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51

Preclinical in vitro and in vivo evaluation of the potent and specific cyclin-dependent kinase 2 inhibitor NU6102 and a water soluble prodrug NU6301

Huw D. Thomas, Lan-Zhen Wang, Celine Roche, Johanne Bentley, Yuzhu Cheng, Ian R. Hardcastle, Bernard T. Golding, Roger J. Griffin, Nicola J. Curtin, David R. Newell

Journal:

European Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 665 KB

english, 2011

52

DNA interstrand cross-linking and TP53 status as determinants of tumour cell sensitivity in vitro to the antibody-directed enzyme prodrug therapy ZD2767

Noel R. Monks, David C. Blakey, Simon J. East, Robert I. Dowell, Joanne A. Calvete, Nicola J. Curtin, Christine E. Arris, David R. Newell

Journal:

European Journal of Cancer

Year:

2002

Language:

english

File:

PDF, 183 KB

english, 2002

53

Nucleoside Transport Inhibitors: Structure−Activity Relationships for Pyrimido[5,4- d ]pyrimidine Derivatives That Potentiate Pemetrexed Cytotoxicity in the Presence of α 1 -Acid Glycoprotein

Saravanan, Kappusamy, Barlow, Hannah C., Barton, Marion, Calvert, A. Hilary, Golding, Bernard T., Newell, David R., Northen, Julian S., Curtin, Nicola J., Thomas, Huw D., Griffin, Roger J.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.48 MB

english, 2011

54

Novel Benzimidazole and Quinazolinone Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose)polymerase*

ROGER J. GRIFFIN, SHEILA SRINIVASAN, ALEX W. WHITE, KAREN BOWMAN, A. HILARY CALVERT, NICOLA J. CURTIN, DAVID R. NEWELL, BERNARD T. GOLDING

Journal:

Journal of Pharmacy and Pharmacology

Year:

1996

Language:

english

File:

PDF, 387 KB

english, 1996

55

Discovery of Potent Chromen-4-one Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) Using a Small-Molecule Library Approach

Hardcastle, Ian R., Cockcroft, Xiaoling, Curtin, Nicola J., El-Murr, Marine Desage, Leahy, Justin J. J., Stockley, Martin, Golding, Bernard T., Rigoreau, Laurent, Richardson, Caroline, Smith, Graeme C

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 429 KB

english, 2005

56

Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles

Arris, Christine E., Boyle, F. Thomas, Calvert, A. Hilary, Curtin, Nicola J., Endicott, Jane A., Garman, Elspeth F., Gibson, Ashleigh E., Golding, Bernard T., Grant, Sharon, Griffin, Roger J., Jewsbur

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 542 KB

english, 2000

57

Synthesis and biological evaluation of 5-substituted O4-alkylpyrimidines as CDK2 inhibitors

Marchetti, Francesco, Cano, Céline, Curtin, Nicola J., Golding, Bernard T., Griffin, Roger J., Haggerty, Karen, Newell, David R., Parsons, Rachel J., Payne, Sara L., Wang, Lan Z., Hardcastle, Ian R.

Journal:

Organic & Biomolecular Chemistry

Year:

2010

Language:

english

File:

PDF, 369 KB

english, 2010

58

Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinase 2

Marchetti, Francesco, Sayle, Kerry L., Bentley, Johanne, Clegg, William, Curtin, Nicola J., Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Haggerty, Karen, Harrington, Ross W., Mesguiche,

Journal:

Organic & Biomolecular Chemistry

Year:

2007

Language:

english

File:

PDF, 252 KB

english, 2007

59

Poly(ADP-ribose) polymerase (PARP) and PARP inhibitors

Nicola J. Curtin

Journal:

Drug Discovery Today: Disease Models

Year:

2012

Language:

english

File:

PDF, 155 KB

english, 2012

60

Tricyclic Benzimidazoles as Potent Poly(ADP-ribose) Polymerase-1 Inhibitors

Skalitzky, Donald J., Marakovits, Joseph T., Maegley, Karen A., Ekker, Anne, Yu, Xiao-Hong, Hostomsky, Zdenek, Webber, Stephen E., Eastman, Brian W., Almassy, Robert, Li, Jianke, Curtin, Nicola J., Ne

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 247 KB

english, 2003

61

Therapeutic applications of PARP inhibitors: Anticancer therapy and beyond

Curtin, Nicola J., Szabo, Csaba

Journal:

Molecular Aspects of Medicine

Year:

2013

Language:

english

File:

PDF, 1.71 MB

english, 2013

62

Pyranone, Thiopyranone, and Pyridone Inhibitors of Phosphatidylinositol 3-Kinase Related Kinases. Structure−Activity Relationships for DNA-Dependent Protein Kinase Inhibition, and Identification of the First Potent and Selective Inhibitor of the Ataxia Telangiectasia Mutated Kinase

Hollick, Jonathan J., Rigoreau, Laurent J. M., Cano-Soumillac, Celine, Cockcroft, Xiaoling, Curtin, Nicola J., Frigerio, Mark, Golding, Bernard T., Guiard, Sophie, Hardcastle, Ian R., Hickson, Ian, Hu

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 310 KB

english, 2007

63

PARP inhibitors for cancer therapy

Curtin, Nicola J.

