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1

Antitumor studies. Part 1: Design, synthesis, antitumor activity, and AutoDock study of 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides as a new class of antitumor agents

Hamed I. Ali, Keiichiro Tomita, Eiichi Akaho, Hiroto Kambara, Shinji Miura, Hiroyuki Hayakawa, Noriyuki Ashida, Yutaka Kawashima, Takehiro Yamagishi, Hisao Ikeya, Fumio Yoneda, Tomohisa Nagamatsu

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 998 KB

english, 2007

2

Antitumor studies. Part 5: Synthesis, antitumor activity, and molecular docking study of 5-(monosubstituted amino)-2-deoxo-2-phenyl-5-deazaflavins

Ajaya R. Shrestha, Hamed I. Ali, Noriyuki Ashida, Tomohisa Nagamatsu

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 605 KB

english, 2008

3

Synthesis of bis(pyridodipyrimidines) as autorecycling redox catalysts and their remarkable turnover in the oxidation of alcohols

Yoneda, Fumio, Tanaka, Kiyoshi, Yamato, Hirotake, Moriyama, Kenji, Nagamatsu, Tomohisa

Journal:

Journal of the American Chemical Society

Year:

1989

Language:

english

File:

PDF, 484 KB

english, 1989

4

Autorecycling oxidation of alcohols catalysed by pyridodipyrimidines as an NAD(P)+ model

Nagamatsu, Tomohisa, Yamato, Hirotake, Ono, Masami, Takarada, Shigeki, Yoneda, Fumio

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1992

Language:

english

File:

PDF, 1015 KB

english, 1992

5

ChemInform Abstract: Facile and General Syntheses of 3- and/or 5-Substituted 7-β-D-Ribofuranosyl-7H-[1,2,4]triazolo[3,4-i]purines as a New Class of Potential Xanthine Oxidase Inhibitors.

Tomohisa Nagamatsu, Hiroo Yamasaki, Toshihiko Akiyama, Sachiko Hara, Kenya Mori, Hitoshi Kusakabe

Journal:

Year:

1999

File:

PDF, 37 KB

1999

6

ChemInform Abstract: Facile and General Syntheses of 3- and/or 5-Substituted 7H-Pyrazolo[4,3-e]-1,2,4-triazolo[4,3-c]pyrimidines as a New Class of Potential Xanthine Oxidase Inhibitors.

Tomohisa Nagamatsu, Takayuki Fujita

Journal:

Year:

1999

File:

PDF, 32 KB

1999

7

ChemInform Abstract: Novel Xanthine Oxidase Inhibitor Studies. Part 2. Synthesis and Xanthine Oxidase Inhibitory Activities of 2-Substituted 6-Alkylidenehydrazino- or 6-Arylmethylidenehydrazino-7H-purines and 3- and/or 5-Substituted 9H-1,2,4-Triazolo[3,4-i]purines.

Tomohisa Nagamatsu, Hiroo Yamasaki, Takayuki Fujita, Kazuki Endo, Haruhiko Machida

Journal:

Year:

2000

File:

PDF, 35 KB

2000

8

ChemInform Abstract: Novel Xanthine Oxidase Inhibitor Studies. Part 3. Convenient and General Syntheses of 3-Substituted 7H-Pyrazolo[4,3-e]-1,2,4-triazolo[4,3-c]pyrimidin-5(6H)-ones as a New Class of Potential Xanthine Oxidase Inhibitors.

Tomohisa Nagamatsu, Takayuki Fujita, Kazuki Endo

Journal:

Year:

2000

File:

PDF, 34 KB

2000

9

ChemInform Abstract: General Syntheses of 1-Alkyltoxoflavin and 8-Alkylfervenulin Derivatives of Biological Significance by the Regioselective Alkylation of Reumycin Derivatives and the Rates of Transalkylation from 1-Alkyltoxoflavins into Nucleophiles.

Tomohisa Nagamatsu, Hirofumi Yamasaki

Journal:

Year:

2001

Language:

english

File:

PDF, 36 KB

english, 2001

10

ChemInform Abstract: The First Reliable, General Synthesis of the 5-Oxo Derivatives of 5,6-Dihydro-1,2,4-triazolo[4,3-c]pyrimidine and the Rates of Isomerization of the [4,3-c] Compounds into Their [1,5-c] Isomers.

Tomohisa Nagamatsu, Takayuki Fujita

Journal:

Year:

2002

File:

PDF, 30 KB

2002

11

Syntheses, Transformation, and Biological Activities of 7-Azapteridine Antibiotics: Toxoflavin, Fervenulin, Reumycin and Their Analogues

Tomohisa Nagamatsu

Journal:

Year:

2002

File:

PDF, 25 KB

2002

12

ChemInform Abstract: The Facile Synthesis of 6-Azapurines by Transformation of Toxoflavins (7-Azapteridines).

