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51

Malondialdehyde, a Product of Lipid Peroxidation, Is Mutagenic in Human Cells

Niedernhofer, L. J., Daniels, J. S., Rouzer, C. A., Greene, R. E., Marnett, L. J.

Journal:

Journal of Biological Chemistry

Year:

2003

Language:

english

File:

PDF, 221 KB

english, 2003

52

Deoxyhexanucleotide containing a vinyl chloride induced DNA lesion, 1,N6-ethenoadenine: synthesis, physical characterization, and incorporation into a duplex bacteriophage M13 genome as part of an amber codon

Basu, Ashis K., Niedernhofer, Laura J., Essigmann, John M.

Journal:

Year:

1987

Language:

english

File:

PDF, 1.76 MB

english, 1987

53

Choline phosphate cytidylyltransferase-α is a novel antigen detected by the anti-ERCC1 antibody 8F1 with biomarker value in patients with lung and head and neck squamous cell carcinomas

Vaezi, Alec E., Bepler, Gerold, Bhagwat, Nikhil R., Malysa, Agnes, Rubatt, Jennifer M., Chen, Wei, Hood, Brian L., Conrads, Thomas P., Wang, Lin, Kemp, Carolyn E., Niedernhofer, Laura J.

Journal:

Year:

2014

Language:

english

File:

PDF, 635 KB

english, 2014

54

Tet-Mediated Formation of 5-Hydroxymethylcytosine in RNA

Fu, Lijuan, Guerrero, Candace R., Zhong, Na, Amato, Nicholas J., Liu, Yunhua, Liu, Shuo, Cai, Qian, Ji, Debin, Jin, Seung-Gi, Niedernhofer, Laura J., Pfeifer, Gerd P., Xu, Guo-Liang, Wang, Yinsheng

Journal:

Journal of the American Chemical Society

Year:

2014

Language:

english

File:

PDF, 701 KB

english, 2014

55

Advances in Understanding the Complex Mechanisms of DNA Interstrand Cross-Link Repair

Clauson, C., Scharer, O. D., Niedernhofer, L.

Journal:

Cold Spring Harbor Perspectives in Biology

Year:

2013

Language:

english

File:

PDF, 1.12 MB

english, 2013

56

Temperature-Dependent Formation of a Conjugate between Tris(hydroxymethyl)aminomethane Buffer and the Malondialdehyde−DNA Adduct Pyrimidopurinone

Niedernhofer, Laura J., Riley, Michael, Schnetz-Boutaud, Nathalie, Sanduwaran, Geeganage, Chaudhary, Ajai K., Reddy, G. Ramachandra, Marnett, Lawrence J.

Journal:

Chemical Research in Toxicology

Year:

1997

Language:

english

File:

PDF, 332 KB

english, 1997

57

Dedifferentiation rescues senescence of progeria cells but only while pluripotent

Laura J Niedernhofer,Joseph C Glorioso,Paul D Robbins

Journal:

Stem Cell Research & Therapy

Year:

2011

Language:

english

File:

PDF, 340 KB

english, 2011

58

DNA damage drives accelerated bone aging via an NF- κ B-dependent mechanism

Chen, Qian, Liu, Kai, Robinson, Andria R, Clauson, Cheryl L, Blair, Harry C, Robbins, Paul D, Niedernhofer, Laura J, Ouyang, Hongjiao

Journal:

Journal of Bone and Mineral Research

Year:

2013

Language:

english

File:

PDF, 6.81 MB

english, 2013

59

An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints

Vo, Nam, Niedernhofer, Laura J., Nasto, Luigi Aurelio, Jacobs, Lloydine, Robbins, Paul D., Kang, James, Evans, Christopher H.