Journal:

Expert Reviews in Molecular Medicine

Year:

2005

Language:

english

File:

PDF, 423 KB

english, 2005

64

Probing the ATP Ribose-Binding Domain of Cyclin-Dependent Kinases 1 and 2 with O 6 -Substituted Guanine Derivatives

Gibson, Ashleigh E., Arris, Christine E., Bentley, Johanne, Boyle, F. Thomas, Curtin, Nicola J., Davies, Thomas G., Endicott, Jane A., Golding, Bernard T., Grant, Sharon, Griffin, Roger J., Jewsbury,

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 751 KB

english, 2002

65

1-Substituted (Dibenzo[ b,d ]thiophen-4-yl)-2-morpholino-4 H -chromen-4-ones Endowed with Dual DNA-PK/PI3-K Inhibitory Activity

Cano, Céline, Saravanan, Kappusamy, Bailey, Chris, Bardos, Julia, Curtin, Nicola J., Frigerio, Mark, Golding, Bernard T., Hardcastle, Ian R., Hummersone, Marc G., Menear, Keith A., Newell, David R., R

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.13 MB

english, 2013

66

[Molecular Biology Intelligence Unit] Poly(ADP-Ribosyl)ation || PARP Inhibitors and Cancer Therapy

Curtin, Nicola J.

Year:

2006

Language:

english

File:

PDF, 2.15 MB

english, 2006

67

Resistance-Modifying Agents. 8. 1 Inhibition of O 6 -Alkylguanine-DNA Alkyltransferase by O 6 -Alkenyl-, O 6 -Cycloalkenyl-, and O 6 -(2-Oxoalkyl)guanines and Potentiation of Temozolomide Cytotoxicity in Vitro by O 6 -(1-Cyclopentenylmethyl)guanine

Griffin, Roger J., Arris, Christine E., Bleasdale, Christine, Boyle, F. Thomas, Calvert, A. Hilary, Curtin, Nicola J., Dalby, Christine, Kanugula, Sreenivas, Lembicz, Nicola K., Newell, David R., Pegg

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 215 KB

english, 2000

68

Resistance-Modifying Agents. 5. 1 Synthesis and Biological Properties of Quinazolinone Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase (PARP)

Griffin, Roger J., Srinivasan, Sheila, Bowman, Karen, Calvert, A. Hilary, Curtin, Nicola J., Newell, David R., Pemberton, Louise C., Golding, Bernard T.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 173 KB

english, 1998

69

DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin

Ciszewski, Wojciech M., Tavecchio, Michele, Dastych, Jarosław, Curtin, Nicola J.

Journal:

Breast Cancer Research and Treatment

Year:

2014

Language:

english

File:

PDF, 436 KB

english, 2014

70

Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants

van der Valk, Ralf J.P., Duijts, Liesbeth, Timpson, Nicolas J., Salam, Muhammad T., Standl, Marie, Curtin, John A., Genuneit, Jon, Kerhof, Marjan, Kreiner-Møller, Eskil, Cáceres, Alejandro, Gref, Anna

Journal:

Journal of Allergy and Clinical Immunology

Year:

2014

Language:

english

File:

PDF, 1.75 MB

english, 2014

71

Primary hepatocellular carcinoma localised by a radiolabelled monoclonal antibody

Markham, Nicholas, Ritson, Anne, James, Oliver, Curtin, Nicola, Bassendine, Margaret, Sikora, Karol

Journal:

Journal of Hepatology

Year:

1986

Language:

english

File:

PDF, 7.00 MB

english, 1986

72

PARP inhibitors for anticancer therapy

Journal:

Biochemical Society Transactions

Year:

2014

Language:

english

File:

PDF, 302 KB

english, 2014

73

Therapeutic potential of drugs to modulate DNA repair in cancer

Journal:

Expert Opinion on Therapeutic Targets

Year:

2007

Language:

english

File:

PDF, 262 KB

english, 2007

74

DNA Repair in Cancer Therapy || The Role of PARP in DNA Repair and its Therapeutic Exploitation

Curtin, Nicola J.

