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1

β-Deuteration of N -nitrosoethylmethylamine causes a shift in DNA methylation from rat liver to esophagus

von Hofe, Eric, Schmerold, Ivo, Nims, Raymond W., Keefer, Larry K., Reist, Elmer J., Kleihues, Paul

Journal:

Year:

1991

Language:

english

File:

PDF, 483 KB

english, 1991

2

ICH Quality Guidelines (An Implementation Guide) || ICH M7

Teasdale, Andrew, Elder, David, Nims, Raymond W.

Year:

2017

Language:

english

File:

PDF, 242 KB

english, 2017

3

ICH Quality Guidelines (An Implementation Guide) || Impurities in New Drug Substances and New Drug Products

Teasdale, Andrew, Elder, David, Nims, Raymond W.

Year:

2017

Language:

english

File:

PDF, 253 KB

english, 2017

4

Sensitivity of isoenzyme analysis for the detection of interspecies cell line cross-contamination

Raymond W. Nims, Adam P. Shoemaker, Marcie A. Bauernschub, Laura J. Rec, John W. Harbell

Journal:

In Vitro Cellular & Developmental Biology - Animal

Year:

1998

Language:

english

File:

PDF, 1.31 MB

english, 1998

5

Induction of hepatic cytochrome P-450 mediated alkoxyresorufin O-dealkylase activities in different species by prototype P-450 inducers

Ronald A. Lubet, Jia-Lin Syi, Judd O. Nelson, Raymond W. Nims

Journal:

Chemico-Biological Interactions

Year:

1990

Language:

english

File:

PDF, 891 KB

english, 1990

6

Cytochrome P450 induction in feral Cricetid rodents: a review of field and laboratory investigations

Charles W Qualls Jr., Ronald A. Lubet, Robert L Lochmiller, Chandikumar S Elangbam, James W. Lish, Raymond W Nims

Journal:

Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology

Year:

1998

Language:

english

File:

PDF, 149 KB

english, 1998

7

Best practices for the use and evaluation of animal serum as a component of cell culture medium

Nims, Raymond W., Harbell, John W.

Journal:

In Vitro Cellular & Developmental Biology - Animal

Year:

2017

Language:

english

File:

PDF, 4.10 MB

english, 2017

8

Best practices in cell culture: an overview

Baust, John M., Buehring, Gertrude Case, Campbell, Lia, Elmore, Eugene, Harbell, John W., Nims, Raymond W., Price, Paul, Reid, Yvonne A., Simione, Frank

Journal:

In Vitro Cellular & Developmental Biology - Animal

Year:

2017

Language:

english

File:

PDF, 343 KB

english, 2017

9

ICH Quality Guidelines (An Implementation Guide) || Q8(R2)

Teasdale, Andrew, Elder, David, Nims, Raymond W.

Year:

2017

Language:

english

File:

PDF, 594 KB

english, 2017

10

ICH Quality Guidelines (An Implementation Guide) || ICH Q3D Elemental Impurities

Teasdale, Andrew, Elder, David, Nims, Raymond W.

Year:

2017

Language:

english

File:

PDF, 541 KB

english, 2017

11

ICH Quality Guidelines (An Implementation Guide) || ICH Q6B Specifications

Teasdale, Andrew, Elder, David, Nims, Raymond W.

Year:

2017

Language:

english

File:

PDF, 240 KB

english, 2017

12

ICH Quality Guidelines (An Implementation Guide) || ICH Q10 Quality Systems

Teasdale, Andrew, Elder, David, Nims, Raymond W.

Year:

2017

Language:

english

File:

PDF, 347 KB

english, 2017

13

ICH Quality Guidelines (An Implementation Guide) || Index

Teasdale, Andrew, Elder, David, Nims, Raymond W.

Year:

2017

Language:

english

File:

PDF, 130 KB

english, 2017

14

Best practices for detecting and mitigating the risk of cell culture contaminants

Nims, Raymond W., Price, Paul J.

