailiuk, Pavel, Tolmachev, Andrey

Journal:

Year:

2011

Language:

english

File:

PDF, 127 KB

english, 2011

36

A Convenient Route to Trifluoromethyl-Substituted Cyclopropane Derivatives

Mykhailiuk, Pavel, Afonin, Sergii, Ulrich, Anne, Komarov, Igor

Journal:

Year:

2008

Language:

english

File:

PDF, 100 KB

english, 2008

37

Trifluoromethyl-Substituted Analogues of 1-Aminocyclobutane-1-carboxylic Acid

Radchenko, Dmytro, Mykhailiuk, Pavel, Bezdudny, Andrii, Komarov, Igor

Journal:

Year:

2009

Language:

english

File:

PDF, 81 KB

english, 2009

38

Noncatalytic Electrophilic Oxyalkylation of Some Five-Membered Heterocycles with 2-(Trifluoroacetyl)-1,3-azoles

Khodakovskiy, Pavel, Mykhailiuk, Pavel, Volochnyuk, Dmitriy, Tolmachev, Andrey

Journal:

Year:

2010

Language:

english

File:

PDF, 134 KB

english, 2010

39

A Facile Synthesis of Isomeric C-(2,2,2-Trifluoroethyl)anilines

Trofymchuk, Sergii, Bezdudny, Andrii, Pustovit, Yurii, Lukin, Oleg, Boyko, Alexander, Chekotylo, Alexey, Tolmachev, Andrei, Mykhailiuk, Pavel

Journal:

Year:

2012

Language:

english

File:

PDF, 168 KB

english, 2012

40

An Improved Synthesis of 2-, 3-, and 4-(Trifluoromethyl)cyclohexylamines

Alekseenko, Anatoliy, Denis, Klukovsky, Lukin, Oleg, Mykhailiuk, Pavel, Shishkin, Oleg, Pustovit, Yurii

Journal:

Year:

2012

Language:

english

File:

PDF, 231 KB

english, 2012

41

Multigram Synthesis of trans-2-(Trifluoromethyl)cyclopropanamine

A. Bezdudny, D. Klukovsky, N. Simurova, P. Mykhailiuk, O. Shishkin, Y. Pustovit

Year:

2011

Language:

english

File:

PDF, 108 KB

english, 2011

42

Facile Synthesis of 2-(2-Ethoxy-1,2-dioxoethyl)azoles

O. Geraschenko, P. Khodakovskiy, O. Shishkin, P. Mykhailiuk, O. Zaporozhets, A. Tolmachev

Year:

2011

Language:

english

File:

PDF, 150 KB

english, 2011

43

Novel Synthetic Approaches to (Trifluoromethyl)triazoles

Sibgatulin, Dmytriy, Bezdudny, Andrii, Mykhailiuk, Pavel, Voievoda, Nataliia, Kondratov, Ivan, Volochnyuk, Dmitry, Tolmachev, Andrey

Journal:

Year:

2010

Language:

english

File:

PDF, 77 KB

english, 2010

44

Direct Noncatalytic Electrophilic Trifluoroacetylation of Electron-Rich Pyrazoles

Yarmoliuk, Dmytro, Arkhipov, Viatcheslav, Stambirskyi, Maksym, Dmytriv, Yurii, Shishkin, Oleg, Tolmachev, Andrei, Mykhailiuk, Pavel

Journal:

Year:

2014

Language:

english

File:

PDF, 237 KB

english, 2014

45

Noncatalytic Electrophilic Oxyalkylation of Anilines with 2-Trifluoroacetyl-1,3-benzothiazole

P. Khodakovskiy, P. Mykhailiuk, D. Volochnyuk, A. Tolmachev

Year:

2010

Language:

english

File:

PDF, 128 KB

english, 2010

46

Noncatalytic Electrophilic Alkylation of 1H-Indole with 2-Trifluoroacetyl-1,3-heterazoles

P. Khodakovskiy, P. Mykhailiuk, D. Volochnyuk, A. Tolmachev

Year:

2010

Language:

english

File:

PDF, 102 KB

english, 2010

47

Noncatalytic Electrophilic Oxyalkylation of 3-Aminopyrazoles with 2-(Trifluoroacetyl)-1,3-azoles

Khodakovskiy, Pavel, Mykhailiuk, Pavel, Volochnyuk, Dmitriy, Tolmachev, Andrey

Journal:

Year:

2010

Language:

english

File:

PDF, 101 KB

english, 2010

48

Regioselective Reaction of Ethyl 5-Acetyl-3,4-dihydropyridine-1(2H)-carboxylate with Hydrazines: A Facile Approach to New Pyrazole Derivatives

Maximov, Nazar, Mykhailiuk, Pavel, Golovach, Sergey, Tverdokhlebov, Anton, Voitenko, Zoya, Tolmachev, Andrey

Journal:

Year:

2010

Language:

english

File:

PDF, 117 KB

english, 2010

49

Cu-catalyzed O-Difluoromethylation of Functionalized Aliphatic Alcohols: An Access to Complex Organic Molecules with OCF2H group.

Levchenko, Kostiantyn, Datsenko, Olexandr P., Serhiichuk, Oleh, Tolmachev, Andrei, Iaroshenko, Viktor O., Mykhailiuk, Pavel K.

Journal:

Journal of Organic Chemistry

Year:

2016

Language:

english

File:

PDF, 726 KB

english, 2016

50

Unexpected Reactivity of Trifluoromethyl Diazomethane (CF 3 CHN 2 ): Electrophilicity of the Terminal N-Atom

Arkhipov, Anton V., Arkhipov, Viatcheslav V., Cossy, Janine, Kovtunenko, Volodymir O., Mykhailiuk, Pavel K.

Journal:

Organic Letters

Year:

2016

Language:

english

File:

PDF, 980 KB

english, 2016