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1

Reduction−Alkylation Strategies for the Modification of Specific Monoclonal Antibody Disulfides

Sun, Michael M. C., Beam, Kevin S., Cerveny, Charles G., Hamblett, Kevin J., Blackmore, Richard S., Torgov, Michael Y., Handley, Felicia G. M., Ihle, Nathan C., Senter, Peter D., Alley, Stephen C.

Journal:

Bioconjugate Chemistry

Year:

2005

Language:

english

File:

PDF, 282 KB

english, 2005

2

Nickel-catalyzed intramolecular [4+4] cycloadditions. 4. Enantioselective total synthesis of (+)-asteriscanolide

Wender, Paul A., Ihle, Nathan C., Correia, Carlos R. D.

Journal:

Journal of the American Chemical Society

Year:

1988

Language:

english

File:

PDF, 447 KB

english, 1988

3

ChemInform Abstract: Nicotinamide N-Oxides as CXCR2 Antagonists.

Neil S. Cutshall, Rocky Ursino, Kristin A. Kucera, John Latham, Nathan C. Ihle

Journal:

Year:

2001

File:

PDF, 30 KB

2001

4

Nicotinanilides as Inhibitors of Neutrophil Chemotaxis.

Neil S. Cutshall, Kristin A. Kucera, Rocky Ursino, John Latham, Nathan C. Ihle

Journal:

Year:

2002

File:

PDF, 26 KB

2002

5

Nickel-catalyzed intramolecular [4+4] cycloadditions: 2. Allylic stereoinduction and modelling studies in the preparation of bicyclo[6.4.0]dodecadienes

Paul A. Wender, Nathan C. Ihle

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 249 KB

english, 1987

6

Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors

Melissa S Egbertson, Bohumil Bednar, Ben C Askew, Rodney A Bednar, Karen Brashear, Michael J Breslin, Mark E Duggan, Thorsten E Fisher, Wasyl Halczenko, John H Hutchinson, Nathan Ihle, John D Prugh, J

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 174 KB

english, 2000

7

Nicotinamide N-Oxides as CXCR2 antagonists

Neil S Cutshall, Rocky Ursino, Kristin A Kucera, John Latham, Nathan C Ihle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 141 KB

english, 2001

8

Nonpeptide αvβ3 antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide

Robert S. Meissner, James J. Perkins, Le T. Duong, George D. Hartman, William F. Hoffman, Joel R. Huff, Nathan C. Ihle, Chih-Tai Leu, Rose M. Nagy, Adel Naylor-Olsen, Gideon A. Rodan, Sevgi B. Rodan,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 138 KB

english, 2002

9

Nicotinanilides as inhibitors of neutrophil chemotaxis

Neil S. Cutshall, Kristin A. Kucera, Rocky Ursino, John Latham, Nathan C. Ihle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 126 KB

english, 2002

10

The skin and hair as surrogate tissues for measuring the target effect of inhibitors of phosphoinositide-3-kinase signaling

Ryan Williams, Amanda F. Baker, Nathan T. Ihle, Ashley R. Winkler, Lynn Kirkpatrick, Garth Powis

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2006

Language:

english

File:

PDF, 340 KB

english, 2006

11

Pharmacokinetics and Pharmacodynamics of L-703,014, a Potent Fibrinogen Receptor Antagonist, After Intravenous and Oral Administration in the Dog

Jeffrey S. Barrett, Robert J. Gould, Joan D. Ellis, Marie M. Holahan, Maria T. Stranieri, Joseph J. Lynch, George D. Hartman, Nathan Ihle, Mark Duggan, Ofir A. Moreno, Anthony D. Theoharides

Journal:

Pharmaceutical Research

Year:

1994

File:

PDF, 893 KB

1994

12

Inhibitors of phosphatidylinositol-3-kinase in cancer therapy

Nathan T. Ihle, Garth Powis

Journal:

Molecular Aspects of Medicine

Year:

2010

Language:

english

File:

PDF, 495 KB

english, 2010

13

Nickel-catalyzed intramolecular [4 + 4]-cycloadditions: a new method for the synthesis of polycycles containing eight-membered rings

Wender, Paul A., Ihle, Nathan C.

