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1

Comparative in vitro activity of carbapenem antibiotics against respiratory pathogens isolated in recent years

A. Watanabe, Hiroaki Kikuchi, Tohru Kikuchi, Afzalunnesa Binte Lutfor, Yutaka Tokue, Hiroshi Takahashi, Shigeru Fujimura, Satoru Shoji, Yoshihiro Honda, Yushi Nakai, Toshihiro Nukiwa

Journal:

Journal of Infection and Chemotherapy

Year:

1999

Language:

english

File:

PDF, 62 KB

english, 1999

2

Atypical adenomatous hyperplasia and adenocarcinoma of the human lung: Their heterology in form and analogy in immunohistochemical characteristics

Masuko Mori, Fumiaki Tezuka, Ryoji Chiba, Yoshihiko Funae, Minro Watanabe, Toshihiro Nukiwa, Tohru Takahashi

Journal:

Year:

1996

Language:

english

File:

PDF, 955 KB

english, 1996

3

Identification of a 910-Kb region of common allelic loss in chromosome bands 16q24.1–q24.2 in human lung cancer

Masami Sato, Yuriko Mori, Akira Sakurada, Shinichi Fukushige, Yuichi Ishikawa, Eiju Tsuchiya, Yasuki Saito, Toshihiro Nukiwa, Shigefumi Fujimura, Akira Horii

Journal:

Genes, Chromosomes and Cancer

Year:

1998

Language:

english

File:

PDF, 395 KB

english, 1998

4

Identification of a CTL-directed epitope encoded by an intron of the putative tumor suppressor gene Testin of the common fragile site 7G region: a peptide vaccine candidate for HLA-B52+ and HLA-62+ cancer patients

Shinya Ohkouchi, Naoki Kawamoto, Makoto Koga, Fumi Sakanashi, Shigeki Shichijo, Yasuo Saijo, Toshihiro Nukiwa, Kyogo Itoh, Akira Yamada

Journal:

European Journal of Immunology

Year:

2003

Language:

english

File:

PDF, 238 KB

english, 2003

5

Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells

Hong Xin, Toshiaki Kikuchi, Sita Andarini, Shinya Ohkouchi, Takuji Suzuki, Toshihiro Nukiwa, Huqun, Koichi Hagiwara, Tasuku Honjo, Yasuo Saijo

Journal:

European Journal of Immunology

Year:

2005

Language:

english

File:

PDF, 286 KB

english, 2005

6

Dendritic cells modified to express fractalkine/CX3CL1 in the treatment of preexisting tumors

Mio Nukiwa, Sita Andarini, Jamal Zaini, Hong Xin, Masahiko Kanehira, Takuji Suzuki, Tatsuro Fukuhara, Hiroyuki Mizuguchi, Takao Hayakawa, Yasuo Saijo, Toshihiro Nukiwa, Toshiaki Kikuchi

Journal:

European Journal of Immunology

Year:

2006

Language:

english

File:

PDF, 294 KB

english, 2006

7

Suppression of metastasis of human pancreatic cancer to the liver by transportal injection of recombinant adenoviral NK4 in nude mice

Mitsuhiko Murakami, Eishi Nagai, Kazuhiro Mizumoto, Michiyo Saimura, Kenoki Ohuchida, Naoki Inadome, Kunio Matsumoto, Toshikazu Nakamura, Makoto Maemondo, Toshihiro Nukiwa, Masao Tanaka

Journal:

International Journal of Cancer

Year:

2005

Language:

english

File:

PDF, 396 KB

english, 2005

8

A novel human monoclonal antibody, TONO-1, reactive with T-lymphocytic leukemia cells

Muneo Numasaki, Yoshihiro Fukuoka, Toshio Kudo, Hisaaki Saeki, Takehiko Tachibana, Masakichi Motomiya, Toshihiro Nukiwa

Journal:

International Journal of Cancer

Year:

1995

Language:

english

File:

PDF, 719 KB

english, 1995

9

Exploratory analysis of a phase III trial of pirfenidone identifies a subpopulation of patients with idiopathic pulmonary fibrosis as benefiting from treatment

Arata Azuma, Yoshio Taguchi, Takashi Ogura, Masahito Ebina, Hiroyuki Taniguchi, Yasuhiro Kondoh, Moritaka Suga, Hiroki Takahashi, Koichiro Nakata, Atsuhiko Sato, Shoji Kudoh, Toshihiro Nukiwa, Pirfeni

Journal:

Respiratory Research

Year:

2011

Language:

english

File:

PDF, 459 KB

english, 2011

10

A Pro → Leu substitution in codon 369 of the alpha-1-antitrypsin deficiency variant PI MHeerlen

Marten H. Hofker, Toshihiro Nukiwa, Heleen M. B. Paassen, Marcel Nelen, Johannes A. Kramps, Eduard C. Klasen, Rune R. Frants, Ronald G. Crystal

Journal:

Year:

1989

Language:

english

File:

PDF, 522 KB

english, 1989

11

Preliminary report on DU-6859a for lower respiratory tract infection

Toshihiro Nukiwa, Kaoru Shimada, Kohei Hara, Shigeki Odagiri, Hiroyuki Kobayashi

Journal:

Journal of Infection and Chemotherapy

Year:

1996

Language:

english

File:

PDF, 549 KB

english, 1996

12

Rapidly progressive primary adenocarcinoma of the lung with signet-ring cells responding to 5-fluorouracil and leucovorin: A case report

Makoto Maemondo, Yasuo Saijo, Masahito Ebina, Tatsuya Abe, Masahiro Yaekashiwa, Ken Satoh, Toshihiro Nukiwa

Journal:

International Journal of Clinical Oncology

Year:

1997

Language:

english

File:

PDF, 1004 KB

english, 1997

13

Alternative splicing ofhMSH2in normal human tissues

Yuriko Mori, Hiromi Shiwaku, Shinichi Fukushige, Shigeru Wakatsuki, Masami Sato, Toshihiro Nukiwa, A. Horii

Journal:

Year:

1997

Language:

english

File:

PDF, 128 KB

english, 1997

14

Evaluation of dosing designs of carbapenems for severe respiratory infection using Monte Carlo simulation

Akira Watanabe, Shigeru Fujimura, Toshiaki Kikuchi, Kazunori Gomi, Katsuhiro Fuse, Toshihiro Nukiwa

Journal:

Journal of Infection and Chemotherapy

Year:

2007

Language:

english

File:

PDF, 414 KB

english, 2007

15

In vitro antimicrobial activity and penetration rate into sputum of gatifloxacin, a novel 6-fluoro-8-methoxy quinolone, and its therapeutic efficacy in respiratory infections

A. Watanabe, Tohru Kikuchi, Afzalunnesa Binte Lutfor, Yutaka Tokue, Hiroshi Takahashi, Shigeru Fujimura, Satoru Shoji, Yoshihiro Honda, Yushi Nakai, Toshihiro Nukiwa

Journal:

Journal of Infection and Chemotherapy

Year:

1999

Language:

english

File:

PDF, 89 KB

english, 1999

16

Nucleotide sequence analysis of a human monoclonal antibody 22-13 reactive with lung tumor-associated antigen

Muneo Numasaki, Kazuyasu Nakamura, Yoshihiro Fukuoka, Nobuyuki Sato, Hisaaki Saeki, Takehiko Tachibana, Nobuo Hanai, Toshihiro Nukiwa, Toshio Kudo

Journal:

Immunology Letters

Year:

1998

Language:

english

File:

PDF, 288 KB

english, 1998

17

Contiguous Four-guanosine Sequence in c-myc Antisense Phosphorothioate Oligonucleotides Inhibits Cell Growth on Human Lung Cancer Cells: Possible Involvement of Cell Adhesion Inhibition

Yasuo Saijo, Bine Uchiyama, Tatsuya Abe, Ken Satoh, Toshihiro Nukiwa

Journal:

Year:

1997

File:

PDF, 767 KB

1997

18

Inhibition of Experimental Metastasis of Human Fibrosarcoma Cells by Anti-recombinant 37-kDa Laminin Binding Protein Antibody

Koh Narumi, Akira Inoue, Masashi Tanaka, Mamoru Isemura, Tadashi Shimo-Oka, Tatsuya Abe, Toshihiro Nukiwa, Ken Satoh

Journal:

Year:

1999

Language:

english

File:

PDF, 381 KB

english, 1999

19

Multifunctional interleukin-1β promotes metastasis of human lung cancer cells in SCID mice via enhanced expression of adhesion-, invasion- and angiogenesis-related molecules

Seiji Yano, Hiroshi Nokihara, Akihiko Yamamoto, Hisatsugu Goto, Hirohisa Ogawa, Takanori Kanematsu, Toyokazu Miki, Hisanori Uehara, Yasuo Saijo, Toshihiro Nukiwa, Saburo Sone