Tomohisa Nagamatsu, Jun Ma, Fumio Yoneda

Journal:

Year:

2009

File:

PDF, 31 KB

2009

13

ChemInform Abstract: Novel and Facile Synthesis and Evaluation of Antitumor Activities of 6,7-Bisaryl-1-(β-D-ribofuranosyl)pteridine-2,4(1H,3H)-diones.

Rafiya Khan Kandahary, Abugafar M. L. Hossion, Noriyuki Ashida, Tomohisa Nagamatsu

Journal:

Year:

2010

File:

PDF, 57 KB

2010

14

Potentiometric determination of alkaline phosphatase in blood serum using a hordenine-sensitive membrane electrode

Takashi Katsu, Koji Yamanaka, Shima Hiramaki, Takao Tanaka, Tomohisa Nagamatsu

Journal:

Electroanalysis

Year:

1996

Language:

english

File:

PDF, 424 KB

english, 1996

15

Antitumor studies. Part 3: Design, synthesis, antitumor activity, and molecular docking study of novel 2-methylthio-, 2-amino-, and 2-(N-substituted amino)-10-alkyl-2-deoxo-5-deazaflavins

Hamed I. Ali, Noriyuki Ashida, Tomohisa Nagamatsu

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 1018 KB

english, 2007

16

Antitumor studies. Part 4: Design, synthesis, antitumor activity, and molecular docking study of novel 2-substituted 2-deoxoflavin-5-oxides, 2-deoxoalloxazine-5-oxides, and their 5-deaza analogs

Hamed I. Ali, Noriyuki Ashida, Tomohisa Nagamatsu

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 865 KB

english, 2008

17

Synthesis, biological active molecular design, and molecular docking study of novel deazaflavin–cholestane hybrid compounds

Ajaya R. Shrestha, Takashi Shindo, Noriyuki Ashida, Tomohisa Nagamatsu

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.24 MB

english, 2008

18

Antitumor studies – Part 2: Structure–activity relationship study for flavin analogs including investigations on their in vitro antitumor assay and docking simulation into protein tyrosine kinase

Hamed I. Ali, Keiichiro Tomita, Eiichi Akaho, Munetaka Kunishima, Yutaka Kawashima, Takehiro Yamagishi, Hisao Ikeya, Tomohisa Nagamatsu

Journal:

European Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.51 MB

english, 2008

19

Synthesis and regioselective N- and O-alkylation of 3-alkyl-5-phenyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones and 2-phenyl-9-propyl-9H-purin-6(1H)-one with evaluation of antiviral and antitumor activities

Rafiqul Islam, Noriyuki Ashida, Tomohisa Nagamatsu

Journal:

Year:

2008

Language:

english

File:

PDF, 633 KB

english, 2008

20

Tris(2-ethylhexyl) phosphate and tricresyl phosphate as new neutral carriers for organic ammonium ion-selective membrane electrodes

Takashi Katsu, Dafeng Xu, Kotoyo Tsuji, Tomohisa Nagamatsu

Journal:

Analytica Chimica Acta

Year:

1997

Language:

english

File:

PDF, 166 KB

english, 1997

21

Liquid crystalline dienophiles as regiochemical director in bimolecular Diels-Alder reactions

Tatsuya Yamaguchi, Takuro Yoshida, Tomohisa Nagamatsu, Takehisa Kunieda, Takeshi Honda, Masaaki Hirobe

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 282 KB

english, 1991

22

Highly efficient oxazolone-derived reagents for beta-lactam formation from beta-amino acids

Takehisa Kunieda, Tomohisa Nagamatsu, Tsunehiko Higuchi, Masaaki Hirobe

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 242 KB

english, 1988

23

Highly stereocontrolled photodimerization of tetramethyluracil by smectic liquid crystalline phase

Tomohisa Nagamatsu, Chikako Kawano, Yasutaka Orita, Takehisa Kunieda

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 279 KB

english, 1987

24

Preparation of chiral 5-deazaflavin derivatives and their asymmetric reduction of ethyl benzoylformate

Kiyoshi Tanaka, Tomoya Okada, Fumio Yoneda, Tomohisa Nagamatsu, Kazunori Kuroda

Journal:

Tetrahedron Letters

Year:

1984

Language:

english

File:

PDF, 146 KB

english, 1984

25

Transformation of toxoflavin into fervenulin via 1-demethyltoxoflavin

Fumio Yoneda, Tomohisa Nagamatsu

Journal:

Tetrahedron Letters

Year:

1973

Language:

english

File:

PDF, 170 KB

english, 1973

26

A comparative study of AutoDock and PMF scoring performances, and SAR of 2-substituted pyrazolotriazolopyrimidines and 4-substituted pyrazolopyrimidines as potent xanthine oxidase inhibitors