Journal:

In Vitro Cellular & Developmental Biology - Animal

Year:

2017

Language:

english

File:

PDF, 1.70 MB

english, 2017

15

Best practices for authenticating cell lines

Nims, Raymond W., Reid, Yvonne

Journal:

In Vitro Cellular & Developmental Biology - Animal

Year:

2017

Language:

english

File:

PDF, 4.05 MB

english, 2017

16

Assessment of a respiratory face mask for capturing air pollutants and pathogens including human influenza and rhinoviruses

Zhou, S. Steve, Lukula, Salimatu, Chiossone, Cory, Nims, Raymond W., Suchmann, Donna B., Ijaz, M. Khalid

Journal:

Journal of Thoracic Disease

Year:

2018

Language:

english

File:

PDF, 1.96 MB

english, 2018

17

Effectiveness of Dettol Antiseptic Liquid for Inactivation of Ebola Virus in Suspension

Cutts, Todd A., Ijaz, M. Khalid, Nims, Raymond W., Rubino, Joseph R., Theriault, Steven S.

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 1.26 MB

english, 2019

18

Overview of the nonclinical quality and toxicology testing for recombinant biopharmaceuticals produced in mammalian cells

Hervé Lebrec, Padma Narayanan, Raymond Nims

Journal:

Journal of Applied Toxicology

Year:

2010

Language:

english

File:

PDF, 553 KB

english, 2010

19

Overview of the nonclinical quality and toxicology testing for recombinant biopharmaceuticals produced in mammalian cells

Hervé Lebrec, Padma Narayanan, Raymond Nims

Journal:

Journal of Applied Toxicology

Year:

2011

File:

PDF, 29 KB

2011

20

Hepatic cytochrome P450 2B induction by ethyl/ phenyl-substituted congeners of phenobarbital in the B6C3F1 mouse

Dr. Raymond W. Nims, Ronald A. Lubet, Bhalchandra A. Diwan, Donna W. Mellini, William E. Utermahlen Jr., Paul E. Thomas

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

1994

Language:

english

File:

PDF, 930 KB

english, 1994

21

Absence of enantioselectivity in the pharmacodynamics of P450 2B induction by 5-ethyl-5-phenylhydantoin in the male rat liver or in cultured rat hepatocytes

Dr. Raymond W. Nims, Jaspreet S. Sidhu, Paul E. Thomas, Donna W. Mellini, Victor C. Nelson, Curtis J. Omiecinski, Ronald A. Lubet

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

1994

Language:

english

File:

PDF, 1007 KB

english, 1994

22

Convenient Colorimetric and Fluorometric Assays for S-Nitrosothiols

John A. Cook, Sungmee Y. Kim, Diane Teague, Murali C. Krishna, Roberto Pacelli, James B. Mitchell, Yoram Vodovotz, Raymond W. Nims, Danae Christodoulou, Allen M. Miles, Matthew B. Grisham, David A. Wi

Journal:

Analytical Biochemistry

Year:

1996

Language:

english

File:

PDF, 180 KB

english, 1996

23

Extraction, stability, and quantitation of ellagic acid in various fruits and nuts

Elaine M. Daniel, Alexander S. Krupnick, Young-Hun Heur, Jane A. Blinzler, Raymond W. Nims, Gary D. Stoner

Journal:

Journal of Food Composition and Analysis

Year:

1989

Language:

english

File:

PDF, 724 KB

english, 1989

24

Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins: A chemical discussion of the differential biological effects of these redox related products of NOS

Katrina M. Miranda, Raymond W. Nims, Douglas D. Thomas, Michael G. Espey, Deborah Citrin, Michael D. Bartberger, Nazareno Paolocci, Jon M. Fukuto, Martin Feelisch, David A. Wink

Journal:

Journal of Inorganic Biochemistry

Year:

2003

Language:

english

File:

PDF, 500 KB

english, 2003

25

Induction of hepatic CYP1A activity as a biomarker for environmental exposure to Aroclor®1254 in feral rodents

Ronald A. Lubet, Raymond W. Nims, Lisa E. Beebe, Stephen D. Fox, Haleem J. Issaq, Karen McBee

Journal:

Archives of Environmental Contamination and Toxicology

Year:

1992

Language:

english

File:

PDF, 767 KB

english, 1992

26

The induction of alkoxyresorufin metabolism: A potential indicator of environmental contamination

Ronald A. Lubet, F. Peter Guengerich, Raymond W. Nims

Journal:

Archives of Environmental Contamination and Toxicology

Year:

1990

Language:

english

File:

PDF, 737 KB

english, 1990

27

Chemical enhancement of simian adenovirus SA7 oncogenic transformation of Syrian golden hamster embryo (SHE) cells

Ronald A. Lubet, Leonard M. Schechtman, Edith Kiss, Raymond W. Nims

Journal:

Methods in Cell Science

Year:

1986

Language:

english

File:

PDF, 710 KB

english, 1986

28

Toxicokinetics ofN-nitrosodimethylamine in the Syrian golden hamster

Anthony J. Streeter, Raymond W. Nims, Priscilla P. Wu, Daniel L. Logsdon

Journal:

Archives of Toxicology

Year:

1990

Language:

english

File:

PDF, 507 KB

english, 1990

29

Single-dose toxicokinetics ofN-nitrosomethylethylamine andN-nitrosomethyl (2,2,2-trideuterioethyl)amine in the rat

Anthony J. Streeter, Raymond W. Nims, Lucy M. Anderson, Young-Hun Heur, Eric von Hofe, Paul Kleihues, Victor C. Nelson, Bruce A. Mico, Larry K. Keefer

Journal:

Archives of Toxicology

Year:

1990

Language:

english

File:

PDF, 758 KB

english, 1990

30

Effects of the oxazolidinedione anticonvulsants trimethadione and dimethadione and the barbiturate homolog 5,5-dimethylbarbituric acid onN-nitrosodiethylamine-initiated renal and hepatic carcinogenesis in the F344/NCr rat

Bhalchandra A. Diwan, Raymond W. Nims, John R. Henneman, Jerrold M. Ward, Ronald A. Lubet, Jerry M. Rice

Journal:

Archives of Toxicology

Year:

1992

Language:

english

File:

PDF, 2.25 MB

english, 1992

31

Short tandem repeat profiling: part of an overall strategy for reducing the frequency of cell misidentification

Raymond W. Nims, Greg Sykes, Karin Cottrill, Pranvera Ikonomi, Eugene Elmore

Journal:

In Vitro Cellular & Developmental Biology - Animal

Year:

2010

Language:

english

File:

PDF, 392 KB

english, 2010

32

Preferential activation of 6-aminochrysene and 2-aminoanthracene to mutagenic moieties by different forms of cytochrome P450 in hepatic 9000 × g supernatants from the rat

Ronald A. Lubet, Cindy E. McKinney, John W. Cameron, F. Peter Guengerich, Raymond W. Nims

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1989

Language:

english

File:

PDF, 819 KB

english, 1989

33

Induction of cytochrome P450 and other drug metabolizing enzymes in rat liver following dietary exposure to Aroclor 1254

Ronald A. Lubet, Collins R. Jones, Diana L. Stockus, Stephen D. Fox, Raymond W. Nims

Journal:

Toxicology and Applied Pharmacology

Year:

1991

Language:

english

File:

PDF, 945 KB

english, 1991

34

Measurement of cytochrome P-450 dependent dealkylation of alkoxy-phenoxazones in hepatic S9s and hepatocyte homogenates: effects of dicumarol

Ronald A. Lubet, Raymond W. Nims, Richard T. Mayer, John W. Cameron, Leonard M. Schechtman

Journal:

Mutation Research Letters

Year:

1985

Language:

english

File:

PDF, 343 KB

english, 1985

35

Root cause investigation of a viral contamination incident occurred during master cell bank (MCB) testing and characterization – A case study

Dayue Chen, Raymond Nims, Sandra Dusing, Pamela Miller, Wen Luo, Michelle Quertinmont, Bhavin Parekh, Josh Poorbaugh, Jeri Ann Boose, E. Morrey Atkinson

Journal:

Year:

2008

Language:

english

File:

PDF, 518 KB

english, 2008

36

Gamma irradiation of animal sera for inactivation of viruses and mollicutes – A review

Raymond W. Nims, Gay Gauvin, Mark Plavsic

Journal:

Year:

2011

Language:

english

File:

PDF, 684 KB

english, 2011

37

Colorimetric Methods for the Determination of Nitric Oxide Concentration in Neutral Aqueous Solutions

Raymond W. Nims, John F. Darbyshire, Joseph E. Saavedra, Danae Christodoulou, Ingeborg Hanbauer, George W. Cox, Matthew B. Grisham, Franciose Laval, John A. Cook, Murali C. Krishna, David A. Wink

Journal:

Year:

1995

File:

PDF, 558 KB

1995

38

Cytosol-mediated reduction of resorufin: A method for measuring quinone oxidoreductase

Raymond W. Nims, Russell A. Prough, Ronald A. Lubet

Journal:

Archives of Biochemistry and Biophysics

Year:

1984

Language:

english

File:

PDF, 634 KB

english, 1984

39

Dealkylation of pentoxyresorufin: A rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat

Ronald A. Lubet, Richard T. Mayer, John W. Cameron, Raymond W. Nims, M.Danny Burke, Thomas Wolff, F.Peter Guengerich

Journal:

Archives of Biochemistry and Biophysics

Year:

1985

Language:

english

File:

PDF, 525 KB

english, 1985

40

Cytosol-mediated reduction of resorufin fluorescence: effects on the ethoxyresorufin O-deethylase (ETR) assay

Raymond W. Nims, Ronald A. Lubet

Journal:

Biochemical Pharmacology

Year:

1983

Language:

english

File:

PDF, 119 KB

english, 1983

41

A pleiotropic response to phenobarbital-type enzyme inducers in the F344/NCr rat: Effects of chemicals of varied structure

Ronald A. Lubet, Konstantin H. Dragnev, Dharam P. Chauhan, Raymond W. Nims, Bhalchandra A. Diwan, Jerrold M. Ward, Collins R. Jones, Jerry M. Rice, Mark S. Miller

Journal:

Biochemical Pharmacology

Year:

1992

Language:

english

File:

PDF, 1.66 MB

english, 1992

42

A markedly diminished pleiotropic response to phenobarbital and structurally-related xenobiotics in Zucker rats in comparison with F344/NCr or DA rats

Ronald A. Lubet, Raymond W. Nims, Konstantin H. Dragnev, Collins R. Jones, Bhalchandra A. Diwan, Deborah E. Devor, Jerrold M. Ward, mark S. Miller, Jerry M. Rice

Journal:

Biochemical Pharmacology

Year:

1992

Language:

english

File:

PDF, 1.14 MB

english, 1992

43

Comparative pharmacodynamics of CYP2B induction by phenobarbital in the male and female F344/NCr rat

Raymond W. Nims, Ronald A. Lubet, Collins R. Jones, Donna W. Mellini, Paul E. Thomas

Journal:

Biochemical Pharmacology

Year:

1993

Language:

english

File:

PDF, 822 KB

english, 1993

44

Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolized by cytochromes P4501A2 AND 2B, respectively, in the rat and mouse

Pratibha V. Nerurkar, Sang S. Park, Paul E. Thomas, Raymond W. Nims, Ronald A. Lubet

Journal:

Biochemical Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.28 MB

english, 1993

45

The chemopreventive agent diallyl sulfide: A structurally atypical phenobarbital-type inducer

Konstantin H. Dragnev, Raymond W. Nims, Ronald A. Lubet

Journal:

Biochemical Pharmacology

Year:

1995

Language:

english

File:

PDF, 873 KB

english, 1995

46

Metabolism of a liver-selective nitric oxide-releasing agent, V-PYRRO/NO, by human microsomal cytochromes P450

Keiko Inami, Raymond W. Nims, Aloka Srinivasan, Michael L. Citro, Joseph E. Saavedra, Arthur I. Cederbaum, Larry K. Keefer

Journal:

Year:

2006

Language:

english

File:

PDF, 204 KB

english, 2006

47

Use of the cytosensor microphysiometer to predict results of a 21-day cumulative irritation patch test in humans

Wendell E. Landin, Greg C. Mun, Raymond W. Nims, John W. Harbell

Journal:

Toxicology in Vitro

Year:

2007

Language:

english

File:

PDF, 184 KB

english, 2007

48

Regulation of gene expression of various Phase I and Phase II drug-metabolizing enzymes by tamoxifen in rat liver

Edward T. Hellriegel, George A. Matwyshyn, Peiwen Fei, Konstantin H. Dragnev, Raymond W. Nims, Ronald A. Lubet, Ah-Ng Tony Kong

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.09 MB

english, 1996

49

Induction of hepatic CYP1A in male F344/NCr rats by dietary exposure to Aroclor 1254: Examination of immunochemical, RNA, catalytic, and pharmacokinetic endpoints

Raymond W. Nims, Lisa E. Beebe, Konstantin H. Dragnev, Paul E. Thomas, Stephen D. Fox, Haleem J. Issaq, Collins R. Jones, Ronald A. Lubet

Journal:

Environmental Research

Year:

1992

Language:

english

File:

PDF, 1.91 MB

english, 1992

50

Dose-response relationships for cytochrome P450 induction by phenobarbital in the cotton rat (Sigmodon hispidus)

Collins R Jones, Ronald A Lubet, John R Henneman, Raymond W Nims

Journal:

Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology

Year:

1998

Language:

english

File:

PDF, 138 KB

english, 1998

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