Year:

2012

Language:

english

File:

PDF, 610 KB

english, 2012

75

PARP inhibitors target ATM+p53-defective gastric cancer

Curtin, Nicola J

Journal:

Year:

2014

Language:

english

File:

PDF, 120 KB

english, 2014

76

Social Class and Belonging: Implications for Graduate Students' Career Aspirations

Joan M. Ostrove, Abigail J. Stewart and Nicola L. Curtin

Journal:

The Journal of Higher Education

Year:

2011

Language:

english

File:

PDF, 1.90 MB

english, 2011

77

Development of pharmacodynamic biomarkers for ATR inhibitors

Chen, Tao, Middleton, Fiona K., Falcon, Susanna, Reaper, Philip M., Pollard, John R., Curtin, Nicola J.

Journal:

Molecular Oncology

Year:

2015

Language:

english

File:

PDF, 2.31 MB

english, 2015

78

Poly(ADP-ribose) polymerase inhibitors in Ewing sarcoma

Vormoor, Britta, Curtin, Nicola J.

Journal:

Current Opinion in Oncology

Year:

2014

Language:

english

File:

PDF, 255 KB

english, 2014

79

Understanding what students bring to the classroom: Moderators of the effects of diversity courses on student attitudes.

Cole, Elizabeth R., Case, Kim A., Rios, Desdamona, Curtin, Nicola

Journal:

Cultural Diversity and Ethnic Minority Psychology

Year:

2011

Language:

english

File:

PDF, 6.05 MB

english, 2011

80

[Cancer Drug Discovery and Development] PARP Inhibitors for Cancer Therapy Volume 83 || Targeting Tumour Hypoxia with PARP Inhibitors: Contextual Synthetic Lethality

Curtin, Nicola J., Sharma, Ricky A.

Year:

2015

Language:

english

File:

PDF, 1.56 MB

english, 2015

81

[Cancer Drug Discovery and Development] PARP Inhibitors for Cancer Therapy Volume 83 || Radiosensitisation by Poly(ADP-ribose) Polymerase Inhibition

Curtin, Nicola J., Sharma, Ricky A.

Year:

2015

Language:

english

File:

PDF, 1.53 MB

english, 2015

82

[Cancer Drug Discovery and Development] PARP Inhibitors for Cancer Therapy Volume 83 || Multitasking Roles for Poly(ADP-ribosyl)ation in Aging and Longevity

Curtin, Nicola J., Sharma, Ricky A.

Year:

2015

Language:

english

File:

PDF, 2.26 MB

english, 2015

83

[Cancer Drug Discovery and Development] PARP Inhibitors for Cancer Therapy Volume 83 || The Role of PARPs in DNA Strand Break Repair

Curtin, Nicola J., Sharma, Ricky A.

Year:

2015

Language:

english

File:

PDF, 2.29 MB

english, 2015

84

[Cancer Drug Discovery and Development] PARP Inhibitors for Cancer Therapy Volume 83 || Classification of PARP Inhibitors Based on PARP Trapping and Catalytic Inhibition, and Rationale for Combinations with Topoisomerase I Inhibitors and Alkylating Agents

Curtin, Nicola J., Sharma, Ricky A.

Year:

2015

Language:

english

File:

PDF, 1.66 MB

english, 2015

85

[Cancer Drug Discovery and Development] PARP Inhibitors for Cancer Therapy Volume 83 || Disruption of DNA Repair by Cell Cycle and Transcriptional CDK Inhibition

Curtin, Nicola J., Sharma, Ricky A.

Year:

2015

Language:

english

File:

PDF, 1.37 MB

english, 2015

86

[Cancer Drug Discovery and Development] PARP Inhibitors for Cancer Therapy Volume 83 || Overview of PARP Inhibitor Design and Optimization

Curtin, Nicola J., Sharma, Ricky A.

Year:

2015

Language:

english

File:

PDF, 1.94 MB

english, 2015

87

[Cancer Drug Discovery and Development] PARP Inhibitors for Cancer Therapy Volume 83 || Resistance to PARP Inhibitors Mediated by Secondary BRCA1/2 Mutations

Curtin, Nicola J., Sharma, Ricky A.

Year:

2015

Language:

english

File:

PDF, 1.53 MB

english, 2015

88

[Cancer Drug Discovery and Development] PARP Inhibitors for Cancer Therapy Volume 83 || Structure Based Design of PARP Inhibitors

Curtin, Nicola J., Sharma, Ricky A.