Journal:

Journal of Orthopaedic Research

Year:

2013

Language:

english

File:

PDF, 99 KB

english, 2013

60

Age-related dystrophic changes in corneal endothelium from DNA repair-deficient mice

Roh, Danny S., Du, Yiqin, Gabriele, Michelle L., Robinson, Andria R., Niedernhofer, Laura J., Funderburgh, James L.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.06 MB

english, 2013

61

Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration

Nasto, Luigi A., Robinson, Andria R., Ngo, Kevin, Clauson, Cheryl L., Dong, Qing, St. Croix, Claudette, Sowa, Gwendolyn, Pola, Enrico, Robbins, Paul D., Kang, James, Niedernhofer, Laura J., Wipf, Pete

Journal:

Journal of Orthopaedic Research

Year:

2013

Language:

english

File:

PDF, 1.56 MB

english, 2013

62

Hyper telomere recombination accelerates replicative senescence and may promote premature aging

Hagelstrom, R. T., Blagoev, K. B., Niedernhofer, L. J., Goodwin, E. H., Bailey, S. M.

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 820 KB

english, 2010

63

The Structure-Specific Endonuclease Ercc1-Xpf Is Required To Resolve DNA Interstrand Cross-Link-Induced Double-Strand Breaks

Niedernhofer, L. J., Odijk, H., Budzowska, M., van Drunen, E., Maas, A., Theil, A. F., de Wit, J., Jaspers, N. G. J., Beverloo, H. B., Hoeijmakers, J. H. J., Kanaar, R.

Journal:

Molecular and Cellular Biology

Year:

2004

Language:

english

File:

PDF, 704 KB

english, 2004

64

Endogenous formation and repair of oxidatively induced G[8-5 m]T intrastrand cross-link lesion

Wang, J., Cao, H., You, C., Yuan, B., Bahde, R., Gupta, S., Nishigori, C., Niedernhofer, L. J., Brooks, P. J., Wang, Y.

Journal:

Nucleic Acids Research

Year:

2012

Language:

english

File:

PDF, 403 KB

english, 2012

65

Comparison of mice with accelerated aging caused by distinct mechanisms

Gurkar, Aditi U., Niedernhofer, Laura J.

Journal:

Experimental Gerontology

Year:

2015

Language:

english

File:

PDF, 414 KB

english, 2015

66

XPF Expression Correlates with Clinical Outcome in Squamous Cell Carcinoma of the Head and Neck

Vaezi, A., Wang, X., Buch, S., Gooding, W., Wang, L., Seethala, R. R., Weaver, D. T., D'Andrea, A. D., Argiris, A., Romkes, M., Niedernhofer, L. J., Grandis, J. R.

Journal:

Clinical Cancer Research

Year:

2011

Language:

english

File:

PDF, 818 KB

english, 2011

67

Immunodetection of DNA Repair Endonuclease ERCC1-XPF in Human Tissue

Bhagwat, N. R., Roginskaya, V. Y., Acquafondata, M. B., Dhir, R., Wood, R. D., Niedernhofer, L. J.

Journal:

Cancer Research

Year:

2009

Language:

english

File:

PDF, 704 KB

english, 2009

68

Validation of ERCC1-XPF Immunodetection - Response

Niedernhofer, L. J., Bhagwat, N. R., Wood, R. D.

Journal:

Cancer Research

Year:

2010

Language:

english

File:

PDF, 53 KB

english, 2010

69

Pharmacologic IKK/NF-κB inhibition causes antigen presenting cells to undergo TNFα dependent ROS-mediated programmed cell death

Tilstra, Jeremy S., Gaddy, Daniel F., Zhao, Jing, Davé, Shaival H., Niedernhofer, Laura J., Plevy, Scott E., Robbins, Paul D.

Journal:

Scientific Reports

Year:

2014

Language:

english

File:

PDF, 4.55 MB

english, 2014

70

The XPA-binding domain of ERCC1 Is Required for Nucleotide Excision Repair but Not Other DNA Repair Pathways

Orelli, B., McClendon, T. B., Tsodikov, O. V., Ellenberger, T., Niedernhofer, L. J., Scharer, O. D.

Journal:

Journal of Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 1.76 MB

english, 2010

71

ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair

Ahmad, A., Robinson, A. R., Duensing, A., van Drunen, E., Beverloo, H. B., Weisberg, D. B., Hasty, P., Hoeijmakers, J. H. J., Niedernhofer, L. J.

