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51

Assay of labile estrogen o-quinones, potent carcinogenic molecular species, by high performance liquid chromatography–electrospray ionization tandem mass spectrometry with phenazine derivatization

Kouwa Yamashita, Akina Masuda, Yuka Hoshino, Sachiko Komatsu, Mitsuteru Numazawa

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2010

Language:

english

File:

PDF, 899 KB

english, 2010

52

Gas chromatography–mass spectrometric analysis of oxidative reactions of [19,19-2H2]19-hydroxy-3-deoxy androgens by placental aromatase: Absence of a deuterium-isotope effect

Masao Nagaoka, Mitsuteru Numazawa

Journal:

Year:

2005

Language:

english

File:

PDF, 322 KB

english, 2005

53

Inhibition of estrone sulfatase by aromatase inhibitor-based estrogen 3-sulfamates

Mitsuteru Numazawa, Takako Tominaga, Yoko Watari, Yasue Tada

Journal:

Year:

2006

Language:

english

File:

PDF, 266 KB

english, 2006

54

Synthesis of pyridine-carboxylate derivatives of hydroxysteroids for liquid chromatography–electrospray ionization-mass spectrometry

Kouwa Yamashita, Sayuri Kobayashi, Satoshi Tsukamoto, Mitsuteru Numazawa

Journal:

Year:

2007

Language:

english

File:

PDF, 351 KB

english, 2007

55

Highly sensitive determination of estrone and estradiol in human serum by liquid chromatography–electrospray ionization tandem mass spectrometry

Kouwa Yamashita, Mitsunobu Okuyama, Yoko Watanabe, Seijiro Honma, Sayuri Kobayashi, Mitsuteru Numazawa

Journal:

Year:

2007

Language:

english

File:

PDF, 303 KB

english, 2007

56

Simultaneous determination of tetrahydrocortisol, allotetrahydrocortisol and tetrahydrocortisone in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry

Kouwa Yamashita, Risa Nakagawa, Mitsunobu Okuyama, Seijiro Honma, Madoka Takahashi, Mitsuteru Numazawa

Journal:

Year:

2008

Language:

english

File:

PDF, 801 KB

english, 2008

57

Aromatization of androstenedione and 16α-hydroxyandrostenedione in human placental microsomes: Kinetic analysis of inhibition by the 19-oxygenated and 3-deoxy analogs

Mitsuteru Numazawa, Yoko Watari, Sachiko Komatsu, Kouwa Yamashita, Masao Nagaoka

Journal:

Year:

2008

Language:

english

File:

PDF, 535 KB

english, 2008

58

Chemical aromatization of 19-hydroxyandrosta-1,4-diene-3,17-dione with acid or alkaline: Elimination of the 19-hydroxymethyl group as formaldehyde

Mitsuteru Numazawa, Kouwa Yamashita, Nao Kimura, Madoka Takahashi

Journal:

Year:

2009

Language:

english

File:

PDF, 275 KB

english, 2009

59

Development of highly sensitive quantification method for testosterone and dihydrotestosterone in human serum and prostate tissue by liquid chromatography–electrospray ionization tandem mass spectrometry

Kouwa Yamashita, Yoshimichi Miyashiro, Hitoe Maekubo, Mitsunobu Okuyama, Seijiro Honma, Madoka Takahashi, Mitsuteru Numazawa

Journal:

Year:

2009

Language:

english

File:

PDF, 364 KB

english, 2009

60

6β,19-Bridged androstenedione analogs as aromatase inhibitors

Sachiko Komatsu, Ayaka Yaguchi, Kouwa Yamashita, Masao Nagaoka, Mitsuteru Numazawa

Journal:

Year:

2009

Language:

english

File:

PDF, 391 KB

english, 2009

61

4- and 6-(p-Sulphamoylphenyl)androstenediones: Studies of aromatase inhibitor-based oestrone sulphatase inhibition

Yoko Watari, Satoshi Yamaguchi, Madoka Takahashi, Masao Nagaoka, Mitsuteru Numazawa

Journal:

Year:

2010

Language:

english

File:

PDF, 262 KB

english, 2010

62

Probing the binding pocket of the active site of aromatase with 2-phenylaliphatic androsta-1,4-diene-3,17-dione steroids