Journal:

Journal of the American Chemical Society

Year:

1986

Language:

english

File:

PDF, 322 KB

english, 1986

14

Preparation of 4-Alkyl-2-[ N -( tert -butoxycarbonyl)amino]pyridines by Alkylation, Nucleophilic Addition, and Acylation of 2-[ N -( tert -Butoxycarbonyl)amino]-4-picoline 1

Ihle, Nathan C., Krause, Amy E.

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 103 KB

english, 1996

15

Nonpeptide α v β 3 Antagonists. 1. Transformation of a Potent, Integrin-Selective α IIb β 3 Antagonist into a Potent α v β 3 Antagonist

Duggan, Mark E., Duong, Le T., Fisher, John E., Hamill, Terence G., Hoffman, William F., Huff, Joel R., Ihle, Nathan C., Leu, Chih-Tai, Nagy, Rose M., Perkins, James J., Rodan, Sevgi B., Wesolowski, G

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 243 KB

english, 2000

16

Non-Peptide Fibrinogen Receptor Antagonists. 7. Design and Synthesis of a Potent, Orally Active Fibrinogen Receptor Antagonist

Duggan, Mark E., Naylor-Olsen, Adel M., Perkins, James J., Anderson, Paul S., Chang, Charles T.-C., Cook, Jacquelynn J., Gould, Robert J., Ihle, Nathan C., Hartman, George D.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.66 MB

english, 1995

17

Palladium-catalyzed intramolecular alkyne-carbon monoxide-alkene insertion cascade for synthesis of .alpha.-methylenecyclopentenones

Ihle, Nathan C., Heathcock, Clayton H.

Journal:

Journal of Organic Chemistry

Year:

1993

Language:

english

File:

PDF, 526 KB

english, 1993

18

Inhibiting PI-3-K for glioma therapy

Powis, Garth, Ihle, Nathan T., Yung, W.K. Alfred

Journal:

Year:

2009

Language:

english

File:

PDF, 329 KB

english, 2009

19

Outlier analysis of functional genomic profiles enriches for oncology targets and enables precision medicine

Zhu, Zhou, Ihle, Nathan T., Rejto, Paul A., Zarrinkar, Patrick P.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.13 MB

english, 2016

20

The Pten-Parkin Axis: At the Nexus of Cancer and Neurodegeneration

Ihle, Nathan T., Abraham, Robert T.

Journal:

Year:

2017

Language:

english

File:

PDF, 552 KB

english, 2017

21

Control Strategy for Small Molecule Impurities in Antibody-Drug Conjugates

Gong, Hai H., Ihle, Nathan, Jones, Michael T., Kelly, Kathleen, Kott, Laila, Raglione, Thomas, Whitlock, Scott, Zhang, Qunying, Zheng, Jie

Journal:

AAPS PharmSciTech

Year:

2018

Language:

english

File:

PDF, 513 KB

english, 2018

22

An inhibitor of the pleckstrin homology domain of CNK1 selectively blocks the growth of mutant KRAS cells and tumors

Indarte, Martin, Puentes, Roisin, Maruggi, Marco, Ihle, Nathan T., Grandjean, Geoffrey, Scott, Michael, Ahmed, Zamal, Meuillet, Emmanuelle J., Zhang, Shuxing, Lemos, Robert, Du-Cuny, Lei, Layng, Fabia

Journal:

Cancer Research

Year:

2019

Language:

english

File:

PDF, 1.82 MB

english, 2019

23

An inhibitor of the pleckstrin homology domain of CNK1 selectively blocks the growth of mutant KRAS cells and tumors

Indarte, Martin, Puentes, Roisin, Maruggi, Marco, Ihle, Nathan T., Grandjean, Geoffrey, Scott, Michael, Ahmed, Zamal, Meuillet, Emmanuelle J., Zhang, Shuxing, Lemos, Robert, Du-Cuny, Lei, Layng, Fabia

Journal:

Cancer Research

Year:

2019

File:

PDF, 1.82 MB

2019

24

Correction: An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors

Indarte, Martin, Puentes, Roisin, Maruggi, Marco, Ihle, Nathan T., Grandjean, Geoffrey, Scott, Michael, Ahmed, Zamal, Meuillet, Emmanuelle J., Zhang, Shuxing, Lemos, Robert, Du-Cuny, Lei, Layng, Fabia

Journal:

Cancer Research

Year:

2019

File:

PDF, 156 KB

2019

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