Journal:

Molecular and Cellular Biology

Year:

2008

Language:

english

File:

PDF, 492 KB

english, 2008

72

Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders

Choi, Siwon, Wang, Wei, Ribeiro, Alexandrew J.S., Kalinowski, Agnieszka, Gregg, Siobhan Q., Opresko, Patricia L., Niedernhofer, Laura J., Rohde, Gustavo K., Dahl, Kris Noel

Journal:

Nucleus (Landes Bioscience)

Year:

2011

Language:

english

File:

PDF, 2.17 MB

english, 2011

73

XPF-ERCC1 Participates in the Fanconi Anemia Pathway of Cross-Link Repair

Bhagwat, N., Olsen, A. L., Wang, A. T., Hanada, K., Stuckert, P., Kanaar, R., D'Andrea, A., Niedernhofer, L. J., McHugh, P. J.

Journal:

Molecular and Cellular Biology

Year:

2009

Language:

english

File:

PDF, 2.42 MB

english, 2009

74

Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms

Schumacher, Björn, van der Pluijm, Ingrid, Moorhouse, Michael J., Kosteas, Theodore, Robinson, Andria Rasile, Suh, Yousin, Breit, Timo M., van Steeg, Harry, Niedernhofer, Laura J., van IJcken, Wilfred

Journal:

Year:

2008

Language:

english

File:

PDF, 644 KB

english, 2008

75

Simultaneous Quantification of Methylated Cytidine and Adenosine in Cellular and Tissue RNA by Nano-Flow Liquid Chromatography–Tandem Mass Spectrometry Coupled with the Stable Isotope-Dilution Method

Fu, Lijuan, Amato, Nicholas J., Wang, Pengcheng, McGowan, Sara J., Niedernhofer, Laura J., Wang, Yinsheng

Journal:

Analytical Chemistry

Year:

2015

Language:

english

File:

PDF, 786 KB

english, 2015

76

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California - ()] C109. EFFECTS OF SENESCENCE AND MANIFESTATIONS OF AGING IN THE LUNG - Defective DNA Repair On The Ercc1-/Mice Causes Accelerated Aging And Increased Susceptibility To Lung Injury And Fibrosis

Bustos, Martha L., Bueno, Marta, Robison, a, Sciurba, Joseph, Mroz, L, Niedernhofer, L, Mora, Ana L., Kaminski, N, Rojas, Mauricio

Year:

2012

Language:

english

File:

PDF, 20 KB

english, 2012

77

NF-κB Negatively Impacts the Myogenic Potential of Muscle-derived Stem Cells

Lu, Aiping, Proto, Jonathan D, Guo, Lulin, Tang, Ying, Lavasani, Mitra, Tilstra, Jeremy S, Niedernhofer, Laura J, Wang, Bing, Guttridge, Denis C, Robbins, Paul D, Huard, Johnny

Journal:

Molecular Therapy

Year:

2012

Language:

english

File:

PDF, 639 KB

english, 2012

78

The Geropathology Research Network: An Interdisciplinary Approach for Integrating Pathology Into Research on Aging

Ladiges, Warren, Ikeno, Yuji, Niedernhofer, Laura, McIndoe, Richard A., Ciol, Marcia A., Ritchey, Jerry, Liggitt, Denny

Journal:

The Journals of Gerontology Series A Biological Sciences and Medical Sciences

Year:

2015

Language:

english

File:

PDF, 835 KB

english, 2015

79

In vivo detection and replication studies of α-anomeric lesions of 2′-deoxyribonucleosides

Amato, Nicholas J., Zhai, Qianqian, Navarro, Diana C., Niedernhofer, Laura J., Wang, Yinsheng

Journal:

Nucleic Acids Research

Year:

2015

Language:

english

File:

PDF, 3.86 MB

english, 2015

80

mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging

Takayama, Koji, Kawakami, Yohei, Lavasani, Mitra, Mu, Xiaodong, Cummins, James H, Yurube, Takashi, Kuroda, Ryosuke, Kurosaka, Masahiro, Fu, Freddie H, Robbins, Paul D., Niedernhofer, Laura J., Huard,

Journal:

Journal of Orthopaedic Research

Year:

2016

Language:

english

File:

PDF, 1.07 MB

english, 2016

81

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms: Table 1.