Journal:

Year:

2003

Language:

english

File:

PDF, 387 KB

english, 2003

20

A naturally occurring p73 mutation in a p73-p53 double-mutant lung cancer cell line encodes p73α protein with a dominant-negative function

Huqun, Yoshiyuki Endo, Hong Xin, Mitsu Takahashi, Toshihiro Nukiwa, Koichi Hagiwara

Journal:

Year:

2003

Language:

english

File:

PDF, 437 KB

english, 2003

21

Secretory leukocyte peptidase inhibitor and lung cancer

Toshihiro Nukiwa, Takuji Suzuki, Tatsuro Fukuhara, Toshiaki Kikuchi

Journal:

Year:

2008

Language:

english

File:

PDF, 204 KB

english, 2008

22

Suppression of surfactant protein A by an epidermal growth factor receptor tyrosine kinase inhibitor exacerbates lung inflammation

Akira Inoue, Hong Xin, Takuji Suzuki, Masahiko Kanehira, Yoshio Kuroki, Tatsuro Fukuhara, Toshiaki Kikuchi, Makoto Maemondo, Toshihiro Nukiwa, Yasuo Saijo

Journal:

Year:

2008

Language:

english

File:

PDF, 254 KB

english, 2008

23

Systemic NK4 gene therapy inhibits tumor growth and metastasis of melanoma and lung carcinoma in syngeneic mouse tumor models

Yuko Kishi, Keiji Kuba, Takahiro Nakamura, Jinhua Wen, Yoshinori Suzuki, Shinya Mizuno, Toshihiro Nukiwa, Kunio Matsumoto, Toshikazu Nakamura

Journal:

Year:

2009

Language:

english

File:

PDF, 7.23 MB

english, 2009

24

Japanese chest physicians face hopes and enigmas of gefitinib, a molecular targeting drug for lung cancer

Toshihiro Nukiwa

Journal:

Year:

2004

Language:

english

File:

PDF, 30 KB

english, 2004

25

Epidemiological and clinical features of idiopathic pulmonary alveolar proteinosis in Japan

Yoshikazu INOUE, Koh NAKATA, Toru ARAI, Ryushi TAZAWA, Emi HAMANO, Toshihiro NUKIWA, Koichiro KUDO, Naoto KEICHO, Nobuyuki HIZAWA, Etsuro YAMAGUCHI, Ryosuke EDA, Kazunori OISHI, Yuuka MAEDA, Yukiko KO

Journal:

Year:

2006

Language:

english

File:

PDF, 291 KB

english, 2006

26

Granulocyte-macrophage colony-stimulating factor inhalation therapy for patients with idiopathic pulmonary alveolar proteinosis: a pilot study; and long-term treatment with aerosolized granulocyte-macrophage colony-stimulating factor: a case report

Ryushi TAZAWA, Koh NAKATA, Yoshikazu INOUE, Toshihiro NUKIWA

Journal:

Year:

2006

Language:

english

File:

PDF, 155 KB

english, 2006

27

Novel arbekacin- and amikacin-modifying enzyme of methicillin-resistant Staphylococcus aureus

Shigeru Fujimura, Yutaka Tokue, Hiroshi Takahashi, Takao Kobayashi, Kazunori Gomi, Tatsuya Abe, Toshihiro Nukiwa, Akira Watanabe

Journal:

FEMS Microbiology Letters

Year:

2000

Language:

english

File:

PDF, 254 KB

english, 2000

28

Induction of antitumor immunity by combined immunogene therapy using IL-2 and IL-12 in low antigenic Lewis lung carcinoma

Tanaka, Masashi, Saijo, Yasuo, Sato, George, Suzuki, Takuji, Tazawa, Ryushi, Satoh, Ken, Nukiwa, Toshihiro

Journal:

Cancer Gene Therapy

Year:

2000

Language:

english

File:

PDF, 584 KB

english, 2000

29

Tumor suppression effect using NK4, a molecule acting as an antagonist of HGF, on human gastric carcinomas

Hirao, Shuya, Yamada, Yukishige, Koyama, Fumikazu, Fujimoto, Heisuke, Takahama, Yasushi, Ueno, Masato, Kamada, Kiyoshi, Mizuno, Takashi, Maemondo, Makoto, Nukiwa, Toshihiro

Journal:

Cancer Gene Therapy

Year:

2002

Language:

english

File:

PDF, 303 KB

english, 2002

30

Intraperitoneal injection of adenovirus-mediated NK4 gene suppresses peritoneal dissemination of pancreatic cancer cell line AsPC-1 in nude mice

Saimura, Michiyo, Nagai, Eishi, Mizumoto, Kazuhiro, Maehara, Naoki, Okino, Hidenobu, Katano, Mitsuo, Matsumoto, Kunio, Nakamura, Toshikazu, Narumi, Kou, Nukiwa, Toshihiro

Journal:

Cancer Gene Therapy

Year:

2002

Language:

english

File:

PDF, 566 KB

english, 2002

31

Gallbladder cancer treatment using adenovirus expressing the HGF/NK4 gene in a peritoneal implantation model

Tanaka, Toshihiro, Shimura, Hideo, Sasaki, Takamitsu, Narumi, Kou, Maemondo, Makoto, Nukiwa, Toshihiro, Matsumoto, Kunio, Nakamura, Toshikazu, Ikeda, Seiyo

Journal:

Cancer Gene Therapy

Year:

2004

Language:

english

File:

PDF, 377 KB

english, 2004

32

Suppression of peritoneal implantation of gastric cancer cells by adenovirus vector-mediated NK4 expression

Fujiwara, Hitoshi, Kubota, Takeshi, Amaike, Hisashi, Inada, Satoshi, Takashima, Kazuhiro, Atsuji, Kiyoto, Yoshimura, Mamoru, Maemondo, Makoto, Narumi, Ko, Nukiwa, Toshihiro

Journal:

Cancer Gene Therapy

Year:

2004

Language:

english

File:

PDF, 338 KB

english, 2004

33

Expansion of human autologous cytotoxic T lymphocytes on fixed target tumor cells

Ken-ichi Horiuchi, Hideo Tsurushima, Berm Soo Kim, Shu Qin Liu, Kaoru Saijo, Yasuo Saijo, Toshihiro Nukiwa, Nakao Nomura, Masatoshi Matsumura, Tadao Ohno

Journal:

Year:

1998

Language:

english

File:

PDF, 63 KB

english, 1998

34

Gene transduction of NK4, HGF antagonist, inhibitsin vitroinvasion andin vivogrowth of human pancreatic cancer

Naoki Maehara, Eishi Nagai, Kazuhiro Mizumoto, Norihiro Sato, Kunio Matsumoto, Toshikazu Nakamura, Ko Narumi, Toshihiro Nukiwa, Masao Tanaka

Journal:

Clinical and Experimental Metastasis

Year:

2002

Language:

english

File:

PDF, 355 KB

english, 2002

35

Amylase mRNA transcripts in normal tissues and neoplasms: the implication of different expressions of amylase isogenes

Kuniaki Seyama, Toshihiro Nukiwa, Kazuhisa Takahashi, Hideki Takahashi, Shiro Kira

Journal:

Journal of Cancer Research and Clinical Oncology

Year:

1994

Language:

english

File:

PDF, 1.10 MB

english, 1994

36

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

Yoichiro Mitsuishi, Keiko Taguchi, Yukie Kawatani, Tatsuhiro Shibata, Toshihiro Nukiwa, Hiroyuki Aburatani, Masayuki Yamamoto, Hozumi Motohashi

Journal:

Year:

2012

Language:

english

File:

PDF, 2.21 MB

english, 2012

37

Acute eosinophilic pneumonia associated with the inhalation of phosgene gas under the presence of cigarette smoking

Tsutomu Tamada, Masayuki Nara, Koji Murakami, Soshi Muramatsu, Masahito Ebina, Toshihiro Nukiwa

Journal:

Respiratory Medicine CME

Year:

2011

Language:

english

File:

PDF, 584 KB

english, 2011

38

Chronic solitary pulmonary nodule due to unsuspected pulmonary infarction from silent pulmonary embolism

Hidetaka SATO, Makoto MIKI, Shohichi NAKAYAMA, Tatsuya ABE, Hiroshi OHUCHI, Toyoharu ISAWA, Toshihiro NUKIWA

Journal:

Year:

1996

Language:

english

File:

PDF, 806 KB

english, 1996

39

Molecular basis of alpha-1-antitrypsin deficiency

Mark Brantly, Toshihiro Nukiwa, Ronald G. Crystal

Journal:

The American Journal of Medicine

Year:

1988

Language:

english

File:

PDF, 5.46 MB

english, 1988

40

Regulation of indoleamine 2,3-dioxygenase activity in the small intestine and the epididymis of mice