Madoka Takahashi, Kouwa Yamashita, Mitsuteru Numazawa

Journal:

Year:

2010

Language:

english

File:

PDF, 586 KB

english, 2010

63

Androst-5-Ene-7,17-dione: A novel class of suicide substrate of aromatase

Mitsuteru Numazawa, Ayako Mutsumi, Kumiko Hoshi, Yuko Tanaka

Journal:

Biochemical and Biophysical Research Communications

Year:

1992

Language:

english

File:

PDF, 387 KB

english, 1992

64

19-hydroxy-4-androsten-17-one: Potential competitive inhibitor of estrogen biosynthesis

Mitsuteru Numazawa, Ayako Mutsumi, Kumiko Hoshi, Ryoji Koike

Journal:

Biochemical and Biophysical Research Communications

Year:

1989

Language:

english

File:

PDF, 293 KB

english, 1989

65

Probing the binding pocket of the active site of aromatase with 6-ether or 6-ester substituted androst-4-ene-3,17-diones and their diene and triene analogs

Mitsuteru Numazawa, Momoko Shelangouski, Mina Nagasaka

Journal:

Year:

2000

Language:

english

File:

PDF, 279 KB

english, 2000

66

Time-dependent aromatase inactivation by 4β,5β-epoxides of the natural substrate androstenedione and its 19-oxygenated analogs

Mitsuteru Numazawa, Akiko Yoshimura, Mii Tachibana, Momoko Shelangouski, Maya Ishikawa

Journal:

Year:

2002

Language:

english

File:

PDF, 193 KB

english, 2002

67

Production of 16β-(acetoxy)acetoxy derivatives by reaction of 17-keto steroid enol acetates with lead (IV) acetate

Mitsuteru Numazawa, Momoko Shelangouski, Masamichi Nakakoshi

Journal:

Year:

2001

Language:

english

File:

PDF, 176 KB

english, 2001

68

Structure–activity relationships of 3-deoxy androgens as aromatase inhibitors. synthesis and biochemical studies of 4-substituted 4-ene and 5-ene steroids

Masao Nagaoka, Yoko Watari, Hiromi Yajima, Kaoru Tsukioka, Yasuyo Muroi, Keiko Yamada, Mitsuteru Numazawa

Journal:

Year:

2003

Language:

english

File:

PDF, 157 KB

english, 2003

69

Probing the active site of aromatase with 2-methyl-substituted androstenedione analogs

Mitsuteru Numazawa, Yoko Watari, Keiko Yamada, Nao Umemura, Wakako Handa

Journal:

Year:

2003

Language:

english

File:

PDF, 189 KB

english, 2003

70

Studies directed toward a mechanistic evaluation of aromatase inhibition by androst-5-ene-7,17-dione: Time-dependent inactivation by the 19-nor and 5β,6β-epoxy derivatives

Mitsuteru Numazawa, Mii Tachibana

Journal:

Year:

1997

Language:

english

File:

PDF, 636 KB

english, 1997

71

Reaction of androst-5-en-17-one with hypobromous acid and its use for synthesis of 19-oxygenated 5-ene and 4-en-6-one steroids

Mitsuteru Numazawa, Keiko Yamada

Journal:

Year:

1998

Language:

english

File:

PDF, 697 KB

english, 1998

72

6-Alkylandrosta-4,6-diene-3,17-diones and their 1,4,6-triene analogs as aromatase inhibitors: Structure-activity relationships

Mitsuteru Numazawa, Mariko Oshibe, Satoshi Yamaguchi

Journal:

Year:

1997

Language:

english

File:

PDF, 681 KB

english, 1997

73

Synthesis of 19-oxygenated derivatives of the competitive inhibitor of aromatase, 5-androstene-4,17-dione

Mitsuteru Numazawa, Keiko Yamada

Journal:

Year:

1999

Language:

english

File:

PDF, 219 KB

english, 1999

74

Studies on the catalytic function of aromatase: aromatization of 6-alkoxy-substituted androgens

Mitsuteru Numazawa, Momoko Ando, Rika Zennyoji

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2002

Language:

english

File:

PDF, 217 KB

english, 2002

75

Aromatization of 16α-hydroxyandrostenedione by human placental microsomes: effect of preincubation with suicide substrates of androstenedione aromatization

Mitsuteru Numazawa, Mii Tachibana, Ayako Mutsumi, Akiko Yoshimura, Yoshio Osawa

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2002

Language:

english

File:

PDF, 172 KB

english, 2002

76

6-Phenylaliphatic-substituted androst-4-ene-3,17-diones as aromatase inhibitors: structure-activity relationships

Mitsuteru Numazawa, Satoshi Yamaguchi

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

1998

Language:

english

File:

PDF, 269 KB

english, 1998

77

Biological aromatization of Δ4,6- and Δ1,4,6-androgens and their 6-alkyl analogs, potent inhibitors of aromatase

Mitsuteru Numazawa, Akiko Yoshimura

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

1999

Language:

english

File:

PDF, 177 KB

english, 1999

78

Efficient C-21 deoxygenation of 21-alkoxy-20-keto corticoid steroids with trimethylsilyl iodide in the presence of methanol

Nagaoka, Masao, Kunitama, Yurie, Numazawa, Mitsuteru

Journal:

Journal of Organic Chemistry

Year:

1991

Language:

english

File:

PDF, 689 KB

english, 1991

79

Stereospecific synthesis of 16.alpha.-hydroxy-17-oxo steroids by controlled alkaline hydrolysis of corresponding 16-bromo-17-ketones and its reaction mechanism

Numazawa, Mitsuteru, Nagaoka, Masao, Osawa, Yoshio

Journal:

Journal of Organic Chemistry

Year:

1982

Language:

english

File:

PDF, 810 KB

english, 1982

80

Novel and regiospecific synthesis of 2-amino estrogens via Zincke nitration

Mitsuteru Numazawa, Katsuhiko Kimura

Journal:

Year:

1983

Language:

english

File:

PDF, 471 KB

english, 1983

81

Mechanistic aspects of rearrangement of 16α-hydroxy-17-keto steroids to the 17β-hydroxy-16-keto isomers

Mitsuteru Numazawa, Masao Nagaoka, Hisao Matsuzaki, Kouwa Yamashita, Sachiko Komatsu, Yoshio Osawa

Journal:

Year:

2008

Language:

english

File:

PDF, 570 KB

english, 2008

82

Improved synthesis of 16α-hydroxylated androgens: Intermediates of estriol formation in pregnancy

Numazawa Mitsuteru, Osawa Yoshio

Journal:

Year:

1978

Language:

english

File:

PDF, 473 KB

english, 1978

83

Synthesis and some reactions of 6-bromoandrogens: Potential affinity ligand and inactivator of estrogen synthetase

Mitsuteru Numazawa, Yoshio Osawa

Journal:

Year:

1979

Language:

english

File:

PDF, 762 KB

english, 1979

84

Synthesis of 16α-bromoacetoxy androgens and 17 β-bromoacetylamino-4-androsten-3-one: Potential affinity labels of human placental aromatase

Numazawa Mitsuteru, Osawa Yoshio

Journal:

Year:

1981

Language:

english

File:

PDF, 593 KB

english, 1981

85

A short efficient synthesis of 16-oxygenated estratriene 3-sulfates

Mitsuteru Numazawa, Katsuhiko Kimura, Masao Nagaoka

Journal:

Year:

1981

Language:

english

File:

PDF, 499 KB

english, 1981

86

Controlled alkaline hydrolysis of steroidal α-bromoketones: New conditions and synthesis of 2α-hydroxy-3-ones

Mitsuteru Numazawa, Masao Nagaoka

Journal:

Year:

1982

Language:

english

File:

PDF, 478 KB

english, 1982

87

Stereoselective hydrolysis of 16α-halo-17-keto steroids and long-range substitution effects on the hydrolysis of 16α-bromo-17-ketones and 2α-bromo-3-ketones

Mitsuteru Numazawa, Mieko Ogata, Kanna Abiko, Masao Nagaoka

Journal:

Year:

1985

Language:

english

File:

PDF, 381 KB

english, 1985

88

New preparation and controlled alkaline hydrolysis of 21-bromo-20-oxopregnenes. A facile synthesis of deoxycorticoids