Burd, Christin E., Gill, Matthew S., Niedernhofer, Laura J., Robbins, Paul D., Austad, Steven N., Barzilai, Nir, Kirkland, James L.

Journal:

The Journals of Gerontology Series A Biological Sciences and Medical Sciences

Year:

2016

Language:

english

File:

PDF, 628 KB

english, 2016

82

MOLECULAR PATHOLOGY ENDPOINTS USEFUL FOR AGING STUDIES

Niedernhofer, L.J., Kirkland, J.L., Ladiges, W.

Journal:

Ageing Research Reviews

Year:

2016

Language:

english

File:

PDF, 616 KB

english, 2016

83

Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage

Yu, Yang, Cui, Yuxiang, Niedernhofer, Laura J., Wang, Yinsheng

Journal:

Chemical Research in Toxicology

Year:

2016

Language:

english

File:

PDF, 1.72 MB

english, 2016

84

Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism

Flores, Rafael R., Clauson, Cheryl L., Cho, Joonseok, Lee, Byeong-Chel, McGowan, Sara J., Baker, Darren J., Niedernhofer, Laura J., Robbins, Paul D.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.09 MB

english, 2017

85

Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype

Ngo, Kevin, Patil, Prashanti, McGowan, Sara J., Niedernhofer, Laura J., Robbins, Paul D., Kang, James, Sowa, Gwendolyn, Vo, Nam

Journal:

Mechanisms of Ageing and Development

Year:

2017

Language:

english

File:

PDF, 1.03 MB

english, 2017

86

Progressive Enzephalomyelitis mit Rigidität und Myoklonus; Progressive encephalomyelitis with rigidity and myoclonus;

Niedernhöfer, P., Schwabe, J., Seidel, G.

Journal:

Year:

2017

Language:

german

File:

PDF, 142 KB

german, 2017

87

Oxidation Products of 5-Methyl Cytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice

Zarakowska, Ewelina, Czerwinska, Jolanta, Tupalska, Agnieszka, Yousefzadeh, Matt J, Gregg, Siobhán Q, St. Croix, Claudette M, Niedernhofer, Laura J, Foksinski, Marek, Gackowski, Daniel, Szpila, Anna,

Journal:

The Journals of Gerontology Series A Biological Sciences and Medical Sciences

Year:

2018

Language:

english

File:

PDF, 875 KB

english, 2018

88

Neurodegeneration as the presenting symptom in 2 adults with xeroderma pigmentosum complementation group F

Shanbhag, Niraj M., Geschwind, Michael D., DiGiovanna, John J., Groden, Catherine, Godfrey, Rena, Yousefzadeh, Matthew J., Wade, Erin A., Niedernhofer, Laura J., Malicdan, May Christine V., Kraemer, K

Journal:

Neurology: Genetics

Year:

2018

Language:

english

File:

PDF, 507 KB

english, 2018

89

SAE Technical Paper Series [SAE International 1969 International Automotive Engineering Congress and Exposition - (JAN. 13, 1969)] SAE Technical Paper Series - Tomorrow - The Federal Government and Restraint Systems

Niedernhofer, Dean F., Carter, Robert L.