Ryotaro Yoshida, Toshihiro Nukiwa, Yasuyoshi Watanabe, Motokazu Fujiwara, Fusao Hirata, Osamu Hayaishi

Journal:

Archives of Biochemistry and Biophysics

Year:

1980

Language:

english

File:

PDF, 850 KB

english, 1980

41

The activation of bovine pineal tryptophan 5-monooxygenase

Arata Ichiyama, Shinichiro Hori, Yohko Mashimo, Toshihiro Nukiwa, Haruo Makuuchi

Journal:

Year:

1974

Language:

english

File:

PDF, 391 KB

english, 1974

42

Prevalence of community-acquired respiratory tract infections associated with Q fever in Japan

Hiroshi Takahashi, Yutaka Tokue, Toru Kikuchi, Takao Kobayashi, Kazuhiro Gomi, Ikuo Goto, Hiroyuki Shiraishi, Hideto Fukushi, Katuya Hirai, Toshihiro Nukiwa, Akira Watanabe

Journal:

Diagnostic Microbiology and Infectious Disease

Year:

2004

Language:

english

File:

PDF, 78 KB

english, 2004

43

Identification and characterization of a novel Rho GTPase activating protein implicated in receptor-mediated endocytosis

Tomohiro Sakakibara, Yasuo Nemoto, Toshihiro Nukiwa, Hiroshi Takeshima

Journal:

Year:

2004

Language:

english

File:

PDF, 566 KB

english, 2004

44

Blockage of HGF/c-Met system by gene therapy (adenovirus-mediated NK4 gene) suppresses hepatocellular carcinoma in mice

Gakuhei Son, Tadamichi Hirano, Ekihiro Seki, Yuji Iimuro, Toshihiro Nukiwa, Kunio Matsumoto, Toshikazu Nakamura, Jiro Fujimoto

Journal:

Journal of Hepatology

Year:

2006

Language:

english

File:

PDF, 1.04 MB

english, 2006

45

Serum neutralizing capacity of GM-CSF reflects disease severity in a patient with pulmonary alveolar proteinosis successfully treated with inhaled GM-CSF

Toru Arai, Emi Hamano, Yoshikazu Inoue, Ryushi Tazawa, Toshihiro Nukiwa, Mitsunori Sakatani, Koh Nakata

Journal:

Respiratory Medicine

Year:

2004

Language:

english

File:

PDF, 163 KB

english, 2004

46

Molecular basis of alpha-1-antitrypsin deficiency

Mark Brantly, Toshihiro Nukiwa, Ronald G. Crystal

Journal:

The American Journal of Medicine

Year:

1988

Language:

english

File:

PDF, 3.50 MB

english, 1988

47

Transition from Squamous Cell Carcinoma to Adenocarcinoma in Adenosquamous Carcinoma of the Lung

Hironobu Kanazawa, Masahito Ebina, Nozomu Ino-oka, Minoru Shimizukawa, Toru Takahashi, Shigefumi Fujimura, Tadashi Imai, Toshihiro Nukiwa

Journal:

The American Journal of Pathology

Year:

2000

Language:

english

File:

PDF, 3.18 MB

english, 2000

48

Severe acute interstitial pneumonia and gefitinib

Akira Inoue, Yasuo Saijo, Makoto Maemondo, Kazunori Gomi, Yutaka Tokue, Yuichiro Kimura, Masahito Ebina, Toshiaki Kikuchi, Takuya Moriya, Toshihiro Nukiwa

Journal:

Year:

2003

Language:

english

File:

PDF, 625 KB

english, 2003

49

Expression of the 37-kDa laminin binding protein in murine lung tumor cell correlates with tumor angiogenesis

Masashi Tanaka, Ko Narumi, Mamoru Isemura, Mayumi Abe, Yasufumi Sato, Tatsuya Abe, Yasuo Saijo, Toshihiro Nukiwa, Ken Satoh

Journal:

Year:

2000

Language:

english

File:

PDF, 613 KB

english, 2000

50

Administration of wild-type p53 adenoviral vector synergistically enhances the cytotoxicity of anti-cancer drugs in human lung cancer cells irrespective of the status of p53 gene

Akira Inoue, Koh Narumi, Nobumichi Matsubara, Shun-ichi Sugawara, Yasuo Saijo, Ken Satoh, Toshihiro Nukiwa

Journal:

Year:

2000

Language:

english

File:

PDF, 166 KB

english, 2000

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