Numazawa, Mitsuteru, Nagaoka, Masao

Journal:

Journal of Organic Chemistry

Year:

1985

Language:

english

File:

PDF, 489 KB

english, 1985

89

Inhibition study of human placental aromatase with 3-deoxy- and 6-oxo-steroids using [1β-3H]16α-hydroxyandrostenedione as a substrate: A comparison to that using [1β-3H]androstenedione

Numazawa, Mitsuteru, Mutsumi, Ayako

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

1993

Language:

english

File:

PDF, 224 KB

english, 1993

90

A time-dependent inactivation of aromatase by 19-oxygenated androst-4-ene-3,6,17-triones

Numazawa, Mitsuteru, Mutsumi, Ayako, Hoshi, Kumiko, Kigawa, Hiroki, Oshibe, Mariko

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

1991

Language:

english

File:

PDF, 636 KB

english, 1991

91

4-Oxygenated androst-5-en-17-ones and their 7-oxo derivatives as aromatase inhibitors

Numazawa, Mitsuteru, Tachibana, Mii, Tateda, Yoki

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

1996

Language:

english

File:

PDF, 684 KB

english, 1996

92

Time-Dependent Inactivation of Aromatase by 6-Alkylandrosta-1,4-diene-3,17-diones. Effects of Length and Configuration of the 6-Alkyl Group †

Numazawa, Mitsuteru, Oshibe, Mariko, Yamaguchi, Satoshi, Tachibana, Mii

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 235 KB

english, 1996

93

Controlled alkaline hydrolysis of 16-bromo-17-keto steroids without ketol rearrangement and its reaction mechanism

Numazawa, Mitsuteru, Osawa, Yoshio

Journal:

Journal of the American Chemical Society

Year:

1980

Language:

english

File:

PDF, 392 KB

english, 1980

94

Reaction of 16-bromo-17-oxo steroids with potassium cyanide

Numazawa, Mitsuteru, Satoh, Mutsumi, Satoh, Satoshi, Nagaoka, Masao, Osawa, Yoshio

Journal:

Journal of Organic Chemistry

Year:

1986

Language:

english

File:

PDF, 325 KB

english, 1986

95

Synthesis of Androst-5-en-7-ones and Androsta-3,5-dien-7-ones and Their Related 7-Deoxy Analogs as Conformational and Catalytic Probes for the Active Site of Aromatase

Numazawa, Mitsuteru, Mutsumi, Ayako, Tachibana, Mii, Hoshi, Kumiko

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1006 KB

english, 1994

96

Conformational analysis of steroids: polymorphic forms of 17.beta.-acetoxy-6.beta.-bromo-4-androsten-3-one

Duax, William L., Numazawa, Mitsuteru, Osawa, Yoshio, Strong, Phyllis D., Weeks, Charles M.

Journal:

Journal of Organic Chemistry

Year:

1981

Language:

english

File:

PDF, 676 KB

english, 1981

97

Reductive dehalogenation of 2,4-dihalogeno estrogens having a 3-hydroxy substituent by formic acid, potassium iodide, or ascorbic acid

Numazawa, Mitsuteru, Kimura, Katsuhiko, Ogata, Mieko, Nagaoka, Masao

Journal:

Journal of Organic Chemistry

Year:

1985

Language:

english

File:

PDF, 432 KB

english, 1985

98

6-Alkyl- and 6-Arylandrost-4-ene-3,17-diones as Aromatase Inhibitors. Synthesis and Structure-Activity Relationships

Numazawa, Mitsuteru, Oshibe, Mariko

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.56 MB

english, 1994

99

Aromatase Reaction of 3-Deoxyandrogens: Steric Mode of the C-19 Oxygenation and Cleavage of the C 10 −C 19 Bond by Human Placental Aromatase †

Numazawa, Mitsuteru, Nagaoka, Masao, Sohtome, Norishige

Journal:

Year:

2005

Language:

english

File:

PDF, 119 KB

english, 2005

100

Synthesis and Structure−Activity Relationships of 6-Substituted Androst-4-ene Analogs as Aromatase Inhibitors

Numazawa, Mitsuteru, Kamiyama, Takayuki, Tachibana, Mii, Oshibe, Mariko

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 261 KB

english, 1996