Year:

1969

Language:

english

File:

PDF, 650 KB

english, 1969

90

Modeling Alzheimer’s disease in progeria mice. An age-related concept

Sharma, Kavita, Darvas, Martin, Keene, C. Dirk, Niedernhofer, Laura J., Ladiges, Warren

Journal:

Pathobiology of Aging & Age-related Diseases

Year:

2018

Language:

english

File:

PDF, 848 KB

english, 2018

91

Age-dependent changes in intervertebral disc cell mitochondria and bioenergetics

Hartman, R, Patil, P, Tisherman, R, St. Croix, C, Niedernhofer, LJ, Robbins, PD, Ambrosio, F, Van Houten, B, Sowa, G, Vo, N

Journal:

European Cells and Materials

Year:

2018

Language:

english

File:

PDF, 1.89 MB

english, 2018

92

Cellular Senescence in Intervertebral Disc Aging and Degeneration

Patil, Prashanti, Niedernhofer, Laura J., Robbins, Paul D., Lee, Joon, Sowa, Gwendolyn, Vo, Nam

Journal:

Current Molecular Biology Reports

Year:

2018

Language:

english

File:

PDF, 491 KB

english, 2018

93

DNA DAMAGE: THE MOST STALWART PILLAR OF AGING

Niedernhofer, L J

Journal:

Innovation in Aging

Year:

2018

Language:

english

File:

PDF, 83 KB

english, 2018

94

ERCC1 and XRCC1 as biomarkers for lung and head and neck cancer

Vaezi,, Niedernhofer, Laura, Feldman,

Journal:

Pharmacogenomics and Personalized Medicine

Year:

2011

Language:

english

File:

PDF, 681 KB

english, 2011

95

Systemic clearance of p16 INK4a ‐positive senescent cells mitigates age‐associated intervertebral disc degeneration

Patil, Prashanti, Dong, Qing, Wang, Dong, Chang, Jianhui, Wiley, Christopher, Demaria, Marco, Lee, Joon, Kang, James, Niedernhofer, Laura J., Robbins, Paul D., Sowa, Gwendolyn, Campisi, Judith, Zhou,

Journal:

Year:

2019

Language:

english

File:

PDF, 1.84 MB

english, 2019

96

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Fuhrmann-Stroissnigg, Heike, Santiago, Fernando E., Grassi, Diego, Ling, YuanYuan, Niedernhofer, Laura J., Robbins, Paul D.

Journal:

Journal of Visualized Experiments

Year:

2019

Language:

english

File:

PDF, 764 KB

english, 2019

97

Creating the Next Generation of Translational Geroscientists

Newman, John C., Sokoloski, Julie L., Robbins, Paul D., Niedernhofer, Laura J., Reed, May J., Wei, Jeanne, Austad, Steven N., Barzilai, Nir, Cohen, Harvey Jay, Kuchel, George A., Kirkland, James L., P

Journal:

Journal of the American Geriatrics Society

Year:

2019

Language:

english

File:

PDF, 346 KB

english, 2019

98

Creating the Next Generation of Translational Geroscientists

Newman, John C., Sokoloski, Julie L., Robbins, Paul D., Niedernhofer, Laura J., Reed, May J., Wei, Jeanne, Austad, Steven N., Barzilai, Nir, Cohen, Harvey Jay, Kuchel, George A., Kirkland, James L., P

Journal:

Journal of the American Geriatrics Society

Year:

2019

File:

PDF, 346 KB

2019

99

Urinary Extracellular Vesicles Carrying Klotho Improve the Recovery of Renal Function in an Acute Tubular Injury Model

Grange, Cristina, Papadimitriou, Elli, Dimuccio, Veronica, Pastorino, Cecilia, Molina, Jordi, O’Kelly, Ryan, Niedernhofer, Laura J., Robbins, Paul D., Camussi, Giovanni, Bussolati, Benedetta

Journal:

Molecular Therapy

Year:

2019

File:

PDF, 3.99 MB

2019

100

Attenuation of ataxia telangiectasia mutated signalling mitigates ageâassociated intervertebral disc degeneration

Han, Yingchao, Zhou, ChaoâMing, Shen, Hongxing, Tan, Jun, Dong, Qing, Zhang, Lei, McGowan, Sara J., Zhao, Jing, Sowa, Gwendolyn A., Kang, James D., Niedernhofer, Laura J., Robbins, Paul D., Vo, Nam

Journal:

Year:

2020

File:

PDF, 2.35 MB

2020

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