Year:

2015

Language:

english

File:

PDF, 2.92 MB

english, 2015

89

[Cancer Drug Discovery and Development] PARP Inhibitors for Cancer Therapy Volume 83 || Combination of PARP Inhibitors with Clinical Radiotherapy

Curtin, Nicola J., Sharma, Ricky A.

Year:

2015

Language:

english

File:

PDF, 1.54 MB

english, 2015

90

[Cancer Drug Discovery and Development] PARP Inhibitors for Cancer Therapy Volume 83 || History of the Discovery of Poly (ADP-ribose)

Curtin, Nicola J., Sharma, Ricky A.

Year:

2015

Language:

english

File:

PDF, 1.11 MB

english, 2015

91

mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibition

Massey, Andrew J., Stephens, Peter, Rawlinson, Rebecca, McGurk, Lauren, Plummer, Ruth, Curtin, Nicola J.

Journal:

Molecular Oncology

Year:

2015

Language:

english

File:

PDF, 2.34 MB

english, 2015

92

PARP Inhibitor Development for Systemic Cancer Targeting

Zaremba, Tomasz, Curtin, Nicola

Journal:

Anti-Cancer Agents in Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 349 KB

english, 2007

93

The differential impact of discrimination on health among Black and White women

Versey, H. Shellae, Curtin, Nicola

Journal:

Social Science Research

Year:

2016

Language:

english

File:

PDF, 1.11 MB

english, 2016

94

Poly(ADP-Ribose) Polymerase in Cervical Cancer Pathogenesis

Kotsopoulos, Ioannis C., Kucukmetin, Ali, Mukhopadhyay, Asima, Lunec, John, Curtin, Nicola J.

Journal:

International Journal of Gynecological Cancer

Year:

2016

Language:

english

File:

PDF, 917 KB

english, 2016

95

Transient treatment with CDK inhibitors eliminates proliferative potential even when their abilities to evoke apoptosis and DNA damage are blocked

Scrace, Simon F., Kierstan, Peter, Borgognoni, Jenifer, Wang, Lan-Zhen, Denny, Sarah, Wayne, Joanne, Bentley, Carol, Cansfield, Andrew D., Jackson, Philip S., Lockie, Andrea M., Curtin, Nicola J., New

Journal:

Year:

2008

Language:

english

File:

PDF, 990 KB

english, 2008

96

Imagestream detection and characterisation of circulating tumour cells – A liquid biopsy for hepatocellular carcinoma?

Ogle, Laura F., Orr, James G., Willoughby, Catherine E., Hutton, Claire, McPherson, Stuart, Plummer, Ruth, Boddy, Alan V., Curtin, Nicola J., Jamieson, David, Reeves, Helen L.

Journal:

Journal of Hepatology

Year:

2016

Language:

english

File:

PDF, 1.45 MB

english, 2016

97

Poly(ADP-ribose) polymerase-1 (PARP-1) pharmacogenetics, activity and expression analysis in cancer patients and healthy volunteers

Zaremba, Tomasz, Thomas, Huw D., Cole, Michael, Coulthard, Sally A., Plummer, Elizabeth R., Curtin, Nicola J.

Journal:

Biochemical Journal

Year:

2011

Language:

english

File:

PDF, 982 KB

english, 2011

98

PARP activity in peripheral blood lymphocytes as a predictive biomarker for PARP inhibition in tumor tissues - A population pharmacokinetic/pharmacodynamic analysis of rucaparib

Wang, Diane D., Li, Chunze, Sun, Wan, Zhang, Shuzhong, Shalinsky, David R., Kern, Kenneth A., Curtin, Nicola J., Sam, Wai-Johnn, Kirkpatrick, Tanya R., Plummer, Ruth

Journal:

Clinical Pharmacology in Drug Development

Year:

2015

Language:

english

File:

PDF, 1.13 MB

english, 2015

99

High-resolution imaging for the detection and characterisation of circulating tumour cells from patients with oesophageal, hepatocellular, thyroid and ovarian cancers

Dent, Barry M., Ogle, Laura F., O'Donnell, Rachel L., Hayes, Nicholas, Malik, Ujjal, Curtin, Nicola J., Boddy, Alan V., Plummer, E. Ruth, Edmondson, Richard J., Reeves, Helen L., May, Felicity E.B., J

Journal:

International Journal of Cancer

Year:

2016

Language:

english

File:

PDF, 461 KB

english, 2016

100

Changes in developmental-specific enzyme activities during experimental hepatocarcinogenesis in the rat in vivo

CURTIN, NICOLA J., SNELL, KEITH

Journal:

Biochemical Society Transactions

Year:

1980

Language:

english

File:

PDF, 148 KB

english, 1980