Hamed I. Ali, Takayuki Fujita, Eiichi Akaho, Tomohisa Nagamatsu

Journal:

Journal of Computer-Aided Molecular Design

Year:

2010

Language:

english

File:

PDF, 1.21 MB

english, 2010

27

New phosphorylating agents for general synthesis of mixed phosphate esters

Tomohisa Nagamatsu, Takehisa Kunieda

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 239 KB

english, 1987

28

Quorum sensing and the LysR-type transcriptional activator ToxR regulate toxoflavin biosynthesis and transport in Burkholderia glumae

Jinwoo Kim, Jung-Gun Kim, Yongsung Kang, Ji Youn Jang, Geetanjali J. Jog, Jae Yun Lim, Suhyun Kim, Hiroaki Suga, Tomohisa Nagamatsu, Ingyu Hwang

Journal:

Molecular Microbiology

Year:

2004

Language:

english

File:

PDF, 416 KB

english, 2004

29

A novel light-dependent selection marker system in plants

Serry Koh, Hongsup Kim, Jinwoo Kim, Eunhye Goo, Yun-Jung Kim, Okhee Choi, Nam-Soo Jwa, Jun Ma, Tomohisa Nagamatsu, Jae Sun Moon, Ingyu Hwang

Journal:

Plant Biotechnology Journal

Year:

2011

Language:

english

File:

PDF, 871 KB

english, 2011

30

Synthesis and properties of 6-benzyl analogs of toxoflavin

Fumio Yoneda, Tomohisa Nagamatsu, Misuzu Ichiba

Journal:

Journal of Heterocyclic Chemistry

Year:

1974

File:

PDF, 123 KB

1974

31

A new method for the transformation of toxoflavins to fervenulins

Fumio Yoneda, Tomohisa Nagamatsu

Journal:

Journal of Heterocyclic Chemistry

Year:

1974

File:

PDF, 138 KB

1974

32

Synthesis of 8-methylpyrido[2,3-d:6,5-d'x]dipyrimidine-2,4,6(3H,10H,7H)-triones and their use in the oxidation of alcohols

Kenji Moriyama, Tomohisa Nagamatsu, Fumio Yoneda

Journal:

Journal of Heterocyclic Chemistry

Year:

1986

Language:

english

File:

PDF, 188 KB

english, 1986

33

Polycyclic N-hetero compounds. XXXVII. A convenient synthesis and evaluation of anti-platelet aggregation activity of 1,2,4,5-tetrahydro[1]- benzothiepino[4,5-e]imidazo[1,2-c]pyrimidine and its related compounds

Tomohisa Nagamatsu, Keiichi Kinoshita, Kenji Sasaki, Taiji Nakayama, Takashi Hirota

Journal:

Journal of Heterocyclic Chemistry

Year:

1991

File:

PDF, 236 KB

1991

34

Polycyclic N-hetero compounds. XXXV. Syntheses and anti-platelet aggregation activity of 5,6-Dihydro-4H-benzo[3,4]cyclohept[1,2-e]imidazo[1,2-c]pyrimidines with an oxygen function at the 1-position

Kenji Sasaki, Yuhki Sekiya, Tomohisa Nagamatsu, Hiromi Ohtomo, Taiji Nakayama, Takashi Hirota

Journal:

Journal of Heterocyclic Chemistry

Year:

1991

File:

PDF, 406 KB

1991

35

Synthesis of vertical-type bis(pyridodipyrimidines) as a redox catalyst and their autorecycling oxidation of alcohols

Hirotake Yamato, Tomohisa Nagamatsu, Fumio Yoneda

Journal:

Journal of Heterocyclic Chemistry

Year:

1991

File:

PDF, 145 KB

1991

36

Polycyclic N-hetero compounds. XLIII. Syntheses and properties of 2-substituted 1-acetoxy-6-acetyl-5,6-dihydro-4H-imidazo[1′,2′:1,6]-pyrimido[5,4-d][1]benzazepines viaN-(6,7-dihydro-5H-pyrimido[5,4-d]-[1]benzazepin-4-yl)amino acids and their analogous mesoionic compounds, and their related compounds as a series of potential blood platelet aggregation inhibitors

Tomohisa Nagamatsu, Yoshiji Hantani, Kenji Sasaki, Hiromi Ohtomo, Taiji Nakayama, Takashi Hirota

Journal:

Journal of Heterocyclic Chemistry

Year:

1993

File:

PDF, 717 KB

1993

37

Polycyclic N-heterocyclic compounds. XLI. Synthesis of 4-substituted 6,7-dihydro-5H-pyrimido[5,4-d][1]benzazepines, 1,2,5,6-tetrahydro-4H-imidazo[1′,2′:1,6]pyrimido[5,4-d][1]benzazepines and their related compounds as a series of potential blood platelet aggregation inhibitors

Tomohisa Nagamatsu, Yoshiji Hantani, Minoru Yamada, Kenji Sasaki, Hiromi Ohtomo, Taiji Nakayama, Takashi Hirota

Journal:

Journal of Heterocyclic Chemistry

Year:

1993

File:

PDF, 847 KB

1993

38

A new, general synthesis of purines

Yoneda, Fumio, Nagamatsu, Tomohisa

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1976

Language:

english

File:

PDF, 491 KB

english, 1976

39

Synthesis of pyrazolo[3,4-d]pyrimidines by intramolecular cycloaddition of azahexatrienes

Yoneda, Fumio, Nagamatsu, Tomohisa, Nagamura, Tetsuya, Senga, Keitaro

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1977

Language:

english

File:

PDF, 280 KB

english, 1977

40

Novel xanthine oxidase inhibitor studies. Part 3. Convenient and general syntheses of 3-substituted 7H-pyrazolo[4,3-e]-1,2,4-triazolo[4,3-c]pyrimidin-5(6H)-ones as a new class of potential xanthine oxidase inhibitors

Nagamatsu, Tomohisa, Fujita, Takayuki, Endo, Kazuki

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

2000

Language:

english

File:

PDF, 181 KB

english, 2000

41

Facile and General Synthesis of 8-Substituted 2-Methylthiopurin-6-ones

Yoneda, Fumio, Nagamatsu, Tomohisa, Yamasaki, Hiroo

Journal:

Year:

1992

Language:

english

File:

PDF, 350 KB

english, 1992

42

Syntheses of isoalloxazines, alloxazines, toxoflavins, and fervenulins by oxidative cyclization of the Michael-type adducts from substituted 6-aminouracils and azo-compounds

Yoneda, Fumio, Sakuma, Yoshiharu, Nagamatsu, Tomohisa, Mizumoto, Shunjiro

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1976

Language:

english

File:

PDF, 581 KB

english, 1976

43

Novel synthetic route to heterocycles via intramolecular cycloaddition of azalogs of hexatriene. New syntheses of purines and pyrazolo[3,4-d]pyrimidines

Yoneda, Fumio, Higuchi, Masatsugu, Nagamatsu, Tomohisa

Journal:

Journal of the American Chemical Society

Year:

1974

Language:

english

File:

PDF, 250 KB

english, 1974

44

Transmethylation from toxoflavines to nucleophiles

Yoneda, Fumio., Nagamatsu, Tomohisa.

Journal:

Journal of the American Chemical Society

Year:

1973

Language:

english

File:

PDF, 290 KB

english, 1973

45

New syntheses of flavins

Sakuma, Yoshiharu, Nagamatsu, Tomohisa, Yoneda, Fumio

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1975

Language:

english

File:

PDF, 124 KB

english, 1975

46

Autorecycling system for the specific 1,4-reduction of ?, ?-unsaturated carbonyl compounds catalysed by 1,5-dihydro-5-deazaflavin

Nagamatsu, Tomohisa, Kuroda, Kazunori, Mimura, Norio, Yanada, Reiko, Yoneda, Fumio

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1994

Language:

english

File:

PDF, 451 KB

english, 1994

47

A new, general, and convenient synthesis of 5-deazaflavins (5-deazaisoalloxazines)

Nagamatsu, Tomohisa, Hashiguchi, Yuko, Higuchi, Mastsugu, Yoneda, Fumio

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1982

Language:

english

File:

PDF, 191 KB

english, 1982

48

General syntheses of 1-alkyltoxoflavin and 8-alkylfervenulin derivatives of biological significance by the regioselective alkylation of reumycin derivatives and the rates of transalkylation from 1-alkyltoxoflavins into nucleophiles

Nagamatsu, Tomohisa, Yamasaki, Hirofumi

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

2001

Language:

english

File:

PDF, 150 KB

english, 2001

49

Facile and general syntheses of 3- and/or 5-substituted 7H-pyrazolo[4,3-e]-1,2,4-triazolo[4,3-c]pyrimidines as a new class of potential xanthine oxidase inhibitors†

Nagamatsu, Tomohisa, Fujita, Takayuki

Journal:

Chemical Communications

Year:

1999

Language:

english

File:

PDF, 51 KB

english, 1999

50

Facile, general and productive syntheses of the fluorescent wye (4,9-dihydro-4,6-dimethyl-9-oxo-1H-imidazo[1,2-a]purine) in phenylalanine tRNA, its 2-substituted derivatives and 7-aza analogues

Nagamatsu, Tomohisa, Yamasaki, Hiroo

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1995

Language:

english

File:

PDF, 342 KB

english, 1995

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